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Antibiotic therapy and early onset sepsis
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Antibiotic therapy and early onset sepsis
1.
ANTIBIOTIC THERAPY AND
EARLY ONSET SEPSIS. Neoreviews 2012;13;e86
2.
SEPSIS NEONATAL S R
I S + H E M O C U LT I V O O L C R . Muy temprana Temprana. Tardía.
3.
RN A TÉRMINO E.U.A. GBS.
4.
RN PRETERMINÓ. Primeras 72
horas.
5.
LATINOAMÉRICA, ASIA, ÁFRICA. Gram
negativos. Klebsiella 35%. Gram positivos. S. aureus. 25%.
6.
PROFILAXIS INTRAPARTO. AMPICILINA VS
S.G.B. I N T R A PA R T O . E. COLI RESISTENTE. S.G.B. RESISTENTE A AMPICILINA. NO SE CREAN RESISITENCIAS.
7.
TERAPIA EMPÍRICA VS
DEFINITIVA EN S.N. TEMPRANA. AMPICILINA + G E N TA M I C I N A . E. COLI 78% RESISTENCIA AMPICILINA. 4% RESISTENCIA G E N TA M I C I N A .
8.
TERAPIA EMPÍRICA. Ampicilina +
Cefotaxima. Carbapenem o meropenem.
9.
GRACIAS. Carlos Arturo Ayala
Palacios. R1 PM.
Notas do Editor
Primeras 24 horas, mayor mortalidad y rara vez meningitis.
CDC Primeros 3 dias SN Temprana, posterior Tardia.
Paises en vias de desarrollo.
Antibioticos de amplio espectro inducen fungemia
Descontinuar antibioticos 2-3 dias posterior a cultivos negativos.Proteccion SNC.Beta Lactamasas Resistencias.
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