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ADOLESCENT SEXUAL RISK BEHAVIOR:  WHAT DOES RESEARCH SAY AND WHAT CAN CLINICIANS DO?  Larry K. Brown, M.D. Bradley/Hasbro Children’s Research Center Professor of Psychiatry,  The Warren Alpert Medical School of Brown University Providence, Rhode Island Research Supported by NIMH Grants: R01 MH 63008; R01 MH 66641; U01 MH 66785;  T32 MH 07878   and Lifespan/Tufts/Brown Center for AIDS Research (CFAR)
Disclosure Statements ,[object Object],[object Object]
Objectives ,[object Object],[object Object],[object Object]
Rhode Island Hospital Investigators  Celia Lescano, Wendy Hadley, Christopher Houck,  Marina Tolou-Shams, Christie Rizzo, Nancy Beausoleil & Laura Whiteley Co-Investigators  Brown University : Christy Esposito, Ronald Seifer & Caron Zlotnick  Emory University:  Ralph DiClemente  Syracuse University , Michael Carey University of Illinois, Chicago:  Geri Donenberg  University of Pennsylvania : Daniel Romer HIV Prevention Team
 
 
 
AIDS Risk Groups in the 1980s H emophiliacs   H omosexuals   H eroin Addicts   H aitians
Adolescents in the U.S. are at Risk ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lessons Learned ,[object Object],[object Object],[object Object],[object Object]
Adolescent Study  Outcome Analysis ,[object Object]
HIV – Related Risk Behaviors Percent Comparative Risk Profile Mental Health Treatments (n=795) & National Sample (YRBS) HIV Risk Behaviors
Adolescent HIV Prevention Cluster Analysis Among At-Risk Community Youth Girls (n=645) 62 Unprotected Sex (upper half) Marijuana ( past 30 days) Cocaine (ever) Suicide Attempt (ever) Arrest (ever) 38 13 42 2 75 12 54 14 54 Houck, Lescano, Brown, et al,  J. Ped. Psych , 2006 PROPORTION
Adolescent HIV Prevention ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Safe Sexual Behavior Information Motivation Behavioral   Skills Sexual Behavior IMB Model-Fisher & Fisher
Environmental Conditions Personal   Attributes HIV Risk Family Context Peer & Partner  Relations Donenberg & Pao,  JAACAP , 2005. Social Personal Framework HIV risk among adolescents with psychiatric disorders is increased because of difficulties in the following areas (Brown,  JAACAP , 1997)
[object Object],[object Object],[object Object],[object Object],[object Object],Personal Attributes Substance use/abuse Trauma history Psychopathology Condom Attitudes Prevention Skills Family Context Family Dysfunction Communication/Monitoring Parental Attitudes Previous Risk Behaviors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adolescent Sexual Behavior ,[object Object]
Personal Attributes that Influence HIV Risk Behavior ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Assessment: Personal Attributes that Influence HIV Risk Behavior ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Practice:  Personal Attributes that Influence HIV Risk Behavior ,[object Object],[object Object],[object Object],[object Object]
Adolescent Study    Outcome Analysis ,[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Personalize Risk
Crack/Cocaine Use Among Adolescents with Psychiatric Disorders (N=282) ,[object Object],[object Object],Variable O.R. P Crack/Cocaine Use 3.0 .04 Gender (Female) 3.3 .01 Age (>14) 2.4 .08 Race (White) 1.6 .42 Sexual Abuse Hx 2.0 .13 Low Self Restraint 1.2 .68 Alcohol (weekly or daily) 1.6 .40 Marijuana (weekly or daily) 1.7 .36
HIV Behavior: Differences by Sexual Abuse Brown,  American Journal of Psychiatry  2000 ; 157 : 1713-5
HIV Risk of Adolescents in Mental Health Treatment Self-Cutting  and Sexual Risk  (N= 196) 35% of sample were self-cutters; 40% > 3X Brown, et al,  Psych Services , 2005 *Gender, race, age entered in MLR  Variable Adj OR* p Self-cutting 3.6 .04 HIV self-efficacy 3.6 .04 Sexual abuse 3.0 .05
Clinical Practice:  Personal Factors that Influence HIV Risk Behavior ,[object Object],[object Object],[object Object],[object Object]
Condom Use Self-Efficacy During Distress and Risk Behaviors (n=133) Affective Arousal:  High Self Efficacy  Low Self Efficacy  Lescano, C.M. & Brown, L.K.,  Journal of Prevention Intervention in the Community , 2007. PROPORTION
Triggers Feelings You Take Charge! Feelings Take Charge!
TAKING  CHARGE  OF  FEELINGS Get Out Get away or get your mind off of Triggers. Let It Out Do something to keep your feelings from getting bottled up. Think It Out Look for other ways to think about Triggers.
Emotion Regulation (DBT, Linehan) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
D  istract yourself R  emember a plan B  reathe deeply and relax A  pply positive thinking L  eave the situation A  llow the feeling to pass   N  ame people who care about you C  onsider other options E  xpress yourself positively UNSAFE SAFE
 
Clinical Practice:  Personal Attributes that Influence HIV Risk Behavior ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Steps to Condom Use ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Peer and Partner Influences on HIV Risk Behavior ,[object Object],[object Object],[object Object]
Peer and Partner Influences on  HIV Risk Behavior ,[object Object],[object Object],Lescano, Vazquez, Brown, et al., J Adol Health, 2006. Main Partner (N=861) Casual Partner (N=460) p Male 34% 61% .000 # of Partners 1.2 2.3 .001 % Condom Use 37% 47% .001 Unprotected sex acts 18.9 21.5 .65
HIV Prevention:  Peers are important ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Practice:  Peer/Partner Influence ,[object Object],[object Object],[object Object],[object Object]
Adolescents With Psychiatric Disorders Family Context & HIV Risk ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adolescents With Psychiatric Disorders Family Context & HIV Risk: Family Communication Leads to: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Family Context & Adolescent HIV Risk Parent-teen condom discussion  and condom use at last sex Hadley, Brown, et al.,  AIDS & Behavior , 2009.
[object Object],[object Object],[object Object],Talking with Teens About Sex
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
 
Six Month Outcomes  (n=354) PROPORTION
[object Object],[object Object],Family   Adol. only  HP  p Outcomes (Past 90 Days) (n=113)  (n=123)  (n=118) Unprotected Sex Acts* 4.4 (5.3)  6.0 (5.8)  6.5 (6.0)  .04 Self-Cut (# of times)  0.5   0.7   1.3  .11 Mediators Condom Discussion w/Parent   82%   63%  64%  .00  Comfort Condom Discussion  6.3 (1.9)  5.2 (1.8)  4.9 (1.7)  .01  Positive Communication 36.1 (7.8)  35.2 (8.8)  35.0 (7.3)  .09 *Sexually Active Only
 
Community/Media Influences on HIV Risk Behavior ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Attempted Calls to the CDC National AIDS Hotline January 1991-January 1992 Thousands Month
Community/Media Influences on HIV Risk Behavior ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Practice-Community/Media Factors ,[object Object],[object Object],[object Object],[object Object]
Cultural Influence on HIV Risk Behaviors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CDISC Diagnostic Data
Psychopathology and Sexual Risk (N=840) Unprotected  Ever had Sex  Last Sex 1  STIs 1 1 Among sexually active only 2 OR adjusted for age, gender, race, alcohol use, and psychiatric hospitalization. Diagnostic Category (#of participants) % Adj  OR 2 % Adj OR 2 % Adj OR 2 Mania (153) 62 1.9 39 1.7 21 5.1 Internalizing (48) 44 1.0 30 1.2 6 0.7 Externalizing (282) 53 2.3 23 1.9 12 2.1 Comorbid (252) 56 1.8 32 2.4 10 2.0 None (105) 43 1.0 12 1.0 9 1.0

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Brown 1 20 10

  • 1. ADOLESCENT SEXUAL RISK BEHAVIOR: WHAT DOES RESEARCH SAY AND WHAT CAN CLINICIANS DO? Larry K. Brown, M.D. Bradley/Hasbro Children’s Research Center Professor of Psychiatry, The Warren Alpert Medical School of Brown University Providence, Rhode Island Research Supported by NIMH Grants: R01 MH 63008; R01 MH 66641; U01 MH 66785; T32 MH 07878 and Lifespan/Tufts/Brown Center for AIDS Research (CFAR)
  • 2.
  • 3.
  • 4. Rhode Island Hospital Investigators Celia Lescano, Wendy Hadley, Christopher Houck, Marina Tolou-Shams, Christie Rizzo, Nancy Beausoleil & Laura Whiteley Co-Investigators Brown University : Christy Esposito, Ronald Seifer & Caron Zlotnick Emory University: Ralph DiClemente Syracuse University , Michael Carey University of Illinois, Chicago: Geri Donenberg University of Pennsylvania : Daniel Romer HIV Prevention Team
  • 5.  
  • 6.  
  • 7.  
  • 8. AIDS Risk Groups in the 1980s H emophiliacs H omosexuals H eroin Addicts H aitians
  • 9.
  • 10.
  • 11.
  • 12. HIV – Related Risk Behaviors Percent Comparative Risk Profile Mental Health Treatments (n=795) & National Sample (YRBS) HIV Risk Behaviors
  • 13. Adolescent HIV Prevention Cluster Analysis Among At-Risk Community Youth Girls (n=645) 62 Unprotected Sex (upper half) Marijuana ( past 30 days) Cocaine (ever) Suicide Attempt (ever) Arrest (ever) 38 13 42 2 75 12 54 14 54 Houck, Lescano, Brown, et al, J. Ped. Psych , 2006 PROPORTION
  • 14.
  • 15. Safe Sexual Behavior Information Motivation Behavioral Skills Sexual Behavior IMB Model-Fisher & Fisher
  • 16. Environmental Conditions Personal Attributes HIV Risk Family Context Peer & Partner Relations Donenberg & Pao, JAACAP , 2005. Social Personal Framework HIV risk among adolescents with psychiatric disorders is increased because of difficulties in the following areas (Brown, JAACAP , 1997)
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25. HIV Behavior: Differences by Sexual Abuse Brown, American Journal of Psychiatry 2000 ; 157 : 1713-5
  • 26. HIV Risk of Adolescents in Mental Health Treatment Self-Cutting and Sexual Risk (N= 196) 35% of sample were self-cutters; 40% > 3X Brown, et al, Psych Services , 2005 *Gender, race, age entered in MLR Variable Adj OR* p Self-cutting 3.6 .04 HIV self-efficacy 3.6 .04 Sexual abuse 3.0 .05
  • 27.
  • 28. Condom Use Self-Efficacy During Distress and Risk Behaviors (n=133) Affective Arousal: High Self Efficacy Low Self Efficacy Lescano, C.M. & Brown, L.K., Journal of Prevention Intervention in the Community , 2007. PROPORTION
  • 29. Triggers Feelings You Take Charge! Feelings Take Charge!
  • 30. TAKING CHARGE OF FEELINGS Get Out Get away or get your mind off of Triggers. Let It Out Do something to keep your feelings from getting bottled up. Think It Out Look for other ways to think about Triggers.
  • 31.
  • 32. D istract yourself R emember a plan B reathe deeply and relax A pply positive thinking L eave the situation A llow the feeling to pass N ame people who care about you C onsider other options E xpress yourself positively UNSAFE SAFE
  • 33.  
  • 34.
  • 35.  
  • 36.
  • 37.
  • 38.
  • 39.
  • 40.
  • 41.
  • 42.
  • 43.  
  • 44. Family Context & Adolescent HIV Risk Parent-teen condom discussion and condom use at last sex Hadley, Brown, et al., AIDS & Behavior , 2009.
  • 45.
  • 46.
  • 47.
  • 48.  
  • 49. Six Month Outcomes (n=354) PROPORTION
  • 50.
  • 51.  
  • 52.
  • 53. Attempted Calls to the CDC National AIDS Hotline January 1991-January 1992 Thousands Month
  • 54.
  • 55.
  • 56.
  • 57.
  • 58.  
  • 59.
  • 60.
  • 61.
  • 62.
  • 64. Psychopathology and Sexual Risk (N=840) Unprotected Ever had Sex Last Sex 1 STIs 1 1 Among sexually active only 2 OR adjusted for age, gender, race, alcohol use, and psychiatric hospitalization. Diagnostic Category (#of participants) % Adj OR 2 % Adj OR 2 % Adj OR 2 Mania (153) 62 1.9 39 1.7 21 5.1 Internalizing (48) 44 1.0 30 1.2 6 0.7 Externalizing (282) 53 2.3 23 1.9 12 2.1 Comorbid (252) 56 1.8 32 2.4 10 2.0 None (105) 43 1.0 12 1.0 9 1.0

Editor's Notes

  1. We obtained diagnostic data on all 721 participating teens through the Computerized Diagnostic Interview for Children which was self-administered to both parents and adolescents on a laptop computer. Diagnostically we found that about a 1/3 of the sample reported a mood disorder and about 50% reported an externalizing disorder. 85% of the sample met criteria for any disorder And _ had a comorbid diagnosis.