1. Connected Health Research
and Innovation at the
University of Ulster
Professor Jim McLaughlin
Director Of the Engineering Research Institute & NIBEC
University of Ulster - and Founder of Intelesens
Stanford Engineering (ME421)
Feb 25 2013

2. Northern Irish inventors from a
population of 1.7 million
 1906: Royal Victoria Hospital  1965: Portable defibrillator
claims to be the first air- created by Frank Pantridge
conditioned public building in
 1967: Pulsar discovered by
the world. (Sirocco Works)
Jocelyn Bell Burnell
 Three point linkage, patented  1970s: Positive end-
by Harry Ferguson of County expiratory pressure
Down – led to early tractors technique for treatment of
 Disintegration of an atomic pulmonary contusion -
developed by staff at the
(splitting the atom) discovered RVH, Belfast
by Ernest Walton et al.
 Others great achievements:
 Ejection seat - first live test of the building of the Titanic
a reliable, successful modern (worlds largest ship in 1912),
ejection seat developed by the development of the
James Martin pneumatic tyre (John
Dunlop) and a range of
aerospace achievements.

3. Nanotechnology and Integrated Bioengineering Centre
(NIBEC)
Engineering Research Institute
£30million funding since 2001
EPSRC; BIS;
INI; HEA;
DEL; SFI;
Wellcome MRC;
Trust; Leverhulme;
EU; R&D Office;
NSF (US Irl Industry;
Partnership) Philanthropic

4. Multi-disciplinary
research centre
applying
nanotechnology and
bioengineering to
the following thrusts:

5. THE DISTRIBUTION OF ACUTE CORONARY DEATHS The Acute MI
Mc NEILLY (BELFAST), 1965-66, 818 DEATHS
Myocardial
100
preservation %
100
90
90 100
100
History: 80
80
PERCENTAGE ALIVE
PERCENTAGE ALIVE
70
70
60
60
50
50
Average patient
Average patient
40
40
response time
response time
30
30
20
20
10
10
0
0 0
0
NIBEC founded in 0.1
0.1
HR
HR
0.2
0.2
HR
HR
1
1
DAY
DAY
INTERVAL AFTER ONSET
INTERVAL AFTER ONSET
7
7
DAY
DAY
0
0 1
1 2
2 3
3
Hrs. from symptom onset
4
4
1985 by Professor
John Anderson
Traced back to
Professor
Partridges idea of
mobile coronary
care
New building in
1994 and 2004

6. History of
Success in CH

7. • Engineering • Computing
• Sensors, Science
Devices,
Wireless • AAL, Big
Data, Cloud
Engineering
Computing
Science
Professor Jim
McLaughlin: Ulster
Lead Nursing Business
• Nursing • Business
•Biomedical •Business Models,
Science Economic
•Sports Science Assessment

9. Infrastructure
 SMART HOME & SMART WARD
 SMART Doctors Surgery
 SERG : Ambient Assisted Living
 Data Analysis/DSP/Labview
Project Laboratories
 Patient Testing Laboratories
 NIBEC: Nanotechnology,
Microfluidics; Cell- /Micro- Biology
Laboratories; Microfabrication
Cleanrooms
 Terrace House and Playing Field
Testing
 Plans for new Innovation Centre
(Manufacturing)…Rapid Proto
typing

10. Connected Health Themes at Ulster
 Wireless Vital Signs Monitoring
 Point of Care Diagnostics Systems
 Sensor Technology
 M-Health
 Ambient Assisted Living
 Clinical Trialing
 Economic Assessment and Valuation
 Technology Transfer…spin outs and
licensing
 Personalized Medicine (BSRI)
 CTRIC and UUM (ISRC)

11. Connected Health Themes at Ulster
Sensor Technology
 ECG, EMG, EEG  Biosensors:
 SpO2 (Reflective) Glucose and
 PWV (piezo) Cardiac Enzymes
via IDE’s
 Accelerometers
(MEMS)  Micro- SPR
 Respiration Rate  Micro-Raman
 GSR  Micro-E-nose
(plasma)
 Cardiac Mapping
All about higher sensitivity &specificity – less false alerts Micro-E-nose (plasma)

12. Key research topics
 AF sensing/pattern  Pulse Wave
recognition Velocity
 Sleep Apnoea  Remote Foetal
early warning monitoring
 Smart MEWS  Hypo- detection in
based multi- Diabetics
sensing Algorithms  Non Invasive
 De-hydration Glucose
Sensing Monitoring
 NIBP systems  Novel Wearable
 Cardiac Mapping Electrode Systems

13. The NIBEC POC Cardiac
Enzyme Impedance

16. 3. Innovation
Wireless Vital Signs
Platforms
 Intelesens has developed its
platform as the basis of OEM
products temperature
ecg
 Short range or cellular telemetry SpO2
 Range of vital signs possible
 Respiration
respiration rate accelerometer
 Blood oxygen (late 2007)
 Temperature
 Motion, activity and falls
 Cardiac output
 ECG
 Compact, light, easy to wear

17. Ubiquitous surveillance monitoring system
 Full ambulation
 Wi-Fi connectivity
 Simple, easy, unobtrusive, low-cost
 Alert management

19. Atrial Fibrillation captured with Aingeal device
Example of CSR captured

20. Smart: ECG Pattern Recognition
 Bradyarrhythmia
 Ventricular Tachycardia
 Supra Ventricular Tachycardia
 Self-terminating Ventricular Fibrillation
 Asystole
 Atrial Flutter
 Atrial Fibrillation
 1st Degree Heart Block
 2nd Degree Heart Block •Congenital heart defects
 3rd Degree Heart Block •Congestive heart failure
•Heart muscle disease
•Heart valve disorders
Clinical Study complete with Ulster Hospital: •Other diseases, such as lung conditions
Dr Roy Harper and currently undergoing one at •External forces such as electric shock or severe
UI and Dublin chest injury

22. Heartsine
Corporate Headquarters:
HeartSine Technologies, Inc.
The 1970’s NIBEC Vision 940 Calle Amanecer
Suite E
San Clemente, CA 92673
United States
Phone: 1.949.218.0092
Fax: 1.949.218.0093
Toll Free: 1.866.HRT.SINE
European
Office:
HeartSine Technologies, Ltd.
Canberra House
203 Airport Road West
Belfast, BT3 9ED
Northern Ireland
Phone: +44 (0)28 9093 9400
Fax: +44 (0)28 9093 9401
http://www.heartsine.com

24. Non-U.S. Only
A 360º ECG
for a complete view of the heart
Touchscreen color monitor
Recently acquired by Verathron 80-Lead Technology Benefits:

25. The Vision – Self Care Model
 Sensor – analysis –
diagnostics – feedback –
immediate therapy Worn
Vital
 Vital signs alert and Signs
Cloud
immediate worn therapy Analytics
Detection
 For example – heart attack
and possible patch based
TPA delivery Feedback
 Or respiration rate and
dosage feedback for therapy
 Require POC diagnostics and
improved drug delivery
techniques
Worn Drug Therapy

27. Founder and Managing Director: Dr. Suzanne Roghieh
Saffie-Siebert
Professor Jim McLaughlin Director and CSO
John Hartnett and Tim Brundle (Investors and Directors)
Scientists: Drs. Nessim Troabi-Pour; Mukhtar Ahmed;
Jeremy Hamill
SiSaf scooped a major prize – for development of an innovative
drug-delivery system at the Irish Technology Leadership Group’s
(ITLG) annual awards ceremony in Silicon Valley, California.

28. The SiSaf Difference
 Solubility – Improved up to 40%
 Biocompatibility – Organic Solid
Nanoparticles
 Active Delivery – Self beneficial
compound
 Control Release – Tailor made
release profile
 Penetration – Into and through skin
 Absorption – Improved through
localization and SR
 Localization – High concentrated
molecule

29. Impact of Connected Health @Ulster
Professors McLaughlin, Anderson  35 patents, 3 companies and many licences
and McAdams have a 25 year  Created over 120 jobs across all 3 Connected
history of developing successful Health spin-outs
patent exploitation in the area of
medical sensors and electro-
 Saved lives, improved the quality of life and cut
stimulation devices, following the costs.
impact that Pantridge, Adgey and  Technologies are used by the Wellcome Trust,
Anderson had on mobile coronary CIMIT and various companies as exemplars of the
care in Northern Ireland. future of healthcare.
 The concept of Connected Health in Northern
Ireland was derived from much of our early work.
This has inspired many initiatives such as the:
 BEST Centre, CHIC, ECHCampus (2009-2012) and now
the European Connected Health Alliance (2011-);
Their more recent work, with over 35 patents, has been
commercialised to companies such as Heartsine Inc., Northern Ireland Connected Health-ECO; culminating
Samsung, Intelesens Ltd. Heartscape Inc., Tyco, SHL
Telemedicine, Phillips and Air Products. These companies’
with NIMAC which joint agreement between USA,
products have now been well established and include the Finland, ROI, Northern Ireland, the Manchester and
world’s best selling disposable ecg electrode, telemedicine
based 12 lead electrodes, the most compact AED marketed Catalonia; Northern Ireland DHSSPSNI & DETI signing a
and a smart wireless chest based ecg, respiration rate,
temperature and SpO2 monitor. strategic and joint Connected Health MOU

30. ECH - Alliance
and
the new Northern
Ireland Connected
Health Eco System
 “Delivering leadership for the development of Connected and Mhealth
markets and practice across Europe and beyond”
 Joint MOU between DETI and DOH in Northern Ireland (better health and jobs)
 Setting up of a NI CH Eco System – Clinicians- Business- Academia
 Strong links with Boston – Finland – Catalonia – Manchester

33. EU-US eHealth Business
Marketplace – Boston USA 2012

34. The recipe for Connected
Health Device Innovation
 Good Product design – from concept to scale-up
 User needs – cost reduction (evidence) – regulatory
 Accurate and flexible business model
 A good users based - ECO system (smart market analysis)
 Miniaturised and robust technology
 Portable – Cloud based solutions – still some security issues
 High quality data analytics
 Early warning with clear patient & clinical benefits
 Smart Back-end systems
 And most of all functional & well designed (intuitive) and
meets all FDA – CE approvals and easily validated

35. Conclusion
 History of Success
 University of Ulster Capability and experience
 Strong Clinical Integration
 Technology Transfer – spin-outs – CHIC’s future Role
 ECHA- The Northern Ireland CH Eco System
 Finally - We need a systems and design approach to
adopting this new form of delivering Healthcare – with
sensors, diagnostics, communications, software,
clinical specifications, health economics, regulatory
drivers and business models all playing a key role to
drive our Healthcare Provision and Economy