Pathology hematology 3

Sickle cell anemia Hemolytic anemia

Sickle cell anemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Pathology

Clinical features: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Frontal Bossing X-ray: ‘Hair-on-end’ skull Chronic leg ulcer

Diagnosis: ,[object Object],Sickle cells Normal RBC

2. Hb electrophoresis – Identification & quantification of HbS (80% Hbs, absence of HbA; HbF & HbA 2 variably increased)

[object Object],[object Object],[object Object],[object Object]

Complications: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],*Gamna Gandy nodules / siderotic nodules / fibrosiderotic nodules

An enlarged spleen due to splenic sequestration crisis in a patient with sickle anemia

Sickle cells are seen in splenic red pulp in a case of splenic sequestration crisis.

Kidney: Hemosidrin deposit LIVER: HEMOSIDEROSIS Hemosiderin deposits

Alloimmune/ Isoimmune: 1) Hemolytic Transfusion Reaction 2) Hemolytic Disease of the Newborn Hemolytic anemia RBCs are lysed as a result of the action of antibodies of another individual

Hemolytic Transfusion Anemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hemolytic Disease of the Newborn ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Normal vascular system ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Vascular defects ,[object Object],[object Object],[object Object],[object Object]

Henoch-Schönlein purpura ,[object Object],[object Object],[object Object],[object Object],[object Object]

Hereditary hemorrhagic telangiectasia ,[object Object],[object Object],[object Object],[object Object],[object Object]

Platelets ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Idiopathic Thrombocytopenic Purpura (ITP) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clinical features & Treatment: ,[object Object],[object Object],[object Object],[object Object],[object Object]

Disorder of blood coagulation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Factor VIII Def. ,[object Object],[object Object],[object Object],[object Object],[object Object]

Hemophilia A ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Von Willebrand’s Ds. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Factor IX Def. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pathology hematology 3

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Pathology hematology 3