How to Troubleshoot Apps for the Modern Connected Worker
Handling RNA sequences containing modified nucleosides with BioPython modules
1. BioPython modules for handling
RNA sequences containing modified
nucleosides.
Tomasz Puton, Kristian Rother,
Magdalena Rother, Janusz M. Bujnicki
Laboratory of Structural Bioinformatics
Adam Mickiewicz University, Poznań, Poland
http://bioinformatics.amu.edu.pl/Lab/
International Institute of Molecular and Cell Biology
Warsaw, Poland http://iimcb.genesilico.pl/
2. BioPython – a set of freely available tools for
biological computation written in Python.
http://biopython.org/
7. Problem:
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There are 115 known post-
transcriptionally modified nucleosides
in RNA.
Known as: Moreover, several nomenclature
wybutosine
schemes exist in parallel.
yW
Y
16G
14. Example applications (part 1):
ModeRNA: A tool for comparative modeling of
RNA 3D structure.
http://iimcb.genesilico.pl/moderna/
Our software models modified RNA 3D structures!
Open source project!
15. Example applications (part 2):
CompaRNA: A server for continuous benchmarking of
automated methods for RNA structure prediction
POSTER NUMBER: W17
SUNDAY, JULY 11: 12:40 p.m. – 2.30 p.m.
http://comparna.amu.edu.pl/
Uses open source software e.g.
BioPython, PyCogent & ModeRNA
16. Thank you for attention!
Tomasz Puton Kristian Rother
t.puton@amu.edu.pl krother@rubor.de
Magdalena Rother Janusz M. Bujnicki
lenam@amu.edu.pl iamb@genesilico.pl