The CDD Vault is a 1) Lightweight Solution for Chemical Registration & SAR for budget sensitive labs that is also 2) Collaborative to Scale

1. A Web-Based Collaborative Drug Discovery Platform
Barry Bunin, Ph.D.
CEO and President
Collaborative Drug Discovery, Burlingame, CA.
www.collaborativedrug.com
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
Copyright © 2011 All Rights Reserved Collaborative Drug Discovery

2. CDD for Private, Collaborative, & Public Research
• Users: 21,197 unique logins last year (scalable in the cloud)
• Interoperability/Standards: csv/SMILES, sdfiles, PubMed,
ChemSpider-Pubchem, REST Based Architecture for APIs
• Employing technology to facilitate partnerships: both pre- and
post-IP agreements supported
• Expanding the precompetitive space: the key is supporting
traditional (IP sensitive), collaborative (pre-IP), and open (post-IP) –
all these are real use cases
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
Copyright © 2011 All Rights Reserved Collaborative Drug Discovery

3. © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate

4. CDD Platform For Collaborating with IP Sensitive SAR Data
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
Copyright © 2009 All Rights Reserved Collaborative Drug Discovery

5. Data Partitioning for Multiple Collaborations
Consolidated
CDD DB
Pr
oj Proj
tB
A
j e ct ec e ct D
ec
Company A Pro tC
oj
Pr
Collaborator 1 Collaborator 2 Collaborator 3 Collaborator 4
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
Copyright © 2009 All Rights Reserved Collaborative Drug Discovery

6. Collaborative Capabilities for
Efficient International Drug Discovery
Individual Pain Points Organizational Need Technical Solution
Keep scientist’s data Collaboration is as much Temporal data access
private until ready to about more efficient work controls
share (i.e. with the rest of within a single
their groups) organization as between
organizations.
Allow scientists to Control of chemical or Spatial data partitioning
partition or sequester data biological data access
to enable selective data based on Project-specific
sharing permissions
Allow collaboration in Control based on type of Sequester by data
scientist’s natural data – especially given a classification
workflow (i.e. without marketplace with
uploading data multiple specialization in
times in multiple places) synthesis, screening,
discovery, development
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
Copyright © 2011 All Rights Reserved Collaborative Drug Discovery

7. User Roles and Privileges in CDD
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate

8. CDD Convenient Mining & Export Options
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate

9. CDD Configurable IC50 Dose Response Capabilities
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate

10. © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate

11. Secure and Low TCO (Total Cost of Ownership)
CDD database system
• Web based (log in securely into to your database from any
computer).
• We host the server for you
• Highly secure, all traffic encrypted, server in a secure
professionally hosted environment.
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
Copyright © 2009 All Rights Reserved Collaborative Drug Discovery

12. CDD Drug Repurposing 2009 Case Study #1
Result
New leads reveal known
drugs that reverse
chloroquine resistance
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate

13. CDD 2011 EU PPP Case Study #2
© 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate