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Happiness and the brain Dick Swaab Netherlands Institute for Neuroscience, Amsterdam. .
Reward and Happiness ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
VMAT-2: associated with  self-transcendence scale  of spirituality (Cloninger)
TLE A patient with ecstatic epileptic attacs saw Jesus. He had an astrocytoma of the  temporal lobe. The attacs diappeared after temporal lobectomy.
[object Object],[object Object]
Carmelite Nuns ,[object Object],[object Object],[object Object],[object Object],[object Object]
Yoga
 
 
 
[object Object],[object Object]
 
2 times more martial problems, 2 times more unfaithful….
 
OXT/AVP ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Coding versus causality ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Kent et al., Psychopharmacol. (2008) 199: 457-480 pleasantness odors water during thirst taste and smell monetary reward Medial OPFC
Kent et al.,  OFC and pleasantness ratings of food
 
 
 
Coding versus causality ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Hedonic hotspots : Nucl. Accumbens, ventral pallidum and nucleus brachialis.  Kent et al., Psychopharmacol.,(2008) 199: 457-480
Coding versus causality ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
OCD
Does DBS produce pure “wanting” rather than “liking”?
Coding versus causality ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
* *
2003:  no tuber cinereum,  no infundibulum,  no pituitary stalk,  no corp. mamill., no bottom of 3 rd   ventricle  (concirmed by  endoscopy) TEMP, CLOCK and MEMORY DIET AGRRESION Not: sex, attention,  sleep Craniopharyngioma,  operation, 1990 (than 18 years old
Neurotransmitters and reward systems ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
Anhedonia ,[object Object],[object Object],[object Object]
 
 
A.Kalsbeek
 
Anhedonia ,[object Object],[object Object],[object Object]
 
Makris et al.,
 
RR >2 for depression, schizophrenia  and obesity, 1.6 for addiction.
 
 
Conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Biol.Psych. 2008, 64, 192-2002.
Glucocorticoid hypothesis (Atypical depression) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Happiness and the brain Dick Swaab Netherlands Institute for Neuroscience, Amsterdam.
Makris et al.,
Neurotransmitters and reward systems ,[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
 
 
 
The neurobiology of depression Dick Swaab Netherlands Institute for Neuroscience, Amsterdam. Depression as a multi-causal networksyndrome
L-Dopa
 
 
 
 
 
 

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Dick Swaab Geluk