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Fall 2013
Cathy Mahon,PA
Instructor

Chapter 1

Anatomy
and
Physiology
Means
literally to
“cut
apart”
Function
and vital
processes
Define A&P
Study of
the
structure of
the body
Answers the
question of
HOW the body
works!

The body is made up of
approximately 50-100 trillion
cells
Over the course of a lifetime of 75
years we will inhale and exhale
roughly 236 million liters of air
The average length of the small
intestine in the human male is 22 ft
6 inches and in female 23 ft 4 inches
Did you know?

Anatomy
Micro: seen
with
microscope
Macro
Gross
Anatomy:
Bones
Micro vs Macro
Anatomy
Cytology Chest x-ray
Histology

Morphology
Description
of forms and
structures
Describes
shapes and
sizes
Define Morphology
The gene for sickle cell anemia when
expressed as a recessive trait protects
one from contracting malaria. Which
race of humans in the U.S. has the
highest incidence of sickle cell anemia?
The P.A./Instructor asks:
A.Caucasian or White
B.Native American
C.African American
D.Asian American

Disease
Literally
means “not
at ease” Condition
in which
body fails
to function
normally
Define Disease

Pathology
Pathophysiology
The Language of
Disease
The study of disease characteristics including cause and effect
The science that investigates abnormal body function

Etiology
Nosocomial
Epidemiology
Communicable
Contagious
The Language of
Disease
The cause of illness and disease
Acquired in medical facility
The study of transmission, frequency
occurrence and distribution of disease
Spread person to person, animal to
person, insect to person
Readily or easily transmitted

Center for
Disease
Control
Keeps
track of
diseases
worldwide
Began
60 years
ago
The Language of
Disease

Endemic-
continually
present in
population
Epidemic-
occurs
suddenly and
in large
numbers in
one region
Pandemic-
spreads
country or
worldwide
The Language of
Disease

What infectious disease was one
of two to be eradicated world
wide in 1979 through vaccination
campaigns?
A. Chicken Pox
B. Small Pox
C. Whooping Cough
D. Herpes Simplex
The P.A./Instructor asks:

Complete the 8 questions for
Section 1-1
Test Your Knowledge

Word
Root
Prefix
Prefix
Word
Root
Suffix Suffix
Medical Terminology
+
+

abdomin o plasty
Combining Forms
Word
Root Vowel Suffix
Adding a vowel to the word root makes easier to say

Write down as many “ologists” as you
can think of in two minutes.
Hint: Think of all of the different doctors
who are specialists that you or your
family have been to over the years.
The Language of A&P

Review of medical terminology-
Using the flash cards to test your
partner.
Find the word root and the prefix
and/or suffix
The Language of A&P

Complete the 11 questions for
Section 1-2
Test Your Knowledge
Medical
Terminology
Written
language
Health
professionals
Metric
System
Mathematical
language
Health
Professionals
The Language of A&P

Metric
Int’l System
of Units
Power of
ten
English
U.S
Customary
System
Inconsistent
units
Metric System vs
English

Metric
Centimeters,
milliliters,
kilometers,
kilograms
Used all around
the world and
U.S. health
professionals
English
Inches, pounds,
miles and
gallons
Used mainly in
United States
Metric System vs
English

•Anabolism
•Catabolism
Metabolism
•Negative feedback loop
•Positive feedback loop
Homeostasis
A&P Disease Concepts

•Building phase
•Simple compounds built up for
growth, repair and reproduction
Anabolism
•Breakdown phase
•Complex substances broken
down into simpler substances
Catabolism
Anabolism vs.
Catabolism

A state of being that utilizes
physiological process to MONITOR
and MAINTAIN a stable internal
environment
What is Homeostasis?
•The reaction of system to
stimulus is to do the opposite
•E.g. The body reacts to fevers & if
it’s too hot, system cools
Negative
feedback
loop
•Increases the magnitude of
change away from ideal set point
•E.g. Contraction of uterus from
increasing oxytocin levels until
baby is born
Positive
feedback
loop
Homeostasis

Explain how the body brings
the body temperature back to
normal if it gets too cold?
The P.A./Instructor asks:
By shivering, the muscles of the
body contract rapidly and
involuntarily, generating heat

Signs
Objective
Measurable
Symptoms
Subjective
Perceived
by patient
Assessment of Disease
Blood pressure
Pulse
Respirations
Temperature
Vital Signs
Pain
Tachycardia
Itching
Hypotension
Blurred vision
Sign or Symptoms?
SIGN SYMPTOM

Grouping of signs
and symptoms
relating to a
specific disease
What is a syndrome?
Marfan’s
Syndrome
Metabolic
Syndrome
Acquired
Immune
Deficiency
Syndrome
Down’s
Syndrome

Chief
complaint:
Why is the
patient here?
Were symptoms
sudden or
gradual?
History of
present illness
Ask open ended questions
Let patient explain how they
feel
Medical History Including previous
hospitalizations and
surgeries
Disease Concepts:
Diagnosis
Diagnosis means “know through completely”

Disease Factors
Disease starts with an imbalance in the body
Stress &
Inactivity
Immune
system
dysfunction
Delayed
healing
Poor
diet

Prognosis
Remission
Relapses
Exacerbation
More Disease Concepts
Once a disease
process is
identified, we
can predict an
outcome and
monitor for
disappearance or
recurrence of
signs/symptoms
as well as acute
flare ups.

Terminal
Mortality
Morbidity
More Disease Concepts
Disease
processes
may lead to
death or
disability and
cases are
recorded and
studied later

Complete the 3 questions for
Section 1-3
Test Your Knowledge

TAKE A BREAK
FIVE MINUTES

Any disease producing microorganism.
Some are pathogenic ONLY when they
enter PORTALS OF ENTRY or grow in
uncontrolled manner.
What is a pathogen?

Portals of Entry
Openings in the body where
pathogens can enter

•Chemicals
•Temperature
•Radiation
•Allergens
•Foreign
substance
•Injury
•Trauma
•Bacteria
•Virus
Skin
Immune
response
Allergic
Inflam-
mation
Body’s Defense System

Redness
Heat
Swelling
Pain
Signs of Inflammation

Vector
Contact-direct or
indirect
Common Vehicle
Airborne
Disease Process-
Pathogens
Disease
producing
organisms that
enter the body
are called
“pathogenic”
and have
FOUR main
routes of
transmission

Insect
Animal
Vector Transmission
Vector
Insects can
carry malaria
and animals
like birds can
carry flu
virus

Biological
Mechanical
Vector Transmission
Vector
Pathogen lives
in animal or
insect
Pathogen
present on
surface of
animal or insect

Direct
Indirect
Contact Transmission
Contact
Contact can
be with
infected
tissue or
waste or
contaminated
material

Blood
products
IV
tubing
Food
Common Vehicle
Transmission
Common
Vehicle-
contaminated

Respiratory
droplets
Air droplets
from
equipment
AirborneTransmission
Airborne

Source Transport Entry
Standard Precautions
Assume that everyone is carrying a
communicable disease and break the chain of
infection to stop the spread of infectious
disease.

Gloves
Masks
Goggles
Face shields
PLUS: Prevention of Needle Sticks
Standard Precautions-
PPE

What is the single most important practice to reduce
the spread of (transmission) of infectious agents in a
health care setting (or anywhere)?
The P.A./Instructor
Asks:
A. Wearing Gloves
B. Wiping counter tops clean
C. Hand hygiene
D.Wearing a white coat

Complete the 2 questions for
Section 1-4 and
Discuss the Case study
Test Your Knowledge

Chapter Two

Stand
Erect
Feet
Together
Arms
at the
side
Palms
Up
Reading the Map of
Human Body

Body Positions
Supine
Lateral
Prone

Trendelenburg
Originally used to
position the pelvic
organs correctly during
surgery by Frederick
Trendelenburg, then
used to help raise blood
pressure in patients
going into shock

 NOW ONLY RECOMMEDED:
Current
Recommendations
The Trendelenburg position is clinically useful for:
*Insertion or removal of central venous catheters
*Certain spinal anesthetic techniques
The Trendelenburg position is probably not indicated or may have harmful
effects in:
*Resuscitation of patients who are hypotensive
*Patients in whom mechanical ventilation is difficult, or patients with
decreased vital capacity
*Patients who have increased intracranial pressure
*Patients who have cerebral edema
*Patients who have increased intraocular pressure
*Patients with ischemia of the lower limbs

 45-60 degree head elevation
Fowler Position
Can be used to relax
tension of the abdominal
muscles, allowing for
improved breathing in
immobile patients as it
alleviates compression of
the chest due to gravity,
and to increase comfort
during eating and other
activities.

Disease Concepts
 Body position
can affect a
patient’s signs
(observable)
and symptoms
(what a patient
feels).
Jugular Venous Distension
Orthostatic hypotension
Orthopnea
SIGN SYMPTOM

Complete the 4 questions for
Section 2-1
Test Your Knowledge

 A plane, when referring to directions, is an
imaginary line drawn through an object; in this case
the HUMAN BODY
Body Planes/Directions

THREE BODY PLANES
Transverse , Sagittal and Frontal

 Same as horizontal or cross section and divides the
body into TOP AND BOTTOM (superior and
inferior)
TRANSVERSE

Cranial-head/skull
Caudal-tail
Directions: Top to
Bottom

SAGITTAL
Divides the body into RIGHT AND LEFT SIDES
If each side is equal, it is a “mid-sagittal”cut

Medial Medial
Medial Direction
MEDIAL means toward the MIDLINE of the body
from either the left or right side of the body

Lateral Lateral
Lateral Direction
LATERAL means away from or LEAVING the
midline of the body to the left or right

FRONTAL
Divides the body BACK and FRONT
• Posterior
• Dorsal
• Back
• Anterior
• Ventral
• Front

Superficial Superficial
Superficial Direction
Close to the Surface of
ANY PART OF THE BODY

Deep Deep
Deep Direction
Away from the surface of
ANY PART OF THE BODY

Proximal Proximal
Proximal Direction
Near a point of reference or
origin of the body

Distal Distal
Distal Direction
Away from ANY point of reference in the body

Internal
External
External
External
External
External vs Internal
INSIDE VS. OUTSIDE

Center
of Body
Peripheral
Peripheral
Peripheral
Peripheral
Central vs Peripheral
CENTER VS. OUTER REGIONS
Outer regions
Outer regions
Outer regions
Outer regions

Central Part of Body
Head and Torso
*Vital Organs
for Survival

Peripheral Part of Body
Arms and Legs or
“extremities”
*Non-vital to
survival

Which condition can contribute
to the formation of a blood clot
that starts in the leg (DVT) and
can go to the lung?
A. Varicose Veins
B. Use of blood thinners
C. Venous stasis
D. Use of TED hose (support stockings)
The P.A./Instructor asks:

Complete the 10 questions for
Section 2-2
Test Your Knowledge

TAKE A BREAK
FIVE MINUTES

Body Cavities
Body cavities
divided
between front
and back by
SPINAL
VERTEBRAE

FRONT Body Cavities
Anterior means
FRONT,
Posterior means
BACK or
behind, in
reference to
SPINE

FRONT Body Cavities
Ventral also
means FRONT,
Dorsal also
means BACK or
behind, in
reference to
SPINE

FRONT Body Cavities
Anterior
• Thoracic
Anterior
• Abdominopelvic

What large muscle divides the
thoracic cavity from the
abdominopelvic cavity?
A. Psoas
B. Biceps
C. Gluteus maximus
D. Diaphragm
The P.A./Instructor asks:

FRONT Body Cavities
Thoracic Cavity
Contains:
• Heart
• Lungs
• Large Vessels-Aorta,
Superior Vena Cava

FRONT Body Cavities
Heart has its own
cavity called the
PERIDCARDIAL
Cavity or SAC

FRONT Body Cavities
Abdominal Cavity
Contains:
• Stomach
• Intestines
• Liver, Gallbladder
• Pancreas
• Spleen

FRONT Body Cavities
Pelvic Cavity Contains:
• Bladder
• Reproductive Organs
• End of Large Intestine

Dividing Front & Back
The spine is
CENTRALLY
located with
30 vertebrae
and divides
the anterior
and posterior
cavities

Dividing Front & Back
There are
SEVEN
Cervical
vertebrae like
SEVEN days
in a week

Dividing Front & Back
There are
TWELVE
Thoracic
vertebrae like
TWELVE
months in a
year

Dividing Front & Back
There are
FIVE
Lumbar
vertebrae like
FIVE fingers
on a hand

Dividing Front & Back
There are
FIVE
Fused
SACRAL
vertebrae like
FIVE fingers
on a hand

Dividing Front & Back
There is ONE
COCCYX or
TAIL at the
end of the
spine

BACK Body Cavities
Posterior
•Spinal
Posterior
•Cranial

BACK Body Cavities
Spinal Cavity Contains:
• Spinal Cord

BACK Body Cavities
Cranial Cavity Contains:
• Brain

Complete the 6 questions for
Section 2-3
Test Your Knowledge

BODY REGIONS
NINE REGIONS OF
THE BODY
1. Right Hypochondriac
2. Epigastric
3. Left Hypochondriac
4. Right Lumbar
5. Umbilical
6. Left Lumbar
7. Right Iliac
8. Hypogastric
9. Left Iliac

BODY REGIONS-
Quadrants
Easier to
describe a
patient’s
symptoms by
using
quadrants as a
way to identify
a body region

BODY REGIONS
Anterior
and
Posterior
Body
Regions*
*Page 35 and 36

Which type of hernia is most
common in newborn babies
after “cutting the cord”?
A. Umbilical
B. Femoral
C. Inguinal
D. Ventral
The P.A./Instructor asks:

Complete the 5 questions for
Section 2-4
Test Your Knowledge

Radiology-Viewing the
Body

Air-Least Dense
DARK
Tissue/Fat DARK OR LIGHT
Water- MID RANGE
Bone/Metal LIGHT
Radiology-Viewing the
Body

PA posterior to anterior
PA back to front
Distance 6 feet from
machine to film
Radiology-Viewing the
Body

AP anterior to posterior
PA front to back
Distance 4 feet from
machine to film
Used in hospitals-patient in
bed
Radiology-Viewing the
Body

Radiology-Viewing the
Body
Focused
Beam that
circles the
body
Thin slices for
greater detail

CT SCAN
Allows for 3
dimensional view, like a
loaf of sliced bread gives
better idea of total shape
of loaf

Radiology-Viewing the
Body
Magnetic
energy to
create cross
section imagesPatient cannot move or have
metal objects in their body

Radiology-Viewing the
Body
Sound waves
that allow you
to view body
parts in real
time
No radiation
involved

On page 39 in your book, what
is wrong with the description of
the xray on the left?
The P.A./Instructor asks:
The label identifies it as showing “typical” joint
changes associated with osteoarthritis. It is
actually an xray of a patient who has had a
TOTAL KNEE REPLACEMENT

Review case study and
Complete the Review Questions on
page 41 and 42
Test Your Knowledge

Let’s watch the videos of the
bones of the skull
Bones of Skull
http://www.youtube.com/watch?v=BcdEwPkfyvs
Use your handouts and
label the parts

Bones of the Spine-on
the Quiz

Chapter 3

Biochemistry of Life
Vital
and
with interactions
between
molecules

Tissue
Atoms
Elements
Molecules
Cells
Biochemistry of Life
Phyisiology is how Chemistry
relates to a living organism

Power of TEN
Watch animation on website
www.scaleofuniverse.com
Making what’s seemingly
invisible and only in our
imagination, visible and REAL

Element
Fe
Fe
Fe
Fe
Atoms, Elements & Ions
Smallest
unit of
matter
that retains
unique
chemical
properties
Fe =Iron

Molecules
Two or more
elements joined
together
O=Oxygen
O
O
O
O
O
O
Oxygen in the air is two
elements joined together

Compounds
Molecules with
more than one
element
H=Hydrogen
O=Oxygen
O
H
H
H
O
O
A carbohydrate is a combination of
three elements: carbon, hydrogen
and oxygen
C
C
C
C=Carbon

Protons
Electrons
Neutrons
Parts of the Atom
Smallest
recognizable
unit of an
element

Atoms, Elements & Ions
Elements
are listed
in periodic
table based
on number
of protons
*abbreviated with 1 or 2 letters

What important trace element
found in seafood is necessary
for the activity of the thyroid?
The P.A./Instructor asks:
A.Manganese
B.Copper
C.Zinc
D.Iodine

Protons Electrons
Parts of the Atom
Number of
PROTONS is
equal to
ELECTRONS
=

Protons Electrons
Protons & Electrons
=+ _
Protons are
positively
charged and
electrons
are
negatively
charged

Protons Electrons
Ions-Electric Charge
_
+ _
Atoms that
lose an
electron are
positively
charged
IONS

Protons
ElectronElectron
Ions-Electric Charge
- -
Atoms that
gain an
electron are
negatively
charged
IONS
+

Protons
ElectronElectron
Polar Ion with Charge
- -
Polarity
refers to
atoms with
an electric
charge
either
negative…
+

Protons Electrons
Polar Ion with Charge
_
+ _
…OR
positively
charged

POSITIVE NEGATIVE
Ions with a Charge
OPPOSITES ATTRACT!!!!!
Positive ions attracted to
negative ions

Positive Positive
Ions with a Charge
SIMILARS REPEL!!!!!
Positive ions repelled by
positive ions

 Charged Ions
found in the
body, influence
muscles,
nervous systems
and fluid
balance
ELECTROLYTES
Cl-
Na+
Na+
Na+
K+
Na+
Sodium, Potassium, Chloride, Magnesium, Phosphate

What organ in the body is
responsible for regulating the
electrolyte balance?
The P.A./Instructor asks:
A.Heart
B.Liver
C.Pancreas
D.Kidney

ACIDS AND BASES
Electrolytes
(Ions) that can
conduct
electricity and
break down
water into its
separate parts

ACIDS
Release
hydrogen H+
ions when
dissolved in
water

BASES
Accept
hydrogen H+
ions when
dissolved in
water

Acid Base Concentration
pH stands for “potential of hydrogen”
to be attracted to OH-

Acid Base Concentration
The lower the number, the less OH- ions and the more
there is H+ ions available to be released

Regulating Acid/Bases
O2
CO2
Respiratory system takes in O2 and gets rid of
excess CO2 which is a weak acid with kidneys
excreting excess acids in the body

TAKE A BREAK
FIVE MINUTES

BONDING

Joining
of
elements
Covalent
Ionic
Chemical Bonding
Molecules
are formed
by joining
elements

Covalent Bonding
Electron Electron
Joining Elements to form Molecules by
Sharing of Electrons
.
.

Ionic Bonding
Joining Elements to form Molecules by
one atom Donating Electrons to another

Polar Covalent
Electron Electron
One atom takes more than its share of
electrons, creating a weak charge
. -.+ XX

Ionic
Polar
Covalent
Covalent
Comparing Bonds
Highly charged Weakly charged Not charged

WATER IS LIFE

WE ARE WATER
Water is a
polar solvent
with polar
covalent bonds
with a slight
charge

WATER is H20
Oxygen takes more
of its share of
electrons than
hydrogen and carries
a weak charge that
attracts other
charged molecules
-
+
+

MIXES EASILY
with H2O
Charged molecules
like oxygen,
phosphorus and
nitrogen are
attracted to one end
or another of H20
-
+
+

DOES NOT MIX EASILY
with H2O
Molecules that do
not carry a charge
will not mix easily
with H2O like
Fats and Oils
-
+
+

CELL MEMBRANES
Hydrophobic fat layer on the outside of
cell membrane regulates movement in
and out of the cell.

HYDROGEN BONDS
Hydrogen bonds
between H20 are
weak and increase
water’s capacity to
store heat meaning
water can heat up
and cool down
slower than air
-
+
+

Why does someone who does
not sweat become easily
overheated?
The P.A./Instructor asks:
Because moisture (water) on the skin
allows it to heat up more slowly than dry
skin and keeps it at a more normal
temperature longer.

SOLUTIONS
Dissolving one substance in another
Solute Solvent Solution
Solute-substance that is dissolved
Solvent substance doing the dissolving

SOLUTIONS
Dissolving one substance in another
Electro
lytes Water Solution
Solute-substance that is dissolved
Solvent substance doing the dissolving

Solutions at Home
Mix ¼ cup of sugar
with 1 cup of H20 and
heat until solute is
dissolved in solvent

Solute Concentration
Amount of solute dissolved in solvent
Solute
¼ cup
Solvent
1 cup
Solution
Solute is sugar
Solvent is water

Complete the 5 questions in
Section 3-1
Test Your Knowledge

BIOLOGICAL MOLECULES
Found in living systems

Carbohydrates
Lipids
Proteins
Nucleic Acids
BIOLOGICAL MOLECULES

Carbohydrates
Used for
energy and
structural
molecules

Monosaccharides
Simple sugars

Disaccharides
Disaccharides are
two simple sugars
+

Polysaccharides
Stored
energy in
liver

LIPIDS
Mainly carbon
and hydrogen
and very little
oxygen

LIPIDS
Fats and oils
contain glycerol
used for energy
storage,
communication
and protection

WAXES
Fatty acid with
alcohol. The most
hydrophobic for
protection

PHOSPHOLIPIDS
Two fatty acid
“tails” and
phosphate
“head” and key
ingredient in cell
membranes

STEROIDS
Lipids with
carbon atoms
arranged in
rings for
structure or
communication
between cells

TAKE A BREAK
FIVE MINUTES

PROTEINS
Carbon
Hydrogen
Oxygen
Nitrogen
A special linkage unique to proteins called the
PEPTIDE BOND ties the amino acids together

VERSATILE PROTEINS
Collagens Enzymes
Muscle
proteins
Antibodies
Hormones

PROTEINS
Cytosine
Guanine
Adenosine
Thymine
The structure of a protein is determined
by order of amino acids

NUCLEIC ACIDS
ibo
cid
ucleic
Controls the activities of cells and contains your
genetic code responsible for cellular reproduction

NUCLEIC ACIDS
eoxyribo
cid
ucleic
Controls the activities of cells and contains your
genetic code responsible for cellular reproduction

Complete the 5 questions in
Section 3-2
Test Your Knowledge

METABOLISM

All
chemical
operations
in the body
Anabolism
Catabolism
METABOLISM

All
chemical
operations
in the body
Nutrients to
Fuel the
body
Produces
Waste
METABOLISM

Metabolism
Anabolism
Dehydration Build
up
Catabolism
BreakdownHydrolysis
METABOLISM

Anabolism
Simple
compounds built
for growth, repair
and reproduction
Dehydration
removes H20 to
form large
molecules
Catabolism
Complex substances
broken down
Hydrolysis adds
H20 to break up
large molecules
Anabolism vs Catabolism

What common condition in
patients slows the metabolism
causing weight gain?
The P.A./Instructor asks:
A.Diabetes
B.Hypertension
C.Hypothyroidism
D.Arthritis

ENZYMES

ENZYMES

Enzymes to the Rescue
Chemical
reactions in
cells are TOO
SLOW and
need help so
they can use the
materials

ENZYMES
Enzymes
are
unchanged
by the
chemical
reaction

ENZYMES
Protein molecules with
special binding sites
Molecules that need help in a
chemical reaction

ENZYMES
Enzymes
are
matched
to
SPECIFIC
substrate

ENZYMES
Substrates
compete
for
binding
sites until
all are
filled

“Ride the ENZYME”
Biological molecules bind to enzymes
and are carried like riders in a roller
coaster. Enzymes return for more
molecules/passengers when
reaction/ride is complete

“You Can’t Ride the
ENZYME”
Enzymes can also prevent the
substrate molecule from
binding/riding the roller coaster

CELL ENERGY & ATP
We all need food
for energy, but
HOW DOES IT
GET TO THE
CELLS?

Cellular Respiration
Glucose Oxygen ATP
Inside the
mitochondria, glucose
is combined with O2
and made into high
energy molecule

ATP-Stored Energy
denosine
ri
hosphate Made up of a base, a sugar and
three “tri” phosphate groups held
by HIGH ENERGY BONDS

ADP-Released Energy
denosine
i
hosphate When bonds are broken, energy is
released and molecule becomes
“di”and is ready to pick up
another phosphate

Complete the 4 questions in
Section 3-3, Case Study and Review
Questions
Test Your Knowledge

Oct 3, 2013
Exam on Chapters 1-3
Go to myhealthprofessionskit.com
Most of the test questions will come from
worksheets and the website: multiple choice, fill
in the blank, true or false, matching and
short essay
Test Your Knowledge

Chapter 4 The Cells
Each structure of the body is made up of
“building blocks” called THE CELLS

Chapter 4 The Cells
Each cell has its own component parts
cytoplasm
nucleolus
ribosome
Cell membrane
mitochondria
nucleus
centrosomes
endoplasmic reticulum
Golgi apparatus

Specialized
Cells
Organs
Organ
System
Organelles
Cells
Chapter 4 The Cells
Human

All of the following organs are
part of the gastrointestinal
system except?
The P.A./Instructor asks:
A.Kidney
B.Gallbladder
C. Colon
D.Esophagus
 Cells contain chemicals and structures and make up
 ALL LIVING THINGS
CELLS of LIFE

MICROSCOPIC CELLS
Our body is made up almost entirely of microscopic
cells and cannot be seen with the naked eye. The
nerve cell is the largest and can be
TWO FEET LONG

MICROSCOPIC CELLS
Cells come in various shapes and sizes
Flat
Round
Threadlike
Irregular

Carbohydrates
Lipids
Proteins
Nucleic Acids
Review:
BIOLOGICAL MOLECULES

Cell Structure
Almost all cells possess a nucleus, organelles, cytoplasm
and a cell membrane each with a special purpose
cytoplasm
nucleolus
ribosome
cell membrane
mitochondria
nucleus
Golgi apparatus
endoplasmic reticulum

Cell Membrane
Surrounds the cytoplasm as a protective
covering with a defined border and
definite shape

Selectively Permeable
Allows materials in and out of the cell and
decide specifically which things are not
allowed

Specialized Structures
Contains specialized structures: channels,
tunnels or carriers

Identification Markers
Markers on the cell membrane identify the
cell as belonging to specific individual and
set off an “attack” of foreign cells

Cell Membrane
Transport Methods

Passive
Across the
membrane
No energy
Active
Across the
membrane
Requires
energy
Transport Methods

Diffusion
Osmosis
Filtration
Facilitated Diffusion
PASSIVE TRANSPORT

Diffusion
Higher Concentration to lower concentration

Concentration Gradient
Higher Concentration minus lower concentration

Concentration Gradient
Nature likes a nice equal balance
The water
assumes same
color & flavor
as the powder
Traffic moves
when
concentration of
cars decreases

Diffusion
Diffusion is necessary for
O2 to go from lungs to
blood and for CO2 to go
from blood to lungs and
out into the air

What specialized cell in the blood
carries oxygen to the cells of the body
as well as carry carbon dioxide out of
body?
The P.A./Instructor asks:
A.White Blood Cells
B. Alveoli
C. Platelets
D.Red Blood Cells

Diffusion
Osmosis
Filtration
Facilitated Diffusion
PASSIVE TRANSPORT

Osmosis
A solute, like sugar, cannot pass through
membrane, but water goes from low to higher
concentration of the SOLUTE

Osmosis
H20 travels through semipermeable membrane
until SOLUTE concentrations are equalized

Diffusion
Substance moves from
High to low
concentration through
cell membrane
Osmosis
Water alone moves from
low to high solute
concentration through
semi-permeable
membrane
Diffusion vs. Osmosis

OSMOTIC PRESSURE
Ability of a substance to “pull” H20 toward
area of high concentration of the solute

Diffusion
Osmosis
Filtration
Facilitated Diffusion
PASSIVE TRANSPORT

FILTRATION
Pressure is exerted to force H20 and its dissolved
material across the membrane

FILTRATION-Kidneys
Major supplier of force is the pumping of heart which
forces blood into the kidney where filtration takes place

Diffusion
Osmosis
Filtration
Facilitated Diffusion
PASSIVE TRANSPORT

FACILITATED
DIFFUSION
A substance is helped across the membrane on a
“carrier protein”

FACILITATED
DIFFUSION
The protein is specific for each substance and is
available to carry it through the membrane

Complete the 7 questions in
Section 4-1
And briefly explain one of the two
diseases, Cystic Fibrosis or Diabetes
as it relates to passive transport
Test Your Knowledge

TAKE A BREAK
FIVE MINUTES

Passive
Across the
membrane
No energy
Active
Across the
membrane
Requires
energy
Transport Methods

Active Transport Pumps
Endocytosis
Exocytosis
ACTIVE TRANSPORT

Active Transport Pumps
Uses a protein carrier with energy from ATP to
move a substance as it moves UP the gradient

Active Transport Pumps
Na+ and ATP used in active transport pump
needed to transmit a nerve impulse

Active Transport Pumps
Endocytosis
Exocytosis
ACTIVE TRANSPORT

Endo
Used for
intake
Phago or
pinocytosis
Exo
Exit out of
the cell
Uses ATP
for energy
Endo vs Exocytosis

ENDOCYTOSIS
Used for intake of LIQUID AND FOOD when
substance is too large to diffuse across membrane

ENDOCYTOSIS
Cell membrane surrounds substance forming a vesicle
and becomes separate from original membrane

PHAGOCYTOSIS
Solid particle engulfed in a cell

PINOCYTOSIS
Liquid substance engulfed in a cell

EXOCYTOSIS
Happens when cell needs to transport substances out of
itself. After substance made, it is surrounded by vesicle
and moves to cell membrane, where it is expelled

Endo vs. exocytosis
Intake of liquid and food versus
transport of substances out of the cell

Complete the 3 questions in
Section 4-2
And briefly explain familial
hypercholesterolemia
Test Your Knowledge

Cell Structure
cytoplasm
nucleolus
ribosome
Cell membrane
mitochondria
nucleus
endoplasmic reticulum
Golgi apparatus
centrosomes

CYTOPLASM
A watery solution of organic and inorganic
chemicals ENCLOSED in the cell membrane

Nucleus & Nucleolus
Nucleus is control center of cell with chromatin that
contains DNA which can form chromosomes
containing genes that create new cells

Nucleus & Nucleolus
The DNA material inside the genes is what
determines
inherited characteristics

Nucleolus
Nucleolus is inside the nucleus and it’s main
function is to synthesize RNA that forms ribosomes

Ribosome
Found on the endoplasmic reticulum or in
cytoplasm and is the site where enzymes and
proteins are made for cell repair & reproduction

Centrosome
Specialized regions of cell designed to build
new cell structures to replace old.

Centrosome
The tubular centrioles inside the centrosome come
in pairs and are involved in the division of the cell

Mitochondria
Provide up to 95% of body’s energy for cellular
repair, movement and reproduction

Mitochondria-
Liver vs Sperm
Cells with more
activity need more
mitochondria

Mitochondria
Enzymes in mitochondria help take in O2 and use to
produce energy in form of ATP which the cell uses

Endoplasmic Reticulum
A series of channels formed from folded membranes,
there are two kinds ROUGH and SMOOTH

Rough & Smooth ER
Rough has ribosomes on its surface responsible for synthesis
of protein. Smooth synthesizes lipids and steroids

Golgi Apparatus
Receives protein from ER, processes and stores it by
surrounding it with a vesicle, then it is expelled at cell
membrane by EXOCYTOSIS

Golgi Apparatus
Organs with high secretory function such as pancreatic cells
and salivary glands contain high numbers of Golgi apparatus

Golgi Apparatus
Lysosomes are proteins made in the Golgi apparatus and stay
in the cell

Lysosomes
Lysosomes are proteins made in the Golgi apparatus and
contain enzymes to clean up debris & waste as well as aid in
destroying unwanted bacteria by phagocytosis

Vesicles & Cytoskeleton
A transport vesicle carries
substance made by Golgi
apparatus
Made up of
microtubules/filaments &
give cell its shape

Flagella and Cilia
Has a whipped shaped tail
used for movement
Short hair-like projections
on outer cell creating
wavelike movement

What common activity by
humans can cause emphysema
by destroying cilia in the lung?
The P.A./Instructor asks:
A.Drinking alcohol
B.Chewing tobacco
C. Eating chocolate
D.Smoking cigarettes

Complete the 4 questions in
Section 4-3
Test Your Knowledge

TAKE A BREAK
FIVE MINUTES

Cellular Reproduction
The process of
making a new cell
occurs in MITOSIS
and cell division-
one cell divides
into two
IDENTICAL cells
in ASEXUAL
REPRODUCTION

Cellular Reproduction
Cells of human
body have several
chromosomes in
nucleus with DNA
“packages” of
chromatin

Cellular Reproduction
Chromosomes
carry instructions
from cell on how to
function and
reproduce.
All chromosomes
are copied just
before cell divides

Cellular Reproduction
Cells divide by
binary fission.
There is NO
nucleus or
organelles. DNA
copies itself &
cytoplasm splits in
half when cell
divides

CELL CYCLE
There are TWO
PHASES of the
cell’s life:
INTERPHASE
And
MITOTIC PHASE

INTERPHASE
80-90% of time
spent in
INTERPHASE
when cell is not
dividing but
functioning
normally

MITOTIC PHASE
Actual cell
dividing during
MITOSIS when
genetic material
is divided and
CYTOKINESIS

MITOTIC PHASE
MITOSIS occurs in
your body any
time your cells
need to be replaced
during REPAIR &
REGENERATION
and
GROWTH and
LENGTHENING

FOUR PHASES
Prophase
Metaphase
Anaphase
Telephase

PROPHASE
The nucleus disappears, chromosomes visible and
centrioles move to the sides of the cell. “Guide wire”
spindles form to anchor chromosomes

METAPHASE
The chromosomes line up in the
center of the cell

ANAPHASE
The chromosomes split and the spindles pull
them apart

TELEPHASE
The chromosomes go to the far end of the cell, the
spindle disappears and the nuclei reappear

CYTOKINESIS
The cell divides in half and the “mother” cell has
now formed into two identical “daughter” cells

An example of mitosis in your
body includes all of these things
except:
The P.A./Instructor asks:
A.Healing of laceration
B.Growing an inch in childhood
C. Larger biceps w/exercise
D.Ovum produced for ovulation

Sexual Reproduction
Meiosis occurs
when four cells are
produced from one,
each having only
HALF the genetic
material and so are
NOT IDENTICAL
to the “mother” cell

Sexual Reproduction
The sperm and
egg are joined
during
fertilization
and allow the
reproduction of
the human
being

Complete the 4 questions in
Section 4-4
Test Your Knowledge

MICROORGANISMS
Bacteria
*
Virus
*
Fungi
Protozoa

MICROORGANISMS
 Bacteria produce
disease and can
either be a pathogen
or NORMAL FLORA
Normal flora are found in
mouth, vagina and intestines
including this E.coli

MICROORGANISMS
 Viruses (Latin for
“poison”)are
particles that have
core containing
genetic material
DNA or
RNA,covered by
protein coat
CAPSID
Must take over cellular
activities as it cannot grow or
reproduce by itself

MICROORGANISMS
Fungi are one
celled or multi-
celled filaments
called “mycelia”
that travel
outside of the
cell or by release
of spores
Yeast, aspergillus, candidiasis and cryptococcus

MICROORGANISMS
 Protozoa are one
celled organisms
found in ponds and
soil with diseases
caused by drinking
contaminated H20 or
by being bitten by an
insect carrying them
Mosquitoes living in
contaminated H20 carry
malaria

MICROORGANISMS
Cause Disease-Pathogens
Bacteria
*
Virus
*
Fungi
Protozoa

MICROORGANISMS
Cause Disease-Bacteria
Bacteria release toxins
*
Bacteria destroy tissue,
blood cells, inhibit ribosome
*
Bacteria increase BP, blood
clotting, fluid in lungs and
cause paralysis
Bacteria cause fever,
tachycardia, SOB
Antibiotics kill
the prokaryotic
without
harming
eurkaryotic cell

MICROORGANISMS
Cause Disease-Virus
Viruses shut down a cell
*
Viruses destroy cells &
trigger other infections
*
Viruses cause fever, aches,
fatigue and immune system
can destroy most of them
Antibiotics do not kill
viruses. Antivirals can
adversely affect host cells
Viruses
contain either
DNA or RNA
in their core

MICROORGANISMS
Cause Disease-Fungi
Fungi are inhaled or
ingested or in open
wounds
*
Fungi are resistant to
environmental changes
*
Fungi are opportunistic in
immune compromised
Difficult to treat as drugs
are highly toxic
Fungal
infections of
skin are
common

MICROORGANISMS
Cause Disease-Protozoa
Protozoa cause disease
by ingesting H20
*
Protozoa are parasites
living in human cell
*
Most cause serious
chronic disease including
malaria
Some are mild diseases
like Giardia in water

Because of its overuse early on, this
antibiotic is no longer as effective
against bacterial infections:
The P.A./Instructor asks:
A.Penicillin
B.Doxycycline
C.Sulfa
D.Erythromycin

Chapter 4 Case Study and Review
Questions
Test Your Knowledge

KETOACIDOSIS

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