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1. DANIEL E. SOFFER, MD, FACC, FSCAI
Certification:
United States Medical Licensing Examination (USMLE)
Step I and II - Passed, 1st Attempt - 1993, Step III -
st
Passed, 1 Attempt - 1995
1994 Educational Commission for Foreign Medical
Graduates (ECFMG # 0-476-774-5)
1997 Board Certified and Diplomate, American Board of
Internal Medicine (ABIM)
2000 Board Certified and Diplomate, ABIM,
Cardiovascular Disease # 179302
2002 Board Certified and Diplomate, ABIM, Interventional
Cardiology
2011 Board Certified, Endovascular Medicine, American
Board of Vascular Medicine
Present Basic and Advanced Cardiac Life Support (BCLS
and ACLS)
Licensing: DEA # BS6887294
Michigan License # 4301076758
New York License # 224099-1
North Carolina License # 2002-01311
Current Position: Co- Director, Carotid Endovascular Services
Intervntional Cardiology
Zena and Michael A Wiener Cardiovascular Institute
Marie Josee and Henry R. Kravis Center for Cardiovascular Health
Mount Sinai Medical Center
One Gustave L. Levy Place, Box 1030
New York, NY 10029-6574
Director, Vascular Medicine Laboratory
The Mount Sinai Heart and Vascular Center
485 Madison Avenue, New York, NY 10022
Previous Position: Associate Director, Fellowship Program
Interventional Cardiology, Structural Heart, Endovascular & Carotid Interventions
Department of Interventional Cardiology
Lenox Hill Heart and Vascular Institute
New York, NY 10075
Carolina Heart PA
Interventional Cardiology, Structural Heart, Endovascular & Carotid Interventions
Pitt County Memorial Hospital
Greenville, North Carolina
2. Current Clinical Associate Professor of Medicine
Appointment: Department of Internal Medicine
Mount Sinai School of Medicine
Previous Clinical Associate professor of medicine
Appointments: Department of Internal Medicine
Brody School of Medicine
East Carolina University
Greenville, North Carolina
Postgraduate Training and Fellowships:
9/2000-8/2002 Fellowship (PGY 7-8), Interventional Cardiology, Peripheral and Carotid
Interventions, Structural heart, Aortic and Mitral valvuloplasty
William Beaumont Hospital, Royal Oak, MI
7/1997-6/2000 Fellowship (PGY 4-6), Clinical Cardiology
Lenox Hill Hospital, New York, NY
7/1995-6/1997 Residency (PGY 2-3), Internal Medicine
Lenox Hill Hospital, New York, NY
7/1994-6/1995 Internship (PGY 1), Internal Medicine
Lenox Hill Hospital, New York, NY
Medical Education and Academic Honors:
10/1985-4/1993 M.D., Ben Gurion University of the Negev, Beer Sheva, Israel
Summer 1989 Visiting Honorary Student, Cardiothoracic Surgery
Üelleval Hospital, Oslo, Norway
Summer 1990 Selected Honorary Student, Cardiology and Emergency Medicine
Albert Einstein College of Medicine, Bronx, New York
1990 and 1991 Two - Time Recipient, Swiss Foundation Scholarship
(Awarded to the top 8 out of 200 students for clinical excellence in medicine)
1991-1992 Thesis: “Changes in Pressure Exerted on the Foot During Pregnancy”
Ben Gurion University of the Negev, Beer Sheva, Israel
4/1992-3/1993 Rotating Internship, Chaim Sheba Medical Center, Tel Hashomer, Israel
Military Service: First Lieutenant, Medical Corps
Israel Defense Forces
1981-1982 Combat Medic and Medic Course Instructor
1983-1984 Medic Course Commander
1984-1985 Chief Instructing Officer, School of Military Medicine
3. High School Education:
1977-1981 Makif Yahud, Yahud, Israel
Major Subjects: Biology and Chemistry
Graduated with High Honors
Memberships/Fellowships:
1985-Present CMAS world underwater federation
1997-Present American College of Cardiology – Fellow
2003-present The Society for Cardiac Angiography & Interventions- Fellow
Primary Investigator / Sub-investigator
Primary Investigator, Evaluation of the Cascade Abrazo Analyzer and DTM (Direct Thrombin Monitor) Test
Card Bivalirudin (“Abrazo DTM”), Sponsored by Helena Labs.
Primary Investigator, ORBIT II Pivotal Trial to Evaluate the Safety and Efficacy of the Diamondback 360°®
Orbital Atherectomy System in Treating De Novo, Severely Calcified Coronary Lesions, Sponsored by
Cardiovascular Systems Inc. (CSI).
SUPERB Comparison of the Supera PERipheral System to a Performance Goal derived from Balloon
Angioplasty Clinical Trials in the Superficial Femoral Artery, Sponsored by IDEV Technologies, Inc.
Choice Carotid Stenting For High Surgical Risk Patients; Evaluating Outcomes Through The CollectIon Of Clinical
Evidence
Sapphire WW - STENTING AND ANGIOPLASTY WITH PROTECTION IN PATIENTS AT HIGH-RISK FOR
ENDARTERECTOMY Protocol Number P06-3603
Protect Protected Carotid Artery Stenting in Subjects at High Risk for CEA
Proguard Trial- Protection During Carotid Stenting in High Risk Patients with the TriActive ProGUARD System
VIVA Trial - VIVEXX™ Carotid Revascularization for High Surgical Risk Patients with Extracranial Carotid Artery
Stenosis using the Bard® VIVEXX™ Carotid Stent and Emboshield® Bare Wire™ Rapid Exchange Embolic
Protection System
MAVERIC III – Medtronic Evaluation of the Medtronic AVE Self-Expanding Carotid Stent System with Distal
Protection in the Treatment of Carotid Stenosis
Tracer A Multi-center, Randomized, Double-Blind, Placebo- Controlled Study to Evaluate the Safety and Efficacy
of SCH 530348 in Addition to Standard of Care in Subjects With Acute Coronary Syndrome: Thrombin Receptor
Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA·CER)
Zomaxx II ZOMAXX II- Trial-A Randomized, Controlled Trial to Evaluate the Safety and Efficacy of the
Zomaxx™ Drug Eluting Coronary Stent System as Compared to the Taxus™ Express2™ Paclitaxel-Eluting Stent in
de novo Coronary Artery Lesions
Gravitas Gauging Responsiveness with A VerifyNow assay- Impact on Thrombosis And Safety (GRAVITAS)
4. Xience XIENCE™ V Everolimus Eluting Coronary Stent System (EECSS) USA Post-Approval Study
Reform REFORM- Evaluation of Effectiveness and Safety of the Formula™ Balloon-Expandable Stent for Renal
Artery Stenosis
Endeavor SVS A Clinical Evaluation of the Medtronic Endeavor Zotarolimus-Eluting Coronary Stent System in the
Treatment of Single De novo Lesions in Small Diameter Native Coronary Arteries (Endeavor SVS)
Resolute A Clinical Evaluation of the Medtronic Endeavor® Resolute Zotarolimus-Eluting Coronary Stent System in
the Treatment of De Novo Lesions in Native Coronary Arteries with a Reference Vessel Diameter of 2.25 mm to 4.2
mm - The Medtronic RESOLUTE US Clinical Trial
Realism EVEREST II Continued Access Registry
Intense Iliac artery treatmeNT with thE iNvatec Scuba cobalt chromium stEnt (INTENSE) Study
Liberte TAXUS Libertē Post-Approval Study
Superb Comparison of the SUpera® PERipheral System to a Performance Goal derived from Balloon Angioplasty
Clinical Trials in the Superficial Femoral Artery (The SUPERB Study)
Dapt A prospective, multi-center, randomized, double-blind trial to assess the effectiveness and safety of 12 versus
30 months of dual antiplatelet therapy (DAPT) in subjects undergoing percutaneous coronary intervention (PCI) with
either drug-eluting stent (DES) or bare metal stent (BMS) placement for the treatment of coronary artery lesions.
FREEDOM Trial – Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of
Multivessel Disease
DELTA MI Trial – Direct Inhibition of Protein Kinase C Enzyme to Limit Total Infarct Size in Acute Myocardial
Infarction
PREMIUM Trial- Prospective Randomized Investigation to Evaluate Incidence of Headache Reduction in Subjects
with Migrane and Patent Foramen Ovale Using the AMPLATZER PFO Occluder Compared to Medical Management
AMEthyst Trial – A Prospective, Multicenter, Randomized Study to Evaluate the Safety and Efficacy of the
Interceptor Embolic Protection Device During Transluminal Percutaneous Coronary Interventions on Saphenous
Grafts
EVENT Registry- A Multicenter Registry for the Evaluation of Drug Eluting Stents and Ischemic Events
DYNAMIC Registry- Dynamic Evaluation of Percutaneous Intervention
ASPIRE Trial- Angioplasty in SVG’s with Post Intervention Removal of Embolic Debris
ZILVER Trial – Evaluation of the Zilver® PTX™ Vascular Stent in the Above-the-Knee Femoropopliteal
Artery Clinical Study Protocol: Phase I
SIRIUS Trial - A Multicenter, Randomized, Double-Blind study of the SIROLIMUS Coated Bx VELOCITY Stent
in the Treatment of Patients with de-novo Coronary Artery Lesions
CARDIOSEAL Septal Occlusion System Registry
5. TRAP Vascular Filtration System Trial – Randomized Study of TRAP Filter Device in Saphenous Vein Graft
PTCA/Stenting
A Phase II Randomized Multicenter Clinical Study To Evaluate the Safety and Efficacy of the TandemHeart
pVAD System vs. Conventional Therapy for Treatment of Cardiogenic Shock
TherOx AO System AMIHOT Trial – Acute Myocardial Infarction with Hyperoxemic Therapy
FIRE Trial- Distal Protection with BSC/EPI Filterwire vs. PercuSurge Guardwire During SVG Stenting
COOL-MI Trial - Hypothermia as an Adjunctive Therapy to PTCA in Patients with Acute MI
BARRICADE Trial – PCI with the JOMED PTFE Covered Stent in Degenerated Saphenous Vein Grafts
Publications & Presentations:
Carotid Artery Stenting in Elderly Patients: Importance of Case Selection
Cathet Cardiovasc Intervent 2008;72:318-324
Paul T.L. Chiam, Gary S. Roubin,Sriram S. Iyer, Richard M. Green, Daniel E. Soffer,
Christina Brennan, Jiri J. Vitek
Prospective Evaluation of Aggressive Medical Therapy for Atherosclerotic renal artery
stenosis, with Renal Artery Stenting Reserved for Previously Injured Heart, Brain, or
Kidney
Hanzel G, Balon H, Wong D, Soffer D, Lee DT, Safian RD
Am J Cardiol. 2005 Nov 1;96(9):1322-7 Epub 2005 Sep 1
Impact of Angina Class on Inhibition of Platelet Aggregation Following Clopidogrel
Loading in Patients Undergoing Coronary Intervention: Do We Need More Aggressive
Dosing Regimens in Unstable Angina?
Cathet Cardiovasc Intervent 2003;59:21-25
Daniel Soffer1, Issam Moussa2, Kishore J. Harjai1, Judith Boura1, Simon R. Dixon1, Cindy L.
Grines1, William W. O’Neill1 , Gary S. Roubin2, Jeffrey W. Moses2,
William Beaumont Hospital, Royal Oak, MI; Lenox Hill Heart and Vascular Institute, New
York, NY, USA
Sub-Optimal Inhibition of Platelet Aggregation Following Tirofiban Bolus in Patients
Undergoing Coronary Intervention for Unstable Angina Pectoris
Am J Cardiol 2003;91:872-875
Daniel Soffer1, Issam Moussa2, Murat Karatepe2, Kishore J. Harjai1, Judith Boura1, Simon R.
Dixon1, Cindy L. Grines1, William W. O’Neill 1, Gary S. Roubin2
Jeffrey W. Moses2
William Beaumont Hospital, Royal Oak, MI; Lenox Hill Heart and Vascular Institute, New
York, NY, USA
Images in cardiology: postpartum intramural hematoma-evaluation by computed
tomographic angiography.
J Clin Hypertens (Greenwich). 2009 Nov;11(11):656.
Haden G, Polenta S, Jelnin V, Soffer D, Hecht H.
6. Platelet Aggregtion Inhibition in Patients Receiving Statins Either Fully or Partially
Metabolized by CYP3A4
Polena S, Gupta MP, Shaikh H, Zazzali K, Coplan N, Gintnutas J, Labana SS, Soffer D
Proc West Pharmacol Soc. 2008;51:60-2
Renal Stenting Preserves Single Kidney GFR and Renal Mass Compared to Medical
Therapy in Patients with Renal Artery Stenosis: 17 Months Follow-up
Presented at the Transcatheter and Cardiovascular Therapeutics, Washington DC, 2002
Daniel Soffer, Daniel T. Lee, Helena Balon, Staci Barnhart, Judith A. Boura, Simon R. Dixon,
William W. O’Neill, Robert D. Safian
William Beaumont Hospital, Royal Oak, MI
Inter-assay Variability in the Degree of Platelet Inhibition Following GPIIb/IIIa Receptor
Blockade in Patients Undergoing Coronary Intervention: A Comparison of Three
Different Point-of-Care Assays.
Presented at the 51th annual session of the American College of Cardiology, 2002
Daniel Soffer1, William W. O’Neill1, Kishore J. Harjai1, Judith Boura1, Robert D. Safian1,
Cindy Grines1, Issam Moussa2, Gary S. Roubin2, Jeffrey W. Moses2.
William Beaumont Hospital, Royal Oak, MI; Lenox Hill Heart and Vascular Institute, New
York, NY, USA
The Impact of Clinical Presentation on the Degree of Platelet Inhibition at Baseline and
following Glycoprotein IIb/IIIa Receptor Blockade in Patients Undergoing Percutaneous
Coronary Intervention (abstract)
Presented at the 49th annual session of the American College of Cardiology, 2000
J Am Coll Cardiol 2000;35, Supp 43A
Soffer D, Taviloglu G, New G, Kreps E, Collins M, Iyer S, Roubin G,
Moses J, Coplan N, Moussa I
Lenox Hill Heart and Vascular Institute, New York, NY, USA
What is the Appropriate Loading Dose of Clopidogrel Prior to Stent Implantation?
Insights from a Platelet Inhibition Study (abstract)
Presented at the 49th annual session of the American College of Cardiology, 2000
J Am Coll Cardiol 2000;35, Supp 307A
Soffer D, Taviloglu G, New G, Kreps E, Collins M, Iyer S, Roubin G, Colombo A, Moses J,
Coplan N, Moussa I
Lenox Hill Heart and Vascular Institute, New York, NY, USA
Is it Safe to Perform Coronary Intervention in Patients with Occult Blood in Stool and
Stable Hemoglobin? (abstract)
Presented at the 49th annual session of the American College of Cardiology, 2000
J Am Coll Cardiol 2000;35, Supp 32A
Taviloglu G, Soffer D, New G, Baiocco P, Aboufares A, Glasser L, Zlatanic J, Coplan N,
Moses J, Moussa I
Lenox Hill Heart and Vascular Institute, New York, NY, USA
7. Does Clinical presentation Impact Platelet Inhibition at Baseline and Following
Glycoprotein IIb/IIIa Receptor Blockade in Patents Undergoing Percutaneous Coronary
Intervention? (abstract)
Presented at the Transcatheter and Cardiovascular Therapeutics, Washington DC, 2000
Karatepe M, Soffer D, Mani A, Taviloglu G, Kreps E, Collins M, Iyer S, Coplan N, Roubin G
Lenox Hill Heart and Vascular Institute, New York, NY, USA
Clopidogrel Loading Prior to Coronary Stent Implantation, What is the Appropriate
Dose? (abstract)
Presented at the Transcatheter and Cardiovascular Therapeutics, Washington DC, 2000
Karatepe M, Mani A, Soffer D, Taviloglu G, Kreps E, Collins M, Iyer S, Glasser L, Coplan N,
Roubin G
Lenox Hill Heart and Vascular Institute, New York, NY, USA
The Relationship Between Creatine Kinase Elevation after Single Vessel Intervention and
Long-Term Outcome, Causation or Association? (abstract)
Presented at the 73rd scientific sessions of the American Heart Association, 2000
Aboufares A, Lasic Z, Khanna A, Minutillo J, Soffer D,
Taviloglu G, Coplan N, Moses J, Moussa I
Lenox Hill Heart and Vascular Institute, New York, NY, USA
References: Available upon request