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CHRONIC NON-COMMUNICABLE DISEASES

1. INTRODUCTION
       Chronic non-communicable diseases refers to many conditions which are
chronic, lifestyle related and are likely to continue progressively unless intervened.
Cardiovascular diseases, stroke, diabetes, cancer, and chronic respiratory diseases
accounted for 80% of all deaths due to non-communicable diseases 1. Mental
disorders ca0075se a significant morbidity burden. The                 prevalence    of
non-communicable diseases and the resulting number of related deaths are
expected to increase substantially in the future particularly in low and middle income
countries due to population growth, ageing in conjunction with economic transition,
changes in behavioural, occupational and environmental risk factors. The growing
population and their increased life expectancy compete intensely for the scarce
resources and reflected in the basic indicators of the country1. The global burden of
non-communicable diseases continues to grow; tackling it constitutes one of the
major challenges for development in the twenty-first century.2

2. DEFINITION
       According to WHO (2011) “Chronic disease is an impairment of bodily
structure or function that necessitates a modification of the patient’s normal
life and has persisted over an extended period of time.”

      “Chronic diseases as comprise all impairments or deviations from
normal, which have one or more of the following characteristics: Permanent,
Leave residual disability, caused by non reversible pathological alteration, It
requires special training of the patient for rehabilitation ,Maybe expected to
require a long period of supervision, observation or care” 3
                                (The commission on chronic illness in USA -1951)

      A non-communicable disease, or NCD, is a medical condition or disease
which by definition is non-infectious and non-transmissible between persons. NCDs
may be chronic diseases of long duration and slow progression, or they may result in
more rapid death. (WHO-2011)

 3. MAGNITUDE OF THE PROBLEM
3.1 Disease Burden
    As per the records of World Health Organization (WHO), 57 million people
       deaths that occurred in the world in 2008, 36 million (63%) were the result of
       NCDs.1 Four-fifths of these deaths were low, in middle-income countries, and
       29% of those deaths were in people under 60 years, compared with 13% in
       high-income countries. Without intervention, deaths from NCD are set to
       increase by 15% between 2010 and 2020, according to WHO predictions, with
       the biggest increases occurring in the African, Eastern Mediterranean and
       South East Asian regions.1
    NCDs account for more than two fifth (43 per cent) of the
       DALYs(Disability-Adjusted Life-Years) and among this group cardiovascular
       diseases, diabetes and cancer together accounted for 40 per cent of the NCD
       related DALYs in India.4,,5,6


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3.2 Socio Economic Burden
        In India, the economic impact of deaths due to cardiovascular diseases,
stroke and diabetes were estimated at 8.7 billion dollars in 2005, with a projected
rise of 54 billion dollars by 2015.1 In India, the estimated annual income loss on
account of NCD was 258 billion to 1 trillion in 2004. Of this, 32% was attributable to
cardiovascular diseases, 18% to chronic respiratory diseases and 15% to diabetes. It
is believed that non-communicable diseases (NCDs) are completely eliminated; the
estimated GDP (Gross Domestic Product) in a year would have been 4-10 per cent
higher2.

4. GAPS IN NATURAL HISTORY
There are many gaps in our knowledge about the natural history of chronic diseases.
These gaps cause difficulties in aetiological investigations and research. Those are:3
    Absence of known Agent: In most of NCDs the cause is not known.
    Multifactorial Causation: There will be many causes, in absence of causative
      agents, risk factors are studied as follows:
             An attribute or exposure that is significantly associated with
             development of disease.
             If determinant is modified by intervention, it reduces possibility of
             occurrence of disease.
             Risk factors can be causative, contributory or predictive.
             They can be modifiable or non modifiable
             They can be individual or community risk factors
             Epidemiological studies are needed to identify risk factors
    Long Latent Period: It is the period between the first exposure to suspected
      cause and the eventual development of disease. This makes difficult to link
      suspected causes with outcomes.
    Indefinite onset of the Disease: Most NCD are slow in onset and
      development. Distinction between diseased and non-diseased may be difficult
      to establish.

5. MAJOR CHRONIC NON-COMMUNICABLE DISEASES
As per WHO (World Health Organization) Working Group, the following disease
conditions are the major chronic non-communicable diseases.7
    Diabetes Mellitus
    Cardio-Vascular Diseases
    Cancer
    Stroke
    Chronic Respiratory Diseases (CRD)
    Mental and Behavioural Disorders

5.1 DIABETES MELLITUS
        It is a chronic disorder characterized by raised blood sugar levels that occur
when the pancreas does not produce enough insulin or when the body cannot
effectively use the insulin it produces. Uncontrolled diabetes may lead to serious
damage to many of the body's systems, especially the nerves and blood vessels.3



                                          2
5.1.1 Magnitude of the Problem
      Disease Burden
        The number of diabetics in India is expected to increase from 51 million in
        2010 to 87 million by2030.8
        Currently 39.5 million people in India have pre diabetes, and of them, seven
        million people will develop diabetes every year.9
        Epidemiological studies indicate that the prevalence of diabetes is higher in
        urban India, and is increasing faster as compared to the rural population.

     Socio Economic Burden
      An individual with diabetes may spend around twice as much on medical care
      compared to a contemporary individual without diabetes.
      While the mean direct annual cost for outpatient care for all patients with
      diabetes in India was Rs 4724/-, those without complications had an 18%
      lower cost.5
      Being diagnosed with diabetes is traumatizing and imposes a long term
      psychological burden on the individual and the family.
      Complications from diabetes, such as diabetic neuropathy, amputations, renal
      failure and blindness are the major causes of disability.

5.2 CARDIO-VASCULAR DISEASES
Cardio Vascular Diseases (CVDs) are a group of disorders of the heart and blood vessels, it
 includes the following: 10
     a) Coronary Heart Disease (CHD)
     b) Cerebro Vascular Disease
     c) Peripheral Arterial Disease
     d) Rheumatic Heart Disease
     e) Congenital Heart Disease
     f) Deep Vein Thrombosis and Pulmonary Embolism
 Here, we will deal exclusively with Coronary Heart Disease (CHD), the most important cause
 of deaths among cardiovascular diseases.

 5.2.1 CORONARY HEART DISEASE (CHD)
  Coronary Heart Disease is a disease of blood vessels in which arteries that provide blood
 and oxygen to the heart muscles are get narrowed or even completely blocked that leads to
 heart attacks.3

 5.2.1.1 Magnitude of the Problem
      Disease Burden
  Coronary Heart Disease is the leading cause of death in India, accounted 2.25 million
     deaths in 2010 (excluding stroke) and is projected to reach 2.94 million deaths in 2015 5,11
      Socio-economic burden
  India is estimated to have lost 8.7 billion dollars in 2017 because of Coronary heart disease.5




                                                3
5.3 CANCER
        Cancer is a term used for disease in which cells of the body grows and divide in an
 uncontrolled manner to produce abnormal cells. These cancer cells invade adjoining parts of
 the body and may spread to other organs. This process of spread to distant organs is called
 metastasis which is a major cause of death in cancer. Cancer can affect any part of the body.
 Cancer is also known as malignancies and neoplasms.1, 3

 5.3.1 Magnitude of the Problem
       Disease Burden
        Cancer is one of the leading causes of death among adults in India, annually
     accounting for about 9, 49,000 new cases and 6, 34,000 deaths in 2010. 12

      Socio Economic Burden
     Males with cancer are likely to have a 43.9% greater likelihood of imposing catastrophic
 expenses on their households and a 24% greater likelihood of impoverishing their
 households than matched counterparts without cancer. They also use more health care
 services in both the public and the private sectors. Females with cancer also report higher
 health care use, health spending, and risks of impoverishing their households than their
 matched counterparts.2


 5.4 STROKE
         A stroke is caused by the interruption of the blood supply to the brain, usually
 blood vessels may rupture or blocked by a clot. This cuts off the supply of oxygen
 and nutrients, causing damage to the brain tissues. A Transient Ischemic Attack
 (TIA) is a transient episode of loss of brain function caused by blockage of blood flow
 in the arteries of the brain. The symptoms of TIA improve within 24 hours.3

 5.4.1 Magnitude of the Problem

     Disease Burden
      Strokes are estimated to have caused 1.45 million cases in India during 2010
      with projected increase to 1.67 million cases in 201513.
      The average age of stroke patients in India is seen to be less than that in
      developed countries and affects the most productive part of their life.
      Many of the stroke patients are left with permanent disability. Common
      disabilities include pain, stiffness, depression, memory loss, and difficulty in
      speaking and understanding.

     Socio Economic Burden
      India is estimated to have lost 8.7 billion dollars in 2005 because of stroke and
      projected to lose 54.0 billion dollars in 2015 due to this disease.5, 13.

5.6 CHRONIC RESPIRATORY DISEASES (CRD)
        Chronic respiratory diseases (CRD) include a large number of chronic
 diseases of the lungs and respiratory systems. The most common Chronic
 Respiratory Disease which causes an enormous health burden is chronic obstructive
 pulmonary disease (COPD). COPD is a continuously progressive disease which
 leads to marked breathing disability ultimately resulting in premature deaths. 14

                                               4
5.6.1 Magnitude of the problem

     Disease Burden
     According to the Million Deaths Study (2001-2003), the chronic respiratory
      diseases were the second commonest cause of death in Indians in the age
      group of 25-69 years, after cardiovascular diseases15.
     The Disability Adjusted Life Years (DALY) lost due to Chronic respiratory
      diseases (CRDs) was estimated as 3% of 291 million for all NCDs, i.e. around
      8.7 million DALYs in 200516.

     Socio Economic Burden
     The annual cost of treatment of COPD has been estimated to be over Rs.
      35,000 crores for the year 2011 and over Rs. 48,000 crores for 201617.
     Psychological and economic burden is imposed on the families due to
      progressive disease disability, frequent exacerbations and hospitalizations.
     COPD in children poses psychological stress for themselves as well as their
      parents and results in poor educational performance.

 5.7 MENTAL AND BEHAVIOURAL DISORDERS
        Mental and behavioural disorders are conditions that lead to disturbances in
 thinking, feeling, emotions, reactions, intelligence, judgment, decision making and
 behaviour. The presence of these disorders can impair a person's ability to deal with
 ordinary demands of the life. These conditions are varied in nature and intensity,
 ranging from minor disorders such as anxiety, depression, simple phobias, and
 substance abuse such as alcohol, tobacco to severe forms of illness like as
 schizophrenia, mood disorders and severe mental retardation. The disorders may
 also be specific to certain age groups (children & elderly) and with specific reference
 to some situations (aftermath of disasters).18

 5.7.1 Magnitude of the Problem

     Disease Burden
     As per WHO, the global prevalence of mental and behavioural disorders are
      estimated to be about 10% and they constitute four of the 10 leading causes
      of disability (15% of DALYs lost) with one in four families suffering the
      burden.1
     About 1, 50,000 deaths are estimated to occur due to suicides in India every
      year. Apart from greater vulnerability and socio-cultural attitudes, people from
      lower income levels also do not have access to quality mental health care.
      The age group of 15-49 years are affected with most mental disorders except
      those disorders specific to pediatric and geriatric age groups.19, 20

     Socio-Economic Burden
     Apart from direct costs of travel, medication, hospital visits and rehabilitation,
      the indirect productivity losses due to mental disorders are more significant.
     Mental disorders cause significant amount of disabilities in the affected, which
      affect their education, occupation, married life, social and recreation activities
      and interfere in productivity and quality of life 21.



                                           5
Selected Mental Health, Neurological and Behavioural Disorders: All India estimates
for the year 2010 shown in figure-1 21




6. OTHER CHRONIC NON COMMUNICABLE DISEASES INCLUDE                                 23,07



        Chronic Kidney Disease                    Hearing Loss
        Congenital Diseases                       Autism Spectrum Disorders (ASD)
        Iodine Deficiency Disorders               Fluorosis
        Oro-Dental Diseases                       Hereditary Blood Disorders
        Injuries                                  Burns
        Dementia                                  Epilepsy
        Musculo Skeletal Disorders                Geriatric Disorders
        Disasters

7. RISK FACTORS
       The underlying socio-economic, cultural, political and environmental
determinants for NCDs include Globalization, Urbanization and Population ageing.
The risk factors for NCDs are classified in terms of their amenability to interventions
as modifiable risk factors, non-modifiable risk factors and intermediate risk factors. 3,4

7.1 Modifiable Risk Factors
 Tobacco Use
    Tobacco consumed in any form, whether smoked or chewed and second-hand
tobacco smoke exposures are associated with adverse health effects. It is
associated with cardiovascular diseases, cancers, chronic respiratory disease, and
other communicable and non communicable diseases.
 Alcohol Consumption
    There is a direct relationship between higher levels of alcohol consumption and
rising risk of cardiovascular diseases and some liver diseases. Heavy episodic
drinking (binge drinking) is especially associated with cardiovascular diseases.




                                            6
 Consumption of Fruits, Vegetables and Processed Food
    Inadequate consumption of fruits and vegetables (less than five servings /day)
increases the risk for cardiovascular diseases, stomach cancer and colorectal
cancer. The consumption of high levels of high-energy foods, such as processed
foods that are high in fats and sugars, promotes obesity. Consumption of > 5 gram of
dietary salt/ day predisposes to higher blood pressure levels and increased risk of
cardiovascular diseases. Consumption of high amounts of saturated fats and transfat
increases the risk of coronary heart disease and diabetes.
 Physical Inactivity
    Low physical activity is an important cause of overweight and obesity.
Participation in 150 minutes of moderate physical activity for every week or
equivalent activity is estimated to reduce the risk of cardiovascular disease,
diabetes, breast and colon cancer, and depression.
 Poverty
    Poverty means that there is less purchasing power in the homes. This low
purchasing power results in compromising on the choices that is made at the
household level. This results in major health-damaging behaviors such as tobacco
use, harmful use of alcohol, inadequate consumption of fruits and vegetables and
preferential use of less expensive and unhealthy foods among the vulnerable and
marginalized groups of people.
 Environment
    Environmental risk factors are contributing to the NCD’s’ like as Air Pollution,
water Pollution, Occupational Hazards and Exposure to Radiation.
 Inadequate Health Services
    Failure and inability to obtain preventive health services such as screening,
regular follow up are major predisposing factors to the NCDs. Also, some late
diagnosis of disease conditions, untreated infections may lead to carcinomas.
 Stress Factors
    Acute and chronic stresses such as Homelessness, Stressful work conditions
and Situations as in Natural and Manmade Disasters are major causes for many
physiological and psychological disorders.

7.2 Non modifiable risk factors

The Risk factors, which cannot be modified are called as non-modifiable risk factors,
as follows:
 Age: Elderly and children are the vulnerable group to get the diseases basically.
 Sex: There will be some difference between the disease ratios among the
    gender.
 Family History of Genetic Factors: Genetic factors are major risk factors which
    cannot be modified.
 Personality: Individual personality may contribute in development of the non
    communicable diseases.

7.3 Intermediate Risk Factors
     Obesity and Overweight (overweight (BMI>=25) or Obese (BMI>=30))
       Physical inactivity and inappropriate nutrition are directly reflected in the
growing burden of overweight in the Indian population predominantly in the urban
areas. Central obesity is an important risk factor for diabetes and appears to better
predict the risk of diabetes among Indians in Asian region.

                                         7
 Hyperlipidemias(>200 mg/dl)
       People with hyperlipidemias (most often high cholesterol) are at increased risk
of ischemic heart diseases, stroke, and other vascular diseases.
        Raised blood Pressure (>120/80 mmhg)
       Raised blood pressure is considered as modern life style disorder in the
present scenario. It is a major risk factor for cardiovascular diseases.
        Raised Blood Glucose(>120 mg/dl)
       Raised blood glucose increases the propensity to macro vascular and micro
vascular complications, such as cardiovascular diseases, cerebro vascular disease,
retinopathy, nephropathy, neuropathy and diabetic foot, all of which account for
considerable mortality and morbidity

8. IMPACT ON ECONOMIES, HEALTH SYSTEMS, HOUSEHOLDS AND
INDIVIDUALS

       The impact of the mounting NCD challenge cannot be fully understood
 without considering the broad range of direct and indirect effects on economies
 and health systems, as well as on the affected individual and his or her household.
 These effects, in aggregate, drive economic and human development outcomes
 including the decreased country productivity and competitiveness, greater fiscal
 pressures, diminished health outcomes, increased poverty and inequity, and
 reduced opportunities for society, households and individuals 2,5,14
Impact on Economies
       Reduced labor supply and outputs
       Additional costs to employers
       Lower returns on human capital investments
       Lower tax revenues
       Increased public health and social welfare expenditures
Impact on Health systems
        Increased consumption of NCD-related healthcare
        High medical treatment costs (per episode and over time)
        Demand for more effective treatments (e.g., cost of technology and
        innovation)
        Health system adaptation and costs. (e.g., organization, service delivery,
        financing)
Impact on Households and Individuals
        Reduced well-being
        Increased disabilities
        Premature deaths
        Household income decreases, or impoverishment, Savings and assets loss
        Higher health expenditures, including catastrophic spending
9. PREVENTION OF NON-COMMUNICABLE DISEASES
  Prevention of NCDs can be done through following method 3,11
   Primordial prevention: Through the prevention of emergence or development
     of risk factors in the population or in the countries in which they have not yet
     appeared. Efforts are directed towards discouraging children from adopting
     harmful life styles.


                                          8
 Primary prevention: Action taken prior to the onset of disease which removes
   the possibility that the disease will ever occur. Effort will be done through health
   promotion and specific protection
  Secondary prevention: Action which halts the progress of the disease at its
   incipient stage and prevents complications.
  Tertiary prevention: All measures available to reduce impairments and
   disabilities minimize suffering due to departure from good health and promote
   patient’s adjustment to irremediable conditions. Effort will be done through
   disability limitations and rehabilitation

10. GLOBAL AND NATIONAL EFFORTS TOWARDS “NCD” CONTROL
IN INDIA

10.1 Innovation to Counter NCD.
        The World Health Assembly held in the month of May 2012 set a global target
to reduce deaths under 70 years of age due to NCD by 25% before 2025. Innovation
will be essential to achieve this target; the innovations may act on the biological risk
factors of NCD such as hypertension, high blood sugar, high blood lipids and
obesity, on the behavioural risk factors like as tobacco, poor diet, physical inactivity
and the harmful use of alcohol or on the social determinants of NCD. The types of
innovation WHO identified are: biological and information technology, medical
devices, changes in the workforce, greater involvement of patient’s and civil society
and organizational innovations. 22

10.2 Drivers of Innovation Diffusion
       To have impact, innovations must diffuse widely, but within health systems
they all too often do not diffuse.
Drivers of diffusion include: Professional discussion by stakeholders like market,
consumers, government, international organizations and business.

However, there are some barriers, those are:
     Existing healthcare providers and professional hierarchies might resist
        changes that threaten their dominance and income
     Fears that innovations will not be safe and the risk that financial benefits
        from the innovation might occur in a different budget from that of the costs,
        and might take some years to become visible and be appreciated.

       India has shown its commitment to prevention and control of NCDs. India was
among the first signatories to the Framework Convention for Tobacco Control
(FCTC) and has endorsed the Global Strategy on Diet, Physical Activity and Health.
The Government of India has implemented legislations and policies in accordance
with the FCTC.22

10.3 Ongoing National Programmes for prevention & Control of Non
Communicable Diseases:
   Government of India had supported the States in Prevention and Control of
 NCDs through several vertical programmes. They are as follows: 23
    National Cancer Control Program (1975)
    National Blindness Control Program (1976)

                                           9
   National Mental Health Program (1982)
      National Iodine Deficiency Disorders Control Program (1986)
      National Tobacco Control Program (2007)      th
      Trauma Care Facility on National Highways(9 Plan)
      National Deafness Control Program (2006-07)
      National Program for Prevention and Control of Fluorosis (2007-08)
      Pilot Project on Oral Health (2007-08)
      National Program for Prevention & Control of Cancer, Diabetes,
       cardiovascular diseases (CVD) and Stroke (2010-11)
      National Program for Health Care of the Elderly (2010-11)
      Pilot Program for Prevention of Burn injuries (2010-11)
      Up gradation of Department of Physical Medicine & Rehabilitation (PMR) in
       Medical Colleges (2010-11)
      Disaster Management/Mobile Hospitals (2010-11)
      Organ and Tissue Transplant biomaterial centers (2010-11)

11. WHO BEST BUYS FOR CONTROL OF NON-COMMUNICABLE
DISEASES
    World Health Organization has led global efforts to address NCDs through
      development of different instruments. Those are Population level interventions
      and Individual Level Interventions.7,23,24
11.1 Population level Interventions
    NCDs can best be addressed by a combination of primary prevention, targeting
whole population, by measures that targeting high-risk individuals and by improved
access to essential health-care interventions for people with NCDs.
     Enforcing bans on tobacco advertising, promotion and sponsorship.
     Raising taxes on tobacco.
     Strong legislative effort for tobacco control: Government of India had ratified
        the National Anti-Tobacco Legislation in 2007, which bans smoking in public
        places throughout the country.
     Restricting access to retailed alcohol.
     Enforcing bans on alcohol advertising.
     Raising taxes on alcohol.
     Promoting salt reduction in the community through awareness generation
        and reducing salt content of processed foods.
     Regulatory mechanism for fruits and vegetable prices.
     Promoting public awareness about diet (Replacing trans-fat in food with
        polyunsaturated fat) and physical activity, through mass media.
     Comprehensive policies on food production, nutrition, marketing, and
        transport to promote primordial prevention of CVDs. (Cardio-vascular
        diseases)
     Modifying the environment (building the play grounds & parks for relaxation).
     Promoting use of cleaner alternate fuels in kitchens.
     Improved monitoring and strict enforcement of air quality norms in urban as
        well as rural areas.
     Public education on air-quality and measures to reduce air pollution.
     Developing alternative financing models that protect citizens from the
        catastrophic financial impact of chronic diseases including CVDs.(Cardio-
        vascular diseases)

                                         10
 A major initiative in CVD control has been the launch of the National
        Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular
        Diseases and Stroke [NPCDCS) in 2010. This envisages early diagnosis,
        risk reduction, and appropriate management of these diseases at primary
        health care level.
      Protection from occupational carcinogens
      Protection against HBV( Hepatitis B virus) and HPV (Human papilloma virus)
        by vaccination
 The National Cancer Control Programme was revised in 1984. This programme has
now been integrated into the National Programme for Prevention and Control of
Cancer, Cardiovascular Diseases, Diabetes and Stroke since 2011. The data on
cancer is collected by hospital and population based cancer registries, collated and
published by the National Cancer Registry Programme (NCRP) of the Indian Council
of Medical Research (ICMR).

11.2 Individual Level Interventions
    Screening and early diagnosis of disease in all health care settings
    Individual health education towards prevention of diseases and promotion of
     health.
    Counselling, drug therapy, specific treatment and rehabilitations.

12.STRENGTHENING HEALTH SYSTEMS TOWARDS NCDs IN INDIA23
    Development and implementation of clinical practice guidelines and standards at
     different levels of health care centre.
    Adequate supply of drugs at all health care centre
    Providing better counseling services for lifestyle changes including cessation
     of tobacco use and Public education about diabetes and its complications.
    A multi-sectoral approach beyond the health sector is required to curb the
     diabetes epidemic, for example, labeling of food items with nutrition facts,
     making healthy food options available at schools and workplaces, compulsory
     physical activities in educational institutes.
    Training of primary health care staff in management of chronic respiratory
     diseases.
    Cancer awareness and screening for cervical, breast and oral cancer should be
     introduced at the primary health care level in the National Rural Health Mission
     (NRHM).
    Diagnostic and management facilities for above said cancers should be introduced at
     the district level.
    Specialized treatment services for cancers in medical colleges and other hospitals.
    Home support for palliative and rehabilitative services should be introduced at the
     primary health care level.
    Training of doctors and nurses to identify and manage all kind of diseases
    Establishment of vascular (cardiac and stroke] units at district level and
     medical college hospitals.
    Establishment of ambulance and referral systems.
    Greater investment in infrastructure and manpower to improve capacity for prevention
     and control of NCDs.
    Accreditation to improve quality of care at different levels, including private sectors.



                                            11
12.1 National Effort towards Mental Health Problems24

     Policy & Health System Interventions

        Revised District Mental Health Programme incorporating public health
        approaches to cover all districts
        Implementation of the revised Mental Health Care Act to facilitate rights of the
        mentally ill along with strengthening of implementation
        Capacity building of policy makers and programme managers to enhance
        mental health care delivery, implementation, monitoring and evaluation
        Human resource development with training of doctors, health care workers
        and peripheral workers
        Expanding the role of mental hospitals and medical college psychiatry units to
        integrate preventive, curative, promotive and rehabilitative services along with
        manpower development and research
        Strengthening educational and employment opportunities for those who have
        recovered from mental disorders
        Integrating mental health with other activities in health sector with AYUSH
        systems of medicine, and other related sectors
        Involvement of NGOs in stigma reduction, rehabilitation, public awareness
        building and advocacy issues.
    India has a National Mental Health Programme for more than 25 years with
curative, preventive, promotive and rehabilitative components covering policy and
programme issues. The programme is at present being implemented across 100
districts and is likely to be expanded to the entire country during 2012-17.

13. SPECIFIC ACTIONS BY DIFFERENT STAKEHOLDERS
       There are some specific actions to be performed by the stakeholders in the
society to prevent and control of NCDs.7
 Government
   a. Revision of National Health Policy to address NCDs or formulate a NCD
       Policy.
   b. Setting-up an Inter-Ministerial Group or Group of Ministers to address critical
       inter-sectoral issues (urban development, road transport, agriculture, food
       processing, finance, human resource development, information and
       broadcasting, industry, trade & commerce, communications)
   c. Assessing health impact of all major developmental programmes
   d. Adopting regulatory and fiscal measures to influence dietary behaviour
       (regulation of sugar, salt and transfat in food products) tobacco and alcohol
       use
   e. Creating a National Health Promotion Foundation to co-ordinate and catalyze
       all activities related to NCDs

Individuals
   a. Adopting healthy lifestyle and motivating others to do so.
   b. Being an aware and responsible citizen - following regulations and insisting
       others also to do so
   c. Monitoring and changing the behaviour of children (watching TV, diet,
       physical activity) in the family.

                                          12
Communities/Schools/Workplaces
  a. Creating an healthy environment for adoption of healthy behavior
  b. Supporting implementation of regulations
  c. Creating and maintain facilities for physical activity / healthy diets
  d. Incentivizing good behaviours and disincentives the inappropriate behaviors.

Health Professionals
  a) Taking leadership role at individual level as well as community level to
      advocate lifestyle changes
  b) Developing / implementing guidelines for prevention and management of
      NCDs
  c) Strengthening the capacity of health workforce to address NCDs
  d) Conducting appropriate epidemiological, operational and translational
      research to address NCDs.

Non Governmental Organizations
  a)
     Mobilizing the community to adopt Healthy Lifestyles
  b)
     Change the societal "norms"
  c)
     Being a watchdog and monitor implementation of regulations.
14. PLAN OF ACTION TO PREVENT AND CONTROL OF NCDS DURING
12th PLAN
  A comprehensive approach would be required for both prevention and
  management of NCDs in the country. It is proposed to continue ongoing efforts
  and introduce additional programmes to cover important NCDs for public health
  importance through following key points7,24
14.1 KEY COMPONENTS OF NCD PREVENTION AND CONTROL PROGRAMMES
INCLUDE:
 Formulation and implementation of comprehensive policies and programmes to
   address NCDs.
 Strengthening of health system in terms of human resource availability,
   development of standard management guidelines, training at all levels of human
   resources, ensuring availability of drugs and equipments. The role of private
   sector is also important in this regard.
 As NCDs require lifelong treatment and often require costly health care
   interventions, a sustainable and equity-based health financing system needs to
   be set up. This is required to ensure universal coverage for prevention and
   control of NCDs.
 Currently, the surveillance efforts and information system in the country are
   disjointed, ad-hoc and inadequate. There is an urgent need to bring them under a
   common umbrella and integrate it with ongoing disease surveillance systems.

14.2 IMPLEMENTATION


   To ensure long term sustainability of interventions, the programmes would
be built within existing public sector health system and wherever feasible introduce
public private partnership models. Following will be major components of NCD
programmes:

                                        13
 Primary Health Care includes Health promotion, screening , basic medical
    care, home based care & referral system (to be integrated with NRHM-
    National Rural Health Mission)
   Strengthening District Hospitals for diagnosis and management of
    NCDs including rehabilitation and palliative care, NCD Clinic, Intensive Care
    Unit, District Cancer Centre, Dialysis services, Geriatric Centre,
    Physiotherapy Centre, Mental Health Unit, Trauma & Burns Unit,
    strengthening of facilities for Orthopaedic, Oro-dental, Eye and ENT
    Departments, Tobacco Cessation Centre, Obesity Guidance Clinic.
   Tertiary Care for advanced management of complicated cases including
    radiotherapy for cancer, cardiac emergencies including cardiac surgery,
    neurosurgery, organ transplantation.
   Emergency medical care and rapid referral system including Highway
    Trauma Centres and 108 emergency services.
   Health Promotion & Prevention includes legislation, population based
    interventions, Behaviour Change Communication using mass media, mid-
    media and interpersonal counselling and public awareness programmes in
    different settings (Schools, Colleges, Work Places and Industries).

14.3 ESTIMATED BUDGET DURING 12TH FIVE YEAR PLAN

      It is envisaged that for comprehensive and sustainable programme to
prevent, control, manage important non-communicable diseases and key risk
factors across the country, a large investment would be required during the 12th
Plan, Rs. 58,072 crore would be required over the period of 2012-17.

14.4 EXPECTED OUTCOMES

      The programmes and interventions would establish a comprehensive
sustainable system for reducing rapid rise of NCDs, disability as well as deaths due
to NCDs. Broadly, following outcomes are expected at the end of the 12th Plan are:

a) Early detection and timely treatment leading to increase in cure rate and
   survival.
b) Reduction in exposure to risk factors, life style changes leading to reduction in
   NCDs.
c) Improved mental health and better quality of life.
d) Reduction in prevalence of physical disabilities including blindness and
   deafness.
e) Providing user friendly health services to the elderly population of the country
f) Reduction in deaths and disability due to trauma, burns and disasters.
g) Reduction in out-of-pocket expenditure on management of NCDs and thereby
   preventing catastrophic implication on affected individual and families.




                                        14
15. AYUSH and NCDs
         The representative of Government of Sikkim, shared their experience of
controlling NCDs through AYUSH (Ayurveda, Yoga, Unani, Siddha and
Homeopathy) intervention. They also stated that they have identified 72% of
disease of hypertension in a particular village has been considerably brought down
through the AYUSH intervention. Govt of India, and Department of AYUSH with
state health secretaries on 25.4.2012 determined that AYUSH professional and
facilities to be geared up for assisting national health programmes under NPCDCS
(National Programme for Prevention and Control of Cancer, Diabetes,
Cardiovascular disorders). Also, they said Training and IEC (Information Education
Communication) material on preventive & promotive role of AYUSH system in
controlling NCDs would be prepared by Department of AYUSH for sharing with
States.25
16. GLOBALIZATION AND ITS IMPLICATIONS FOR HEALTH CARE
AND NURSING PRACTICE
 Globalization describes the increasing economic and social interdependence
  between countries. Nursing is challenged with responding to the changing health
  needs of the global population that have arisen as a result of globalization. 26
 The World Health Organization (WHO) Global Forum for Government Chief
  Nursing and Midwifery Officers (GCNMO) took place on May 16-17th, 2012, while
  the Triad meeting, Nursing leaders discussed how to strengthen the role of
  nursing and midwifery in NCDs. Leaders agreed that in order to tackle the issue
  of NCDs, continuous development is needed in nursing education, research, and
  nursing leadership in policy. All nursing leaders fully agreed that the issue of
  NCDs should be mediated by nurses using an upstream approach rather than a
  downstream approach. In the downstream approach, nurses treat a problem that
  is already occurred. In the upstream approach, nurses prevent the consequences
  by using their skills and knowledge to educate the patient and prevent the
  disease from occurring in the first place.27
17.0 CONTRIBUTION TOWARDS PREVENTION AND TREATMENT OF
“NCDs” BY NIMHANS
NIMHANS is one of the exceptional foundations rendering wide-range care towards
non communicable diseases through following activities
    Preventive, Promotive Rehabilitative health care has been provided through
      the multidisciplinary team members includes Nurses, Psychiatrist, and
      Neurologist, Neurosurgeons, Psychologist, Social workers, Yoga therapist,
      Ayurvedic personnel and supportive workers from all the departments.
    Community health unit is providing its continuous extraordinary
      comprehensive services through the organizational employees and graduate
      and post graduate students towards NCDs and other diseases in community.




                                       15
 The epidemiology department is giving tremendous support by doing the
       surveillance among all the NCDs. Several research projects with focus on risk
       factors (tobacco, alcohol, stress, physical inactivity, unhealthy diet, along with
       large number of mental health behaviours) have been completed in the
       department. The findings have resulted in developing intervention
       programmes and follow-up studies at different levels.
    Continuous ongoing research work has been performed by all departments
       towards NCDs especially, stroke, epilepsy, psychiatric disorders, other
       neurological and neurosurgical disorders, injuries, genetic disorders and
       psychosocial problems in all age groups.
    Health education and publication departments are delivering incredible, effort
       towards NCDs through awareness programs.
    NIMHANS is one of the major collaborators with Fogarty Indo-US Training
       Program on Chronic Non-Communicable Diseases (CNCD) Across Lifespan
       to reduce the training gap and increase research capacity for CNCDs,
    NIMHANS contributes its enormous effort on Health Policies and National
       Health Programs to prevent and control NCDs, especially District and National
       Mental Health Programs.
18. RESEARCH ABSTRACT
       Decola P et al (2012) highlighted in their stratified representative research
survey of 1600 nurses in eight countries were conducted to understand better, how
nurses perceive their roles in addressing risk factors associated with NCDs as well
as the types of supports required in order to facilitate this work. The study also
explores nurses' changing views of the profession and their practice environment.
Key findings included that 95% of nurses wanted to use their knowledge, skills and
time to educate individuals on the threat and prevention of NCDs, but workload, time
constraints and their perception towards the job of nursing hinder them from
achieving their potential.28
19. CONCLUSION

        Within a couple of decades, NCDs are poised to dominate the health care
needs in most low and middle income countries and to exact a significant human and
economic toll on countries and their population. Despite the magnitude of the
challenges, there is considerable scope for action. Improved health care, early
detection and timely treatment is another effective approach for reducing the impact
of NCDs. Health systems need to be further strengthened to deliver an effective,
realistic and affordable package of interventions and services for people with NCDs.




                                           16
20. REFERENCES

 1.    World Health Organization, Ministery of family welfare. Draft Background paper.
       National Summit on non communicable disorder. New Delhi; 2011;1-30
 2.    Ajay Mahal, Anup Karan, Michael Engelgau. The Economic Implications for Non-
       communicable Disease for India. The World Bank. Jan 2010.
 3.    Park.k. Preventive and Social Medicine.19th Edition. Jabalpur: M/S Banarsidas
       Bhanot publication; 2007. 301-345
 4.    World Health Organization. Global status report on non-communicable diseases.
       Geneva: 2010; 10-30,40,56
 5.    Ministry of Health & Family Welfare, GOI. Report of the National Commission
       on Macroeconomics and Health. New Delhi: 2005;19-20, 276
 6.    Joshi R, Cardona M, Iyengar S, Sukumar A, Raju CR, Raju KR, Raju K, Reddy KS,
       Lopez A, Neal B. Chronic diseases now a leading cause of death in rural India--
       mortality data from the Andhra Pradesh Rural Health Initiative. International Journal
       Epidemiology ; December; 35(6); 2006 ;1522-9
 7.    Report of the Working Group on Disease Burden for 12th Five-year
       Plan,No.2(6)2010-Ministry of Health and Family Welfare, Government of India
       Planning Commission. Yojana Bhavan. New Delhi :Dated 9th May 2011;10-60
 8.    International Diabetes Federation.IDF Diabetes Atlas.4th Edition. December 2009
 9.    Mohan V, Mathur P, Deepa R, Deepa M, Shukla DK, Menon GR, Anand K, Desai
       NG, Joshi PR Mahanta J, Thankappan KR, Shah B. Urban rural differences in
       prevalence of self-reported diabetes in India. The WHO-ICMR Indian NCD risk factor
       surveillance. Diabetes research and clinical practice. 2008; 80:159-168
 10.   World Health Organization. A Prioritized Research Agenda for Prevention and
       Control of Non-communicable Diseases. 2011; 13, 39 (http://www.who.int / about /
       licensing / copyright_form/en/index.html).
 11.   National Institute of Medical Statistics and Indian Council of Medical Research
       (ICMR), 2009, IDSP Non-Communicable Disease Risk Factors Survey, Phase-I
       States of India. National Institute of Medical Statistics and Division of Non-
       Communicable Diseases. Indian Council of Medical Research. New Delhi: India:
       2007-08.
 12.   Ramnath Takiar, Deenu Nadayil, A Nandakumar. Projections of Number of Cancer
       Cases in India (2010-2020) by Cancer Groups. Asian Pacific Journal of Cancer
       Prevention. 2010;Vol 11: 1045
 13.   Ministery of health and family welfare .National commission on macro economics
       and health background papers. GOI. Burden of disease in India forecasting vascular
       disease cases and mortality in India: P207.
 14.   D. Wayne Taylor. The Burden of Non- Communicable Diseases in India. The
       Cameron Institute. 2010;1-10
 15.   Ministry of Home Affairs. Report on causes of death in India. Office of the Registrar
       General of India. New Delhi: 2009; pp 17
 16.   Reddy KS, Shah B, Varghese C, Ramadoss A. Responding to the challenge of
       chronic diseases in India. Lancet. 2005:366:1744-1749.



                                            17
17.   ICMR study .Indian Study on the Asthma, Respiratory symptoms and Chronic
      Bronchitis- (INSEARCH- 2006-09). 2010;p20-28
18.   Vyas J N ,Niraj Ahuja.Text book of post graduate psychiatry. Second Edition. New
      Delhi;Jaypee brothers; 2003.
19.   Gururaj et .al Alcohol related harm. Implication for public health and policy in India
      Nimhans: 2011.
20.   WHO. Investing in mental health. www.who.int / entity / mental.../ Zambia% 20
      Country%20 report.pdf:2003; Page.No. 08-10
21.   WHO country office for India. Mental and Behavioural disorders (2011)
      http://www.whoindia.org; Page No 1-2
22.   Richard Smith, Paul, Corrigan & Christopher Exeter. Countering non-communicable
      disease through innovation. Report of the Non-Communicable Disease Working
      Group. The global health policy summit. 2012;p1-20
23.   Olusoji Adeyi, Owen Smith, Sylvia Robles. Public Policy and the Challenge of
      Chronic Non-communicable Diseases. The world bank .Washington.D.C:2007p;1-
      27,103
24.   World Health Organization. 2008-2013 action plans for the global strategy for the
      prevention and control of non-communicable diseases. Prevent and control
      cardiovascular diseases, cancers, chronic respiratory diseases and diabetes.
      2008:1-34
25.   Department of AYUS, GOI. Minutes of meeting. New Delhi: 17 th may; 2012
26.   Bradbury-Jones C. Globalization and its implications for health care and nursing
      practice. Nurs Stand. 2009; Feb 25-Mar 3; 23 (25): 43 – 7. [Pub Med-indexed for
      MEDLINE)
27.   http:// nursing. duke. Edu / news / nurses-world-address-non communicable-
      diseases student%E2%80%99s-viewpoint, May 25; 2012
28.   Decola P., Benton D., Peterson C., & Matebeni D. Nurses' potential to lead in non-
      communicable disease global crisis. International Nursing Review;2012




                                            18

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  • 1. CHRONIC NON-COMMUNICABLE DISEASES 1. INTRODUCTION Chronic non-communicable diseases refers to many conditions which are chronic, lifestyle related and are likely to continue progressively unless intervened. Cardiovascular diseases, stroke, diabetes, cancer, and chronic respiratory diseases accounted for 80% of all deaths due to non-communicable diseases 1. Mental disorders ca0075se a significant morbidity burden. The prevalence of non-communicable diseases and the resulting number of related deaths are expected to increase substantially in the future particularly in low and middle income countries due to population growth, ageing in conjunction with economic transition, changes in behavioural, occupational and environmental risk factors. The growing population and their increased life expectancy compete intensely for the scarce resources and reflected in the basic indicators of the country1. The global burden of non-communicable diseases continues to grow; tackling it constitutes one of the major challenges for development in the twenty-first century.2 2. DEFINITION According to WHO (2011) “Chronic disease is an impairment of bodily structure or function that necessitates a modification of the patient’s normal life and has persisted over an extended period of time.” “Chronic diseases as comprise all impairments or deviations from normal, which have one or more of the following characteristics: Permanent, Leave residual disability, caused by non reversible pathological alteration, It requires special training of the patient for rehabilitation ,Maybe expected to require a long period of supervision, observation or care” 3 (The commission on chronic illness in USA -1951) A non-communicable disease, or NCD, is a medical condition or disease which by definition is non-infectious and non-transmissible between persons. NCDs may be chronic diseases of long duration and slow progression, or they may result in more rapid death. (WHO-2011) 3. MAGNITUDE OF THE PROBLEM 3.1 Disease Burden  As per the records of World Health Organization (WHO), 57 million people deaths that occurred in the world in 2008, 36 million (63%) were the result of NCDs.1 Four-fifths of these deaths were low, in middle-income countries, and 29% of those deaths were in people under 60 years, compared with 13% in high-income countries. Without intervention, deaths from NCD are set to increase by 15% between 2010 and 2020, according to WHO predictions, with the biggest increases occurring in the African, Eastern Mediterranean and South East Asian regions.1  NCDs account for more than two fifth (43 per cent) of the DALYs(Disability-Adjusted Life-Years) and among this group cardiovascular diseases, diabetes and cancer together accounted for 40 per cent of the NCD related DALYs in India.4,,5,6 1
  • 2. 3.2 Socio Economic Burden In India, the economic impact of deaths due to cardiovascular diseases, stroke and diabetes were estimated at 8.7 billion dollars in 2005, with a projected rise of 54 billion dollars by 2015.1 In India, the estimated annual income loss on account of NCD was 258 billion to 1 trillion in 2004. Of this, 32% was attributable to cardiovascular diseases, 18% to chronic respiratory diseases and 15% to diabetes. It is believed that non-communicable diseases (NCDs) are completely eliminated; the estimated GDP (Gross Domestic Product) in a year would have been 4-10 per cent higher2. 4. GAPS IN NATURAL HISTORY There are many gaps in our knowledge about the natural history of chronic diseases. These gaps cause difficulties in aetiological investigations and research. Those are:3  Absence of known Agent: In most of NCDs the cause is not known.  Multifactorial Causation: There will be many causes, in absence of causative agents, risk factors are studied as follows: An attribute or exposure that is significantly associated with development of disease. If determinant is modified by intervention, it reduces possibility of occurrence of disease. Risk factors can be causative, contributory or predictive. They can be modifiable or non modifiable They can be individual or community risk factors Epidemiological studies are needed to identify risk factors  Long Latent Period: It is the period between the first exposure to suspected cause and the eventual development of disease. This makes difficult to link suspected causes with outcomes.  Indefinite onset of the Disease: Most NCD are slow in onset and development. Distinction between diseased and non-diseased may be difficult to establish. 5. MAJOR CHRONIC NON-COMMUNICABLE DISEASES As per WHO (World Health Organization) Working Group, the following disease conditions are the major chronic non-communicable diseases.7  Diabetes Mellitus  Cardio-Vascular Diseases  Cancer  Stroke  Chronic Respiratory Diseases (CRD)  Mental and Behavioural Disorders 5.1 DIABETES MELLITUS It is a chronic disorder characterized by raised blood sugar levels that occur when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Uncontrolled diabetes may lead to serious damage to many of the body's systems, especially the nerves and blood vessels.3 2
  • 3. 5.1.1 Magnitude of the Problem  Disease Burden The number of diabetics in India is expected to increase from 51 million in 2010 to 87 million by2030.8 Currently 39.5 million people in India have pre diabetes, and of them, seven million people will develop diabetes every year.9 Epidemiological studies indicate that the prevalence of diabetes is higher in urban India, and is increasing faster as compared to the rural population.  Socio Economic Burden An individual with diabetes may spend around twice as much on medical care compared to a contemporary individual without diabetes. While the mean direct annual cost for outpatient care for all patients with diabetes in India was Rs 4724/-, those without complications had an 18% lower cost.5 Being diagnosed with diabetes is traumatizing and imposes a long term psychological burden on the individual and the family. Complications from diabetes, such as diabetic neuropathy, amputations, renal failure and blindness are the major causes of disability. 5.2 CARDIO-VASCULAR DISEASES Cardio Vascular Diseases (CVDs) are a group of disorders of the heart and blood vessels, it includes the following: 10 a) Coronary Heart Disease (CHD) b) Cerebro Vascular Disease c) Peripheral Arterial Disease d) Rheumatic Heart Disease e) Congenital Heart Disease f) Deep Vein Thrombosis and Pulmonary Embolism Here, we will deal exclusively with Coronary Heart Disease (CHD), the most important cause of deaths among cardiovascular diseases. 5.2.1 CORONARY HEART DISEASE (CHD) Coronary Heart Disease is a disease of blood vessels in which arteries that provide blood and oxygen to the heart muscles are get narrowed or even completely blocked that leads to heart attacks.3 5.2.1.1 Magnitude of the Problem  Disease Burden  Coronary Heart Disease is the leading cause of death in India, accounted 2.25 million deaths in 2010 (excluding stroke) and is projected to reach 2.94 million deaths in 2015 5,11  Socio-economic burden India is estimated to have lost 8.7 billion dollars in 2017 because of Coronary heart disease.5 3
  • 4. 5.3 CANCER Cancer is a term used for disease in which cells of the body grows and divide in an uncontrolled manner to produce abnormal cells. These cancer cells invade adjoining parts of the body and may spread to other organs. This process of spread to distant organs is called metastasis which is a major cause of death in cancer. Cancer can affect any part of the body. Cancer is also known as malignancies and neoplasms.1, 3 5.3.1 Magnitude of the Problem  Disease Burden Cancer is one of the leading causes of death among adults in India, annually accounting for about 9, 49,000 new cases and 6, 34,000 deaths in 2010. 12  Socio Economic Burden Males with cancer are likely to have a 43.9% greater likelihood of imposing catastrophic expenses on their households and a 24% greater likelihood of impoverishing their households than matched counterparts without cancer. They also use more health care services in both the public and the private sectors. Females with cancer also report higher health care use, health spending, and risks of impoverishing their households than their matched counterparts.2 5.4 STROKE A stroke is caused by the interruption of the blood supply to the brain, usually blood vessels may rupture or blocked by a clot. This cuts off the supply of oxygen and nutrients, causing damage to the brain tissues. A Transient Ischemic Attack (TIA) is a transient episode of loss of brain function caused by blockage of blood flow in the arteries of the brain. The symptoms of TIA improve within 24 hours.3 5.4.1 Magnitude of the Problem  Disease Burden Strokes are estimated to have caused 1.45 million cases in India during 2010 with projected increase to 1.67 million cases in 201513. The average age of stroke patients in India is seen to be less than that in developed countries and affects the most productive part of their life. Many of the stroke patients are left with permanent disability. Common disabilities include pain, stiffness, depression, memory loss, and difficulty in speaking and understanding.  Socio Economic Burden India is estimated to have lost 8.7 billion dollars in 2005 because of stroke and projected to lose 54.0 billion dollars in 2015 due to this disease.5, 13. 5.6 CHRONIC RESPIRATORY DISEASES (CRD) Chronic respiratory diseases (CRD) include a large number of chronic diseases of the lungs and respiratory systems. The most common Chronic Respiratory Disease which causes an enormous health burden is chronic obstructive pulmonary disease (COPD). COPD is a continuously progressive disease which leads to marked breathing disability ultimately resulting in premature deaths. 14 4
  • 5. 5.6.1 Magnitude of the problem  Disease Burden  According to the Million Deaths Study (2001-2003), the chronic respiratory diseases were the second commonest cause of death in Indians in the age group of 25-69 years, after cardiovascular diseases15.  The Disability Adjusted Life Years (DALY) lost due to Chronic respiratory diseases (CRDs) was estimated as 3% of 291 million for all NCDs, i.e. around 8.7 million DALYs in 200516.  Socio Economic Burden  The annual cost of treatment of COPD has been estimated to be over Rs. 35,000 crores for the year 2011 and over Rs. 48,000 crores for 201617.  Psychological and economic burden is imposed on the families due to progressive disease disability, frequent exacerbations and hospitalizations.  COPD in children poses psychological stress for themselves as well as their parents and results in poor educational performance. 5.7 MENTAL AND BEHAVIOURAL DISORDERS Mental and behavioural disorders are conditions that lead to disturbances in thinking, feeling, emotions, reactions, intelligence, judgment, decision making and behaviour. The presence of these disorders can impair a person's ability to deal with ordinary demands of the life. These conditions are varied in nature and intensity, ranging from minor disorders such as anxiety, depression, simple phobias, and substance abuse such as alcohol, tobacco to severe forms of illness like as schizophrenia, mood disorders and severe mental retardation. The disorders may also be specific to certain age groups (children & elderly) and with specific reference to some situations (aftermath of disasters).18 5.7.1 Magnitude of the Problem  Disease Burden  As per WHO, the global prevalence of mental and behavioural disorders are estimated to be about 10% and they constitute four of the 10 leading causes of disability (15% of DALYs lost) with one in four families suffering the burden.1  About 1, 50,000 deaths are estimated to occur due to suicides in India every year. Apart from greater vulnerability and socio-cultural attitudes, people from lower income levels also do not have access to quality mental health care. The age group of 15-49 years are affected with most mental disorders except those disorders specific to pediatric and geriatric age groups.19, 20  Socio-Economic Burden  Apart from direct costs of travel, medication, hospital visits and rehabilitation, the indirect productivity losses due to mental disorders are more significant.  Mental disorders cause significant amount of disabilities in the affected, which affect their education, occupation, married life, social and recreation activities and interfere in productivity and quality of life 21. 5
  • 6. Selected Mental Health, Neurological and Behavioural Disorders: All India estimates for the year 2010 shown in figure-1 21 6. OTHER CHRONIC NON COMMUNICABLE DISEASES INCLUDE 23,07  Chronic Kidney Disease  Hearing Loss  Congenital Diseases  Autism Spectrum Disorders (ASD)  Iodine Deficiency Disorders  Fluorosis  Oro-Dental Diseases  Hereditary Blood Disorders  Injuries  Burns  Dementia  Epilepsy  Musculo Skeletal Disorders  Geriatric Disorders  Disasters 7. RISK FACTORS The underlying socio-economic, cultural, political and environmental determinants for NCDs include Globalization, Urbanization and Population ageing. The risk factors for NCDs are classified in terms of their amenability to interventions as modifiable risk factors, non-modifiable risk factors and intermediate risk factors. 3,4 7.1 Modifiable Risk Factors  Tobacco Use Tobacco consumed in any form, whether smoked or chewed and second-hand tobacco smoke exposures are associated with adverse health effects. It is associated with cardiovascular diseases, cancers, chronic respiratory disease, and other communicable and non communicable diseases.  Alcohol Consumption There is a direct relationship between higher levels of alcohol consumption and rising risk of cardiovascular diseases and some liver diseases. Heavy episodic drinking (binge drinking) is especially associated with cardiovascular diseases. 6
  • 7.  Consumption of Fruits, Vegetables and Processed Food Inadequate consumption of fruits and vegetables (less than five servings /day) increases the risk for cardiovascular diseases, stomach cancer and colorectal cancer. The consumption of high levels of high-energy foods, such as processed foods that are high in fats and sugars, promotes obesity. Consumption of > 5 gram of dietary salt/ day predisposes to higher blood pressure levels and increased risk of cardiovascular diseases. Consumption of high amounts of saturated fats and transfat increases the risk of coronary heart disease and diabetes.  Physical Inactivity Low physical activity is an important cause of overweight and obesity. Participation in 150 minutes of moderate physical activity for every week or equivalent activity is estimated to reduce the risk of cardiovascular disease, diabetes, breast and colon cancer, and depression.  Poverty Poverty means that there is less purchasing power in the homes. This low purchasing power results in compromising on the choices that is made at the household level. This results in major health-damaging behaviors such as tobacco use, harmful use of alcohol, inadequate consumption of fruits and vegetables and preferential use of less expensive and unhealthy foods among the vulnerable and marginalized groups of people.  Environment Environmental risk factors are contributing to the NCD’s’ like as Air Pollution, water Pollution, Occupational Hazards and Exposure to Radiation.  Inadequate Health Services Failure and inability to obtain preventive health services such as screening, regular follow up are major predisposing factors to the NCDs. Also, some late diagnosis of disease conditions, untreated infections may lead to carcinomas.  Stress Factors Acute and chronic stresses such as Homelessness, Stressful work conditions and Situations as in Natural and Manmade Disasters are major causes for many physiological and psychological disorders. 7.2 Non modifiable risk factors The Risk factors, which cannot be modified are called as non-modifiable risk factors, as follows:  Age: Elderly and children are the vulnerable group to get the diseases basically.  Sex: There will be some difference between the disease ratios among the gender.  Family History of Genetic Factors: Genetic factors are major risk factors which cannot be modified.  Personality: Individual personality may contribute in development of the non communicable diseases. 7.3 Intermediate Risk Factors  Obesity and Overweight (overweight (BMI>=25) or Obese (BMI>=30)) Physical inactivity and inappropriate nutrition are directly reflected in the growing burden of overweight in the Indian population predominantly in the urban areas. Central obesity is an important risk factor for diabetes and appears to better predict the risk of diabetes among Indians in Asian region. 7
  • 8.  Hyperlipidemias(>200 mg/dl) People with hyperlipidemias (most often high cholesterol) are at increased risk of ischemic heart diseases, stroke, and other vascular diseases.  Raised blood Pressure (>120/80 mmhg) Raised blood pressure is considered as modern life style disorder in the present scenario. It is a major risk factor for cardiovascular diseases.  Raised Blood Glucose(>120 mg/dl) Raised blood glucose increases the propensity to macro vascular and micro vascular complications, such as cardiovascular diseases, cerebro vascular disease, retinopathy, nephropathy, neuropathy and diabetic foot, all of which account for considerable mortality and morbidity 8. IMPACT ON ECONOMIES, HEALTH SYSTEMS, HOUSEHOLDS AND INDIVIDUALS The impact of the mounting NCD challenge cannot be fully understood without considering the broad range of direct and indirect effects on economies and health systems, as well as on the affected individual and his or her household. These effects, in aggregate, drive economic and human development outcomes including the decreased country productivity and competitiveness, greater fiscal pressures, diminished health outcomes, increased poverty and inequity, and reduced opportunities for society, households and individuals 2,5,14 Impact on Economies Reduced labor supply and outputs Additional costs to employers Lower returns on human capital investments Lower tax revenues Increased public health and social welfare expenditures Impact on Health systems Increased consumption of NCD-related healthcare High medical treatment costs (per episode and over time) Demand for more effective treatments (e.g., cost of technology and innovation) Health system adaptation and costs. (e.g., organization, service delivery, financing) Impact on Households and Individuals Reduced well-being Increased disabilities Premature deaths Household income decreases, or impoverishment, Savings and assets loss Higher health expenditures, including catastrophic spending 9. PREVENTION OF NON-COMMUNICABLE DISEASES Prevention of NCDs can be done through following method 3,11  Primordial prevention: Through the prevention of emergence or development of risk factors in the population or in the countries in which they have not yet appeared. Efforts are directed towards discouraging children from adopting harmful life styles. 8
  • 9.  Primary prevention: Action taken prior to the onset of disease which removes the possibility that the disease will ever occur. Effort will be done through health promotion and specific protection  Secondary prevention: Action which halts the progress of the disease at its incipient stage and prevents complications.  Tertiary prevention: All measures available to reduce impairments and disabilities minimize suffering due to departure from good health and promote patient’s adjustment to irremediable conditions. Effort will be done through disability limitations and rehabilitation 10. GLOBAL AND NATIONAL EFFORTS TOWARDS “NCD” CONTROL IN INDIA 10.1 Innovation to Counter NCD. The World Health Assembly held in the month of May 2012 set a global target to reduce deaths under 70 years of age due to NCD by 25% before 2025. Innovation will be essential to achieve this target; the innovations may act on the biological risk factors of NCD such as hypertension, high blood sugar, high blood lipids and obesity, on the behavioural risk factors like as tobacco, poor diet, physical inactivity and the harmful use of alcohol or on the social determinants of NCD. The types of innovation WHO identified are: biological and information technology, medical devices, changes in the workforce, greater involvement of patient’s and civil society and organizational innovations. 22 10.2 Drivers of Innovation Diffusion To have impact, innovations must diffuse widely, but within health systems they all too often do not diffuse. Drivers of diffusion include: Professional discussion by stakeholders like market, consumers, government, international organizations and business. However, there are some barriers, those are:  Existing healthcare providers and professional hierarchies might resist changes that threaten their dominance and income  Fears that innovations will not be safe and the risk that financial benefits from the innovation might occur in a different budget from that of the costs, and might take some years to become visible and be appreciated. India has shown its commitment to prevention and control of NCDs. India was among the first signatories to the Framework Convention for Tobacco Control (FCTC) and has endorsed the Global Strategy on Diet, Physical Activity and Health. The Government of India has implemented legislations and policies in accordance with the FCTC.22 10.3 Ongoing National Programmes for prevention & Control of Non Communicable Diseases: Government of India had supported the States in Prevention and Control of NCDs through several vertical programmes. They are as follows: 23  National Cancer Control Program (1975)  National Blindness Control Program (1976) 9
  • 10. National Mental Health Program (1982)  National Iodine Deficiency Disorders Control Program (1986)  National Tobacco Control Program (2007) th  Trauma Care Facility on National Highways(9 Plan)  National Deafness Control Program (2006-07)  National Program for Prevention and Control of Fluorosis (2007-08)  Pilot Project on Oral Health (2007-08)  National Program for Prevention & Control of Cancer, Diabetes, cardiovascular diseases (CVD) and Stroke (2010-11)  National Program for Health Care of the Elderly (2010-11)  Pilot Program for Prevention of Burn injuries (2010-11)  Up gradation of Department of Physical Medicine & Rehabilitation (PMR) in Medical Colleges (2010-11)  Disaster Management/Mobile Hospitals (2010-11)  Organ and Tissue Transplant biomaterial centers (2010-11) 11. WHO BEST BUYS FOR CONTROL OF NON-COMMUNICABLE DISEASES  World Health Organization has led global efforts to address NCDs through development of different instruments. Those are Population level interventions and Individual Level Interventions.7,23,24 11.1 Population level Interventions NCDs can best be addressed by a combination of primary prevention, targeting whole population, by measures that targeting high-risk individuals and by improved access to essential health-care interventions for people with NCDs.  Enforcing bans on tobacco advertising, promotion and sponsorship.  Raising taxes on tobacco.  Strong legislative effort for tobacco control: Government of India had ratified the National Anti-Tobacco Legislation in 2007, which bans smoking in public places throughout the country.  Restricting access to retailed alcohol.  Enforcing bans on alcohol advertising.  Raising taxes on alcohol.  Promoting salt reduction in the community through awareness generation and reducing salt content of processed foods.  Regulatory mechanism for fruits and vegetable prices.  Promoting public awareness about diet (Replacing trans-fat in food with polyunsaturated fat) and physical activity, through mass media.  Comprehensive policies on food production, nutrition, marketing, and transport to promote primordial prevention of CVDs. (Cardio-vascular diseases)  Modifying the environment (building the play grounds & parks for relaxation).  Promoting use of cleaner alternate fuels in kitchens.  Improved monitoring and strict enforcement of air quality norms in urban as well as rural areas.  Public education on air-quality and measures to reduce air pollution.  Developing alternative financing models that protect citizens from the catastrophic financial impact of chronic diseases including CVDs.(Cardio- vascular diseases) 10
  • 11.  A major initiative in CVD control has been the launch of the National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke [NPCDCS) in 2010. This envisages early diagnosis, risk reduction, and appropriate management of these diseases at primary health care level.  Protection from occupational carcinogens  Protection against HBV( Hepatitis B virus) and HPV (Human papilloma virus) by vaccination The National Cancer Control Programme was revised in 1984. This programme has now been integrated into the National Programme for Prevention and Control of Cancer, Cardiovascular Diseases, Diabetes and Stroke since 2011. The data on cancer is collected by hospital and population based cancer registries, collated and published by the National Cancer Registry Programme (NCRP) of the Indian Council of Medical Research (ICMR). 11.2 Individual Level Interventions  Screening and early diagnosis of disease in all health care settings  Individual health education towards prevention of diseases and promotion of health.  Counselling, drug therapy, specific treatment and rehabilitations. 12.STRENGTHENING HEALTH SYSTEMS TOWARDS NCDs IN INDIA23  Development and implementation of clinical practice guidelines and standards at different levels of health care centre.  Adequate supply of drugs at all health care centre  Providing better counseling services for lifestyle changes including cessation of tobacco use and Public education about diabetes and its complications.  A multi-sectoral approach beyond the health sector is required to curb the diabetes epidemic, for example, labeling of food items with nutrition facts, making healthy food options available at schools and workplaces, compulsory physical activities in educational institutes.  Training of primary health care staff in management of chronic respiratory diseases.  Cancer awareness and screening for cervical, breast and oral cancer should be introduced at the primary health care level in the National Rural Health Mission (NRHM).  Diagnostic and management facilities for above said cancers should be introduced at the district level.  Specialized treatment services for cancers in medical colleges and other hospitals.  Home support for palliative and rehabilitative services should be introduced at the primary health care level.  Training of doctors and nurses to identify and manage all kind of diseases  Establishment of vascular (cardiac and stroke] units at district level and medical college hospitals.  Establishment of ambulance and referral systems.  Greater investment in infrastructure and manpower to improve capacity for prevention and control of NCDs.  Accreditation to improve quality of care at different levels, including private sectors. 11
  • 12. 12.1 National Effort towards Mental Health Problems24  Policy & Health System Interventions Revised District Mental Health Programme incorporating public health approaches to cover all districts Implementation of the revised Mental Health Care Act to facilitate rights of the mentally ill along with strengthening of implementation Capacity building of policy makers and programme managers to enhance mental health care delivery, implementation, monitoring and evaluation Human resource development with training of doctors, health care workers and peripheral workers Expanding the role of mental hospitals and medical college psychiatry units to integrate preventive, curative, promotive and rehabilitative services along with manpower development and research Strengthening educational and employment opportunities for those who have recovered from mental disorders Integrating mental health with other activities in health sector with AYUSH systems of medicine, and other related sectors Involvement of NGOs in stigma reduction, rehabilitation, public awareness building and advocacy issues. India has a National Mental Health Programme for more than 25 years with curative, preventive, promotive and rehabilitative components covering policy and programme issues. The programme is at present being implemented across 100 districts and is likely to be expanded to the entire country during 2012-17. 13. SPECIFIC ACTIONS BY DIFFERENT STAKEHOLDERS There are some specific actions to be performed by the stakeholders in the society to prevent and control of NCDs.7 Government a. Revision of National Health Policy to address NCDs or formulate a NCD Policy. b. Setting-up an Inter-Ministerial Group or Group of Ministers to address critical inter-sectoral issues (urban development, road transport, agriculture, food processing, finance, human resource development, information and broadcasting, industry, trade & commerce, communications) c. Assessing health impact of all major developmental programmes d. Adopting regulatory and fiscal measures to influence dietary behaviour (regulation of sugar, salt and transfat in food products) tobacco and alcohol use e. Creating a National Health Promotion Foundation to co-ordinate and catalyze all activities related to NCDs Individuals a. Adopting healthy lifestyle and motivating others to do so. b. Being an aware and responsible citizen - following regulations and insisting others also to do so c. Monitoring and changing the behaviour of children (watching TV, diet, physical activity) in the family. 12
  • 13. Communities/Schools/Workplaces a. Creating an healthy environment for adoption of healthy behavior b. Supporting implementation of regulations c. Creating and maintain facilities for physical activity / healthy diets d. Incentivizing good behaviours and disincentives the inappropriate behaviors. Health Professionals a) Taking leadership role at individual level as well as community level to advocate lifestyle changes b) Developing / implementing guidelines for prevention and management of NCDs c) Strengthening the capacity of health workforce to address NCDs d) Conducting appropriate epidemiological, operational and translational research to address NCDs. Non Governmental Organizations a) Mobilizing the community to adopt Healthy Lifestyles b) Change the societal "norms" c) Being a watchdog and monitor implementation of regulations. 14. PLAN OF ACTION TO PREVENT AND CONTROL OF NCDS DURING 12th PLAN A comprehensive approach would be required for both prevention and management of NCDs in the country. It is proposed to continue ongoing efforts and introduce additional programmes to cover important NCDs for public health importance through following key points7,24 14.1 KEY COMPONENTS OF NCD PREVENTION AND CONTROL PROGRAMMES INCLUDE:  Formulation and implementation of comprehensive policies and programmes to address NCDs.  Strengthening of health system in terms of human resource availability, development of standard management guidelines, training at all levels of human resources, ensuring availability of drugs and equipments. The role of private sector is also important in this regard.  As NCDs require lifelong treatment and often require costly health care interventions, a sustainable and equity-based health financing system needs to be set up. This is required to ensure universal coverage for prevention and control of NCDs.  Currently, the surveillance efforts and information system in the country are disjointed, ad-hoc and inadequate. There is an urgent need to bring them under a common umbrella and integrate it with ongoing disease surveillance systems. 14.2 IMPLEMENTATION To ensure long term sustainability of interventions, the programmes would be built within existing public sector health system and wherever feasible introduce public private partnership models. Following will be major components of NCD programmes: 13
  • 14.  Primary Health Care includes Health promotion, screening , basic medical care, home based care & referral system (to be integrated with NRHM- National Rural Health Mission)  Strengthening District Hospitals for diagnosis and management of NCDs including rehabilitation and palliative care, NCD Clinic, Intensive Care Unit, District Cancer Centre, Dialysis services, Geriatric Centre, Physiotherapy Centre, Mental Health Unit, Trauma & Burns Unit, strengthening of facilities for Orthopaedic, Oro-dental, Eye and ENT Departments, Tobacco Cessation Centre, Obesity Guidance Clinic.  Tertiary Care for advanced management of complicated cases including radiotherapy for cancer, cardiac emergencies including cardiac surgery, neurosurgery, organ transplantation.  Emergency medical care and rapid referral system including Highway Trauma Centres and 108 emergency services.  Health Promotion & Prevention includes legislation, population based interventions, Behaviour Change Communication using mass media, mid- media and interpersonal counselling and public awareness programmes in different settings (Schools, Colleges, Work Places and Industries). 14.3 ESTIMATED BUDGET DURING 12TH FIVE YEAR PLAN It is envisaged that for comprehensive and sustainable programme to prevent, control, manage important non-communicable diseases and key risk factors across the country, a large investment would be required during the 12th Plan, Rs. 58,072 crore would be required over the period of 2012-17. 14.4 EXPECTED OUTCOMES The programmes and interventions would establish a comprehensive sustainable system for reducing rapid rise of NCDs, disability as well as deaths due to NCDs. Broadly, following outcomes are expected at the end of the 12th Plan are: a) Early detection and timely treatment leading to increase in cure rate and survival. b) Reduction in exposure to risk factors, life style changes leading to reduction in NCDs. c) Improved mental health and better quality of life. d) Reduction in prevalence of physical disabilities including blindness and deafness. e) Providing user friendly health services to the elderly population of the country f) Reduction in deaths and disability due to trauma, burns and disasters. g) Reduction in out-of-pocket expenditure on management of NCDs and thereby preventing catastrophic implication on affected individual and families. 14
  • 15. 15. AYUSH and NCDs The representative of Government of Sikkim, shared their experience of controlling NCDs through AYUSH (Ayurveda, Yoga, Unani, Siddha and Homeopathy) intervention. They also stated that they have identified 72% of disease of hypertension in a particular village has been considerably brought down through the AYUSH intervention. Govt of India, and Department of AYUSH with state health secretaries on 25.4.2012 determined that AYUSH professional and facilities to be geared up for assisting national health programmes under NPCDCS (National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular disorders). Also, they said Training and IEC (Information Education Communication) material on preventive & promotive role of AYUSH system in controlling NCDs would be prepared by Department of AYUSH for sharing with States.25 16. GLOBALIZATION AND ITS IMPLICATIONS FOR HEALTH CARE AND NURSING PRACTICE  Globalization describes the increasing economic and social interdependence between countries. Nursing is challenged with responding to the changing health needs of the global population that have arisen as a result of globalization. 26  The World Health Organization (WHO) Global Forum for Government Chief Nursing and Midwifery Officers (GCNMO) took place on May 16-17th, 2012, while the Triad meeting, Nursing leaders discussed how to strengthen the role of nursing and midwifery in NCDs. Leaders agreed that in order to tackle the issue of NCDs, continuous development is needed in nursing education, research, and nursing leadership in policy. All nursing leaders fully agreed that the issue of NCDs should be mediated by nurses using an upstream approach rather than a downstream approach. In the downstream approach, nurses treat a problem that is already occurred. In the upstream approach, nurses prevent the consequences by using their skills and knowledge to educate the patient and prevent the disease from occurring in the first place.27 17.0 CONTRIBUTION TOWARDS PREVENTION AND TREATMENT OF “NCDs” BY NIMHANS NIMHANS is one of the exceptional foundations rendering wide-range care towards non communicable diseases through following activities  Preventive, Promotive Rehabilitative health care has been provided through the multidisciplinary team members includes Nurses, Psychiatrist, and Neurologist, Neurosurgeons, Psychologist, Social workers, Yoga therapist, Ayurvedic personnel and supportive workers from all the departments.  Community health unit is providing its continuous extraordinary comprehensive services through the organizational employees and graduate and post graduate students towards NCDs and other diseases in community. 15
  • 16.  The epidemiology department is giving tremendous support by doing the surveillance among all the NCDs. Several research projects with focus on risk factors (tobacco, alcohol, stress, physical inactivity, unhealthy diet, along with large number of mental health behaviours) have been completed in the department. The findings have resulted in developing intervention programmes and follow-up studies at different levels.  Continuous ongoing research work has been performed by all departments towards NCDs especially, stroke, epilepsy, psychiatric disorders, other neurological and neurosurgical disorders, injuries, genetic disorders and psychosocial problems in all age groups.  Health education and publication departments are delivering incredible, effort towards NCDs through awareness programs.  NIMHANS is one of the major collaborators with Fogarty Indo-US Training Program on Chronic Non-Communicable Diseases (CNCD) Across Lifespan to reduce the training gap and increase research capacity for CNCDs,  NIMHANS contributes its enormous effort on Health Policies and National Health Programs to prevent and control NCDs, especially District and National Mental Health Programs. 18. RESEARCH ABSTRACT Decola P et al (2012) highlighted in their stratified representative research survey of 1600 nurses in eight countries were conducted to understand better, how nurses perceive their roles in addressing risk factors associated with NCDs as well as the types of supports required in order to facilitate this work. The study also explores nurses' changing views of the profession and their practice environment. Key findings included that 95% of nurses wanted to use their knowledge, skills and time to educate individuals on the threat and prevention of NCDs, but workload, time constraints and their perception towards the job of nursing hinder them from achieving their potential.28 19. CONCLUSION Within a couple of decades, NCDs are poised to dominate the health care needs in most low and middle income countries and to exact a significant human and economic toll on countries and their population. Despite the magnitude of the challenges, there is considerable scope for action. Improved health care, early detection and timely treatment is another effective approach for reducing the impact of NCDs. Health systems need to be further strengthened to deliver an effective, realistic and affordable package of interventions and services for people with NCDs. 16
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