Eating mango skin can help reduce weight by providing 75 fewer calories than mangoes without skin. Compounds in mango skin repress fat cell formation and may help fight metabolic diseases like diabetes. Studies also indicate mango skin can protect against cancer and inflammation through antioxidative compounds like quercetin, mangiferin, and resveratrol. Washing mango skin with hot water prior to eating can remove any chemicals from the skin while still providing health benefits.