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IMAGING OF PANCREAS
      USG &CT
      DR. MEGHA SANGHVI
     M.D. RADIODIAGNOSIS
    ASSISTANT PROFESSOR
    B.J.M.C., CIVIL HOSPITAL,
          AHMEDABAD.
ANATOMY OF PANCREAS

• Length – 15 cm.
• Head, uncinate process,
  neck, body, tail
• Gradually tapering “Horse
  shoe” shape.
• Head – 23 +/- 3 mm
• Neck – 19 +/- 2.5 mm
• Body – 20 +/- 3 mm
• Tail – 15 +/- 2.5 mm
IMAGING MODALITIES
                Imaging of pancreas

• Radiograph – detect calcification (practically
  of no help)
• Barium studies – indirect signs (not helpful)
• USG – differentiation of cystic and solid
  lesions (screening tool & for follow-up)
• CT scan – modality of choice
• MRI and MRCP – complimentary to CT
ULTRASONOGRAPHY
                      Imaging of pancreas
  •   Widely available
  •   Easily accessible
  •   Can be repeated as often as necessary
  •   Cheap
  •   No ionizing radiation
  •   Portability
  •   Other causes of medical and surgical acute abdomen can be
      identified and excluded




PRIMARILY USED AS SCREENING TOOL & FOR FOLLOW UP
CT SCAN
                 Imaging of pancreas
•   Gold standard for all pancreatic pathologies
•   Detects complications
•   Helps in staging of tumors
•   Post processing techniques are of additional help




    MPR                MIP-VESSELS       CURVED MPR-DUCTS
          GOLD STANDARD FOR PANCREAS
MRI/MRCP
                     Imaging of pancreas


• Pancreatic Duct

• Side branches

• Lower end of CBD




           MAINLY A PROBLEM SOLVING TOOL
PATHOLOGY
                 Imaging of pancreas


• Pancreatitis

• Pancreatic divisum

• Tumors

• Traumatic – Laceration and pancreatic duct
  injury
ACUTE PANCREATITIS
               Imaging of pancreas


•   Increase in the volume of pancreas
•   Oedematous changes
•   Peripancreatic fluid collections
•   Peripancreatic fat stranding
•   Haemorrhagic areas
•   Pancreatic necrosis
•   Superinfection
•   Vascular complications
ACUTE PANCREATITIS
    Ultrasonography
ACUTE PANCREATITIS
      CT Scan
ACUTE PANCREATITIS
                 CT Scan
   NECROSIS                SPL.V.THROMBOSIS




PSEUDOANEURYSM




                           PSEUDOANEURYSM
ACUTE PANCREATITIS
      CT Scan
      INFECTED
     COLLECTION
CT severity index - CTSI

            What is CTSI?


A scoring index for grading acute
pancreatitis based on CT scan findings
and extent of pancreatic and
peripancreatic inflammatory changes
CT severity index - CTSI
      Prognostic Indicator                                  points
    Pancreatic inflammation
    Normal pancreas                                          0
    Intrinsic pancreatic abnormalities with or without
      inflammatory changes in peripancreatic fat             2
    Pancreatic or peripancreatic fluid collection or
       peripancreatic fat necrosis                            4

  Pancreatic necrosis
 None 0                                                      0
 minimal                                                     2
 substantial                                                 4

    Extrapancreatic complications (one or more of
     pleural effusion, ascites, vascular complications,
     parenchymal complications, or gastrointestinal tract
     involvement)                                            2
CTSI (Modified)


         Mild     -          0 to 2
         Moderate -          4 to 6
         Severe -           8 to 10


Modified CTSI correlates with length of hospital
stay, need for intervention or surgery, infection
and organ failure
CHRONIC PANCREATITIS
                      Imaging of pancreas


• Parenchymal atrophy / focal bulge

• Parenchymal Calcification

• Ductal dilatation

• Pseudocyst and other complications

• Peripancreatic fascial thickening and blurring of pancreatic
  margins

• Vascular Cx : PV/SV thrombosis, SA pseudoaneurysm
CHRONIC PANCREATITIS
                Ultrasonography




USG cannot diagnose chronic pancreatitis despite
      advanced disease stage at times.
CHRONIC PANCREATITIS
                           CT Scan




    Chronic pancreatitis                    Pseudocyst


CT is more sensitive in diagnosing pancreatic calcification and
parenchymal atrophy than USG.
CT is considered as modality of choice in diagnosing chronic
pancreatitis.
RECURRENT PANCREATITIS
      Imaging of pancreas




      GALL
     STONES


    PANCREATIC
      DIVISUM
PANCREATIC DIVISUM
                         Recurrent pancreatitis

Causes repeated acute pancreatitis.
Failure of the dorsal and ventral pancreatic
primordia to fuse.

The dorsal duct drains into the duodenum at
the minor papilla, and the ventral duct drains
via the major ampulla with the CBD.

MRCP easily reveals the dorsal pancreatic duct
in patients with divisum, whereas cannulation
of the minor papilla of such patients for ERCP is
frequently unsuccessful .                           Dorsal PD


36-year-old woman with h/O Pancreatitis.
                                                                Ventral PD
MRCP shows separate dorsal and ventral pancreatic
duct systems consistent with divisum.
PANCREATIC TUMORS
               Imaging of pancreas



• Benign

• Primary malignant

• Endocrine tumors

• Metastasis
PANCREATIC TUMORS
                        Imaging modalities


• US is the first line imaging test.

• The overall sensitivity & specificity of USG for
  determining resectability of all pancreatic
  carcinomas is only 63% and 83%

• CT – gold standard for diagnosis & staging

• MRCP – for periampullary tumors

• EUS - most sensitive - head tumors < 2 cm.
PANCREATIC TUMORS
                     Imaging features




• Morphologic and contour
  changes
• Mass effect
• Density changes
• Contrast enhancement
• Pancreatic duct changes
• Secondary signs
PANCREATIC TUMORS
                   CT Scan


                             Hypovascular




                                            Lymphnodes
Peritoneal
nodules
PANCREATIC TUMORS
                         CT Scan




Involvement of CBD –T3      Involvement of duodenum – T3
PANCREATIC TUMORS
         CT Scan




Pancreatic Carcinoma with
  Krukenberg metastasis
PANCREATIC TUMORS
              Staging and resectability


• Stage I
                  Resectable
• Stage II

• Stage III
                  Unresectable
• StageIV
VENOUS ENCASEMENT & RESECTABILITY
                   Pancreatic tumors

 • Grade 0: normal fat plane b/w tumor and vessel.
 • Grade 1: loss of fat plane b/t tumor and vessel,
   with or without smooth displacement of the
   vessel.
 • Grade 2: flattening and/or slight irregularity of one
   side of the vessel (<180o)
 • Grade 3: encased vessel with tumor encasing
   >180o, altering its contour and producing
   concentric or eccentric lumen narrowing
 • Grade 4: atleast one major occluded vessel
VENOUS ENCASEMENT & RESECTABILITY
             Pancreatic tumors


 • Grade 0

 • Grade 1   Resectable

 • Grade 2

 • Grade 3   With en bloc venous resection

 • Grade 4   Unresectable
VENOUS ENCASEMENT & RESECTABILITY
           Pancreatic tumors




            Resectable
VENOUS ENCASEMENT & RESECTABILITY
           Pancreatic tumors




           Unresectable
ARTERIAL ENCASEMENT & RESECTABILITY
               Pancreatic tumors


• Encasement or involvement of celiac
  trunk, hepatic artery, gastroduodenal
  artery or superior mesenteric artery –
  unresectable.

• See for – perivascular cuff of soft tissue
ARTERIAL ENCASEMENT & RESECTABILITY
            Pancreatic tumors




                                Coeliac trunk
SMA encasement                  encasement
MUCINOUS CYSTADENOMA
                PANCREATIC TUMORS


•40-50 YEARS
•“MOTHER LESION”
•MALIGNANT POTENTIAL
•MACROCYSTIC
•USUALLY 1 CYST
•PERIPHERAL CALCIFICATION (25%)
•BODY AND TAIL (90%)
SEROUS CYSTADENOMA
              PANCREATIC TUMORS




•60-70 YEARS
“GRANDMOTHER LESION”
•BENIGN
•LOBULATED
•MICROCYSTIC
•CENTRAL SCAR (18%)
INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM (IPMN)
                   PANCREATIC TUMORS
                                         Branch duct type IPMT
                                        Dilatation of the branch ducts



• Classification based on the duct
  architecture

Main duct type- diffuse or segmental
  dilatation of the MPD
Branch duct type-dilatation of branch
  ducts
Combined type – Main + branch ducts
INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM (IPMN)
            PANCREATIC TUMORS
SOLID PAPILLARY & EPITHELIAL NEOPLASM (SPEN)
               PANCREATIC TUMORS




•Rare – low grade
malignancy.
•Commonly seen in
young females
involving pancreatic
tail – “Daughter’s
tumor”
ISLET CELL TUMOR
            PANCREATIC TUMORS


• Neoplasms of
  neuroendocrine
  cells.
• 50% - functioning
  and 50% -
  malignant.
• Diagnostic clue -
  Hypervascularity.
ISLET CELL TUMOR
  PANCREATIC TUMORS
LYMPHOMA
                   PANCREATIC TUMORS




•Focal or diffuse mass
without dilatation of PD.
•Associated with large
lymphnodes.
•Common in immuno-
compromised patients.
PANCREATIC TRAUMA

• The diagnosis of duct injury is critical to subsequent
  treatment of the patient.
• MRCP can accurately depict the integrity of the pancreatic
  duct as well as the site of disruption
• MRCP can reveal the duct that is upstream from the site
  of disruption, which is difficult with ERCP.




                         25 year old male with blunt abdominal
                         injury.MRCP shows complete disruption of
                         pancreatic duct in body region with distal
                         dilatation
CONCLUSION
             Imaging of pancreas


• USG – Used as primary screening tool.
• MDCT – modality of choice – for most
  pancreatic pathologies
• CTSI – important to decide prognosis
• MRCP - complimentary tool for evaluation
  of duct and variations of ductal anatomy
• Staging has a very important role in the
  management and prediction of prognosis
  in pancreatic tumors.
THANK YOU

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Imaging of the Pancreas

  • 1. IMAGING OF PANCREAS USG &CT DR. MEGHA SANGHVI M.D. RADIODIAGNOSIS ASSISTANT PROFESSOR B.J.M.C., CIVIL HOSPITAL, AHMEDABAD.
  • 2. ANATOMY OF PANCREAS • Length – 15 cm. • Head, uncinate process, neck, body, tail • Gradually tapering “Horse shoe” shape. • Head – 23 +/- 3 mm • Neck – 19 +/- 2.5 mm • Body – 20 +/- 3 mm • Tail – 15 +/- 2.5 mm
  • 3. IMAGING MODALITIES Imaging of pancreas • Radiograph – detect calcification (practically of no help) • Barium studies – indirect signs (not helpful) • USG – differentiation of cystic and solid lesions (screening tool & for follow-up) • CT scan – modality of choice • MRI and MRCP – complimentary to CT
  • 4. ULTRASONOGRAPHY Imaging of pancreas • Widely available • Easily accessible • Can be repeated as often as necessary • Cheap • No ionizing radiation • Portability • Other causes of medical and surgical acute abdomen can be identified and excluded PRIMARILY USED AS SCREENING TOOL & FOR FOLLOW UP
  • 5. CT SCAN Imaging of pancreas • Gold standard for all pancreatic pathologies • Detects complications • Helps in staging of tumors • Post processing techniques are of additional help MPR MIP-VESSELS CURVED MPR-DUCTS GOLD STANDARD FOR PANCREAS
  • 6. MRI/MRCP Imaging of pancreas • Pancreatic Duct • Side branches • Lower end of CBD MAINLY A PROBLEM SOLVING TOOL
  • 7. PATHOLOGY Imaging of pancreas • Pancreatitis • Pancreatic divisum • Tumors • Traumatic – Laceration and pancreatic duct injury
  • 8. ACUTE PANCREATITIS Imaging of pancreas • Increase in the volume of pancreas • Oedematous changes • Peripancreatic fluid collections • Peripancreatic fat stranding • Haemorrhagic areas • Pancreatic necrosis • Superinfection • Vascular complications
  • 9. ACUTE PANCREATITIS Ultrasonography
  • 11. ACUTE PANCREATITIS CT Scan NECROSIS SPL.V.THROMBOSIS PSEUDOANEURYSM PSEUDOANEURYSM
  • 12. ACUTE PANCREATITIS CT Scan INFECTED COLLECTION
  • 13. CT severity index - CTSI What is CTSI? A scoring index for grading acute pancreatitis based on CT scan findings and extent of pancreatic and peripancreatic inflammatory changes
  • 14. CT severity index - CTSI Prognostic Indicator points  Pancreatic inflammation  Normal pancreas 0  Intrinsic pancreatic abnormalities with or without inflammatory changes in peripancreatic fat 2  Pancreatic or peripancreatic fluid collection or peripancreatic fat necrosis 4 Pancreatic necrosis  None 0 0  minimal 2  substantial 4 Extrapancreatic complications (one or more of pleural effusion, ascites, vascular complications, parenchymal complications, or gastrointestinal tract involvement) 2
  • 15. CTSI (Modified) Mild - 0 to 2 Moderate - 4 to 6 Severe - 8 to 10 Modified CTSI correlates with length of hospital stay, need for intervention or surgery, infection and organ failure
  • 16. CHRONIC PANCREATITIS Imaging of pancreas • Parenchymal atrophy / focal bulge • Parenchymal Calcification • Ductal dilatation • Pseudocyst and other complications • Peripancreatic fascial thickening and blurring of pancreatic margins • Vascular Cx : PV/SV thrombosis, SA pseudoaneurysm
  • 17. CHRONIC PANCREATITIS Ultrasonography USG cannot diagnose chronic pancreatitis despite advanced disease stage at times.
  • 18. CHRONIC PANCREATITIS CT Scan Chronic pancreatitis Pseudocyst CT is more sensitive in diagnosing pancreatic calcification and parenchymal atrophy than USG. CT is considered as modality of choice in diagnosing chronic pancreatitis.
  • 19.
  • 20. RECURRENT PANCREATITIS Imaging of pancreas GALL STONES PANCREATIC DIVISUM
  • 21. PANCREATIC DIVISUM Recurrent pancreatitis Causes repeated acute pancreatitis. Failure of the dorsal and ventral pancreatic primordia to fuse. The dorsal duct drains into the duodenum at the minor papilla, and the ventral duct drains via the major ampulla with the CBD. MRCP easily reveals the dorsal pancreatic duct in patients with divisum, whereas cannulation of the minor papilla of such patients for ERCP is frequently unsuccessful . Dorsal PD 36-year-old woman with h/O Pancreatitis. Ventral PD MRCP shows separate dorsal and ventral pancreatic duct systems consistent with divisum.
  • 22. PANCREATIC TUMORS Imaging of pancreas • Benign • Primary malignant • Endocrine tumors • Metastasis
  • 23. PANCREATIC TUMORS Imaging modalities • US is the first line imaging test. • The overall sensitivity & specificity of USG for determining resectability of all pancreatic carcinomas is only 63% and 83% • CT – gold standard for diagnosis & staging • MRCP – for periampullary tumors • EUS - most sensitive - head tumors < 2 cm.
  • 24. PANCREATIC TUMORS Imaging features • Morphologic and contour changes • Mass effect • Density changes • Contrast enhancement • Pancreatic duct changes • Secondary signs
  • 25. PANCREATIC TUMORS CT Scan Hypovascular Lymphnodes Peritoneal nodules
  • 26. PANCREATIC TUMORS CT Scan Involvement of CBD –T3 Involvement of duodenum – T3
  • 27. PANCREATIC TUMORS CT Scan Pancreatic Carcinoma with Krukenberg metastasis
  • 28. PANCREATIC TUMORS Staging and resectability • Stage I Resectable • Stage II • Stage III Unresectable • StageIV
  • 29. VENOUS ENCASEMENT & RESECTABILITY Pancreatic tumors • Grade 0: normal fat plane b/w tumor and vessel. • Grade 1: loss of fat plane b/t tumor and vessel, with or without smooth displacement of the vessel. • Grade 2: flattening and/or slight irregularity of one side of the vessel (<180o) • Grade 3: encased vessel with tumor encasing >180o, altering its contour and producing concentric or eccentric lumen narrowing • Grade 4: atleast one major occluded vessel
  • 30. VENOUS ENCASEMENT & RESECTABILITY Pancreatic tumors • Grade 0 • Grade 1 Resectable • Grade 2 • Grade 3 With en bloc venous resection • Grade 4 Unresectable
  • 31. VENOUS ENCASEMENT & RESECTABILITY Pancreatic tumors Resectable
  • 32. VENOUS ENCASEMENT & RESECTABILITY Pancreatic tumors Unresectable
  • 33. ARTERIAL ENCASEMENT & RESECTABILITY Pancreatic tumors • Encasement or involvement of celiac trunk, hepatic artery, gastroduodenal artery or superior mesenteric artery – unresectable. • See for – perivascular cuff of soft tissue
  • 34. ARTERIAL ENCASEMENT & RESECTABILITY Pancreatic tumors Coeliac trunk SMA encasement encasement
  • 35. MUCINOUS CYSTADENOMA PANCREATIC TUMORS •40-50 YEARS •“MOTHER LESION” •MALIGNANT POTENTIAL •MACROCYSTIC •USUALLY 1 CYST •PERIPHERAL CALCIFICATION (25%) •BODY AND TAIL (90%)
  • 36. SEROUS CYSTADENOMA PANCREATIC TUMORS •60-70 YEARS “GRANDMOTHER LESION” •BENIGN •LOBULATED •MICROCYSTIC •CENTRAL SCAR (18%)
  • 37. INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM (IPMN) PANCREATIC TUMORS Branch duct type IPMT Dilatation of the branch ducts • Classification based on the duct architecture Main duct type- diffuse or segmental dilatation of the MPD Branch duct type-dilatation of branch ducts Combined type – Main + branch ducts
  • 38. INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM (IPMN) PANCREATIC TUMORS
  • 39. SOLID PAPILLARY & EPITHELIAL NEOPLASM (SPEN) PANCREATIC TUMORS •Rare – low grade malignancy. •Commonly seen in young females involving pancreatic tail – “Daughter’s tumor”
  • 40. ISLET CELL TUMOR PANCREATIC TUMORS • Neoplasms of neuroendocrine cells. • 50% - functioning and 50% - malignant. • Diagnostic clue - Hypervascularity.
  • 41. ISLET CELL TUMOR PANCREATIC TUMORS
  • 42. LYMPHOMA PANCREATIC TUMORS •Focal or diffuse mass without dilatation of PD. •Associated with large lymphnodes. •Common in immuno- compromised patients.
  • 43. PANCREATIC TRAUMA • The diagnosis of duct injury is critical to subsequent treatment of the patient. • MRCP can accurately depict the integrity of the pancreatic duct as well as the site of disruption • MRCP can reveal the duct that is upstream from the site of disruption, which is difficult with ERCP. 25 year old male with blunt abdominal injury.MRCP shows complete disruption of pancreatic duct in body region with distal dilatation
  • 44. CONCLUSION Imaging of pancreas • USG – Used as primary screening tool. • MDCT – modality of choice – for most pancreatic pathologies • CTSI – important to decide prognosis • MRCP - complimentary tool for evaluation of duct and variations of ductal anatomy • Staging has a very important role in the management and prediction of prognosis in pancreatic tumors.