SlideShare a Scribd company logo
1 of 123
Download to read offline
Anannya ghosh Ritasman Baisya Shinjan Patra  Chirantan Mandal
Medical College &Hospital Bengal 88 college street, Kolkata West Bengal India Anannya ghosh Ritasman Baisya Shinjan Patra  Chirantan Mandal
[object Object],[object Object],[object Object]
A nannya ghosh
[object Object]
glomerulus the great
 
[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
 
 
[object Object],[object Object]
[object Object],[object Object],[object Object]
 
[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object]
 
 
[object Object],[object Object],[object Object],[object Object]
 
 
[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Slit  diaphragm
[object Object],[object Object]
 
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object]
 
[object Object]
 
 
[object Object],[object Object]
[object Object]
Glomerular Physiology  RITASMAN BAISYA
[object Object]
[object Object]
[object Object]
[object Object],[object Object]
[object Object],[object Object]
Fenestration (70 to 90 nm) Slit pore 25 nm
Effect of Size and Electric charge  on GFR
[object Object],Substance MW Filterability Water 18 1 Sodium 23 1 Glucose 180 1 Albumin 69000 0.005
[object Object],[object Object],[object Object]
[object Object],[object Object]
 
Effect of Net Filtration Pressure - The Starling Forces
[object Object],[object Object],[object Object]
[object Object],Under Normal condition the  π B  is considered to be zero.
 
P B NFP P B  - NFP
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
K f  can be altered by the  Messengial Cells .   With contraction of these cells producing decreasing K f , i.e.,  largely due to reduction of surface area of filtration.
[object Object],[object Object],[object Object]
FILTRATION FRACTION The fraction of renal plasma flow that is filtered.  FF = GFR/ Renal Plasma Flow. The value of FF averages about 0.2.
Increase  P B ,  decrease  GFR. Precipitation of Calcium or Uric acid (stones) in urinary tract leads to increased P B .
[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object],[object Object]
Constriction of efferent arteriole. PGC increase If within normal limit. FF increase If severe. RPF decrease GFR decrease. π GC  increase GFR slightly increase.
 
 
Angiotensin II  constricts Efferent arteriole leading to increase P GC  which maintains GFR. Due to Efferent arteriole constriction by Angiotensin II, renal blood flow is decreased, so flow through peritubular capillaries is decreased leading to sodium and water reabsorption. NO causes renal  vasodilatation,  GFR is  increased. Postaglandins, Bradykinin  cause  increase GFR.
[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Glomerulonephritis shinjan patra
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
 
 
[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object]
 
 
[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object]
 
 
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
 
 
 
Chirantan Mandal
Focal Segmental Glomerulosclerosis
 
[object Object],[object Object]
diffuse thickening of the glomerular capillary wall due to the accumulation of Ig deposits along the subepithelial side of the GBM thickened GBM producing “duplication”, as if formation of a new basement Membrame above the existing 1 Membranous  Nephropathy
 
 
 
 
[object Object],[object Object],[object Object],[object Object]
 
 
 
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
immune complex deposition in the glomeruli, peritubular capillary basement membranes due to antibodies Lupus Nephritis
Class Features  Class I Normal looking glomeruli Class II Mesangial expansion Class III Focal proliferative <50% Class IV Diffuse Prolif.  >50% Class V Membranous Class VI Adv. sclerosing lesions
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
 
 
1)subepithelial humps,  as in acute glomerulonephritis 2) epimembranous deposits,  as in MGN 3) subendothelial deposits,  as in SLE nephritis & MPGN 4) mesangial deposits,  as in IgA nephropathy 5) basement membrane.  EN = endothelium EP = epithelium LD =  lamina densa LRE = lamina rara externa LRI = lamina rara interna MC = mesangial cell MM = mesangial matrix
 
 

More Related Content

What's hot

Renal tubular acidosis
Renal tubular acidosisRenal tubular acidosis
Renal tubular acidosisAzad Haleem
 
Approach to the patient with Glomerular Disease.
Approach to the patient with Glomerular Disease.Approach to the patient with Glomerular Disease.
Approach to the patient with Glomerular Disease.Sufindc
 
Membranous nephropathy
Membranous nephropathyMembranous nephropathy
Membranous nephropathyVishal Golay
 
Leukemia,mds,myeloproliferative
Leukemia,mds,myeloproliferativeLeukemia,mds,myeloproliferative
Leukemia,mds,myeloproliferativeHasiburRahman82
 
An approach to a kidney biopsy manan
An approach to a kidney biopsy  mananAn approach to a kidney biopsy  manan
An approach to a kidney biopsy mananManan Shah
 
Cystic diseases of kidney
Cystic diseases of kidneyCystic diseases of kidney
Cystic diseases of kidneydrpallavip
 
Renal Histo-Pathology (II) - Normal Kidney Electron Microscopy - Dr. Gawad
Renal Histo-Pathology (II) - Normal Kidney Electron Microscopy - Dr. GawadRenal Histo-Pathology (II) - Normal Kidney Electron Microscopy - Dr. Gawad
Renal Histo-Pathology (II) - Normal Kidney Electron Microscopy - Dr. GawadNephroTube - Dr.Gawad
 
Acute renal failure 2018
Acute renal failure 2018Acute renal failure 2018
Acute renal failure 2018BMCStudents
 
CHRONIC EOSINOPHILIC LEUKEMIA
CHRONIC EOSINOPHILIC LEUKEMIACHRONIC EOSINOPHILIC LEUKEMIA
CHRONIC EOSINOPHILIC LEUKEMIAnehaneemat
 
Plasmapharesis dr mohamed abd allah
Plasmapharesis dr mohamed abd allahPlasmapharesis dr mohamed abd allah
Plasmapharesis dr mohamed abd allahFarragBahbah
 
Physiological Principles of Hemodialysis - Solve the Crosswords - Dr. Gawad
Physiological Principles of Hemodialysis - Solve the Crosswords - Dr. GawadPhysiological Principles of Hemodialysis - Solve the Crosswords - Dr. Gawad
Physiological Principles of Hemodialysis - Solve the Crosswords - Dr. GawadNephroTube - Dr.Gawad
 
Focal Segmental Glomerulosclerosis (FSGS)
Focal Segmental Glomerulosclerosis (FSGS)Focal Segmental Glomerulosclerosis (FSGS)
Focal Segmental Glomerulosclerosis (FSGS)Tauhid Bhuiyan
 
Renal Handling of Glucose, organic acid, uric acid and protein
Renal Handling of Glucose, organic acid, uric acid and proteinRenal Handling of Glucose, organic acid, uric acid and protein
Renal Handling of Glucose, organic acid, uric acid and proteinWisit Cheungpasitporn
 

What's hot (20)

Renal tubular acidosis
Renal tubular acidosisRenal tubular acidosis
Renal tubular acidosis
 
Approach to the patient with Glomerular Disease.
Approach to the patient with Glomerular Disease.Approach to the patient with Glomerular Disease.
Approach to the patient with Glomerular Disease.
 
Membranous nephropathy
Membranous nephropathyMembranous nephropathy
Membranous nephropathy
 
Plasmapheresis.
Plasmapheresis. Plasmapheresis.
Plasmapheresis.
 
Leukemia,mds,myeloproliferative
Leukemia,mds,myeloproliferativeLeukemia,mds,myeloproliferative
Leukemia,mds,myeloproliferative
 
An approach to a kidney biopsy manan
An approach to a kidney biopsy  mananAn approach to a kidney biopsy  manan
An approach to a kidney biopsy manan
 
Cystic diseases of kidney
Cystic diseases of kidneyCystic diseases of kidney
Cystic diseases of kidney
 
Diabetic nephropathy, patho physiology update
Diabetic nephropathy, patho physiology updateDiabetic nephropathy, patho physiology update
Diabetic nephropathy, patho physiology update
 
Renal Histo-Pathology (II) - Normal Kidney Electron Microscopy - Dr. Gawad
Renal Histo-Pathology (II) - Normal Kidney Electron Microscopy - Dr. GawadRenal Histo-Pathology (II) - Normal Kidney Electron Microscopy - Dr. Gawad
Renal Histo-Pathology (II) - Normal Kidney Electron Microscopy - Dr. Gawad
 
Acute renal failure 2018
Acute renal failure 2018Acute renal failure 2018
Acute renal failure 2018
 
Anemia in CKD
Anemia in CKDAnemia in CKD
Anemia in CKD
 
CHRONIC EOSINOPHILIC LEUKEMIA
CHRONIC EOSINOPHILIC LEUKEMIACHRONIC EOSINOPHILIC LEUKEMIA
CHRONIC EOSINOPHILIC LEUKEMIA
 
Plasmapharesis dr mohamed abd allah
Plasmapharesis dr mohamed abd allahPlasmapharesis dr mohamed abd allah
Plasmapharesis dr mohamed abd allah
 
Renal biopsy
Renal biopsyRenal biopsy
Renal biopsy
 
Physiological Principles of Hemodialysis - Solve the Crosswords - Dr. Gawad
Physiological Principles of Hemodialysis - Solve the Crosswords - Dr. GawadPhysiological Principles of Hemodialysis - Solve the Crosswords - Dr. Gawad
Physiological Principles of Hemodialysis - Solve the Crosswords - Dr. Gawad
 
Focal Segmental Glomerulosclerosis (FSGS)
Focal Segmental Glomerulosclerosis (FSGS)Focal Segmental Glomerulosclerosis (FSGS)
Focal Segmental Glomerulosclerosis (FSGS)
 
Hemodialysis
HemodialysisHemodialysis
Hemodialysis
 
Renal Handling of Glucose, organic acid, uric acid and protein
Renal Handling of Glucose, organic acid, uric acid and proteinRenal Handling of Glucose, organic acid, uric acid and protein
Renal Handling of Glucose, organic acid, uric acid and protein
 
minimal change disease
minimal change diseaseminimal change disease
minimal change disease
 
Complications of peritoneal dialysis
Complications of peritoneal dialysisComplications of peritoneal dialysis
Complications of peritoneal dialysis
 

Viewers also liked

Membranous glomerulonephritis
Membranous glomerulonephritisMembranous glomerulonephritis
Membranous glomerulonephritisMohammad Manzoor
 
Glomerulonephritis at a glance
Glomerulonephritis  at a glanceGlomerulonephritis  at a glance
Glomerulonephritis at a glancedrarindamkg89
 
Microstructure of kidney and ureter part 1
Microstructure of kidney and ureter part 1Microstructure of kidney and ureter part 1
Microstructure of kidney and ureter part 1SMS_2015
 
Basement Membrane Abnormalities
Basement Membrane AbnormalitiesBasement Membrane Abnormalities
Basement Membrane Abnormalitiesedwinchowyw
 
Angiogenesis in health and disease
Angiogenesis in health and diseaseAngiogenesis in health and disease
Angiogenesis in health and diseaseRadhika Sasturkar
 
Basement membrane integrity in oral cancer repair
Basement membrane integrity in oral cancer repairBasement membrane integrity in oral cancer repair
Basement membrane integrity in oral cancer repairThein Tun
 
Renal Pathology
Renal PathologyRenal Pathology
Renal Pathologysantusan
 
Mesangial proliferative GN
Mesangial proliferative GNMesangial proliferative GN
Mesangial proliferative GNedwinchowyw
 
Imaging of vasculitis
Imaging of vasculitis Imaging of vasculitis
Imaging of vasculitis Ahmed Bahnassy
 
Glomerulonephritis and nephrotic syndrome
Glomerulonephritis and nephrotic syndromeGlomerulonephritis and nephrotic syndrome
Glomerulonephritis and nephrotic syndromepsrvanan
 
Cutaneous Vasculitis
Cutaneous VasculitisCutaneous Vasculitis
Cutaneous VasculitisDr Yugandar
 
Direct opthalmoscopy~@Farhana.Islam
Direct opthalmoscopy~@Farhana.IslamDirect opthalmoscopy~@Farhana.Islam
Direct opthalmoscopy~@Farhana.IslamFarhana Islam
 
Central nervous system vasculitis
Central nervous system vasculitisCentral nervous system vasculitis
Central nervous system vasculitisMohammad Baghbanian
 
Opthalmoscopy Uploaded by Parash
Opthalmoscopy Uploaded by ParashOpthalmoscopy Uploaded by Parash
Opthalmoscopy Uploaded by ParashParash39
 

Viewers also liked (20)

Membranous glomerulonephritis
Membranous glomerulonephritisMembranous glomerulonephritis
Membranous glomerulonephritis
 
Glomerulonephritis at a glance
Glomerulonephritis  at a glanceGlomerulonephritis  at a glance
Glomerulonephritis at a glance
 
Glomerular diseases
Glomerular diseasesGlomerular diseases
Glomerular diseases
 
Microstructure of kidney and ureter part 1
Microstructure of kidney and ureter part 1Microstructure of kidney and ureter part 1
Microstructure of kidney and ureter part 1
 
Basement Membrane Abnormalities
Basement Membrane AbnormalitiesBasement Membrane Abnormalities
Basement Membrane Abnormalities
 
Angiogenesis in health and disease
Angiogenesis in health and diseaseAngiogenesis in health and disease
Angiogenesis in health and disease
 
Basement membrane integrity in oral cancer repair
Basement membrane integrity in oral cancer repairBasement membrane integrity in oral cancer repair
Basement membrane integrity in oral cancer repair
 
Renal Pathology
Renal PathologyRenal Pathology
Renal Pathology
 
Mesangial proliferative GN
Mesangial proliferative GNMesangial proliferative GN
Mesangial proliferative GN
 
Imaging of vasculitis
Imaging of vasculitis Imaging of vasculitis
Imaging of vasculitis
 
Ophthalmoscopy
OphthalmoscopyOphthalmoscopy
Ophthalmoscopy
 
Ophthalmoscopy
OphthalmoscopyOphthalmoscopy
Ophthalmoscopy
 
Glomerulonephritis and nephrotic syndrome
Glomerulonephritis and nephrotic syndromeGlomerulonephritis and nephrotic syndrome
Glomerulonephritis and nephrotic syndrome
 
MPGN/MCGN
MPGN/MCGNMPGN/MCGN
MPGN/MCGN
 
Minimal Change Disease
Minimal Change DiseaseMinimal Change Disease
Minimal Change Disease
 
Cutaneous Vasculitis
Cutaneous VasculitisCutaneous Vasculitis
Cutaneous Vasculitis
 
Direct opthalmoscopy~@Farhana.Islam
Direct opthalmoscopy~@Farhana.IslamDirect opthalmoscopy~@Farhana.Islam
Direct opthalmoscopy~@Farhana.Islam
 
Central nervous system vasculitis
Central nervous system vasculitisCentral nervous system vasculitis
Central nervous system vasculitis
 
Opthalmoscopy Uploaded by Parash
Opthalmoscopy Uploaded by ParashOpthalmoscopy Uploaded by Parash
Opthalmoscopy Uploaded by Parash
 
Update on vasculitis
Update on vasculitisUpdate on vasculitis
Update on vasculitis
 

Similar to Glomerulus in health & diseases

PHS 352 lecture 1.pptx
PHS 352 lecture 1.pptxPHS 352 lecture 1.pptx
PHS 352 lecture 1.pptxEasyrexjunior
 
L1-Renal physiology 2018.ppt
L1-Renal physiology 2018.pptL1-Renal physiology 2018.ppt
L1-Renal physiology 2018.pptZarka Sarwar
 
36. kidney 2-08-09
36. kidney 2-08-0936. kidney 2-08-09
36. kidney 2-08-09Nasir Koko
 
L1_Renal_functions &_GFR.pdf
L1_Renal_functions &_GFR.pdfL1_Renal_functions &_GFR.pdf
L1_Renal_functions &_GFR.pdfAkashDeepMondal2
 
Accurate assessment of kidney function in the critically
Accurate assessment of kidney function in the criticallyAccurate assessment of kidney function in the critically
Accurate assessment of kidney function in the criticallyAbdul Rahman Shaikh
 
2. Urinary system physiology.pptx
2. Urinary system physiology.pptx2. Urinary system physiology.pptx
2. Urinary system physiology.pptxMonenusKedir
 
Physiology of urine formation
Physiology of urine formationPhysiology of urine formation
Physiology of urine formationSELINA SRAVANTHI
 
Glomerular filtrate rate GFR's regulation (1).pptx
Glomerular filtrate rate GFR's regulation  (1).pptxGlomerular filtrate rate GFR's regulation  (1).pptx
Glomerular filtrate rate GFR's regulation (1).pptxAbdulGhayur1
 
Aqueous humor dynamics, epidemiology and pathological basis
Aqueous humor dynamics, epidemiology and pathological basisAqueous humor dynamics, epidemiology and pathological basis
Aqueous humor dynamics, epidemiology and pathological basisBipin Bista
 
Physio Renal 2.
Physio Renal 2.Physio Renal 2.
Physio Renal 2.Shaikhani.
 
Determinants of Glomerular filtration Rate.pptx
Determinants of Glomerular filtration Rate.pptxDeterminants of Glomerular filtration Rate.pptx
Determinants of Glomerular filtration Rate.pptxLeviteDeliverance
 
Renal anatomy and physiology in relation.pptx
Renal anatomy and physiology in relation.pptxRenal anatomy and physiology in relation.pptx
Renal anatomy and physiology in relation.pptxibrahimelkathiri1
 
Glomerular disease 2018
Glomerular disease 2018 Glomerular disease 2018
Glomerular disease 2018 BMCStudents
 
1. the nephron
1. the nephron1. the nephron
1. the nephronAmyEmtage
 

Similar to Glomerulus in health & diseases (20)

PHS 352 lecture 1.pptx
PHS 352 lecture 1.pptxPHS 352 lecture 1.pptx
PHS 352 lecture 1.pptx
 
L1-Renal physiology 2018.ppt
L1-Renal physiology 2018.pptL1-Renal physiology 2018.ppt
L1-Renal physiology 2018.ppt
 
36. kidney 2-08-09
36. kidney 2-08-0936. kidney 2-08-09
36. kidney 2-08-09
 
L1_Renal_functions &_GFR.pdf
L1_Renal_functions &_GFR.pdfL1_Renal_functions &_GFR.pdf
L1_Renal_functions &_GFR.pdf
 
Accurate assessment of kidney function in the critically
Accurate assessment of kidney function in the criticallyAccurate assessment of kidney function in the critically
Accurate assessment of kidney function in the critically
 
2. Urinary system physiology.pptx
2. Urinary system physiology.pptx2. Urinary system physiology.pptx
2. Urinary system physiology.pptx
 
Gfr barrier
Gfr barrierGfr barrier
Gfr barrier
 
GLOMERULONEPHRITIS
GLOMERULONEPHRITISGLOMERULONEPHRITIS
GLOMERULONEPHRITIS
 
Renal 1.pptx
Renal 1.pptxRenal 1.pptx
Renal 1.pptx
 
Physiology of urine formation
Physiology of urine formationPhysiology of urine formation
Physiology of urine formation
 
Glomerular filtrate rate GFR's regulation (1).pptx
Glomerular filtrate rate GFR's regulation  (1).pptxGlomerular filtrate rate GFR's regulation  (1).pptx
Glomerular filtrate rate GFR's regulation (1).pptx
 
Aqueous humor dynamics, epidemiology and pathological basis
Aqueous humor dynamics, epidemiology and pathological basisAqueous humor dynamics, epidemiology and pathological basis
Aqueous humor dynamics, epidemiology and pathological basis
 
Physio Renal 2.
Physio Renal 2.Physio Renal 2.
Physio Renal 2.
 
Determinants of Glomerular filtration Rate.pptx
Determinants of Glomerular filtration Rate.pptxDeterminants of Glomerular filtration Rate.pptx
Determinants of Glomerular filtration Rate.pptx
 
Renal haemodynamics
Renal haemodynamicsRenal haemodynamics
Renal haemodynamics
 
Renal anatomy and physiology in relation.pptx
Renal anatomy and physiology in relation.pptxRenal anatomy and physiology in relation.pptx
Renal anatomy and physiology in relation.pptx
 
Glomerular disease 2018
Glomerular disease 2018 Glomerular disease 2018
Glomerular disease 2018
 
Gfr
GfrGfr
Gfr
 
1. the nephron
1. the nephron1. the nephron
1. the nephron
 
renal anatomy.pptx
renal anatomy.pptxrenal anatomy.pptx
renal anatomy.pptx
 

More from Chirantan MD

approach to splenomegaly
approach to splenomegalyapproach to splenomegaly
approach to splenomegalyChirantan MD
 
Snake bite management India
Snake bite management IndiaSnake bite management India
Snake bite management IndiaChirantan MD
 
thalassemia subtypes
thalassemia subtypesthalassemia subtypes
thalassemia subtypesChirantan MD
 
Thallassemia molecular pathogenesis
Thallassemia molecular pathogenesisThallassemia molecular pathogenesis
Thallassemia molecular pathogenesisChirantan MD
 
ECG Final Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 C...
ECG Final Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 C...ECG Final Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 C...
ECG Final Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 C...Chirantan MD
 
CT Scan Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 Col...
CT Scan Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 Col...CT Scan Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 Col...
CT Scan Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 Col...Chirantan MD
 
Pathopyshiology of Intestinal Obstruction CHIRANTAN MANDAL Medical College ko...
Pathopyshiology of Intestinal Obstruction CHIRANTAN MANDAL Medical College ko...Pathopyshiology of Intestinal Obstruction CHIRANTAN MANDAL Medical College ko...
Pathopyshiology of Intestinal Obstruction CHIRANTAN MANDAL Medical College ko...Chirantan MD
 
Introduction of intestinal obstruction Pallavi Shekhar Medical College kolkata
Introduction of intestinal obstruction Pallavi Shekhar  Medical College kolkataIntroduction of intestinal obstruction Pallavi Shekhar  Medical College kolkata
Introduction of intestinal obstruction Pallavi Shekhar Medical College kolkataChirantan MD
 
Clinical aspect of intestinal obstruction Ritasman Baisya Medical College kol...
Clinical aspect of intestinal obstruction Ritasman Baisya Medical College kol...Clinical aspect of intestinal obstruction Ritasman Baisya Medical College kol...
Clinical aspect of intestinal obstruction Ritasman Baisya Medical College kol...Chirantan MD
 
Imaging modalities of intestinal obstruction Mithilesh Kumar Medical College ...
Imaging modalities of intestinal obstruction Mithilesh Kumar Medical College ...Imaging modalities of intestinal obstruction Mithilesh Kumar Medical College ...
Imaging modalities of intestinal obstruction Mithilesh Kumar Medical College ...Chirantan MD
 
General management of intestinal obstruction Arindam Roy Medical College Ko...
General management  of intestinal  obstruction Arindam Roy Medical College Ko...General management  of intestinal  obstruction Arindam Roy Medical College Ko...
General management of intestinal obstruction Arindam Roy Medical College Ko...Chirantan MD
 
Surgical management of intestinal obstruction Shinjan Patra Medical College K...
Surgical management of intestinal obstruction Shinjan Patra Medical College K...Surgical management of intestinal obstruction Shinjan Patra Medical College K...
Surgical management of intestinal obstruction Shinjan Patra Medical College K...Chirantan MD
 
Thalassemia Urmimala
Thalassemia UrmimalaThalassemia Urmimala
Thalassemia UrmimalaChirantan MD
 
Thalassemia major minor & other subtypes Soumaditya
Thalassemia major minor & other subtypes Soumaditya Thalassemia major minor & other subtypes Soumaditya
Thalassemia major minor & other subtypes Soumaditya Chirantan MD
 
Laboratory Diagonosis thalassemia Chirantan
Laboratory Diagonosis  thalassemia Chirantan Laboratory Diagonosis  thalassemia Chirantan
Laboratory Diagonosis thalassemia Chirantan Chirantan MD
 
Parietal cells in health & diseases
Parietal cells in health & diseasesParietal cells in health & diseases
Parietal cells in health & diseasesChirantan MD
 
Types of muscle contraction ushnish
Types of muscle contraction ushnishTypes of muscle contraction ushnish
Types of muscle contraction ushnishChirantan MD
 
Respiratoty response to exercise dipayan
Respiratoty response to exercise dipayanRespiratoty response to exercise dipayan
Respiratoty response to exercise dipayanChirantan MD
 

More from Chirantan MD (20)

approach to splenomegaly
approach to splenomegalyapproach to splenomegaly
approach to splenomegaly
 
Snake bite management India
Snake bite management IndiaSnake bite management India
Snake bite management India
 
HIV AIDS
HIV AIDS HIV AIDS
HIV AIDS
 
thalassemia subtypes
thalassemia subtypesthalassemia subtypes
thalassemia subtypes
 
Thallassemia molecular pathogenesis
Thallassemia molecular pathogenesisThallassemia molecular pathogenesis
Thallassemia molecular pathogenesis
 
ECG Final Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 C...
ECG Final Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 C...ECG Final Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 C...
ECG Final Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 C...
 
CT Scan Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 Col...
CT Scan Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 Col...CT Scan Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 Col...
CT Scan Proff.Sumit Kr Ghosh Dept of Internal Medicine Medical College 88 Col...
 
Pathopyshiology of Intestinal Obstruction CHIRANTAN MANDAL Medical College ko...
Pathopyshiology of Intestinal Obstruction CHIRANTAN MANDAL Medical College ko...Pathopyshiology of Intestinal Obstruction CHIRANTAN MANDAL Medical College ko...
Pathopyshiology of Intestinal Obstruction CHIRANTAN MANDAL Medical College ko...
 
Introduction of intestinal obstruction Pallavi Shekhar Medical College kolkata
Introduction of intestinal obstruction Pallavi Shekhar  Medical College kolkataIntroduction of intestinal obstruction Pallavi Shekhar  Medical College kolkata
Introduction of intestinal obstruction Pallavi Shekhar Medical College kolkata
 
Clinical aspect of intestinal obstruction Ritasman Baisya Medical College kol...
Clinical aspect of intestinal obstruction Ritasman Baisya Medical College kol...Clinical aspect of intestinal obstruction Ritasman Baisya Medical College kol...
Clinical aspect of intestinal obstruction Ritasman Baisya Medical College kol...
 
Imaging modalities of intestinal obstruction Mithilesh Kumar Medical College ...
Imaging modalities of intestinal obstruction Mithilesh Kumar Medical College ...Imaging modalities of intestinal obstruction Mithilesh Kumar Medical College ...
Imaging modalities of intestinal obstruction Mithilesh Kumar Medical College ...
 
General management of intestinal obstruction Arindam Roy Medical College Ko...
General management  of intestinal  obstruction Arindam Roy Medical College Ko...General management  of intestinal  obstruction Arindam Roy Medical College Ko...
General management of intestinal obstruction Arindam Roy Medical College Ko...
 
Surgical management of intestinal obstruction Shinjan Patra Medical College K...
Surgical management of intestinal obstruction Shinjan Patra Medical College K...Surgical management of intestinal obstruction Shinjan Patra Medical College K...
Surgical management of intestinal obstruction Shinjan Patra Medical College K...
 
Thalassemia Urmimala
Thalassemia UrmimalaThalassemia Urmimala
Thalassemia Urmimala
 
Thalassemia major minor & other subtypes Soumaditya
Thalassemia major minor & other subtypes Soumaditya Thalassemia major minor & other subtypes Soumaditya
Thalassemia major minor & other subtypes Soumaditya
 
Laboratory Diagonosis thalassemia Chirantan
Laboratory Diagonosis  thalassemia Chirantan Laboratory Diagonosis  thalassemia Chirantan
Laboratory Diagonosis thalassemia Chirantan
 
Thalassemia Avik
Thalassemia AvikThalassemia Avik
Thalassemia Avik
 
Parietal cells in health & diseases
Parietal cells in health & diseasesParietal cells in health & diseases
Parietal cells in health & diseases
 
Types of muscle contraction ushnish
Types of muscle contraction ushnishTypes of muscle contraction ushnish
Types of muscle contraction ushnish
 
Respiratoty response to exercise dipayan
Respiratoty response to exercise dipayanRespiratoty response to exercise dipayan
Respiratoty response to exercise dipayan
 

Recently uploaded

Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptxBreast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptxNaveenkumar267201
 
High-Performance Thin-Layer Chromatography (HPTLC)
High-Performance Thin-Layer Chromatography (HPTLC)High-Performance Thin-Layer Chromatography (HPTLC)
High-Performance Thin-Layer Chromatography (HPTLC)kishan singh tomar
 
pA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacologypA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacologyDeepakDaniel9
 
How to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyHow to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyZurück zum Ursprung
 
Neurological history taking (2024) .
Neurological  history  taking  (2024)  .Neurological  history  taking  (2024)  .
Neurological history taking (2024) .Mohamed Rizk Khodair
 
AUTONOMIC NERVOUS SYSTEM organization and functions
AUTONOMIC NERVOUS SYSTEM organization and functionsAUTONOMIC NERVOUS SYSTEM organization and functions
AUTONOMIC NERVOUS SYSTEM organization and functionsMedicoseAcademics
 
Pharmacokinetic Models by Dr. Ram D. Bawankar.ppt
Pharmacokinetic Models by Dr. Ram D.  Bawankar.pptPharmacokinetic Models by Dr. Ram D.  Bawankar.ppt
Pharmacokinetic Models by Dr. Ram D. Bawankar.pptRamDBawankar1
 
CPR.nursingoutlook.pdf , Bsc nursing student
CPR.nursingoutlook.pdf , Bsc nursing studentCPR.nursingoutlook.pdf , Bsc nursing student
CPR.nursingoutlook.pdf , Bsc nursing studentsaileshpanda05
 
Basic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptxBasic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptxkomalt2001
 
SGK LEUKEMIA KINH DÒNG BẠCH CÂU HẠT HAY.pdf
SGK LEUKEMIA KINH DÒNG BẠCH CÂU HẠT HAY.pdfSGK LEUKEMIA KINH DÒNG BẠCH CÂU HẠT HAY.pdf
SGK LEUKEMIA KINH DÒNG BẠCH CÂU HẠT HAY.pdfHongBiThi1
 
Using Data Visualization in Public Health Communications
Using Data Visualization in Public Health CommunicationsUsing Data Visualization in Public Health Communications
Using Data Visualization in Public Health Communicationskatiequigley33
 
Male Infertility, Antioxidants and Beyond
Male Infertility, Antioxidants and BeyondMale Infertility, Antioxidants and Beyond
Male Infertility, Antioxidants and BeyondSujoy Dasgupta
 
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdfCONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdfDolisha Warbi
 
EXERCISE PERFORMANCE.pptx, Lung function
EXERCISE PERFORMANCE.pptx, Lung functionEXERCISE PERFORMANCE.pptx, Lung function
EXERCISE PERFORMANCE.pptx, Lung functionkrishnareddy157915
 
Clinical Research Informatics Year-in-Review 2024
Clinical Research Informatics Year-in-Review 2024Clinical Research Informatics Year-in-Review 2024
Clinical Research Informatics Year-in-Review 2024Peter Embi
 
SGK NGẠT NƯỚC ĐHYHN RẤT LÀ HAY NHA .pdf
SGK NGẠT NƯỚC ĐHYHN RẤT LÀ HAY NHA    .pdfSGK NGẠT NƯỚC ĐHYHN RẤT LÀ HAY NHA    .pdf
SGK NGẠT NƯỚC ĐHYHN RẤT LÀ HAY NHA .pdfHongBiThi1
 
ANATOMICAL FAETURES OF BONES FOR NURSING STUDENTS .pptx
ANATOMICAL FAETURES OF BONES  FOR NURSING STUDENTS .pptxANATOMICAL FAETURES OF BONES  FOR NURSING STUDENTS .pptx
ANATOMICAL FAETURES OF BONES FOR NURSING STUDENTS .pptxWINCY THIRUMURUGAN
 

Recently uploaded (20)

Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptxBreast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
 
Rheumatoid arthritis Part 1, case based approach with application of the late...
Rheumatoid arthritis Part 1, case based approach with application of the late...Rheumatoid arthritis Part 1, case based approach with application of the late...
Rheumatoid arthritis Part 1, case based approach with application of the late...
 
High-Performance Thin-Layer Chromatography (HPTLC)
High-Performance Thin-Layer Chromatography (HPTLC)High-Performance Thin-Layer Chromatography (HPTLC)
High-Performance Thin-Layer Chromatography (HPTLC)
 
pA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacologypA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacology
 
How to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyHow to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturally
 
Neurological history taking (2024) .
Neurological  history  taking  (2024)  .Neurological  history  taking  (2024)  .
Neurological history taking (2024) .
 
AUTONOMIC NERVOUS SYSTEM organization and functions
AUTONOMIC NERVOUS SYSTEM organization and functionsAUTONOMIC NERVOUS SYSTEM organization and functions
AUTONOMIC NERVOUS SYSTEM organization and functions
 
Pharmacokinetic Models by Dr. Ram D. Bawankar.ppt
Pharmacokinetic Models by Dr. Ram D.  Bawankar.pptPharmacokinetic Models by Dr. Ram D.  Bawankar.ppt
Pharmacokinetic Models by Dr. Ram D. Bawankar.ppt
 
CPR.nursingoutlook.pdf , Bsc nursing student
CPR.nursingoutlook.pdf , Bsc nursing studentCPR.nursingoutlook.pdf , Bsc nursing student
CPR.nursingoutlook.pdf , Bsc nursing student
 
Basic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptxBasic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptx
 
SGK LEUKEMIA KINH DÒNG BẠCH CÂU HẠT HAY.pdf
SGK LEUKEMIA KINH DÒNG BẠCH CÂU HẠT HAY.pdfSGK LEUKEMIA KINH DÒNG BẠCH CÂU HẠT HAY.pdf
SGK LEUKEMIA KINH DÒNG BẠCH CÂU HẠT HAY.pdf
 
Using Data Visualization in Public Health Communications
Using Data Visualization in Public Health CommunicationsUsing Data Visualization in Public Health Communications
Using Data Visualization in Public Health Communications
 
Male Infertility, Antioxidants and Beyond
Male Infertility, Antioxidants and BeyondMale Infertility, Antioxidants and Beyond
Male Infertility, Antioxidants and Beyond
 
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdfCONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
 
EXERCISE PERFORMANCE.pptx, Lung function
EXERCISE PERFORMANCE.pptx, Lung functionEXERCISE PERFORMANCE.pptx, Lung function
EXERCISE PERFORMANCE.pptx, Lung function
 
Clinical Research Informatics Year-in-Review 2024
Clinical Research Informatics Year-in-Review 2024Clinical Research Informatics Year-in-Review 2024
Clinical Research Informatics Year-in-Review 2024
 
SGK NGẠT NƯỚC ĐHYHN RẤT LÀ HAY NHA .pdf
SGK NGẠT NƯỚC ĐHYHN RẤT LÀ HAY NHA    .pdfSGK NGẠT NƯỚC ĐHYHN RẤT LÀ HAY NHA    .pdf
SGK NGẠT NƯỚC ĐHYHN RẤT LÀ HAY NHA .pdf
 
GOUT UPDATE AHMED YEHIA 2024, case based approach with application of the lat...
GOUT UPDATE AHMED YEHIA 2024, case based approach with application of the lat...GOUT UPDATE AHMED YEHIA 2024, case based approach with application of the lat...
GOUT UPDATE AHMED YEHIA 2024, case based approach with application of the lat...
 
Biologic therapy ice breaking in rheumatology, Case based approach with appli...
Biologic therapy ice breaking in rheumatology, Case based approach with appli...Biologic therapy ice breaking in rheumatology, Case based approach with appli...
Biologic therapy ice breaking in rheumatology, Case based approach with appli...
 
ANATOMICAL FAETURES OF BONES FOR NURSING STUDENTS .pptx
ANATOMICAL FAETURES OF BONES  FOR NURSING STUDENTS .pptxANATOMICAL FAETURES OF BONES  FOR NURSING STUDENTS .pptx
ANATOMICAL FAETURES OF BONES FOR NURSING STUDENTS .pptx
 

Glomerulus in health & diseases

  • 1. Anannya ghosh Ritasman Baisya Shinjan Patra Chirantan Mandal
  • 2. Medical College &Hospital Bengal 88 college street, Kolkata West Bengal India Anannya ghosh Ritasman Baisya Shinjan Patra Chirantan Mandal
  • 3.
  • 5.
  • 7.  
  • 8.
  • 9.  
  • 10.
  • 11.
  • 12.
  • 13.  
  • 14.  
  • 15.
  • 16.
  • 17.  
  • 18.
  • 19.
  • 20.
  • 21.  
  • 22.  
  • 23.
  • 24.  
  • 25.  
  • 26.
  • 27.
  • 28.
  • 30.
  • 31.  
  • 32.
  • 33.
  • 34.
  • 35.  
  • 36.
  • 37.  
  • 38.
  • 39.  
  • 40.  
  • 41.
  • 42.
  • 43. Glomerular Physiology RITASMAN BAISYA
  • 44.
  • 45.
  • 46.
  • 47.
  • 48.
  • 49. Fenestration (70 to 90 nm) Slit pore 25 nm
  • 50. Effect of Size and Electric charge on GFR
  • 51.
  • 52.
  • 53.
  • 54.  
  • 55. Effect of Net Filtration Pressure - The Starling Forces
  • 56.
  • 57.
  • 58.  
  • 59. P B NFP P B - NFP
  • 60.
  • 61.
  • 62. K f can be altered by the Messengial Cells . With contraction of these cells producing decreasing K f , i.e., largely due to reduction of surface area of filtration.
  • 63.
  • 64. FILTRATION FRACTION The fraction of renal plasma flow that is filtered. FF = GFR/ Renal Plasma Flow. The value of FF averages about 0.2.
  • 65. Increase P B , decrease GFR. Precipitation of Calcium or Uric acid (stones) in urinary tract leads to increased P B .
  • 66.
  • 67.  
  • 68.
  • 69. Constriction of efferent arteriole. PGC increase If within normal limit. FF increase If severe. RPF decrease GFR decrease. π GC increase GFR slightly increase.
  • 70.  
  • 71.  
  • 72. Angiotensin II constricts Efferent arteriole leading to increase P GC which maintains GFR. Due to Efferent arteriole constriction by Angiotensin II, renal blood flow is decreased, so flow through peritubular capillaries is decreased leading to sodium and water reabsorption. NO causes renal vasodilatation, GFR is increased. Postaglandins, Bradykinin cause increase GFR.
  • 73.
  • 74.
  • 76.
  • 77.
  • 78.
  • 79.
  • 80.
  • 81.  
  • 82.  
  • 83.
  • 84.  
  • 85.
  • 86.  
  • 87.  
  • 88.
  • 89.  
  • 90.
  • 91.  
  • 92.  
  • 93.
  • 94.
  • 95.
  • 96.  
  • 97.  
  • 98.  
  • 101.  
  • 102.
  • 103. diffuse thickening of the glomerular capillary wall due to the accumulation of Ig deposits along the subepithelial side of the GBM thickened GBM producing “duplication”, as if formation of a new basement Membrame above the existing 1 Membranous Nephropathy
  • 104.  
  • 105.  
  • 106.  
  • 107.  
  • 108.
  • 109.  
  • 110.  
  • 111.  
  • 112.
  • 113.
  • 114. immune complex deposition in the glomeruli, peritubular capillary basement membranes due to antibodies Lupus Nephritis
  • 115. Class Features Class I Normal looking glomeruli Class II Mesangial expansion Class III Focal proliferative <50% Class IV Diffuse Prolif. >50% Class V Membranous Class VI Adv. sclerosing lesions
  • 116.
  • 117.
  • 118.
  • 119.  
  • 120.  
  • 121. 1)subepithelial humps, as in acute glomerulonephritis 2) epimembranous deposits, as in MGN 3) subendothelial deposits, as in SLE nephritis & MPGN 4) mesangial deposits, as in IgA nephropathy 5) basement membrane. EN = endothelium EP = epithelium LD = lamina densa LRE = lamina rara externa LRI = lamina rara interna MC = mesangial cell MM = mesangial matrix
  • 122.  
  • 123.