2. Anaemia :decrease in Hb below 13% in male & 11 % female. Etiology: ↓bone marrow production Lack of iron,amino acid Loss of blood Signs & symptoms Fatigue, palpitations,breathlessness Pallor of skin, mucosa,edema POLYCYTHEMIA:↑ rbc Lack of concentration, headache,fatigue, CVA SICKLE CELL ANAEMIA: Inherited Hb conditions THALESSIMIA : APLASTIC ANEMIA:failure of rbc to form PERNICIOUS ANEMIA:lack of vit b12 HAEMORRHAGIC ANEMIA:removal or destruction of RBC HEMOCHROMATOSIS:excessive deposit of iron in body Bone marrow in sternm, ribs, vertebra & pelvis 120 day .Carry o2& co2 .Antigens A,B,AB & 0 .Rh type RBC,s Biconcave disc contains haemoglobin made of iron +protein diseases Production Life span Function Structure
3. Made of water & solute Blood clotting Plasma IDIPATHIC THROMBOCYTOPENIC PURPURA: ↓ platelets Bone marrow 5 to 9 days Blood clotting Platelets: disc shaped without nucleus LEUKEMIA:cancer of blood Types: ALL:acute lymphoblastic leukemia AML:---------myeloid------------- CLL:chronic lympoblastic---- CML:----------myeloid------ Etiology:radiation exposure, cytotoxic drugs, HIV Symptoms:tiredness, fatigue,bleding tendency, lymphadenopathy, spleen enlargement Treatment::danorubicin,etoperiside, bone marrow transplantation, imatinib mesylate GRANULOCYTOSIS EOSINOPHILA BASOPHILA Bone marrow, lymphoid tissue Few days .To kill microbes .Release enzyme lysozyme .Antibodies production WBC: Have nuclei