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András Nagy
University of Pécs, Medical School,
     Department of Anatomy,
          Pécs, Hungary
Indo-european languagesprings
         -1500 thermal families:
Romance -450 public baths
Germane -largest thermal lake in Europe
Slavic
Pécs
       -BC - Celts, Pannonian tribes
       -CE centuries:
       -1-4th Rome: Pannonia/Valeria/Sopianae
       Early Christian Necropolis – UNESCO
       -5-8th: Huns, Barbarians, Slavs, Avars
       -9th: Charlemagne: Balaton Principality/
        Saltzburg Episcopate/Quinque Basilicae

       -10th: Magyars - semi-nomadic tribes
       -11th: Christian Hungary, Diocese of Pécs
       -13rd: Mongol invasion, population loss
       balanced by immigrant eastern tribes&slavs
       First University of Hungary (1367)
       -16-17th: Ottoman Turks
       Mosques, Minarets, Turkish baths

       -18th: Austrian rule, population loss
       balanced by german, jewish immigrants
       Pécs is a free royal town from 1777

       -19th: Austria-Hungary Monarchy

       -20th: post-WW: soviet industrialization

       -2010: Cultural Capital of Europe
Emotional changes by season

     Human                       Animal husbandry




Seasonal affective                 Breeding
disorder (SAD)                     Metabolism
                                   Behaviour
    Depression
    suicidability                 productivity


                    Mechanisms
季節性感情障害 (SAD)




社会的、心理的要因無く、特定の季節にうつ症状を発症し、そ
れ
以外の季節には自然に寛解する周期性気分障害
有病率 欧米:一般人口の 1 ~ 10%
      日本: うつ病患者の 1 ~ 3%  

 症状 過食、過眠、炭水化物飢餓など

  疫学調査や病態研究により、セロトニン神経系が関連


日長がセロトニン神経機能
に及ぼす影響を解明      SAD の予防、緩和に繋がる
25000

                                    300                         Serotonin levels in Amygdala
                                     0.02                       Forced Swim Test
      22500                                       Bmal1 mRNA contents in the SCN (ISH)                     Vehiculum

                                    250                               情動                                   Melatonin
Immobility time (seconds)




      20000
                                                   季節性感情障害(冬季うつ
                                        ?          病)
                                                  冬季うつ、過食、過眠、炭水化物飢餓など
                                                                                                   212.6
  Mean P33 radioactivity (nCi/mg)




                                    0.015
      17500                         200              189.5555556
                                                                     日長


      15000
                                    150
                                     0.01
                                                    6月              12 月                  6月
      12500

                                    100           冬季うつ病患者( n=29 )の月別うつ発症割合

      10000



                                                                                                  ?
                                    0.005
                                                                                                            Vehiculum
                   50                                               12 月
              7500                                 6月                                      6月               Melatonin
                                                    i.p. inj.


                                                                       (Rosenthal et al., 1984)
              5000                     0
                                       0
                                            ZT2     ZT6
                                                      MEL            ZT10             ZT14        ZT18
                                                                                                  Vehic.   ZT22
                                              2             6          10         14               18       22
                                                                      Zeitgeber Time

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Hungary and Pécs, MIF research

  • 1. András Nagy University of Pécs, Medical School, Department of Anatomy, Pécs, Hungary
  • 2. Indo-european languagesprings -1500 thermal families: Romance -450 public baths Germane -largest thermal lake in Europe Slavic
  • 3.
  • 4.
  • 5.
  • 6.
  • 7. Pécs -BC - Celts, Pannonian tribes -CE centuries: -1-4th Rome: Pannonia/Valeria/Sopianae Early Christian Necropolis – UNESCO -5-8th: Huns, Barbarians, Slavs, Avars -9th: Charlemagne: Balaton Principality/ Saltzburg Episcopate/Quinque Basilicae -10th: Magyars - semi-nomadic tribes -11th: Christian Hungary, Diocese of Pécs -13rd: Mongol invasion, population loss balanced by immigrant eastern tribes&slavs First University of Hungary (1367) -16-17th: Ottoman Turks Mosques, Minarets, Turkish baths -18th: Austrian rule, population loss balanced by german, jewish immigrants Pécs is a free royal town from 1777 -19th: Austria-Hungary Monarchy -20th: post-WW: soviet industrialization -2010: Cultural Capital of Europe
  • 8.
  • 9.
  • 10.
  • 11. Emotional changes by season Human Animal husbandry Seasonal affective Breeding disorder (SAD) Metabolism Behaviour Depression suicidability productivity Mechanisms
  • 12. 季節性感情障害 (SAD) 社会的、心理的要因無く、特定の季節にうつ症状を発症し、そ れ 以外の季節には自然に寛解する周期性気分障害 有病率 欧米:一般人口の 1 ~ 10%       日本: うつ病患者の 1 ~ 3%   症状 過食、過眠、炭水化物飢餓など 疫学調査や病態研究により、セロトニン神経系が関連 日長がセロトニン神経機能 に及ぼす影響を解明 SAD の予防、緩和に繋がる
  • 13. 25000 300 Serotonin levels in Amygdala 0.02 Forced Swim Test 22500 Bmal1 mRNA contents in the SCN (ISH) Vehiculum 250 情動 Melatonin Immobility time (seconds) 20000 季節性感情障害(冬季うつ ? 病) 冬季うつ、過食、過眠、炭水化物飢餓など 212.6 Mean P33 radioactivity (nCi/mg) 0.015 17500 200 189.5555556 日長 15000 150 0.01 6月 12 月 6月 12500 100 冬季うつ病患者( n=29 )の月別うつ発症割合 10000 ? 0.005 Vehiculum 50 12 月 7500 6月 6月 Melatonin i.p. inj. (Rosenthal et al., 1984) 5000 0 0 ZT2 ZT6 MEL ZT10 ZT14 ZT18 Vehic. ZT22 2 6 10 14 18 22 Zeitgeber Time

Editor's Notes

  1. Ladies and Gentleman, As a research fellow from Hungary, my talk is about a short summary of Hungarian culture, history, with a special focus of my home university town Pécs. At the end I will show some of the research results of my stay at Kyushu Daigaku. First, let’s center the world map according to how hungarian people see the Globe. Right in the middle you can see an area: the basin enclosed by these mountains is our homeland, just in the heart of Europe.
  2. This geographical area is called Carpathian basin surrounded by the mountains called Carpathians which are actually the continuation of the Alps to the east. The biggest river in central-east Europe runs here called Danube splitting the basin, to the west of it is my home University town, Pécs. Because of an advantageous geographical location, thermal water can be found with good quality and in great quantities on over 80% of Hungary&apos;s territory. Approximately 1,500 thermal springs can be found in Hungary. There are approximately 450 public baths in Hungary. The country is home to the largest thermal lake in Europe and the largest lake in Central Europe (Lake Balaton). Hungary has a continental climate , [74] with hot summers with low overall humidity levels but frequent rainshowers and mildly cold snowy winters. This area has a special climate where humid and mild wind from northwest, dry and warm wind from southwest, and arctic cold wind from the north-east make the weather in spring and autumn highly unpredictable. Best season to visit Hungary is May and September, like it is for visiting Japan. The next map shows some cultural information about distribution of europe’s languages. Here you can see that Hungary is not related to any of the surrounding neighbours, despite having borders with all three major language families: german, romance and slavs. The language is hungarian, or as we call it MAGYAR, which is related to a completely different language family with the closest relatives in Finland, and in North-west asia. This relative isolation is due to the historical fact that indo-european tribes from Asia colonized Europe about 4000 years ago, while MAGYARS came here only 1000 years ago.
  3. This small animation shows how the magyar tribes moved and conquested the Carpathian basin 1000 years ago, where they were the first to establish a permanent christian state.For several centuries Magyars were living in the area of today’s Kazakhstan, Russia and Ukraine before reaching the Carpathian basin.
  4. And here some typical hungarian folk motifs either from 1000 years ago or today as worn by british formula-1 drivers last year indicating its popularity among world known celebrities.
  5. As i have shown the geographycal Hungary was always a multicultural site. My university town, pécs, is itself a really multicultural city.
  6. Only seven countries (US, USSR, UK, France, Italy, China, and Germany) have won more Summer Olympic gold medals than Hungary.
  7. Hungary revolutionized the sport in the 1950s, laying the tactical fundamentals of Total Football and dominating international football with the remarkable Golden Team which included legends like Ferenc Puskás, top goalscorer of the 20th century,[115][116][117] whom FIFA dedicated[118] its newest award, the Puskás Award.
  8. Medical (Pécs-myself) &amp; agricultural aspects (Kyudai-Yasuo sensei) similar = cooperation