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NPSF Professional Learning Series presents:

                                        The new kid on the patient safety block:
                                             Diagnostic Error in Medicine
                                                      November 16, 2011



Richard E. Anderson, M.D., F.A.C.P        Mark L Graber MD FACP
Chairman and Chief Executive Officer      Senior Scientist, Patient Safety
                                          Portfolio, RTI International
The Doctors Company
                                          Professor Emeritus, Dept of Medicine,
                                          SUNY Stony Brook, NY

                                          mgraber@rti.org
Participant Notification
ACKNOWLEDGEMENT OF COMMERCIAL SUPPORT: There was no commercial support received for this CME activity.

CONTINUING EDUCATION
Physicians: This activity has been planned and implemented in accordance with the Essential Areas and Policies of the
Accreditation Council for Continuing Medical Education through the joint sponsorship of the Institute for the Advancement of Human
Behavior (IAHB) and the National Patient Safety Foundation (NSPF). The IAHB is accredited by the ACCME to provide continuing
medical education for physicians.


AMA PRA Statement: The IAHB designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™
Physicians should only claim credit commensurate with the extent of their participation in the activity.


Nurses:
                   IAHB is an approved provider of continuing nursing education by the Utah Nurses Association, an accredited
                   Approver by the American Nurses Credentialing Center’s Commission on Accreditation. Provider Code P09-03.
This course is co-provided by IAHB and the National Patient Safety Foundation. Maximum of 1 contact hour. Approved status as a
provider refers only to its continuing education activities and does not imply UNA or ANCC Commission on Accreditation
endorsement of any commercial products.


Pharmacists:
     Amedco is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy
     education. 1
      contact hour. UAN: 0453-9999-11-046-L05-P (K)

                                                                                                                                     2


                        NPSF Professional Learning Series                                                               November 16, 2011
Disclosure
All faculty/speakers, planners, abstract reviewers, moderators, authors, co-authors and administrative staff participating in the
continuing medical education programs jointly sponsored by IAHB are expected to disclose to the program audience any/all
relevant financial relationships related to the content of their presentation(s).

The following disclosures of financial relationships have been made by the program planners and presenters:

  Last Name                        First Name                 Disclosure         Resolution   Off-Label Use


  Perry                            Allison                    N                  N/A          N/A
  Grubbs                           Kenneth                    N                  N/A          N/A
  Parker                           Jay                        N                  N/A          N/A
  Chrobak                          Bernice                    N                  N/A          N/A
  Graber                           Mark                       N                  N            N
  Anderson                         Richard                    N                  N/A          N



 Financial Relationship Key:
 G-Grant/Research Support
 C-Consultant/Scientific Advisor
 S-Speaker’s Bureau
 E-Employee
 O-Other
 N-Nothing to disclose
 Resolution Key
 R1-Restricted to Best Available Evidence & ACCME content validation statement
 R2-Removed/Altered Financial Relationship
 R3-Altered Control
 R4-Peer Review with 2nd method of resolution
                                                                                                  Questions?
                                                                                                  Contact Us at info@npsf.org or 617-391-9900
                                                                                                                                                3


                                        NPSF Professional Learning Series                                                            November 16, 2011
Learning objectives

  *   Identify diagnostic error as a major element of risk in
  their practices
  *    Discuss the importance of diagnostic error
  including the costs and consequences to patients and
  organizations
  *   Perform a root cause analysis based on the factors
  known to contribute to diagnostic error
  *     Use tools provided to reduce the risks of diagnostic
  error in their own practice or organization


                                                                     4


           NPSF Professional Learning Series              November 16, 2011
NPSF Professional Learning Series presents:

                                        The new kid on the patient safety block:
                                             Diagnostic Error in Medicine
                                                      November 16, 2011



Richard E. Anderson, M.D., F.A.C.P        Mark L Graber MD FACP
Chairman and Chief Executive Officer      Senior Scientist, Patient Safety
                                          Portfolio, RTI International
The Doctors Company
                                          Professor Emeritus, Dept of Medicine,
                                          SUNY Stony Brook, NY

                                          mgraber@rti.org
Diagnostic Errors




Falls

                                            Wrong Site
Med Errors                                   Surgery




                                                               6


        NPSF Professional Learning Series           November 16, 2011
Nurses:
                                              Its not MY problem !

  Hospitals:
 Its not OUR
  problem !
                                                    Doctors:
                                                  I don’t make
                                                    mistakes !



Diagnostic errors fall in our collective blind spot

                                                                            7


          NPSF Professional Learning Series                      November 16, 2011
DxNos
   Tician
    MD




Diagnosis: “The most critical of a physician’s skills. It is every
doctor’s measure of his abilities; it is the most important ingredient
in his professional self image.”
                                 Pat Croskerry - 2008

                                                                                8


             NPSF Professional Learning Series                       November 16, 2011
Estimates of the Diagnostic Error Rate


 Pathology,             Although higher numbers can be found under artificial
 Radiology              conditions, the estimated error rate in the real world is
                        near 2%
 Clinical Lab           Varies by test, lab, etc, but overall error rate is < .1%




                                                                                               9


                NPSF Professional Learning Series                                   November 16, 2011
Estimates of the Diagnostic Error Rate
Patient              One third of patients relate a Dx error that affected
Surveys              themselves, a family member, or close friend
Second               10-30% of breast cancers are missed on
reviews              mammography;1-2% of cancers misread on biopsy
                     samples
Standard pts         Internists misdiagnosed 13% of patients presenting with
                     common conditions to clinic (COPD, RA, others)
Look backs           30% of subarrachnoid hemorrhage misdiagnosed; 39%
                     of dissecting AAA delayed diagnosis; 25-50% of women
                     with cervical cancer – last PAP abnl on re-read
Autopsies            Major unexpected discrepancies that would have
                     changed the management are found in 10-20%
Expert guess         Arthur Elstein: 10%

                                                                                          10


               NPSF Professional Learning Series                               November 16, 2011
The death of one man is a tragedy,
           the death of millions is a statistic.
                   Joseph Stalin (?)




                                           Maurice Gibb
John Ritter
                                                                     11


       NPSF Professional Learning Series                  November 16, 2011
Where do these
            errors happen ?
             What are the
                common
              conditions ?



                                               12


NPSF Professional Learning Series   November 16, 2011
Inpatient Settings



% adverse events related to diagnostic error:

Harvard Medical Practice Study:            17%
Colorado & Utah:                           7%
Canadian Adverse Event:                    10%


                                                            13


       NPSF Professional Learning Series         November 16, 2011
Diagnostic Error in Ambulatory Settings
 Systematic Review of 21 publications:

 Cancer             In a series of 56 cases, 8 had serious delays in dx
 DementiaEvery pt in a small town was screened: 9% had dementia but only
                               4% had been diagnosed
 Fe-def anemia      High incidence of non-investigation & missed cancer, esp females.
 Asthma             Median delay making the Dx: 3 years, 7 visits
 Tremor             Of 402 pts with presumed Parkinsons, dx correct in only half


 Error-promoting factors:
 • Atypical & nonspecific presentations
 • Rare conditions
 • Comorbid conditions

     Kostopoulou, Delaney and Munro. Diagnostic difficulty and error in primary
     care – A systematic review. Family Practice 400-413, 2008
                                                                                              14


              NPSF Professional Learning Series                                    November 16, 2011
Diagnosis         cases          %
                                                Pulmonary embolism        26         4.5%
                                           Poisoning, ADR, overdose       26         4.5%
                                                       Lung cancer        23         3.9%
Schiff, G. D., O. Hasan, et
al. (2009).                                          Colorectal cancer    19         3.3%
Diagnostic Error in                        Acute coronary syndrome        18         3.1%
Medicine - Analysis of 583                            Breast cancer       18         3.1%
Physician-Reported Errors.
Arch Int Med 169(20):                                     Stroke          15         2.6%
1881-1887.                                   Congestive heart failure     13         2.2%
                                                         Fracture         13         2.2%
                                                         Abscess          11         1.9%
                                                       Pneumonia          10         1.7%

                                          Aortic aneurysm/dissection       9         1.5%
                                                                                            15


                 NPSF Professional Learning Series                               November 16, 2011
What is the cost of
         diagnostic error ?




                                               16


NPSF Professional Learning Series   November 16, 2011
Claims Data: High-severity Cases
Top allegation category: Diagnosis Error




                                                        17


         NPSF Professional Learning Series   November 16, 2011
The rising cost of diagnosis




                                           Igelhart NEJM 2009. Vol 360 p1030
                                                                                          18


           NPSF Professional Learning Series                                   November 16, 2011
Costs and consequences of Dx Error

• Inappropriate testing (Defensive medicine)
• Preventable re-admissions; Preventable
  return visits to the ER; Preventable rescue
  events.
• Physical and psychological harm
  ▫ False positives: Your mammogram shows a
    nodule – I think you have cancer
  ▫ False negatives: Your chest pain sounds
    musculoskeletal (or is it a heart attack ?)

                                                             19


         NPSF Professional Learning Series        November 16, 2011
How can we
           analyze and
           understand
        diagnostic error ?




                                               20


NPSF Professional Learning Series   November 16, 2011
History                                      Exam


                          Diagnosis



                                     Tests


                                                               21


 NPSF Professional Learning Series                  November 16, 2011
Where & When in Dx Process are Errors Occurring?




                                                                              Present; F/up
                                                                                  1%

                                                     Assessment
                                                        33%              History
                                                                          10%


                                                                            Exam
                                                                            10%
                                                     Lab & Radiol
                                                       Testing
                                                         46%




N= 583 Cases

               Schiff, G. D., O. Hasan, et al. (2009). "Diagnostic Error in Medicine - Analysis
               of 583 Physician-Reported Errors." Arch Int Med 169(20): 1881-1887.


                                                                                                             22


                 NPSF Professional Learning Series                                                November 16, 2011
What went wrong ?




                                                23


 NPSF Professional Learning Series   November 16, 2011
Missed and Delayed Diagnoses in the Ambulatory Setting
Gandhi et al. Ann Int Med 2006. 145:488-496



   Analyzed 307 closed malpractice claims involving
     an outpatient diagnostic error from 4 carriers
   • Of the 307 cases:
     ▫ 55% failure to obtain an appropriate test
     ▫ 45% failure to create an appropriate plan for
       follow-up
     ▫ 42% failure to obtain the appropriate history or
       physical exam
     ▫ 37% incorrect interpretation of diagnostic tests

                                                                 24


             NPSF Professional Learning Series        November 16, 2011
The
Healthcare
 System

                                                 The
                                                 Clinician
 The Patient
                                          HARM
                                                                    25


      NPSF Professional Learning Series                  November 16, 2011
Average: 6 distinguishable errors/case
           Etiology of Diagnostic Error
                                         No Fault Error Only
                                                 7%
  Both System and                                                System Error Only
  Cognitive Errors                                                     19%
        46%




                                                     Cognitive Error Only
                                                             28%




                                                                                                26


     NPSF Professional Learning Series                                               November 16, 2011
System-Related Diagnostic Error

                 DOMAIN                                            EXAMPLE
Communication                                        Critical information not passed to the
                                                     next provider
Coordination of Care                                 Medical records not available
Access to Experts                                    No Radiologist on nights
Safety Culture                                       Same errors keep happening
Supervising Trainees                                 Trainee misdiagnosis at night
Work Pressure                                        Rushed history – missed key piece of
                                                     data
Distractions, etc                                    Fatigue, interruptions causing slips
Diagnostic Testing                                   Pre- and Post-analytical errors


                                                                                                  27


                 NPSF Professional Learning Series                                     November 16, 2011
Cognitive-Based Diagnostic Error


               DOMAIN                                           EXAMPLE
Inadequate knowledge                              Doctor didn’t know the disease could
                                                  present this way
Faulty data collection                            Sloppy physical exam; failing to
                                                  review the existing medical records
Faulty synthesis                                  Faulty context and anchoring errors;
                                                  Premature closure (failing to consider
                                                  other possibilities)




                                                                                               28


              NPSF Professional Learning Series                                     November 16, 2011
“ Say … What’s a mountain goat doing
      way up here in a cloud bank ?”              29


NPSF Professional Learning Series      November 16, 2011
Premature closure = Satisficing

= Falling in love with the first puppy …
                             (Herbert Simon)




                                                          30


     NPSF Professional Learning Series         November 16, 2011
So where are we ?




                                                31


 NPSF Professional Learning Series   November 16, 2011
Diagnostic Errors


• Are more common than they should be. They
  cause enormous harm and lost costs.
• Typically involve multiple breakdowns in our
  safety systems, and involve both cognitive and
  system-related issues. They can be analyzed
  using RCA approaches like any other medical
  error




                                                              32


        NPSF Professional Learning Series          November 16, 2011
What can we do to
              reduce the
            likelihood of
         diagnostic error ?




                                               33


NPSF Professional Learning Series   November 16, 2011
AHRQ: Literature Review to Identify Interventions
               to Reduce Dx Error

                         Mark Graber, Hardeep Singh
                              RTI International




Systems:                           43 articles: 6 trials

Cognitive:                         157 articles: 37 trials




                                                                        34


      NPSF Professional Learning Series                      November 16, 2011
Strategies to Reduce Dx Error
                          HEALTHCARE SYSTEMS


     Promote a culture of safety
     Address the common system flaws to
     contribute to diagnostic error
     Provide decision support resources
     Encourage second opinions
     Develop pathways for feedback

                                                          35


     NPSF Professional Learning Series         November 16, 2011
Strategies to Reduce Dx Error
                          HEALTHCARE SYSTEMS

    •IMPROVE COMMUNICATION
    •Take advantage of the EMR
    • Better alerts for critical test results; Better data displays
    • Make sure expertise is available when needed
    • Coordinate care across different providers, sites, systems
    • Making sure prior medical data is available for review
    • Empowering patients; Encourage feedback
    • Ensure screening tests are done

                                                                        36


     NPSF Professional Learning Series                       November 16, 2011
Strategies to Reduce Dx Error
                               NURSES – Our Safety Net


    Help minimize system flaws:
     Ensure good communication
     Help ensure test results are acted upon
    Help the patient communicate
    Be the watchdog for deterioration



                                                                    37


     NPSF Professional Learning Series                   November 16, 2011
Strategies to Reduce Dx Error

                                         PATIENTS

     Be a good historian
     Keep accurate records of your tests
     SPEAK UP ! What else could this be ?
     Get real: Diagnosis is just playing the odds
     Ask what to expect & what the plan is for
          follow-up
                                                               38


     NPSF Professional Learning Series              November 16, 2011
Strategies to Reduce Dx Error

                                         PHYSICIANS

     System errors: Bring them to attention
     and make sure they get fixed.
     Cognitive errors:
           •Improve your knowledge base
           •Improve your clinical reasoning & use EBM
           •Take advantage of decision support resources
           and get help when needed
                                                                 39


     NPSF Professional Learning Series                November 16, 2011
NOVICE
more
                                                                     Monitoring,
                           Inductive                                  antidotes
                           Reasoning
                                                                     GET HELP
                                                                REFLECTIVE PRACTICE
Cost
                                                  Heuristics,
                                                  Automatic
Time
                                             ME                               EXPERT
Effort
                                                                    Expert
                                                                   Thinking



less                                                                          more
                             Accuracy, Reliability
                                                                                          40


         NPSF Professional Learning Series                                     November 16, 2011
Problems                                  Solutions


• Faulty context                            • Reflection – What else
• Premature closure                              could this be ?
• Failed intuition                          • Be comprehensive



                                                                            41


        NPSF Professional Learning Series                        November 16, 2011
How to be Comprehensive

  Use mnemonics and tricks:
    ROWCS
    VITAMIN C C & D

  Electronic decision support
      (Isabel, DxPlain)



                                                     42


      NPSF Professional Learning Series   November 16, 2011
VITAMIN C C & D
             V ascular
              I nfections & intoxications
             T rauma & toxins
             A uto-immune
             M etabolic
             I diopathic & iatrogenic
             N eoplastic
             C ongenital
             C onversion (psychiatric)
             D egenerative

                                                       43


    NPSF Professional Learning Series       November 16, 2011
DXplain

•Chest tightness
•Troponin elevation
•Hypoxemia




                                                         44


          NPSF Professional Learning Series   November 16, 2011
A Checklist for Diagnosis


Obtain YOUR OWN, COMPLETE medical history, & a FOCUSED and
       PURPOSEFUL physical examination

Generate some initial hypotheses; Use EBM;

Pause to reflect – Take a diagnostic “time out”:

   •Was I comprehensive ?
   •Did I consider the inherent flaws of heuristic thinking ?
   •Was my judgment affected by any other bias ?
   •Do I need to make the diagnosis NOW, or can I wait ?
   •What’s the worst case scenario ? What are the ‘don’t miss’ entities ?

Embark on a plan, but acknowledge uncertainty and
   ENSURE A PATHWAY FOR FOLLOW-UP
      Make the PATIENT your PARTNER


                                                                                45


                NPSF Professional Learning Series                    November 16, 2011
NPSF Education Module:
            Reducing Diagnostic Error

•Lectures from Gordy Schiff, Geetha Singhal, Mark Graber
•Workshop on diagnostic error
•Patient and Family Tools and Resources
•Pocket Guide – How Doctors Think
•Ask Me 3
   1. Have I told you enough so you can understand my problem?
   2. What could be causing my problem?
   3. When will I get my test results, and will my other doctors get
      the results too?




                                                                          46


            NPSF Professional Learning Series                  November 16, 2011
In Summary …


• Diagnostic error is a common and serious
  problem, causing enormous harm

• These errors reflect latent system flaws and
  shortcomings in cognition

• The problem is largely ignored by all concerned

• ITS TIME TO DO SOMETHING …..

     And THERE’S A JOB FOR EVERYONE


                                                               47


        NPSF Professional Learning Series           November 16, 2011

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Npsf slides graber

  • 1. NPSF Professional Learning Series presents: The new kid on the patient safety block: Diagnostic Error in Medicine November 16, 2011 Richard E. Anderson, M.D., F.A.C.P Mark L Graber MD FACP Chairman and Chief Executive Officer Senior Scientist, Patient Safety Portfolio, RTI International The Doctors Company Professor Emeritus, Dept of Medicine, SUNY Stony Brook, NY mgraber@rti.org
  • 2. Participant Notification ACKNOWLEDGEMENT OF COMMERCIAL SUPPORT: There was no commercial support received for this CME activity. CONTINUING EDUCATION Physicians: This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of the Institute for the Advancement of Human Behavior (IAHB) and the National Patient Safety Foundation (NSPF). The IAHB is accredited by the ACCME to provide continuing medical education for physicians. AMA PRA Statement: The IAHB designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™ Physicians should only claim credit commensurate with the extent of their participation in the activity. Nurses: IAHB is an approved provider of continuing nursing education by the Utah Nurses Association, an accredited Approver by the American Nurses Credentialing Center’s Commission on Accreditation. Provider Code P09-03. This course is co-provided by IAHB and the National Patient Safety Foundation. Maximum of 1 contact hour. Approved status as a provider refers only to its continuing education activities and does not imply UNA or ANCC Commission on Accreditation endorsement of any commercial products. Pharmacists: Amedco is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. 1 contact hour. UAN: 0453-9999-11-046-L05-P (K) 2 NPSF Professional Learning Series November 16, 2011
  • 3. Disclosure All faculty/speakers, planners, abstract reviewers, moderators, authors, co-authors and administrative staff participating in the continuing medical education programs jointly sponsored by IAHB are expected to disclose to the program audience any/all relevant financial relationships related to the content of their presentation(s). The following disclosures of financial relationships have been made by the program planners and presenters: Last Name First Name Disclosure Resolution Off-Label Use Perry Allison N N/A N/A Grubbs Kenneth N N/A N/A Parker Jay N N/A N/A Chrobak Bernice N N/A N/A Graber Mark N N N Anderson Richard N N/A N Financial Relationship Key: G-Grant/Research Support C-Consultant/Scientific Advisor S-Speaker’s Bureau E-Employee O-Other N-Nothing to disclose Resolution Key R1-Restricted to Best Available Evidence & ACCME content validation statement R2-Removed/Altered Financial Relationship R3-Altered Control R4-Peer Review with 2nd method of resolution Questions? Contact Us at info@npsf.org or 617-391-9900 3 NPSF Professional Learning Series November 16, 2011
  • 4. Learning objectives * Identify diagnostic error as a major element of risk in their practices * Discuss the importance of diagnostic error including the costs and consequences to patients and organizations * Perform a root cause analysis based on the factors known to contribute to diagnostic error * Use tools provided to reduce the risks of diagnostic error in their own practice or organization 4 NPSF Professional Learning Series November 16, 2011
  • 5. NPSF Professional Learning Series presents: The new kid on the patient safety block: Diagnostic Error in Medicine November 16, 2011 Richard E. Anderson, M.D., F.A.C.P Mark L Graber MD FACP Chairman and Chief Executive Officer Senior Scientist, Patient Safety Portfolio, RTI International The Doctors Company Professor Emeritus, Dept of Medicine, SUNY Stony Brook, NY mgraber@rti.org
  • 6. Diagnostic Errors Falls Wrong Site Med Errors Surgery 6 NPSF Professional Learning Series November 16, 2011
  • 7. Nurses: Its not MY problem ! Hospitals: Its not OUR problem ! Doctors: I don’t make mistakes ! Diagnostic errors fall in our collective blind spot 7 NPSF Professional Learning Series November 16, 2011
  • 8. DxNos Tician MD Diagnosis: “The most critical of a physician’s skills. It is every doctor’s measure of his abilities; it is the most important ingredient in his professional self image.” Pat Croskerry - 2008 8 NPSF Professional Learning Series November 16, 2011
  • 9. Estimates of the Diagnostic Error Rate Pathology, Although higher numbers can be found under artificial Radiology conditions, the estimated error rate in the real world is near 2% Clinical Lab Varies by test, lab, etc, but overall error rate is < .1% 9 NPSF Professional Learning Series November 16, 2011
  • 10. Estimates of the Diagnostic Error Rate Patient One third of patients relate a Dx error that affected Surveys themselves, a family member, or close friend Second 10-30% of breast cancers are missed on reviews mammography;1-2% of cancers misread on biopsy samples Standard pts Internists misdiagnosed 13% of patients presenting with common conditions to clinic (COPD, RA, others) Look backs 30% of subarrachnoid hemorrhage misdiagnosed; 39% of dissecting AAA delayed diagnosis; 25-50% of women with cervical cancer – last PAP abnl on re-read Autopsies Major unexpected discrepancies that would have changed the management are found in 10-20% Expert guess Arthur Elstein: 10% 10 NPSF Professional Learning Series November 16, 2011
  • 11. The death of one man is a tragedy, the death of millions is a statistic. Joseph Stalin (?) Maurice Gibb John Ritter 11 NPSF Professional Learning Series November 16, 2011
  • 12. Where do these errors happen ? What are the common conditions ? 12 NPSF Professional Learning Series November 16, 2011
  • 13. Inpatient Settings % adverse events related to diagnostic error: Harvard Medical Practice Study: 17% Colorado & Utah: 7% Canadian Adverse Event: 10% 13 NPSF Professional Learning Series November 16, 2011
  • 14. Diagnostic Error in Ambulatory Settings Systematic Review of 21 publications: Cancer In a series of 56 cases, 8 had serious delays in dx DementiaEvery pt in a small town was screened: 9% had dementia but only 4% had been diagnosed Fe-def anemia High incidence of non-investigation & missed cancer, esp females. Asthma Median delay making the Dx: 3 years, 7 visits Tremor Of 402 pts with presumed Parkinsons, dx correct in only half Error-promoting factors: • Atypical & nonspecific presentations • Rare conditions • Comorbid conditions Kostopoulou, Delaney and Munro. Diagnostic difficulty and error in primary care – A systematic review. Family Practice 400-413, 2008 14 NPSF Professional Learning Series November 16, 2011
  • 15. Diagnosis cases % Pulmonary embolism 26 4.5% Poisoning, ADR, overdose 26 4.5% Lung cancer 23 3.9% Schiff, G. D., O. Hasan, et al. (2009). Colorectal cancer 19 3.3% Diagnostic Error in Acute coronary syndrome 18 3.1% Medicine - Analysis of 583 Breast cancer 18 3.1% Physician-Reported Errors. Arch Int Med 169(20): Stroke 15 2.6% 1881-1887. Congestive heart failure 13 2.2% Fracture 13 2.2% Abscess 11 1.9% Pneumonia 10 1.7% Aortic aneurysm/dissection 9 1.5% 15 NPSF Professional Learning Series November 16, 2011
  • 16. What is the cost of diagnostic error ? 16 NPSF Professional Learning Series November 16, 2011
  • 17. Claims Data: High-severity Cases Top allegation category: Diagnosis Error 17 NPSF Professional Learning Series November 16, 2011
  • 18. The rising cost of diagnosis Igelhart NEJM 2009. Vol 360 p1030 18 NPSF Professional Learning Series November 16, 2011
  • 19. Costs and consequences of Dx Error • Inappropriate testing (Defensive medicine) • Preventable re-admissions; Preventable return visits to the ER; Preventable rescue events. • Physical and psychological harm ▫ False positives: Your mammogram shows a nodule – I think you have cancer ▫ False negatives: Your chest pain sounds musculoskeletal (or is it a heart attack ?) 19 NPSF Professional Learning Series November 16, 2011
  • 20. How can we analyze and understand diagnostic error ? 20 NPSF Professional Learning Series November 16, 2011
  • 21. History Exam Diagnosis Tests 21 NPSF Professional Learning Series November 16, 2011
  • 22. Where & When in Dx Process are Errors Occurring? Present; F/up 1% Assessment 33% History 10% Exam 10% Lab & Radiol Testing 46% N= 583 Cases Schiff, G. D., O. Hasan, et al. (2009). "Diagnostic Error in Medicine - Analysis of 583 Physician-Reported Errors." Arch Int Med 169(20): 1881-1887. 22 NPSF Professional Learning Series November 16, 2011
  • 23. What went wrong ? 23 NPSF Professional Learning Series November 16, 2011
  • 24. Missed and Delayed Diagnoses in the Ambulatory Setting Gandhi et al. Ann Int Med 2006. 145:488-496 Analyzed 307 closed malpractice claims involving an outpatient diagnostic error from 4 carriers • Of the 307 cases: ▫ 55% failure to obtain an appropriate test ▫ 45% failure to create an appropriate plan for follow-up ▫ 42% failure to obtain the appropriate history or physical exam ▫ 37% incorrect interpretation of diagnostic tests 24 NPSF Professional Learning Series November 16, 2011
  • 25. The Healthcare System The Clinician The Patient HARM 25 NPSF Professional Learning Series November 16, 2011
  • 26. Average: 6 distinguishable errors/case Etiology of Diagnostic Error No Fault Error Only 7% Both System and System Error Only Cognitive Errors 19% 46% Cognitive Error Only 28% 26 NPSF Professional Learning Series November 16, 2011
  • 27. System-Related Diagnostic Error DOMAIN EXAMPLE Communication Critical information not passed to the next provider Coordination of Care Medical records not available Access to Experts No Radiologist on nights Safety Culture Same errors keep happening Supervising Trainees Trainee misdiagnosis at night Work Pressure Rushed history – missed key piece of data Distractions, etc Fatigue, interruptions causing slips Diagnostic Testing Pre- and Post-analytical errors 27 NPSF Professional Learning Series November 16, 2011
  • 28. Cognitive-Based Diagnostic Error DOMAIN EXAMPLE Inadequate knowledge Doctor didn’t know the disease could present this way Faulty data collection Sloppy physical exam; failing to review the existing medical records Faulty synthesis Faulty context and anchoring errors; Premature closure (failing to consider other possibilities) 28 NPSF Professional Learning Series November 16, 2011
  • 29. “ Say … What’s a mountain goat doing way up here in a cloud bank ?” 29 NPSF Professional Learning Series November 16, 2011
  • 30. Premature closure = Satisficing = Falling in love with the first puppy … (Herbert Simon) 30 NPSF Professional Learning Series November 16, 2011
  • 31. So where are we ? 31 NPSF Professional Learning Series November 16, 2011
  • 32. Diagnostic Errors • Are more common than they should be. They cause enormous harm and lost costs. • Typically involve multiple breakdowns in our safety systems, and involve both cognitive and system-related issues. They can be analyzed using RCA approaches like any other medical error 32 NPSF Professional Learning Series November 16, 2011
  • 33. What can we do to reduce the likelihood of diagnostic error ? 33 NPSF Professional Learning Series November 16, 2011
  • 34. AHRQ: Literature Review to Identify Interventions to Reduce Dx Error Mark Graber, Hardeep Singh RTI International Systems: 43 articles: 6 trials Cognitive: 157 articles: 37 trials 34 NPSF Professional Learning Series November 16, 2011
  • 35. Strategies to Reduce Dx Error HEALTHCARE SYSTEMS Promote a culture of safety Address the common system flaws to contribute to diagnostic error Provide decision support resources Encourage second opinions Develop pathways for feedback 35 NPSF Professional Learning Series November 16, 2011
  • 36. Strategies to Reduce Dx Error HEALTHCARE SYSTEMS •IMPROVE COMMUNICATION •Take advantage of the EMR • Better alerts for critical test results; Better data displays • Make sure expertise is available when needed • Coordinate care across different providers, sites, systems • Making sure prior medical data is available for review • Empowering patients; Encourage feedback • Ensure screening tests are done 36 NPSF Professional Learning Series November 16, 2011
  • 37. Strategies to Reduce Dx Error NURSES – Our Safety Net Help minimize system flaws: Ensure good communication Help ensure test results are acted upon Help the patient communicate Be the watchdog for deterioration 37 NPSF Professional Learning Series November 16, 2011
  • 38. Strategies to Reduce Dx Error PATIENTS Be a good historian Keep accurate records of your tests SPEAK UP ! What else could this be ? Get real: Diagnosis is just playing the odds Ask what to expect & what the plan is for follow-up 38 NPSF Professional Learning Series November 16, 2011
  • 39. Strategies to Reduce Dx Error PHYSICIANS System errors: Bring them to attention and make sure they get fixed. Cognitive errors: •Improve your knowledge base •Improve your clinical reasoning & use EBM •Take advantage of decision support resources and get help when needed 39 NPSF Professional Learning Series November 16, 2011
  • 40. NOVICE more Monitoring, Inductive antidotes Reasoning GET HELP REFLECTIVE PRACTICE Cost Heuristics, Automatic Time ME EXPERT Effort Expert Thinking less more Accuracy, Reliability 40 NPSF Professional Learning Series November 16, 2011
  • 41. Problems Solutions • Faulty context • Reflection – What else • Premature closure could this be ? • Failed intuition • Be comprehensive 41 NPSF Professional Learning Series November 16, 2011
  • 42. How to be Comprehensive Use mnemonics and tricks: ROWCS VITAMIN C C & D Electronic decision support (Isabel, DxPlain) 42 NPSF Professional Learning Series November 16, 2011
  • 43. VITAMIN C C & D V ascular I nfections & intoxications T rauma & toxins A uto-immune M etabolic I diopathic & iatrogenic N eoplastic C ongenital C onversion (psychiatric) D egenerative 43 NPSF Professional Learning Series November 16, 2011
  • 44. DXplain •Chest tightness •Troponin elevation •Hypoxemia 44 NPSF Professional Learning Series November 16, 2011
  • 45. A Checklist for Diagnosis Obtain YOUR OWN, COMPLETE medical history, & a FOCUSED and PURPOSEFUL physical examination Generate some initial hypotheses; Use EBM; Pause to reflect – Take a diagnostic “time out”: •Was I comprehensive ? •Did I consider the inherent flaws of heuristic thinking ? •Was my judgment affected by any other bias ? •Do I need to make the diagnosis NOW, or can I wait ? •What’s the worst case scenario ? What are the ‘don’t miss’ entities ? Embark on a plan, but acknowledge uncertainty and ENSURE A PATHWAY FOR FOLLOW-UP Make the PATIENT your PARTNER 45 NPSF Professional Learning Series November 16, 2011
  • 46. NPSF Education Module: Reducing Diagnostic Error •Lectures from Gordy Schiff, Geetha Singhal, Mark Graber •Workshop on diagnostic error •Patient and Family Tools and Resources •Pocket Guide – How Doctors Think •Ask Me 3 1. Have I told you enough so you can understand my problem? 2. What could be causing my problem? 3. When will I get my test results, and will my other doctors get the results too? 46 NPSF Professional Learning Series November 16, 2011
  • 47. In Summary … • Diagnostic error is a common and serious problem, causing enormous harm • These errors reflect latent system flaws and shortcomings in cognition • The problem is largely ignored by all concerned • ITS TIME TO DO SOMETHING ….. And THERE’S A JOB FOR EVERYONE 47 NPSF Professional Learning Series November 16, 2011