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Chairman’s Presentation
                34th Annual General Meeting




July 26, 2012
Disclaimer

Certain statements in this release concerning our future growth prospects are forward-looking statements, which are

subject to a number of risks, uncertainties and assumptions that could cause actual results to differ materially from

those contemplated in such forward-looking statements. Important factors that could cause actual results to differ

materially from our expectations include, amongst others general economic and business conditions in India, our ability

to successfully implement our strategy, our research and development efforts, our growth and expansion plans and

technological changes, changes in the value of the Rupee and other currency changes, changes in the Indian and

international interest rates, change in laws and regulations that apply to the Indian and global biotechnology and

pharmaceuticals industries, increasing competition in and the conditions of the Indian biotechnology and

pharmaceuticals industries, changes in political conditions in India and changes in the foreign exchange control

regulations in India. Neither our company, nor our directors, nor any of their respective affiliates have any obligation to

update or otherwise revise any statements reflecting circumstances arising after this date or to reflect the occurrence of

underlying events, even if the underlying assumptions do not come to fruition.
Biotech: A Transformational Force


• Biotech - a transformational force
  that can deliver sustainable
  solutions for global challenges of
  food, health, energy and
  environment
• Biocon engaged in developing
  knowledge and expertise to
  leverage the power of
  Biotechnology to develop
  therapeutics that can make a
  difference to global healthcare
Affordability


                • Affordability - the epicenter of this
                  unfolding bioeconomy
                • Drug Innovation & Therapy Cost to
                  play a key role in the new financial
                  matrix
                • Biocon’s mission aligned with the
                  changing paradigm
                • Focused on innovation to develop
                  affordable biopharmaceuticals for
                  patients across the globe
Biocon’s Five Powerful
              Growth Accelerators
                                               Branded Formulations
Small Molecules




                                                  Novel Molecules


Biosimilars


                         Integrated Research
                               Services
Unlock Value

               • Five business verticals based on
                 differentiated competencies in discovery,
                 development & commercialization
               • Represent our risk balanced strategy
                 underpinned by agile operating bio-
                 networks, robust research pipeline of
                 products and commercialization foray that
                 spans global markets
               • Growth drivers will propel the Company
                 on a growth trajectory and will enable us
                 to unlock value for our stakeholders
New Enablers


Augmenting Manufacturing, Research & Development and
Marketing capabilities to pursue strong sustainable growth




                                Biopharma manufacturing
                                facility at Bio-XCell, Malaysia

 First overseas manufacturing facility in Malaysia
 New State-of-the-art R&D centre in Bangalore
 Strengthening marketing alliances in emerging markets
Five Growth Verticals:

01. Small Molecules: Forward Integration

• Robust portfolio of Active
  Pharmaceutical Ingredients
  (APIs), including generics like
  Statins, Immuno-suppressants and
  Proprietary Products like
  Fidaxomicin
• Next phase of Growth to develop
  and market finished formulations
• Move up the value chain through
  ANDAs and 505 (b)(2) filings
Five Growth Verticals:

02. Biosimilars : Huge Opportunity
• A high potential growth driver for
  Biocon
• Focus on Insulins & MAB’s
• Several innovator products go off
  patent over the next 5-7 years
• Targeted Insulins opportunity:
  ~ US$ 20 bn by 2020
• Targeted MABs opportunity:
  ~ US$ 32 bn
  Have begun unlocking value in emerging markets - Biosimiliar rh insulin
  available in over 30 countries
Five Growth Verticals:

02. Biosimilars: Global Insulins Development Program

• Phase 1 Global Studies successfully
  completed for Insulin Glargine in
  Germany for EU and US markets
• Met all Primary and Secondary
  endpoints
• Positive PK/PD Results indicate
  comparative safety, efficacy and
  immunogenicity with the innovator
  product

 Paves the way for Phase 3 global program for Insulin Glargine
Five Growth Verticals:

02. Biosimilars: Parting Ways with Pfizer

• Global Partnership concluded due to
  change of priority at Pfizer
• Biocon committed to global development
  as per plan
• Funds received from Pfizer to fuel this plan
• Minimal Impact on business continuity

 Shift in marketing strategy from a single global partner to multiple
 regional alliances
Five Growth Verticals:

02. Biosimilars: Mylan Partnership Gains Momentum

                                 • Global Partnership for
                                   developing Biosimilar
                                   Monoclonal Antibodies on
                                   track
                                 • Phase III clinical Trials in India
                                   have begun for anticancer
                                   Biosimilar Herceptin

 Global Phase III Trials for Biosimilar Herceptin expected shortly
Five Growth Verticals:

03. Branded Formulations - Insulins

• India centric business with 70 brands across
                                                          Biocon’s Value Growth YoY*
  six therapy segments
• Several Biocon brands among Top 5                    #4 in overall insulin market
                                                       #1 in the Glargine vial market
• Focus on product differentiation &
  personalized medical support
                                                       Biocon’s Volume Market share*
• INSUPen® Innovative reusable insulin delivery
  device a value add to Insulins portfolio              100 IU Insulin: 17%
                                                        Glargine vials: 85%




                                                       Fastest growing Insulin company*

                                                        Biocon: 53%
                                                        Sanofi Aventis: 29%
 Biocon India’s premier Insulins company registering
                                                        Novo Nordisk: 25%
 fastest growth in this segment
                                                        *ORG IMS MAT May 2012
Five Growth Verticals:

03. Branded Formulations- Oncology, Nephrology
• BIOMAb EGFR® - first novel biologic developed in India,
  revolutionized head & neck cancer - over 5,000 patients
  benefitted so far
• Recent clinical trials in BIOMAb EGFR®, will enable label
  extensions to new indications such as glioblastoma and
  non-small-cell lung cancer
• Evertor™ First and only global generic version of
  everolimus provided affordable access to this cancer
  drug
• Well balanced Nephrology portfolio offers affordable
  treatment options for dialysis & transplant patients
• Most products amongst the top three Brands.
Five Growth Verticals:

04. Novel Molecules: Promising Research Assets
• Key advanced R&D assets
  to unlock value, through
  licensing/ partnerships
• Itolizumab (T1h) – an anti-
  CD6 MAb completed Phase-
  III Psoriasis trial in India.

• BVX-20, an anti-CD 20
  “bio-better” monoclonal
  antibody has shown
  encouraging results

 Partnered program with Amylin for AC165198, addressing diabetes &
 obesity, currently in Phase I clinical trials under a US FDA IND.

 * US IND filed by partner for AC165198
Anti- CD6 MAb: Itolizumab
Drug Highlights

   Targets CD6
   CD6 is a type 1 cell membrane glycoprotein belonging to the scavenger
   receptor cysteine-rich (SRCR) super family group B.
   CD6 is predominantly expressed by T cells & a B cell subset.
   CD6 binds ALCAM (activated leukocyte cell adhesion molecule) which is expressed on:
                        Activated T, cells, B cells & monocytes.
                        Skin fibroblasts, keratinocytes, rheumatoid arthritis synovium.


TREAT-PLAQ Study in Psoriasis
Interim 28 week data presented at JP Morgan Healthcare Conference
in Jan 2012, at San Francisco

                  Total Patient Enrollment                 223
                        Trial Duration                  52 Weeks
               No. of Centers across India                 15
Treat Plaq Study: Efficacy Results
Representative patient samples from each arm.
          Week   Baseline              12 Weeks   28 Weeks

  Trial Arm


  Induction
  Dose Arm




Fixed Dose
       Arm




Placebo Arm
Treat Plaq Study: Summary of 52-week Results

 PRIMARY ENDPOINT                                                                       Result*
 Statistically significant patient cohort with ≥ PASI 75 Vs. placebo at 12 Weeks          

 SECONDARY ENDPOINTS
 Significant Proportion of subjects achieving PASI 50 and PASI 90                         
 Safety & Tolerability                                                                    
 Improvement in PGA scores                                                                
 Considerable Proportion of subjects with PGA score of “clear” or “minimal”               
                  • Plan to file for Marketing Authorization in India
                  • Approach potential partners for global Clinical Trials

PASI: Psoriasis Area Severity Index   PGA: Physicians Global Assessment      *p <0.05
Five Growth Verticals:

05. Integrated Research Services
•    FY’12 strongest year for Syngene
•    Strategy to invest in strengthening our
     scientific team & capability platforms
     in discovery & development has
     allowed us to build stronger, more
     integrated and value creating
     collaborations to support our
     customers
•    Business Model has evolved from ‘fee
     for services’ to ‘integrated
     collaborative & strategic partner’ for
     global bio-pharma customers.


    Our team over 1,600 scientists is the largest team in Life Sciences in India.
Integrated Research Services Model

   Integrated Model spanning discovery & early
     development to late stage clinical studies
                                                            Component
                                                               Play


 Large Portfolio of Offerings combining Chemistry &
       Biologics expertise with cost advantage        Cluster Play




   Custom partnership models ranging from FTE                Integrated
          based to risk-reward models


                                                      Incubative
   Clientele comprising of 100+ large and mid-size
            pharma & biotech companies
Syngene – Abbott Collaboration
State of the art Abbott Nutrition R&D Centre
inaugurated at Biocon Park
                                                Abbott’s first nutrition research
                                                 and development center in
                                                 India.
                                                The center will focus on the
                                                 development of science-
                                                 based, affordable nutrition
                                                 products for maternal & child
                                                 nutrition & diabetes care
                                                Dedicated Team of over 50
                                                 scientists to work along with
                                                 Abbott Team


Clear endorsement of the success of our Integrated Services model
Five Growth Verticals:

05. Integrated Research Services: Way Forward




           Syngene IPO: Preparatory Step taken –
                    made a subsidiary of Syngene
Focus on Innovation: Biocon Research Centre

Our innovation strategy based on Collaborative R&D aimed at maximizing
outcomes through shared risk and reward, whilst delivering affordable innovation.

State-of-the-art Integrated Research &
Development Center (BRC)

                                                First-of-its kind in South East Asia

                                                Venue for world-class research on
                                                 biologics

                                                Spread across 200,000 sq. ft. with:
                                                  Molecular Biology Lab
                                                  Biologics Process Science Labs
                                                  Formulations Development Lab
                                                  Molecular Characterization Lab
                                                  Functional Bioassay Lab
                                                  Preclinical & Clinical Development
                                                   Groups
Corporate Social Responsibility - Healthcare

                                                       9 Arogya Raksha
                                                        Primary Healthcare
                                                        Clinics, meted out
                                                        medical
                                                        consultations to
                                                        over 60,000
                                                        patients
                                                       6 more clinics to
                                                        open this year
                                                       1,00,000 people
                                                        enrolled under
 Focus on integrated healthcare programs and           Arogya Raksha
  primary education                                     Yojana-Micro
 CSR initiatives aligned with the growing health       Health Insurance
  issues of the communities we serve.                   Scheme, in
                                                        Karnataka
Corporate Social Responsibility - Education




  80,000, Maths Work Books ‘Chinnara Ganitha’
   distributed in primary schools in eight districts of
   Karnataka
  Enhanced mathematical skills of students in rural
   schools
Corporate Social Responsibility - Infrastructure




  400 houses built to rehabilitate flood victims of
   Bagalkot district in Karnataka,
  To provide solar lighting to every household as a part of
   our endeavor to offer a sustainable solution for
   electrification.
FY 2012 - FINANCIALS
FY 2012 Key Financials

                              INR million

              FY12          FY11            Branded Formulations
 Revenue     21,483         18,576          Business up 39%
 EBIDTA      5,791          5,732
                                            Research Services up 29%
                      27%           31%
 PAT         3,384          3,399
                      16%           18%
 Net Cash        7,327          4,908

Pfizer Payment:
• Funds received from Pfizer to be used to fulfill our global
   obligations related to clinical development of insulins
• Deferred Recognition of the balance amount of Rs. 4,929
   million remaining in our books as on March 2012, as per
   industry practice and GAAP
Biocon Pays Homage To

      Dr. Neville Bain

                                     Played a key role in building high
                                     standards of Corporate Governance
                                     and Financial Reporting at Biocon

                                     • Illustrious Corporate Career
                                     • Author of several management
                                       books

   Biocon Board Member 1999 - 2012
Looking Ahead


• Focus on Forward integration and
  out-licensing of research assets to
  Unlock Value
• Leverage Research Services with
  differentiated offerings
• Focus on emerging markets to
  accelerate growth
• Continue to enhance Brand equity
  across global markets
THANK YOU

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Biocon AGM 2012 Presentation July 26, 2012

  • 1. Chairman’s Presentation 34th Annual General Meeting July 26, 2012
  • 2. Disclaimer Certain statements in this release concerning our future growth prospects are forward-looking statements, which are subject to a number of risks, uncertainties and assumptions that could cause actual results to differ materially from those contemplated in such forward-looking statements. Important factors that could cause actual results to differ materially from our expectations include, amongst others general economic and business conditions in India, our ability to successfully implement our strategy, our research and development efforts, our growth and expansion plans and technological changes, changes in the value of the Rupee and other currency changes, changes in the Indian and international interest rates, change in laws and regulations that apply to the Indian and global biotechnology and pharmaceuticals industries, increasing competition in and the conditions of the Indian biotechnology and pharmaceuticals industries, changes in political conditions in India and changes in the foreign exchange control regulations in India. Neither our company, nor our directors, nor any of their respective affiliates have any obligation to update or otherwise revise any statements reflecting circumstances arising after this date or to reflect the occurrence of underlying events, even if the underlying assumptions do not come to fruition.
  • 3. Biotech: A Transformational Force • Biotech - a transformational force that can deliver sustainable solutions for global challenges of food, health, energy and environment • Biocon engaged in developing knowledge and expertise to leverage the power of Biotechnology to develop therapeutics that can make a difference to global healthcare
  • 4. Affordability • Affordability - the epicenter of this unfolding bioeconomy • Drug Innovation & Therapy Cost to play a key role in the new financial matrix • Biocon’s mission aligned with the changing paradigm • Focused on innovation to develop affordable biopharmaceuticals for patients across the globe
  • 5. Biocon’s Five Powerful Growth Accelerators Branded Formulations Small Molecules Novel Molecules Biosimilars Integrated Research Services
  • 6. Unlock Value • Five business verticals based on differentiated competencies in discovery, development & commercialization • Represent our risk balanced strategy underpinned by agile operating bio- networks, robust research pipeline of products and commercialization foray that spans global markets • Growth drivers will propel the Company on a growth trajectory and will enable us to unlock value for our stakeholders
  • 7. New Enablers Augmenting Manufacturing, Research & Development and Marketing capabilities to pursue strong sustainable growth Biopharma manufacturing facility at Bio-XCell, Malaysia  First overseas manufacturing facility in Malaysia  New State-of-the-art R&D centre in Bangalore  Strengthening marketing alliances in emerging markets
  • 8. Five Growth Verticals: 01. Small Molecules: Forward Integration • Robust portfolio of Active Pharmaceutical Ingredients (APIs), including generics like Statins, Immuno-suppressants and Proprietary Products like Fidaxomicin • Next phase of Growth to develop and market finished formulations • Move up the value chain through ANDAs and 505 (b)(2) filings
  • 9. Five Growth Verticals: 02. Biosimilars : Huge Opportunity • A high potential growth driver for Biocon • Focus on Insulins & MAB’s • Several innovator products go off patent over the next 5-7 years • Targeted Insulins opportunity: ~ US$ 20 bn by 2020 • Targeted MABs opportunity: ~ US$ 32 bn Have begun unlocking value in emerging markets - Biosimiliar rh insulin available in over 30 countries
  • 10. Five Growth Verticals: 02. Biosimilars: Global Insulins Development Program • Phase 1 Global Studies successfully completed for Insulin Glargine in Germany for EU and US markets • Met all Primary and Secondary endpoints • Positive PK/PD Results indicate comparative safety, efficacy and immunogenicity with the innovator product Paves the way for Phase 3 global program for Insulin Glargine
  • 11. Five Growth Verticals: 02. Biosimilars: Parting Ways with Pfizer • Global Partnership concluded due to change of priority at Pfizer • Biocon committed to global development as per plan • Funds received from Pfizer to fuel this plan • Minimal Impact on business continuity Shift in marketing strategy from a single global partner to multiple regional alliances
  • 12. Five Growth Verticals: 02. Biosimilars: Mylan Partnership Gains Momentum • Global Partnership for developing Biosimilar Monoclonal Antibodies on track • Phase III clinical Trials in India have begun for anticancer Biosimilar Herceptin Global Phase III Trials for Biosimilar Herceptin expected shortly
  • 13. Five Growth Verticals: 03. Branded Formulations - Insulins • India centric business with 70 brands across Biocon’s Value Growth YoY* six therapy segments • Several Biocon brands among Top 5 #4 in overall insulin market #1 in the Glargine vial market • Focus on product differentiation & personalized medical support Biocon’s Volume Market share* • INSUPen® Innovative reusable insulin delivery device a value add to Insulins portfolio 100 IU Insulin: 17% Glargine vials: 85% Fastest growing Insulin company* Biocon: 53% Sanofi Aventis: 29% Biocon India’s premier Insulins company registering Novo Nordisk: 25% fastest growth in this segment *ORG IMS MAT May 2012
  • 14. Five Growth Verticals: 03. Branded Formulations- Oncology, Nephrology • BIOMAb EGFR® - first novel biologic developed in India, revolutionized head & neck cancer - over 5,000 patients benefitted so far • Recent clinical trials in BIOMAb EGFR®, will enable label extensions to new indications such as glioblastoma and non-small-cell lung cancer • Evertor™ First and only global generic version of everolimus provided affordable access to this cancer drug • Well balanced Nephrology portfolio offers affordable treatment options for dialysis & transplant patients • Most products amongst the top three Brands.
  • 15. Five Growth Verticals: 04. Novel Molecules: Promising Research Assets • Key advanced R&D assets to unlock value, through licensing/ partnerships • Itolizumab (T1h) – an anti- CD6 MAb completed Phase- III Psoriasis trial in India. • BVX-20, an anti-CD 20 “bio-better” monoclonal antibody has shown encouraging results Partnered program with Amylin for AC165198, addressing diabetes & obesity, currently in Phase I clinical trials under a US FDA IND. * US IND filed by partner for AC165198
  • 16. Anti- CD6 MAb: Itolizumab Drug Highlights Targets CD6 CD6 is a type 1 cell membrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) super family group B. CD6 is predominantly expressed by T cells & a B cell subset. CD6 binds ALCAM (activated leukocyte cell adhesion molecule) which is expressed on: Activated T, cells, B cells & monocytes. Skin fibroblasts, keratinocytes, rheumatoid arthritis synovium. TREAT-PLAQ Study in Psoriasis Interim 28 week data presented at JP Morgan Healthcare Conference in Jan 2012, at San Francisco Total Patient Enrollment 223 Trial Duration 52 Weeks No. of Centers across India 15
  • 17. Treat Plaq Study: Efficacy Results Representative patient samples from each arm. Week Baseline 12 Weeks 28 Weeks Trial Arm Induction Dose Arm Fixed Dose Arm Placebo Arm
  • 18. Treat Plaq Study: Summary of 52-week Results PRIMARY ENDPOINT Result* Statistically significant patient cohort with ≥ PASI 75 Vs. placebo at 12 Weeks  SECONDARY ENDPOINTS Significant Proportion of subjects achieving PASI 50 and PASI 90  Safety & Tolerability  Improvement in PGA scores  Considerable Proportion of subjects with PGA score of “clear” or “minimal”  • Plan to file for Marketing Authorization in India • Approach potential partners for global Clinical Trials PASI: Psoriasis Area Severity Index PGA: Physicians Global Assessment *p <0.05
  • 19. Five Growth Verticals: 05. Integrated Research Services • FY’12 strongest year for Syngene • Strategy to invest in strengthening our scientific team & capability platforms in discovery & development has allowed us to build stronger, more integrated and value creating collaborations to support our customers • Business Model has evolved from ‘fee for services’ to ‘integrated collaborative & strategic partner’ for global bio-pharma customers. Our team over 1,600 scientists is the largest team in Life Sciences in India.
  • 20. Integrated Research Services Model Integrated Model spanning discovery & early development to late stage clinical studies Component Play Large Portfolio of Offerings combining Chemistry & Biologics expertise with cost advantage Cluster Play Custom partnership models ranging from FTE Integrated based to risk-reward models Incubative Clientele comprising of 100+ large and mid-size pharma & biotech companies
  • 21. Syngene – Abbott Collaboration State of the art Abbott Nutrition R&D Centre inaugurated at Biocon Park  Abbott’s first nutrition research and development center in India.  The center will focus on the development of science- based, affordable nutrition products for maternal & child nutrition & diabetes care  Dedicated Team of over 50 scientists to work along with Abbott Team Clear endorsement of the success of our Integrated Services model
  • 22. Five Growth Verticals: 05. Integrated Research Services: Way Forward Syngene IPO: Preparatory Step taken – made a subsidiary of Syngene
  • 23. Focus on Innovation: Biocon Research Centre Our innovation strategy based on Collaborative R&D aimed at maximizing outcomes through shared risk and reward, whilst delivering affordable innovation. State-of-the-art Integrated Research & Development Center (BRC)  First-of-its kind in South East Asia  Venue for world-class research on biologics  Spread across 200,000 sq. ft. with:  Molecular Biology Lab  Biologics Process Science Labs  Formulations Development Lab  Molecular Characterization Lab  Functional Bioassay Lab  Preclinical & Clinical Development Groups
  • 24. Corporate Social Responsibility - Healthcare  9 Arogya Raksha Primary Healthcare Clinics, meted out medical consultations to over 60,000 patients  6 more clinics to open this year  1,00,000 people enrolled under  Focus on integrated healthcare programs and Arogya Raksha primary education Yojana-Micro  CSR initiatives aligned with the growing health Health Insurance issues of the communities we serve. Scheme, in Karnataka
  • 25. Corporate Social Responsibility - Education  80,000, Maths Work Books ‘Chinnara Ganitha’ distributed in primary schools in eight districts of Karnataka  Enhanced mathematical skills of students in rural schools
  • 26. Corporate Social Responsibility - Infrastructure  400 houses built to rehabilitate flood victims of Bagalkot district in Karnataka,  To provide solar lighting to every household as a part of our endeavor to offer a sustainable solution for electrification.
  • 27. FY 2012 - FINANCIALS
  • 28. FY 2012 Key Financials INR million FY12 FY11 Branded Formulations Revenue 21,483 18,576 Business up 39% EBIDTA 5,791 5,732 Research Services up 29% 27% 31% PAT 3,384 3,399 16% 18% Net Cash 7,327 4,908 Pfizer Payment: • Funds received from Pfizer to be used to fulfill our global obligations related to clinical development of insulins • Deferred Recognition of the balance amount of Rs. 4,929 million remaining in our books as on March 2012, as per industry practice and GAAP
  • 29. Biocon Pays Homage To Dr. Neville Bain Played a key role in building high standards of Corporate Governance and Financial Reporting at Biocon • Illustrious Corporate Career • Author of several management books Biocon Board Member 1999 - 2012
  • 30. Looking Ahead • Focus on Forward integration and out-licensing of research assets to Unlock Value • Leverage Research Services with differentiated offerings • Focus on emerging markets to accelerate growth • Continue to enhance Brand equity across global markets