History Kratom had recently been documented since 2004 and 2005 when it stepped into the spotlight i...

1. Kratom & Kratom History
History
Kratom had recently been documented since 2004 and 2005 when it stepped into the spotlight in
Western and for medical research on its application in different fields. However, the studies done
are still not published. Many countries do not recognize this, and it is mostly illegal. Today, the
international legality of Kratom is uncertain, although there are many advantages that have been
seen. The first mention and documentation of Kratom was in the 19th century by a botanist called
Pieter Willem Korthals who documented its use as a substitute for drugs like opium taken in
different methods such as chewing and as concoction.
The Active Ingredients
Scientists say that mitragynine accounts for 70% of various active alkaloids in Kratom. There are
other minor indole alkaloids that have been identified such as speciogynine, paynantheine,
rhynchophylline, and speciociliatine. There is no clinical research that shows that its leaves produce
the hallucinogenic effects. However, the animal studies show that interaction with Kratom is not
confined to the opiate receptors. There is an element in this herb that is not accounted for which is
known to interact with adrenergic and serotonergic systems.
Early Research
The United Nations published an earlier report describing Kratom as having alkaloids. During an
experiment on animals, it was found out that its long-term uses on the experimental animals reduced
the intake of food and water. In the end, these animals did not develop tolerance to the effects.
Today, there is no open information detailing the Kratom usage in the U.S. This cannot be detected
by any present immune screening systems used to test the use in the laboratories. Today, it is not
known in the U.S whether mortality or morbidity has resulted from green malaysian kratom usage.
However, there are extensive materials on the internet showing how people have abused it in
different forms.
Considerations
There is little information known about the human pharmacology or the toxicology of this ancient
Thai herb. But with people getting to read on internet sites, it can lead to abuse. Various Vitro
studies show convincingly that it contains mitragynine and other elements, which have become

2. potent opiate agonist. In fact, this, according to research can produce analgesia. Research has
showed that the 7-hydroxymitragynine metabolites are more potent than the morphine.
Medical Research
Kratom has shown that it has a vast medical potential during medical research. It has shown to be a
powerful analgesic. According to the Botanical legal defence newsletters, it is argued that the
currently reviewed studies on Kratom and the constituent shows that it lacks acute toxicity, shows
powerful antioxidant and the antibacterial properties. Clinical statistics shows that this herb can be
applied to help in alcohol withdrawals. It is rich in oxindole alkaloid that shows potent modulation
properties. It also contains constituents that have shown anti-cancer properties. Doing research on
peer-reviewed articles and clinical trials shows the medical potential of Kratom. In short, studies
have shown that there are no significant safety issues to the health of human when applied as a
medication.
Legality Issue
To many people, Kratom is legal to use, grow and posses in various European Union countries and
the U.S.A. For any person who comes across it, they have to take responsibility to check whether it
is classified as legal or illegal in their country. From website sources, however, many countries have
banned Kratom. These include Denmark, Malaysia, Sweden, Thailand, Burma, Australia, Lithuania,
Vietnam, Myanmar, Poland and Finland.
In fact, Kratom was banned in its country of origin. The Thai government banned it first in 1943.
Therefore, any person who plants the tree is forced to cut it down. The law was found to be faulty
because this tree was one of the indigenous plants in Thailand and can lead to a long jail term when
found in possession. With the prohibition in Thailand, it has seen its black market prices jump to an
all-time record.