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20081206 Biostatistics
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A talk about common biostatistics in clinical researches
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20081206 Biostatistics
1.
實證統計 楊宗翰 12/6,
2008
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Baseline Characteristics
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Describe Your Data
II
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Results - Treatment
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Appraise - Impact
CER = Control Event Rate, EER = Experimental Event Rate RRR = Relative Risk Reduction (CER-EER)/CER ARR = Absolute Risk Reduction (CER-EER) NNT/NNH = Number Needed to Treat/Harm (1/ARR) 5000 (1/0.02%) 0.02% (0.04-0.02)% 50% (0.04-0.02)/0.04 0.02% 0.04% B 50 (1/2%) 2% (4-2)% 50% (4-2)/4 2% 4% A NNT 益一需治數 ARR 絕對風險降低 RRR 相對風險 降低 EER 實驗組發生率 CER 對照組發生率
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Results - Diagnosis
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Diagnosis 診斷
敏感度 (Sensitivity) 特異度 (Specificity) 陽性預測值 (Positive predictive value) 陰性預測值 (Negative predictive value) 800 200 陰性結果 100 900 陽性結果 沒病 有病
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Diagnosis 診斷
盛行率 Prevalence 800 200 檢查陰性結果 100 900 檢查陽性結果 沒病 有病
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ROC curves
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Results – Meta
Analysis
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Funnel Plot -
Publication Bias
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Results - Cohort
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Survival Analysis
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Kaplan-Meier Survival Curve
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