Stimulants

Psycho-stimulants: Cocaine, Amphetamines ADD/ADHD Weight Loss Nasal Decongestants

Map of Principal Coca-Growing Regions in South America

[object Object],[object Object],[object Object],[object Object]

Reasons Why You Should Use Cocarettes!! ,[object Object],[object Object],[object Object],[object Object],[object Object]

Cocaine ,[object Object],[object Object],[object Object]

Cocaine preparations ,[object Object],sulfuric acid Coca paste (60-80% cocaine) hydrochloric acid Cocaine HCl (80%+ cocaine, but less potent) Boil with water and either baking soda or ammonia Cocaine free base (No HCl) Crack cocaine Boil with ether

Enzyme metabolism of cocaine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Administration ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]

Dose-dependent effects ,[object Object],Outbursts Stereotypic Paranoia Insomnia Agitation Increase BP Lower appetite Improve mood Alertness Low Medium High

Pharmacodynamics ,[object Object],[object Object],[object Object],[object Object],[object Object]

Long-term Pharmacodynamics ,[object Object],[object Object],[object Object],[object Object]

Signs & Symptoms of Acute Intoxication ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hazards of Use ,[object Object],[object Object]

High Dose Effects & Safety Risks ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Reinforcement Potential of Cocaine ,[object Object],[object Object],[object Object],[object Object],[object Object]

Fetal Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Treatment Models ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Additional Treatment Models ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Amphetamines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pharmacodynamics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Neurotransmitter Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]

Signs and Symptoms of Intoxication ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Club Drug ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Symptoms of Use Hazards ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Attention Deficit Disorder & Attention Deficit Hyperactivity Disorder

Sample Diagnostic Criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Stimulant treatment of AD/HD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Selected Stimulant Medications Long Acting Concerta, Metadate CD, Ritalin LA, Adderall XR, Dexedrine Spansules, Daytrana Patch Atomoxetine(Strattera) Intermediate Acting Metadate ER, Ritalin SR Short Acting Ritalin, Adderall, Dexedrine, Dextrostat

Anorectic Agents Oily spotting, flatus, discharge, fecal urgency, GI Orlistat (Xenical) Alli (OTC) Decrease absorption of fat Lipase Inhibitor FDA does not recommend. HTN, DM, glaucoma Ephedra, guarana, chromium picolinate Increase basal metabolic rate Herbals Nervous, HA, HR, BP, palpitations, irritable Fastin, Meridia Ionamin, Beta receptors in hypothalamus Stimulants Side Effects Agent MOA Drug Class

Ephedra banned but…………. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Ephedrine, pseudoephedrine, and phenylephrine for nasal decongestion

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