Thyroid hormone

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Educação Saúde e medicina

Thyroid Hormone Dr. Sadaf Mumtaz 25/02/11

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Thanks Grasmere 20-03-10

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- The thyroid gland is the largest, butterfly-shaped endocrine glands & is located at the base of the neck immediately below the Larynx, on each side of & anterior to the trachea.The thyroid gland consists of two lobes of endocrine tissue (lying on either side of trachea) joined in the middle by a narrow portion of the gland called as the Isthmus.The thyroid has one ofthe highest rates of blood flow per gram of tissue. - In a normal adult male, it weighs 15-20 g but is capable of enormous growth, sometimes achieving a weight of several hundred grams.

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THYROID HORMONE Location: The thyroid gland located below the larynx on each side of and anterior to the trachea. Largest Endocrine Hormone Secretion: secretes: 1. thyroxine (T4) 2. triiodothyronine (T3) 3. Also secretes calcitonin (an important hormone for calcium metabolism) Cell: Thyrotopes secretion is controlled by thyroid-stimulating hormone (TSH) from the anterior pituitary gland. 93% T4 & 7% T3 T4→T3 in tissues Qualitatively same Differ in Rapidity & Intensity of action. T3 is 4 times more potent than T4, but decrease conc. In blood & decrease half life. T3 and T4 combine mainly with thyroxine-binding globulin. More than 90% of Thyroid hormone that binds with cellular receptors is T3. T4 No effect for 2-3 days after injection Long Latent Period. Activity peaks in 10-12 days & ↓↓ with a half life of 15 days. In some cases it takes 6 weeks-2 months. T3 4 times rapid Latent Period 6-12 hours Peak in 2-3 days Composed of large numbers of closed follicles filled with colloid and lined with cuboidal epithelial cells that secrete into the interior of the follicles The major component of colloid is the large glycoprotein Thyroglobulin contains the thyroid hormones within its molecule. 50mg/year, 1mg/week Ingested iodine in the form of iodides Iodides ingested orally are absorbed from GIT ⅕ removed from the blood by thyroid cells for synthesis of hormones; rest excreted through kidneys. Basal membrane of thyroid cells has an active pump to push iodides to interior (Iodine Pump). Normally 30% more conc. Inside Max. active 250% more conc. Inside The rate of Iodine trapping is influenced by conc. of TSH TSH stimulates and hypophysectomy greatly diminishes the activity of the iodide pump in thyroid cells.

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Thyroid hormone

1. Thyroid Hormone Dr. Sadaf Mumtaz 25/02/11

2.

3. Microscopic appearance of thyroid gland

4. Thyroid cellular mechanisms

5.

6. Regulation of thyroid secretion

7. Effect of cold and other neurogenic stimuli on TRH and TSH secretion

8.

9.

10.

11. Thanks Grasmere 20-03-10