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JPNATC Experience On Mortality After Head Injury



   Department of Neurosurgery, JPN Apex Trauma Centre, AIIMS, New Delhi




                          TRAUMA 2008, NEW DELHI
INTRODUCTION

   Injury and Trauma are steadily increasing in the third world and becoming
    a major public health problem.

   By 2020 : 3rd largest killer in the developing world (WHO) - TRAUMA.

   Traumatic brain injury (TBI) is the leading cause of death.

   An estimated cost to society of over dollar 40 billion annually (US).

    Evidence-based guidelines for TBI care have been widely discussed, but
    in-hospital treatment of these patients has been highly variable.




                          TRAUMA 2008, NEW DELHI
AIM OF STUDY



   To evaluate outcome in patients of head injuries in relation to
    post-resuscitation GCS score and mortality.

   A secondary objective was to look for epidemiological factors
    responsible for these head injuries.




                        TRAUMA 2008, NEW DELHI
MATERIAL AND METHODS

   Total cases : 1286.

   Study design : Retrospective.


   Duration : Nov 2007- Oct 2008


   Study population : Head injured patients




                           TRAUMA 2008, NEW DELHI
MATERIAL AND METHODS

INCLUSUSION CRITERIA :

   All admitted patients of head injury under Deptt of Neurosurgery at JPNA
    Trauma Center.
   Age – 1 yr to 80 yrs
   Patients group - Minor head injury (GCS 13-15)
                     Moderate head injury (GCS 9-12)
                     Severe head injury (GCS 8 or less)
   Simple / Compound head injury
   Closed / Penetrating head injury




                           TRAUMA 2008, NEW DELHI
MATERIAL AND METHODS

EXCLUSION CRITERIA :

   Poly-trauma patients admitted under other departments.

   Patients managed through OPD or kept under observation at ED.




                      TRAUMA 2008, NEW DELHI
MATERIAL AND METHODS


   Patients were managed as per departmental
    protocols

   All death files were analyzed for mortality data




                 TRAUMA 2008, NEW DELHI
OBSERVATIONS



            DEMOGRAPHY




                                    SEX
 AGE
                               MALE 907(70.5%)
1-80 yr
                              FEMALE 379 (29.5%)

            TRAUMA 2008, NEW DELHI
OBSERVATIONS


                           7%
                                        > 10 yr
           9%                    5%
16%                                     11-20 yr
                                  4%    21-30 yr
                                        31-40 yr
                                        41-50 yr
                                  19%   51-60yr
27%                                     61-70yr
                      13%
                                        71-80yr




        TRAUMA 2008, NEW DELHI
OBSERVATIONS



Hospital arrival time = 2 hrs to 48 hrs.

Time of injury= 3am-6pm(32%)
                6pm – 3am (68%)




                 TRAUMA 2008, NEW DELHI
OBSERVATIONS


                        Mode of injury          No.(%)
900                        ASSAULT             385(30%)
800                             RTA           887 (69%)
700                        SUICIDAL             12 (1%)
600
500
400
300
200
100
  0
      Assult   RTA   Suicidal


                                      TRAUMA 2008, NEW DELHI
OBSERVATIONS

800

                                 SEVERE, 708
700

600

500

400
      MINOR, 340
300
                   MOD, 238
200

100

 0
                         TRAUMA 2008, NEW DELHI
OBSERVATIONS
700         699


600

500

400
      338                                     MINOR
300                                           MOD
        235                                   SEVERE
200

100

 0                     2 3 9
      CL ED HI
        OS          PENETRATING
                                  TRAUMA 2008, NEW DELHI
                         HI
OBSERVATIONS
PENETRATING HEAD INJURY- ENTRY WOUND




          TRAUMA 2008, NEW DELHI
OBSERVATIONS
700
           636
600

500

400
                                          MINOR
300                                       MODE RATE
                                          S VE
                                           E RE
      216
200     192
                          124
100
                                   72
                              46
 0
      SIMPL HI
           E            COMPOUND
                           HI

                 TRAUMA 2008, NEW DELHI
OUTCOME

  GROUP          NO. OF MORTALITY          TOTAL CASES   %

   Overall               296                  1286       23

  Minor HI                11                   340       3

Moderate HI               36                   238       15

  Severe HI              249                   708       35

Compound HI               62                   242       25

  Closed HI              292                  1272       22

Penetrating HI            4                    14        29



                  TRAUMA 2008, NEW DELHI
OUTCOME


Hospital stay: 2 – 41 days ( mean -15)

    DURATION        NO. OF MORTALITY           TOTAL CASES   %
  (since arrival)
     < 48 hrs.             102                     296       34


   48 hrs - 1 wk.          140                     296       47


     > 1 wk.                54                     296       19




                      TRAUMA 2008, NEW DELHI
OUTCOME


     GROUP             NO. OF MORTALITY          TOTAL CASES   %

Children (> 10 yrs)             67                   248       27

Adult ( 20-50 yrs)             158                   761       20

Elderly ( 50-80 yrs)            71                   277       25


       Male                    204                   907       30

      Female                    92                   379       24




                        TRAUMA 2008, NEW DELHI
REVIEW OF LITERATURE



   Kagan RJ et al found that mortality rates were 26.7 per cent, 36.5 per cent,
    and 41.4 per cent respectively for severe head injured patients in different
    input level 1 set up.



   Fakhry SM, Trask AL, Waller MA, Watts DD in their study found overall
    mortality rate in a reducing pattern 1991-94 to 1997-2000 (17.8% vs.
    13.8%), although this was not statistically significant.




                                  TRAUMA 2008, NEW DELHI
REVIEW OF LITERATURE



   Udekwu P. et al derived that mortality falls steeply between a
    Preresuscitation-GCS score of 3 and 7 followed by a shallow fall. Although
    P-GCS score is related to mortality in head-injured patients, its relationship
    is nonlinear, which casts doubt on its use as a continuous measure or an
    equivalent set of categorical measures incorporated into outcome prediction
    models.

   AIIMS study ( present series) : Mortality as 3%, 15% ,35% for mild, moderate
    and severe head injury. This conforms to other study.




                                     TRAUMA 2008, NEW DELHI
CONCLUSIONS

   Incidence of head injury is increasing.

   Post resuscitation GCS prognosticated outcome.

   Our mortality rates for head injured patients compare
    very favorably with international data.




                        TRAUMA 2008, NEW DELHI

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Jpnatc experience on mortality after head injury

  • 1. JPNATC Experience On Mortality After Head Injury Department of Neurosurgery, JPN Apex Trauma Centre, AIIMS, New Delhi TRAUMA 2008, NEW DELHI
  • 2. INTRODUCTION  Injury and Trauma are steadily increasing in the third world and becoming a major public health problem.  By 2020 : 3rd largest killer in the developing world (WHO) - TRAUMA.  Traumatic brain injury (TBI) is the leading cause of death.  An estimated cost to society of over dollar 40 billion annually (US).  Evidence-based guidelines for TBI care have been widely discussed, but in-hospital treatment of these patients has been highly variable. TRAUMA 2008, NEW DELHI
  • 3. AIM OF STUDY  To evaluate outcome in patients of head injuries in relation to post-resuscitation GCS score and mortality.  A secondary objective was to look for epidemiological factors responsible for these head injuries. TRAUMA 2008, NEW DELHI
  • 4. MATERIAL AND METHODS  Total cases : 1286.  Study design : Retrospective.  Duration : Nov 2007- Oct 2008  Study population : Head injured patients TRAUMA 2008, NEW DELHI
  • 5. MATERIAL AND METHODS INCLUSUSION CRITERIA :  All admitted patients of head injury under Deptt of Neurosurgery at JPNA Trauma Center.  Age – 1 yr to 80 yrs  Patients group - Minor head injury (GCS 13-15) Moderate head injury (GCS 9-12) Severe head injury (GCS 8 or less)  Simple / Compound head injury  Closed / Penetrating head injury TRAUMA 2008, NEW DELHI
  • 6. MATERIAL AND METHODS EXCLUSION CRITERIA :  Poly-trauma patients admitted under other departments.  Patients managed through OPD or kept under observation at ED. TRAUMA 2008, NEW DELHI
  • 7. MATERIAL AND METHODS  Patients were managed as per departmental protocols  All death files were analyzed for mortality data TRAUMA 2008, NEW DELHI
  • 8. OBSERVATIONS DEMOGRAPHY SEX AGE MALE 907(70.5%) 1-80 yr FEMALE 379 (29.5%) TRAUMA 2008, NEW DELHI
  • 9. OBSERVATIONS 7% > 10 yr 9% 5% 16% 11-20 yr 4% 21-30 yr 31-40 yr 41-50 yr 19% 51-60yr 27% 61-70yr 13% 71-80yr TRAUMA 2008, NEW DELHI
  • 10. OBSERVATIONS Hospital arrival time = 2 hrs to 48 hrs. Time of injury= 3am-6pm(32%) 6pm – 3am (68%) TRAUMA 2008, NEW DELHI
  • 11. OBSERVATIONS Mode of injury No.(%) 900 ASSAULT 385(30%) 800 RTA 887 (69%) 700 SUICIDAL 12 (1%) 600 500 400 300 200 100 0 Assult RTA Suicidal TRAUMA 2008, NEW DELHI
  • 12. OBSERVATIONS 800 SEVERE, 708 700 600 500 400 MINOR, 340 300 MOD, 238 200 100 0 TRAUMA 2008, NEW DELHI
  • 13. OBSERVATIONS 700 699 600 500 400 338 MINOR 300 MOD 235 SEVERE 200 100 0 2 3 9 CL ED HI OS PENETRATING TRAUMA 2008, NEW DELHI HI
  • 14. OBSERVATIONS PENETRATING HEAD INJURY- ENTRY WOUND TRAUMA 2008, NEW DELHI
  • 15. OBSERVATIONS 700 636 600 500 400 MINOR 300 MODE RATE S VE E RE 216 200 192 124 100 72 46 0 SIMPL HI E COMPOUND HI TRAUMA 2008, NEW DELHI
  • 16. OUTCOME GROUP NO. OF MORTALITY TOTAL CASES % Overall 296 1286 23 Minor HI 11 340 3 Moderate HI 36 238 15 Severe HI 249 708 35 Compound HI 62 242 25 Closed HI 292 1272 22 Penetrating HI 4 14 29 TRAUMA 2008, NEW DELHI
  • 17. OUTCOME Hospital stay: 2 – 41 days ( mean -15) DURATION NO. OF MORTALITY TOTAL CASES % (since arrival) < 48 hrs. 102 296 34 48 hrs - 1 wk. 140 296 47 > 1 wk. 54 296 19 TRAUMA 2008, NEW DELHI
  • 18. OUTCOME GROUP NO. OF MORTALITY TOTAL CASES % Children (> 10 yrs) 67 248 27 Adult ( 20-50 yrs) 158 761 20 Elderly ( 50-80 yrs) 71 277 25 Male 204 907 30 Female 92 379 24 TRAUMA 2008, NEW DELHI
  • 19. REVIEW OF LITERATURE  Kagan RJ et al found that mortality rates were 26.7 per cent, 36.5 per cent, and 41.4 per cent respectively for severe head injured patients in different input level 1 set up.  Fakhry SM, Trask AL, Waller MA, Watts DD in their study found overall mortality rate in a reducing pattern 1991-94 to 1997-2000 (17.8% vs. 13.8%), although this was not statistically significant. TRAUMA 2008, NEW DELHI
  • 20. REVIEW OF LITERATURE  Udekwu P. et al derived that mortality falls steeply between a Preresuscitation-GCS score of 3 and 7 followed by a shallow fall. Although P-GCS score is related to mortality in head-injured patients, its relationship is nonlinear, which casts doubt on its use as a continuous measure or an equivalent set of categorical measures incorporated into outcome prediction models.  AIIMS study ( present series) : Mortality as 3%, 15% ,35% for mild, moderate and severe head injury. This conforms to other study. TRAUMA 2008, NEW DELHI
  • 21. CONCLUSIONS  Incidence of head injury is increasing.  Post resuscitation GCS prognosticated outcome.  Our mortality rates for head injured patients compare very favorably with international data. TRAUMA 2008, NEW DELHI