The document discusses the endocrine system and how it works with the nervous system to regulate bodily functions and homeostasis. It describes how the endocrine system is made up of glands that secrete hormones directly into the bloodstream to target distant organs and cells. Key glands discussed include the hypothalamus, pituitary gland, thyroid gland, and parathyroid glands. The hypothalamus and pituitary gland work together to control the release of hormones from other glands, maintaining hormonal levels through feedback loops. Hormones produced by these glands control important bodily functions like metabolism, growth, and fluid balance.
2. Endocrine System
Nervous system and endocrine system
Nervous system and endocrine system
are totally interconnected and always
are totally interconnected and always
monitor each other's activities
monitor each other's activities
4. Endocrine System
Endocrine system also collects
Endocrine system also collects
information and sends orders but
information and sends orders but
it is slower, more subtle
it is slower, more subtle
control system
control system
5. Endocrine System
While it acts slowly,
While it acts slowly,
effects last longer than
effects last longer than
those of nervous system
those of nervous system
13. Endocrine System
Effects last for minutes or
even hours or days
Many hormones are
secreted constantly, with
amount secreted changing
as needed
16. Hormones
If hormones bind to
outside of cell, they
can have several
different effects, either
changing cellular
permeability or
sending target cell a
message that changes
enzyme activity
inside cell
18. How Hormones Work
STEROIDS
This special class
This special class
of hormones
of hormones
(steroids) is
(steroids) is
particularly
particularly
powerful because
powerful because
only small
only small
amounts needed
amounts needed
to perform their
to perform their
task
task
19. How Hormones Work
STEROIDS
Steroids are lipid
Steroids are lipid
molecules that can
molecules that can
pass easily through
pass easily through
target cell
target cell
membrane,
membrane,
allowing them to
allowing them to
interact directly
interact directly
with cell's DNA to
with cell's DNA to
change cell activity
change cell activity
22. Homeostasis
Many chemical and physical characteristics of
Many chemical and physical characteristics of
body have standard level (set point) that is
body have standard level (set point) that is
ideal for a particular value
ideal for a particular value
24. Control Systems
The body can
The body can
measure,
measure,
store and
store and
correct for
correct for
ideal set
ideal set
points
points
Example: hypothalamus
stores ideal set point for
temperature
26. Negative Feedback
If any of the body's homeostatic values become
If any of the body's homeostatic values become
seriously disrupted, control systems work to bring
seriously disrupted, control systems work to bring
them back to set point via negative feedback
them back to set point via negative feedback
28. Negative Feedback
Hormones work
Hormones work
same way; if
same way; if
hormone levels
hormone levels
rise, negative
rise, negative
feedback will
feedback will
turn off
turn off
endocrine organ
endocrine organ
that is secreting
that is secreting
the hormone
the hormone
29. Positive Feedback
When a body
When a body
characteristic
characteristic
changes,
changes,
positive
positive
feedback
feedback
increases the
increases the
magnitude of a
magnitude of a
change
change
30. Positive Feedback-Flow
of Sodium Ions
More depolarized a
More depolarized a
neuron becomes, the
neuron becomes, the
more sodium flows
more sodium flows
in, and it becomes
in, and it becomes
more depolarized, so
more depolarized, so
more flows in until
more flows in until
action potential is
action potential is
complete
complete
31. Positive Feedback
•• Hypothalamus
Hypothalamus
orders pituitary to
orders pituitary to
secrete oxytocin
secrete oxytocin
•• Oxytocin
Oxytocin
stimulates
stimulates
uterine
uterine
contractions
contractions
•• Pressure of
Pressure of
uterus stimulates
uterus stimulates
more oxytocin and
more oxytocin and
more contractions
more contractions
until pressure
until pressure
decreases
decreases
32. Positive Feedback
Positive
Positive
feedback not a
feedback not a
way to
way to
regulate your
regulate your
body because it
body because it
increases a
increases a
change away
change away
from set point
from set point
37. Figure 10-4
Sympathetic control of
adrenal gland.
Hormones
Hormones
prolong the
prolong the
effects of
effects of
sympathetic
sympathetic
activity
activity
39. Hormonal Control
One gland is
One gland is
controlled by release
controlled by release
of hormones from
of hormones from
another gland up
another gland up
the chain, which is
the chain, which is
controlled by another
controlled by another
gland's release of
gland's release of
hormones up the
hormones up the
chain
chain
43. Figure 10-5
Hormonal control of adrenal gland
•• Adrenal gland produces
Adrenal gland produces
cortisol; when enough has
cortisol; when enough has
been produced,
been produced,
•• Hypothalamus detects
Hypothalamus detects
and stops sending orders
and stops sending orders
to pituitary which
to pituitary which
•• Stops sending orders to
Stops sending orders to
adrenal
adrenal
•• Adrenal stops making
Adrenal stops making
cortisol
cortisol
44. Humoral Control
Some endocrine organs
Some endocrine organs
directly monitor body's
directly monitor body's
internal environment by
internal environment by
monitoring body fluids,
monitoring body fluids,
such as blood, and
such as blood, and
respond accordingly
respond accordingly
46. Figure 10-6 Control of
blood sugar levels
Necessary
Necessary
changes in
changes in
hormone
hormone
secretion are
secretion are
made
made
accordingly
accordingly
50. Major Endocrine
Glands
•• Important link
Important link
between two
between two
control
control
systems:
systems:
•• Link between the
Link between the
nervous and the
nervous and the
endocrine
endocrine
systems
systems
52. Commander-in-Chief
Also acts as
Also acts as
“commander-in“commander-inchief” of endocrine
chief” of endocrine
system; it controls
system; it controls
pituitary gland
pituitary gland
and most other
and most other
glands in
glands in
endocrine system
endocrine system
53. Figure 10-7
The hypothalamus, anterior and posterior
pituitary glands, and their targets and associated
hormones.
PAGE 259
55. Pituitary Gland
•• Really acts
Really acts
only under
only under
orders from
orders from
hypothalamus
hypothalamus
•• Split into two
Split into two
segments:
segments:
anterior and
anterior and
posterior
posterior
57. Posterior Pituitary
As name suggests
As name suggests
antidiuretic
antidiuretic
hormone (ADH)
hormone (ADH)
decreases
decreases
urination, which
urination, which
decreases fluid
decreases fluid
lost, increasing
lost, increasing
body fluid
body fluid
volume
volume
59. Posterior Pituitary
Important in
Important in
long-term
long-term
control of
control of
blood
blood
pressure,
pressure,
especially
especially
during
during
dehydration
dehydration
60. Posterior Pituitary
Important in
Important in
maintaining
maintaining
uterine
uterine
contractions
contractions
during labor
during labor
Involved in milk
Involved in milk
production in
production in
nursing mothers
nursing mothers
*Function in
*Function in
males is
males is
unknown
unknown
63. Anterior Pituitary
Hormone levels
Hormone levels
are controlled
are controlled
by negative
by negative
feedback to
feedback to
both pituitary
both pituitary
and
and
hypothalamus
hypothalamus
65. Thyroid Gland
Thyroid Gland
Thyroid Gland
located in
located in
anterior
anterior
portion of neck
portion of neck
and is butterfly
and is butterfly
shaped
shaped
67. Thyroid Gland
Control cell
Control cell
metabolism
metabolism
and growth
and growth
Referred to
Referred to
as “thyroid
as “thyroid
hormones”
hormones”
68. Thyroid Gland
Table salt contains
Table salt contains
added iodine to
added iodine to
ensure people get
ensure people get
enough iodine in their
enough iodine in their
diets to make thyroid
diets to make thyroid
hormones
hormones
69. Thyroid Gland
Level of these
Level of these
hormones essential in
hormones essential in
controlling growth
controlling growth
and metabolism of
and metabolism of
body tissues,
body tissues,
particularly in
particularly in
nervous system
nervous system
72. Calcitonin from Thyroid
Thyroid gland
Thyroid gland
secretes third
secretes third
hormone,
hormone,
calcitonin;
calcitonin;
decreases blood
decreases blood
calcium by
calcium by
stimulating bonestimulating bonebuilding cells*
building cells*
73. Parathyroid Glands
Two small pairs
Two small pairs
of glands
of glands
embedded in
embedded in
the posterior
the posterior
surface of the
surface of the
thyroid
thyroid
74. Parathyroid Glands
Increases the
Increases the
level of calcium in
level of calcium in
the bloodstream by
the bloodstream by
stimulating bone
stimulating bone
dissolving cells* by
dissolving cells* by
releasing PTH
releasing PTH
(parathyroid
(parathyroid
hormone)
hormone)
75. Figure 10-8
The thyroid and parathyroid glands.
Calcitonin from thyroid decreases level of
Calcitonin from thyroid decreases level of
calcium and PTH increases level of calcium in
calcium and PTH increases level of calcium in
the blood
the blood
76. Thymus Gland
Both endocrine gland
Both endocrine gland
and lymphatic organ
and lymphatic organ
Located in upper thorax
Located in upper thorax
Produces hormone called
Produces hormone called
thymosin; helps with
thymosin; helps with
maturation of white
maturation of white
blood cells to fight
blood cells to fight
infection
infection
77. Pineal Gland
Tiny gland found
Tiny gland found
in brain
in brain
Shown to
Shown to
produce
produce
hormone
hormone
melatonin, which
melatonin, which
rises and falls
rises and falls
during waking and
during waking and
sleeping hours
sleeping hours
79. Pancreas-Exocrine
Part of pancreas
Part of pancreas
acts as exocrine
acts as exocrine
organ
organ
This part produces
This part produces
and secretes
and secretes
digestive
digestive
enzymes that help
enzymes that help
to break down
to break down
starches, fats, and
starches, fats, and
proteins
proteins
80. Pancreas-Endocrine
Other part of
Other part of
pancreas acts as
pancreas acts as
endocrine
endocrine
organ
organ
Produces
Produces
hormones that
hormones that
regulate blood
regulate blood
sugar
sugar
83. Pancreas-Two Hormones
Makes two
Makes two
hormones that
hormones that
control blood
control blood
glucose: insulin
glucose: insulin
and glucagon
and glucagon
Produced by cells in
Produced by cells in
pancreatic tissue
pancreatic tissue
called islets of
called islets of
Langerhans
Langerhans
86. PA/Instructor Asks:
With increased glucose (solute) in blood (solvent), more
water is drawn across the cell membrane from a lower to a
higher concentration to balance fluid concentrations on both
sides and thereby dehydrating the cell
87. Figure 10-11
The role of glucagon to raise blood sugar
In between eating,
blood glucose levels
decrease and then the
pancreas secretes
glucagon into blood.
One of two things
happens: 1) Adipose
breaks down fat and
releases glucose or 2)
liver breaks down
glycogen
88. Adrenal Glands
Located as a pair,
Located as a pair,
one on top of each
one on top of each
of the kidneys
of the kidneys
Contain two
Contain two
regions:
regions:
Adrenal cortex
Adrenal cortex
(outside) and
(outside) and
medulla (inside)
medulla (inside)
89. Adrenal Glands
Adrenal medulla
Adrenal medulla
releases two hormones:
releases two hormones:
•• Epinephrine
Epinephrine
(adrenalin)
(adrenalin)
•• Norephinephrine
Norephinephrine
(noradrenalin)
(noradrenalin)
which is both a
which is both a
hormone and a
hormone and a
neurotransmitter
neurotransmitter
90. Adrenal Glands
These hormones
These hormones
increase duration
increase duration
of effects of
of effects of
sympathetic
sympathetic
nervous system;
nervous system;
effects last longer
effects last longer
than
than
neurotransmitter
neurotransmitter
92. Adrenal Glands
Cortex makes dozens of
Cortex makes dozens of
steroid hormones,
steroid hormones,
known collectively as
known collectively as
adrenocorticosteroids
adrenocorticosteroids
Released by stimulation
from anterior pituitary gland
93. Adrenal Glands
Many of these hormones
Many of these hormones
are so important that
are so important that
decrease in production
decrease in production
could be fatal quickly
could be fatal quickly
Released by stimulation
from anterior pituitary gland
94. Adrenocorticoids
Adrenal cortex makes dozens of steroids or
Adrenal cortex makes dozens of steroids or
“-corticoids” including glucocorticoids and
“-corticoids” including glucocorticoids and
mineralcorticoids
mineralcorticoids
95. Adrenal Glands
Others “cortex” hormones responsible for regulation
Others “cortex” hormones responsible for regulation
of reproduction and secondary sexual
of reproduction and secondary sexual
characteristics
characteristics
102. PA/Instructor Asks:
You’ve just been given one of the essay questions on
your exam which may include one or more of the
above separate questions. The answer(s) are in your
text and this power point slide presentation
103. GONADS
Include testes and
Include testes and
ovaries and function
ovaries and function
to produce and store
to produce and store
the eggs (ovaries)
the eggs (ovaries)
and sperm (testes)
and sperm (testes)
Also produce number of sex
Also produce number of sex
hormones (testosterone
hormones (testosterone
and estrogen &
and estrogen &
progesterone) which
progesterone) which
control reproduction
control reproduction
104. Case Study
Maria's Story
She is a 35-year-old insulindependent diabetic who
currently takes good care of
herself. She did not take
good care of herself as a
teenager. She is on an
insulin pump to try to
control her blood sugar, but
has recently passed out in
public several times.
105. Case Study Maria's
Story
What condition causes her to
pass out? (hyperglycemia or
hypoglycemia)
Why does this condition
develop?
What is the appropriate
treatment for the early stages
of this condition?
106. Upcoming Exam
on Chapters 9,10 and 11 will
Test
be Nov 12, 2013 and cover:
•PPP for Chapter 9 only;
•Structure of the eye for Chap 11
and steps in “How Hearing
Occurs” including structures
•Chap 10 Power Point &
Worksheet answers
•Essay on blood glucose
maintained by pancreas
•Extra credit on “Concussion”
page 226