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The Physiology of Diabetes
Islet cells of pancreas produce several hormones
 including glucagon & insulin – critically NB in
 metabolism
Glucagon – stimulates release of glucose – acts to
 elevate blood sugar levels
Insulin – decreases level of glucose in blood by causing
 tissue cell membranes to open so that glucose can enter
 the cells more freely
Disorders of the islet cells result in difficulties in sugar
 metabolism
The Physiology of Diabetes
Diabetes mellitus is caused by insulin deficiency
If islet cells do not produce adequate insulin – sugar
 cannot be moved from blood to cells for use
Excessive sugar accumulates in the blood which
 appears in abnormally high levels in the urine
Unregulated or poorly regulated – can cause DEATH or
 COMA
2 Types:
 Type I diabetes – juvenile-onset diabetes
  Autoimmune disease – person’s immune system
    attacks insulin-making cells, destroying them
  Usually occurs before age 30
  Leaves person without the capability to produce
    insulin - dependent on insulin injections
 Type II – adult-onset diabetes
    Usually after the age of 30
    Often affects overweight and poor people
Other Health Problems
Lack of insulin prevents the blood sugar levels from
 being regulated by the body’s control mechanisms
Inability to regulate blood sugar levels can cause:
  Damage to the blood vessels
  Damage to the retina
  Kidney diseases
  Diabetic neuropathy
The Impact of Diabetes
Management of diabetes includes:
 Careful restrictions in diet
 Insulin injections
 Regular exercise
Dietary restrictions include:
 Scheduling of meals and snacks
 Adherence to a set of allowed and disallowed
   foods
The Impact of Diabetes

Blood sugar levels must be tested at least once a day
Done by drawing a blood sample and using the testing
 equipment correctly
Results guide diabetics to appropriate levels of insulin
 injections – source of fear and distress
Regular medical visits are also part of the regimen –
 frightening for children, create scheduling difficulties
 for parents
Reactions that can Interfere with Management

Some diabetics deny the seriousness of the condition
 and ignore lifestyle changes and medication regimens
Others become aggressive and turn their aggression
 either inwardly or outwardly
Many may become dependent, relying on others for
 their care – taking no active part in their own care
Health Psychology’s Involvement with Diabetes
Involved in researching and treating diabetes.
Research:
  ways that diabetics understand & conceptualise their
    illness
  effect of stress on glucose metabolism
  dynamics of families with diabetic children
  factors that influence patient’s compliance with medical
    regimens
Health Psychology’s Involvement with Diabetes
Improving compliance with medical regimens
Stress can play 2 roles in diabetes
   as a possible cause of diabetes
   as a factor in regulation of blood sugar in diabetics
Diabetics’ understanding of the illness affects their
 behaviour
There tends to be an assumption that patients recognize
 the symptoms of high & low blood glucose levels
Symptom perception is very NB in diabetes
 management and unfortunately is not as accurate as
 everyone assumes
Health Psychology’s Involvement with Diabetes
Compliance with the treatment regimen is quite poor
Innovative approaches such as self-monitoring of
 glucose levels have been less successful than expected
  patients fail to use the info they gather to alter their
    treatment.
Patients tend to exhibit unrealistic optimism and
 cognitive distortions.
The addition of hypnosis to a diabetic treatment
 regimen has been shown to be successful amongst
 adolescents – poorest compliers.
Behaviour-oriented programmes such as problem-
 solving skills have been shown to improve diabetics’
 adherence to diet, exercise, & blood glucose testing.
What is Alzheimer’s Disease?
A degenerative disease of the brain
Major source of impairment amongst older people
Can only be diagnosed definitely through autopsy
Brains of Alzheimer’s patients reveal “plaques” &
 tangles of nerve fibers in the cerebral cortex and
 hippocampus – physical basis for Alzheimer’s
2 Forms:
One that occurs before age 60 – early onset
 Due to a genetic defect
One that occurs after the age of 65 – late
 onset
  Related to apolipoprotein E (a protein
   involved in cholesterol metabolism)(E4 form)
   – increases the risk for developing tangles of
   neurons by about 3 times
  E2 form seems to offer some protection
Characteristics of Alzheimer’s

Serious cognitive, language and memory difficulties
Agitation and irritability, aggression,
Sleep disorders
Suspiciousness and paranoia
Incontinence
Sexual disorders
Depression
Delusions
Hallucinations
Characteristics of Alzheimer’s
Memory loss starts with “normal” forgetfulness and
 progresses to the point where Alzheimer’s patients fail
 to recognize family members and forget how to perform
 even routine self-care
Also forget words and exhibit word-finding difficulties
 – dysnomia
Forget where they had put their belongings – relates to
 suspiciousness and paranoia
Helping the Patient
No cure exists
Physical symptoms & accompanying disorders can be
 treated.
Treatment approaches include
  Drugs
  Delaying the progression of cognitive deficits
  Neuroleptic drugs for reducing agitation and aggression
  Use of music and pets to relax the patient,
  Behavioural approaches – identifying antecedents, altering
   the environment
  Progressively Lowered Stress Threshold Model
Helping the Family
Symptoms for the disease are distressing for family
 members
Personality changes and memory difficulties seem
 most distressing
Suspiciousness and paranoia may lead to
 accusations that hurt family members and
 aggressive outbursts can disrupt family functioning
Families tend to find dangerous or embarrassing
 behaviours particularly distressing
Caring for an Alzheimer’s patient greatly disrupts
 family routine
Helping the Family
Alzheimer’s caregivers typically experience feelings of
 loss for the relationship that they once shared with the
 patient
This sense of loss may be similar to bereavement; only
 the person is still alive
Caregivers experiencing the stress of their role exhibit a
 number of their own symptoms:
   Fatigue
   Frustration
   Helplessness
   Grief, shame, embarrassment
   Anger
   Depression
Helping the Family
Research - Alzheimer’s caregivers tend to be more
 distressed, exhibits a poorer immune response, develops
 more infectious diseases
Support received from the friends and family members of
 caregivers can improve the immune functioning of
 Alzheimer’s caregivers
Cognitive-behavioural therapies - manage their negative
 emotions
Support groups that encourage an open, honest sharing of
 feelings, including negative feelings, can provide support
 that families may not be able to give
Support groups can also be sources of information about
 caring for the patients & about community resources that
 provide respite care
Symptoms of HIV and AIDS
HIV progresses over a decade or more through 4
 stages
People vary greatly in the length of time in each
 stage
Stage 1
  Symptoms are not easily distinguishable from those of
   other diseases
  Within approximately a week of infection, people
   frequently experience fever, sore throat, skin rash,
   headache, and other mild symptoms
  First period usually lasts 1 to 8 weeks
Stage 2
  Latent period that may last as long as 10 years
  Infected people are asymptomatic or experience only
    minimal symptoms
Symptoms of HIV and AIDS
Stage 3
  Patients normally have a cluster of symptoms including:
    swollen lymph nodes
    fever
    fatigue
    night sweats
    loss of appetite
    loss of weight
    persistent diarrhea
    white spots in the mouth
    painful skin rash

Stage 4
  Patients’ CD4+ T-lymphocyte cell count drops to 200 or
   less per cubic millimeter of blood
Symptoms of HIV and AIDS
As immune system loses defensive capacities,
 patients become susceptible to various
 opportunistic infectious diseases
These infections involve the lungs, gastrointestinal
 tract, nervous system, liver, bones, and brain
Symptoms include:
  greater weight loss
  general fatigue
  fever
  shortness of breath
  dry cough
  purplish bumps on the skin
  AIDS-related dementia
At this point HIV becomes full-blown AIDS
The Transmission of HIV
The main routes of infection are from:
  person to person during sex
  mother to child during pregnancy or birth
  direct contact with blood or blood products
Concentrations of HIV are especially high in the
 blood and the semen of infected people
Contact with infected semen or blood is a risk
Contact with saliva, urine or tears – much less of a
 risk
No evidence that casual contact spreads the disease
The Transmission of HIV
Most at risk behaviours include:
 Male-male sexual contact
 Injection drug use
 Heterosexual contact
 Transmission during the birth process
Psychologists’ Role in the HIV Epidemic
Early years of the epidemic, psychologists involved in
 both primary and secondary intervention
Primary intervention – changing behaviour to decrease
 HIV transmission
Secondary intervention:
   helping people who are HIV+ to live with the infection
   counseling people about being tested for HIV
   helping patients live with and deal with social & interpersonal
    aspects of HIV
   helping patients adhere to their complex treatment
    programme
Increased survival of HIV+ patients – psychologists’
 knowledge about adherence to medical regimens very
 relevant
Psychologists’ Role in the HIV Epidemic
Encouraging protective measures
Encouragement of people to stop high-risk behaviours or to
 prevent high-risk behaviours by imparting knowledge.
Health care workers also have to protect themselves against
 possible infection.
Helping people with HIV infection
People who believe they are infected and HIV+ people can
 benefit from certain psychological interventions.
People with high-risk behaviours may have difficulty
 deciding whether to be tested for HIV – psychologists can
 provide information & support.
Decision to be tested has both benefits and costs.
Psychologists’ Role in the HIV Epidemic
Benefits
   Knowing HIV status as soon as possible
   Positive test can lead to early treatment – prolong person’s life
   Possible reduction & elimination of behaviours that place others at
    risk
Costs
   May increase anxiety, depression, anger, and psychological distress
   Psychological interventions can reduce distress of people who learn
    they are HIV+
   Cognitive-behavioral stress management interventions – successful
    with boosting positive coping and increasing social support
   Psychologists also play a role in adherence to complex medical
    regimens designed to control HIV infection
   Patients typically take antiretroviral drugs, drugs to combat their side
    effects, drugs to fight opportunistic infections

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Lec3 adjusting to diabetes

  • 1.
  • 2. The Physiology of Diabetes Islet cells of pancreas produce several hormones including glucagon & insulin – critically NB in metabolism Glucagon – stimulates release of glucose – acts to elevate blood sugar levels Insulin – decreases level of glucose in blood by causing tissue cell membranes to open so that glucose can enter the cells more freely Disorders of the islet cells result in difficulties in sugar metabolism
  • 3. The Physiology of Diabetes Diabetes mellitus is caused by insulin deficiency If islet cells do not produce adequate insulin – sugar cannot be moved from blood to cells for use Excessive sugar accumulates in the blood which appears in abnormally high levels in the urine Unregulated or poorly regulated – can cause DEATH or COMA
  • 4. 2 Types:  Type I diabetes – juvenile-onset diabetes  Autoimmune disease – person’s immune system attacks insulin-making cells, destroying them  Usually occurs before age 30  Leaves person without the capability to produce insulin - dependent on insulin injections  Type II – adult-onset diabetes  Usually after the age of 30  Often affects overweight and poor people
  • 5. Other Health Problems Lack of insulin prevents the blood sugar levels from being regulated by the body’s control mechanisms Inability to regulate blood sugar levels can cause: Damage to the blood vessels Damage to the retina Kidney diseases Diabetic neuropathy
  • 6. The Impact of Diabetes Management of diabetes includes: Careful restrictions in diet Insulin injections Regular exercise Dietary restrictions include: Scheduling of meals and snacks Adherence to a set of allowed and disallowed foods
  • 7. The Impact of Diabetes Blood sugar levels must be tested at least once a day Done by drawing a blood sample and using the testing equipment correctly Results guide diabetics to appropriate levels of insulin injections – source of fear and distress Regular medical visits are also part of the regimen – frightening for children, create scheduling difficulties for parents
  • 8. Reactions that can Interfere with Management Some diabetics deny the seriousness of the condition and ignore lifestyle changes and medication regimens Others become aggressive and turn their aggression either inwardly or outwardly Many may become dependent, relying on others for their care – taking no active part in their own care
  • 9. Health Psychology’s Involvement with Diabetes Involved in researching and treating diabetes. Research: ways that diabetics understand & conceptualise their illness effect of stress on glucose metabolism dynamics of families with diabetic children factors that influence patient’s compliance with medical regimens
  • 10. Health Psychology’s Involvement with Diabetes Improving compliance with medical regimens Stress can play 2 roles in diabetes  as a possible cause of diabetes  as a factor in regulation of blood sugar in diabetics Diabetics’ understanding of the illness affects their behaviour There tends to be an assumption that patients recognize the symptoms of high & low blood glucose levels Symptom perception is very NB in diabetes management and unfortunately is not as accurate as everyone assumes
  • 11. Health Psychology’s Involvement with Diabetes Compliance with the treatment regimen is quite poor Innovative approaches such as self-monitoring of glucose levels have been less successful than expected patients fail to use the info they gather to alter their treatment. Patients tend to exhibit unrealistic optimism and cognitive distortions. The addition of hypnosis to a diabetic treatment regimen has been shown to be successful amongst adolescents – poorest compliers. Behaviour-oriented programmes such as problem- solving skills have been shown to improve diabetics’ adherence to diet, exercise, & blood glucose testing.
  • 12.
  • 13. What is Alzheimer’s Disease? A degenerative disease of the brain Major source of impairment amongst older people Can only be diagnosed definitely through autopsy Brains of Alzheimer’s patients reveal “plaques” & tangles of nerve fibers in the cerebral cortex and hippocampus – physical basis for Alzheimer’s
  • 14. 2 Forms: One that occurs before age 60 – early onset Due to a genetic defect One that occurs after the age of 65 – late onset Related to apolipoprotein E (a protein involved in cholesterol metabolism)(E4 form) – increases the risk for developing tangles of neurons by about 3 times E2 form seems to offer some protection
  • 15. Characteristics of Alzheimer’s Serious cognitive, language and memory difficulties Agitation and irritability, aggression, Sleep disorders Suspiciousness and paranoia Incontinence Sexual disorders Depression Delusions Hallucinations
  • 16. Characteristics of Alzheimer’s Memory loss starts with “normal” forgetfulness and progresses to the point where Alzheimer’s patients fail to recognize family members and forget how to perform even routine self-care Also forget words and exhibit word-finding difficulties – dysnomia Forget where they had put their belongings – relates to suspiciousness and paranoia
  • 17. Helping the Patient No cure exists Physical symptoms & accompanying disorders can be treated. Treatment approaches include Drugs Delaying the progression of cognitive deficits Neuroleptic drugs for reducing agitation and aggression Use of music and pets to relax the patient, Behavioural approaches – identifying antecedents, altering the environment Progressively Lowered Stress Threshold Model
  • 18. Helping the Family Symptoms for the disease are distressing for family members Personality changes and memory difficulties seem most distressing Suspiciousness and paranoia may lead to accusations that hurt family members and aggressive outbursts can disrupt family functioning Families tend to find dangerous or embarrassing behaviours particularly distressing Caring for an Alzheimer’s patient greatly disrupts family routine
  • 19. Helping the Family Alzheimer’s caregivers typically experience feelings of loss for the relationship that they once shared with the patient This sense of loss may be similar to bereavement; only the person is still alive Caregivers experiencing the stress of their role exhibit a number of their own symptoms:  Fatigue  Frustration  Helplessness  Grief, shame, embarrassment  Anger  Depression
  • 20. Helping the Family Research - Alzheimer’s caregivers tend to be more distressed, exhibits a poorer immune response, develops more infectious diseases Support received from the friends and family members of caregivers can improve the immune functioning of Alzheimer’s caregivers Cognitive-behavioural therapies - manage their negative emotions Support groups that encourage an open, honest sharing of feelings, including negative feelings, can provide support that families may not be able to give Support groups can also be sources of information about caring for the patients & about community resources that provide respite care
  • 21.
  • 22. Symptoms of HIV and AIDS HIV progresses over a decade or more through 4 stages People vary greatly in the length of time in each stage Stage 1 Symptoms are not easily distinguishable from those of other diseases Within approximately a week of infection, people frequently experience fever, sore throat, skin rash, headache, and other mild symptoms First period usually lasts 1 to 8 weeks Stage 2 Latent period that may last as long as 10 years Infected people are asymptomatic or experience only minimal symptoms
  • 23. Symptoms of HIV and AIDS Stage 3 Patients normally have a cluster of symptoms including:  swollen lymph nodes  fever  fatigue  night sweats  loss of appetite  loss of weight  persistent diarrhea  white spots in the mouth  painful skin rash Stage 4 Patients’ CD4+ T-lymphocyte cell count drops to 200 or less per cubic millimeter of blood
  • 24. Symptoms of HIV and AIDS As immune system loses defensive capacities, patients become susceptible to various opportunistic infectious diseases These infections involve the lungs, gastrointestinal tract, nervous system, liver, bones, and brain Symptoms include: greater weight loss general fatigue fever shortness of breath dry cough purplish bumps on the skin AIDS-related dementia At this point HIV becomes full-blown AIDS
  • 25. The Transmission of HIV The main routes of infection are from: person to person during sex mother to child during pregnancy or birth direct contact with blood or blood products Concentrations of HIV are especially high in the blood and the semen of infected people Contact with infected semen or blood is a risk Contact with saliva, urine or tears – much less of a risk No evidence that casual contact spreads the disease
  • 26. The Transmission of HIV Most at risk behaviours include: Male-male sexual contact Injection drug use Heterosexual contact Transmission during the birth process
  • 27. Psychologists’ Role in the HIV Epidemic Early years of the epidemic, psychologists involved in both primary and secondary intervention Primary intervention – changing behaviour to decrease HIV transmission Secondary intervention:  helping people who are HIV+ to live with the infection  counseling people about being tested for HIV  helping patients live with and deal with social & interpersonal aspects of HIV  helping patients adhere to their complex treatment programme Increased survival of HIV+ patients – psychologists’ knowledge about adherence to medical regimens very relevant
  • 28. Psychologists’ Role in the HIV Epidemic Encouraging protective measures Encouragement of people to stop high-risk behaviours or to prevent high-risk behaviours by imparting knowledge. Health care workers also have to protect themselves against possible infection. Helping people with HIV infection People who believe they are infected and HIV+ people can benefit from certain psychological interventions. People with high-risk behaviours may have difficulty deciding whether to be tested for HIV – psychologists can provide information & support. Decision to be tested has both benefits and costs.
  • 29. Psychologists’ Role in the HIV Epidemic Benefits  Knowing HIV status as soon as possible  Positive test can lead to early treatment – prolong person’s life  Possible reduction & elimination of behaviours that place others at risk Costs  May increase anxiety, depression, anger, and psychological distress  Psychological interventions can reduce distress of people who learn they are HIV+  Cognitive-behavioral stress management interventions – successful with boosting positive coping and increasing social support  Psychologists also play a role in adherence to complex medical regimens designed to control HIV infection  Patients typically take antiretroviral drugs, drugs to combat their side effects, drugs to fight opportunistic infections