Collagen Biochemistry

This lecture will cover ,[object Object],[object Object],[object Object],[object Object],[object Object]

Most of us are probably aware that collagen is a widely used cosmetic agent.

Collagen is the most abundant protein in the animal kingdom

Collagen is essential for maintaining tissue integrity

Collagen biosynthesis Intracellular events

Collagen undergoes post-translational modification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Extracellular modifications ,[object Object],[object Object],[object Object],[object Object]

Ehlers Danlos Highly elastic skin In rare cases it can be fragile Chronic joint pain, joint laxity Scoliosis Increased risk of bone fracture Fragile blood vessels Mitral valve prolapse

Extracellular processing II Collagen cross-linking

Lysyl oxidase initiates cross-link formation ,[object Object],[object Object]

Lathyritic agents underpin the critical importance of collagen cross-links  -aminoproprionitrile

The cross-links of bone & dentine collagen ,[object Object],[object Object],[object Object],[object Object]

Pyrrole & Pyridinium Cross-links

Collagen Biochemistry

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Collagen Biochemistry