1. May 8, 2013
Brian S. Appleby, M.D.
Cleveland Clinic Lou Ruvo Center for Brain Health

2. Hope vs Optimism
Hope (verb, noun): “to desire with
expectation of fulfillment”
Optimism (noun)/Optimistic (adjective)
Celebrate (verb): “to perform publicly”

3. Trainee: “Why do you do this, you
always have bad news to give?”
• Quality vs Quantity of Life (psychiatry)
• Comprehensive Model (geriatric psych)
• Caregiver/Family dyad (dementia care)
• Unmet Need (CJD, young-onset dementia)
• 5 days/week (Cleveland Clinic)

4. -80
-60
-40
-20
0
20
Heart Disease Cancer Stroke Lung disease Accidents Diabetes Influenza Alzheimer’s Kidney disease Septicemia
Change in Death Rate (1999 vs 2010) of Top 10 Causes of Death in U.S.A.
Does NOT take age into account

5. #1 Risk for Alzheimer’s?
AGE
Thies W, Alzheimers Dement 2013

6. Thies W, Alzheimers Dement 2013

7. Estimated aggregate costs of care by payer for
Americans age 65 years and older with
Alzheimer’s disease and other dementias for
2013
Thies W, Alzheimers Dement 2013

8. Thies W, Alzheimers Dement 2013

9. “I'm Givin' Her All She's Got
Captain! If I Push It Any Harder
the Whole Thing's Gonna' Blow”

10. New and Better Disease Models
Aguzzi A, Nature 2009

11. A
B
C
Google searches for “dementia” over time

12. Appleby BS, Prion 2012
U.S. Alzheimer’s Related Publications Over Time

13. What IS Alzheimer’s Disease?

14. What is the Best Way to Treat/
Prevent Alzheimer’s Disease?
LIVE!