22. SIRS with a presumed or confirmed infectious confirmed infectious process sepsis SIRS Infection Severe sepsis Bacteremia
23. Severe sepsis MODS The presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention Death Sepsis with 1 sign of organ failure Cardiovascular (refractory hypotension) Renal Respiratory Hepatic Hematologic CNS Metabolic acidosis Shock
36. Gastrointestinal Dysfunction Hypoperfusion Ischemia of the gut Decreased integrity of the gut lining Decreased peristalsis Translocation of normal GI bacteria into systemic circulation Colonization of normal GI flora up into the orpharynx Systemic infection and SIRS Aspiration of bacteria and initiation of a inflammatory response in the lung
37. Hepatobiliary Dysfunction Hypoperfusion Ischemia of the liver and gallbladder ischemic hepatitis acalculous cholecystitis Jaundice serum transaminase serum bilirubin Right upper pain and tenderness Abdominal distention Unexplained fever Loss of bowel sounds
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39. Renal Dysfunction Hypoperfusion And Renal toxic drugs Ischemia of the Kidney Azotemia Creatinine clearance Fluid and electrolyte imbalances Fluid volume overload Renal Function
40.
41.
42. Central Nervous System Bispectral EEG monitoring Altered level of consciousness Impaired mentation Confusion Delirium Psychosis Lab Clinical
43. Metabolic/Nutritional Negative nitrogen balance Hyperglycemia Hypertriglyceridemia Increased serum lactate Decreased serum albumin,serum transferrin,prealbumin Decreased retinol-binding protein Decreased lean body mass Muscle wasting Severe weight loss Lab Clinical