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1.
Down’s Syndrome
2.
3.
The disorder was
identified as a chromosome 21 trisomy by Jerome Lejeune in 1959.
4.
5.
Half moon face.
6.
Puffy cheeks.
7.
Small eyes.
8.
Mongolian type face.
9.
Microgenia(abnormally small chin).
10.
Macroglossia(enlarged tongue near
the tonsils).
11.
Brushfield spots(white spots
on Iris).
12.
Speech, motor skills
delay.
13.
Short stature(149cm women,157cm
men)
14.
15.
Hematological Malignancies(such as
Leukemia).
16.
Thyroid disorders(hypothyroidism due
to dysfunction of thyroid gland).
17.
Infertility.
18.
Gastrointestinal Problems(duodenal atresia,annular
pancres etc).
19.
Opthalmology(cataracts,glaucoma,refractive errors brushfield
spots).Health benefits- Down syndrome patients experiences reduced incidences of many cancers except leukemia as a direct result of Tumor-suppressor genes on chromosome 21.
20.
Genetics Trisomy
of 21st chromosome
21.
22.