this presentation is about hormone replacement therapy in premature ovarian failure.

1. Hormone Replacement Therapy in Premature Ovarian Failure Amita Suneja Professor UCMS & GTBH

3. Tailor HRT According to Type of POF

4. Type I POF - Prepubertal

5. Individualize the Treatment

7. 14 years Turner’s mosaic

10. Types of HRT Regimens

11. Estrogen Preparations- Indian Market Market name Molecule Strength Prep Dose Evalon Estriol succinate 1.0mg Tab 8-16mg/day Premarin CEE 0.625mg Tab 0.625mg/day Progynova Esradiol valerate 1.0mg/2mg Tab 2mg/day Estraderm patch Or Susten 50 Estradiol 25/50/100 ц g patch 1 every 4 days 50 ц g E 2 Gel Or Sandrena gel Estradiol 1.5mg/2.5g 1mg/gm Dermal gel Once a day Estaspray Estradiol 0.375mg Dermal spray 1-3 accutations/day Premarine gel CEE 0.625mg/gm Daily x 2weeks Vaginal gel then twice a week Evalon gel Estriol 1mg/gm E 2 Gel Estradiol 0.025mg/gm

12. Transdermal Estrogens Estragel 1.5mg/2.5g OD EstaSpray 0.375mg BD

14. Progesterone preparations-Indian Market Drug Route Sequential (10-14 days) continuous MPA Oral 5mg daily 2.5mg daily Norethisterone Oral 1mg daily 0.3 mg daily Norethindrone Oral 2.5mg daily 0.5mg daily Dydrogesterone Oral 10mg daily 5mg daily Drospirenone Oral - 2mg daily Natural progesterone Oral 300mg daily 200mg daily Natural progesterone Vaginal 200mg daily 100mg daily Natural progesterone Vaginal gel 45mg daily 45mg daily LNG-IUS Intra-uterine _ 20mcg daily

17. HRT in Surgical Menopause

18. HRT in Cancer Survivors

19. Stem Cell Transplant - POF

20. HRT - POF

21. Premature ovarian failure Not your failure