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Anesthesia management for Mega liposuction Dr AbhijitNair                                 Dr K Sriprakash                       Consultant Anesthesiologist,  Axon Anesthesia Associates,  Care Hospital,  Hyderabad.
Definition: A cosmetic surgery done to remove    fat from deposits under the skin using a cannula with a powerful suction  It is also called as lipoplasty or fat moulding
Goals of liposuction To remove target fat thereby leaving     desired body contour between suctional     and non suctional areas Achieved by selecting the patients    carefully and using proper method to    avoid contour irregularity  To monitor the patient in a monitored    area by trained personnel to avoid    post operative complications
Patient’s perspective: Sense of confidence Marital reasons ( pre, post ) Reduction in requirement of      anti hypertensives Reduction in doses of OHAs/ Insulin But ends up spending on garments !
History of liposuction: First suction liposuction done by     French Surgeon Charles Dujarier    in 1920 Patient was a famous model       from Paris Died due to gangrene Liposuction went into oblivion     for several decades thereafter
Techniques of liposuction: Dry technique, ( EBL : 20-45% of aspirated volume ) Wet technique, ( EBL : 4-30% of aspirated volume ) Super wet technique, ( EBL : 1% of aspirated volume ) Tumescent technique, ( EBL : 1% of aspirated volume)
Varieties: Ultrasound assisted Power assisted Laser assisted Laser lipolysis
VASER VASER liposuction ( Vibration amplification of sound energy at resonance )
The procedure: Not a benign procedure In 2000, a census survey of 1200 members of ASAPS ( American Society of Aesthetic Plastic Surgeons ) revealed an overall mortality rate of 19.1/100,000 liposuction Pulmonary embolism in 23.1% cases of deaths Clinical Anesthesia. Barash, 6th Edition. Page 854.
Mega liposuction / Large volume liposuction Variable definition When more than 5 liters of total volume is removed from the patient  Most of the complications associated with mega liposuction        are related to fluid shifts and fluid balance, hence the procedure is       described as total volume removed from the patient, including fat,        wetting solution, and blood
There is no distinct boundary line that defines the  limits of safe        surgery When liposuction crosses into the domain of excessive surgical         trauma, it changes from a benign cosmetic procedure into a         potentially lethal process There is no antidote for a toxic  dose of surgical trauma
Safe approach: Prevention of excessive trauma, Use common sense, Respect the patient’s co morbidities
5 pillars of safety: 1)To have a trained Surgeon, 2)To have a trained Anesthesiologist, 3)To have a decent set up, 4)Trained ICU/ operation room staff, 5)To select the patient properly.
Patient selection:   Patient’s characteristics: Unrealistic expectations Co morbidities Pharmacotherapy Previous failures
Skin contour irregularities,     asymmetries, skin laxities,     redundancies to be noted/ drawn Priming in advance for     secondary/ touch up procedures
Cost of procedure: Indeed costly Quality of liposuction more important than cost Discount advertisements – misguides the patient Patient should enquire about the expertise/ experience of surgeon,        place of surgery, set up etc Choosing liposuction based on price may turn out to be expensive if        surgery is not up to the mark
Undesirable outcomes: 1)Incomplete liposuction, 2)Excessive liposuction-       disfigurement, 3)Irregular/ uneven depression, 4)Bad scars
In the US, more than 341,000 liposuction procedures were performed in 2008 Indian data ? But very popular Still, information in textbooks ?!
PAC: Detailed history Highlight co morbidities, OSA, PAH Note ongoing medications   ( NSAIDs,steroids,garlic,anti platelets     to be stopped )  Vitals, Airway, BMI Relevant investigations 2D ECHO
Pre operative instructions    ( Fasting, medications to be       stopped/ to be taken ) Outline the procedure To inform in advance discomfort      due to garments, ooze etc DVT prophylaxis?
Anesthesia management GA with CV Vs Regional GA preferred over Regional     for Mega liposuction Review the patient Balanced Anesthesia Use short acting agents Benzodiazepines, Opioids,     NDMR, Inhalational VIMA Vs TIVA
Premedication: Anti emetics, PPI/ H2 blockers Antibiotic Tranexamic acid / Ethamsylate    / Haemocoagulase Use warm fluids Warming blankets Sequential compression device
Airway:
Intra operative monitoring: Heart rate, Electrocardiogram ( lead II, V5) Blood pressure ( Non invasive/ arterial if adequate sized cuff is not available) Spo2 End tidal CO2 Temperature ( nasopharyngeal/ axillary/ oral, OT) Input/ output Charting every 5 minutes
Hemodynamic changes:            Increase in: Cardiac index Heart rate Mean PAP Stroke volume index RVSWI           Decrease in: MAP SVRI
During surgery , constant communication      between the Surgeon & the Anesthesiologist very important    • Input , output , quality of aspirate etc to be discussed    • NIBP during vigorous suctioning !?   •  NTG, Labetalol, Metoprolol, Narcotics , Inhalational boluses during new area suctioning
Charting: Quantity of wetting solution used,  Amount of lignocaine used       ( should not exceed >35-55 mg/kg)     The epinephrine in the solution :( 50 ug/kg )       decreases systemic absorption of large amount of subcutaneous injection,  Oliguria,  Tachycardia Fat & saline aspirate, Blood loss, Urine output
Fluid management: Controversial practice Consider mega liposuction as burns ? PARKLAND’S formula Insensible losses can’t be predicted 3rd spacing? Colloids Vs Crystalloids! Formulas? Blood loss? Post op hemodilution!
Goals of IVF: To replace pre operative deficit To provide maintenance fluid To avoid pre renal AKI To correct insensible losses Blood transfusion if justified
The formulas: 0.25 ml of IVF for 1 ml aspirated over 4L i.e. 25% of lipo aspirate + maintenance       [ SAFETY CONSIDERATIONS & FLUID RESUSCITAION IN LIPOSUCTION: AN ANALYSIS OF 53 PATIENTS.  Trott, Suzanne A.; Beran, Samuel J.; Rohrich, Rod J.; Kenkel, Jeffrey M.; Adams, William P. Jr.; Klein, Kevin W. Plastic & Reconstructive Surgery. 102(6):2220-2229, November 1998. ] 0.25 ml of IVF for each ml over 5L i.e. 25% of lipo aspirate ( no maintenance )      [ Fluid resuscitation in liposuction: A retrospective review of 89 consecutive patients. Rohrich, Rod J.; Leedy, Jason E.; Swamy, Ravi; Brown, Spencer A.; Coleman, Jayne. Plastic & Reconstructive Surgery. 117(2):431-435, February 2006.}
RESIDUAL VOLUME THEORY: RESIDUAL VOLUME= TOTAL FLUID( Intravenous    fluids + wetting solution + local anesthetic) –   ( TOTAL SALINE IN ASPIRATE, not blood + URINE)    Residual volume/ Patient’s pre op weight = 90- 120 ml/ kg   If < 90 ml/kg, volume resuscitation warranted Sommer B. Advantages and disadvantages of TLA. In: Hanke CW, Sommer B, Sattler G, editors. Tumescent local anaesthesia. New York: Springer; 2001. p. 47-51.           Pitman GH, Aker JS, Tripp ZD. Tumescent liposuction. A surgeon’s perspective. ClinPlastSurg 1996;23:633-4.           Liposuction: Anaesthesia challenges. JayshreeSood et all. IJA 2011;55:220-7.
Example: Total fluid = 4L IVF + 4L wetting solution + 50 ml lignocaine = 8050 ml Total output = 1200 ml saline + 800 ml urine = 2000 ml Residual volume = 8050 – 2000 = 6050 ml Pre op Weight of patient = 100 kg 6050/100 = 60.5 ml/kg Hypovolaemia, needs IVF
Intra operative fluid volume ratio: [Volume of IVF + volume of infiltration] ÷ Aspirate volume If ratio is more, patient is overhydrated Ratio is used to compare different types of fluid resuscitation strategies
Important Anesthesia considerations: Padding of pressure points, in prone    ( axilla, wrist, elbow, eyes, genitals,    brachial plexus, occiput) Avoid unnecessary traction Lubricate eyes Prophylaxis for deep vein thrombosis Use of epinephrine: intra operative oliguria?
Thermoregulation: Cold wetting solutions, IVF Prolonged duration GA OT              Complications: Coagulopathy Oliguria Arrythmias Electrolyte imbalance
Complications: Rare Frustrating for Surgeon, Patient, attenders Minor complications: unpredictable Major: Avoidable ( REMEMBER 5 PILLARS )
Minor complications: Prolonged swelling,  contour related complications, Scarring,  delayed healing,  blistering,  seromas,  hyperchromia
Major complications: PTE,  Deep vein thrombosis,   pulmonary edema due to fluid overload,  penetrating injuries,  skin/ soft tissue necrosis,  shock,  fat embolism,  local anesthesia systemic toxicity ( LAST )  excessive bleeding leading to blood transfusion
Bloody lipo aspirate? Terminate the surgery Reevaluate the technique, enquire     about constituents of infiltration Use more wetting solution with      epinephrine for haemostatic effect
Causes of excessive intra operative bleed: Use of anti platelets Use of NSAIDs, steroids On garlic, garlic pearls, herbal medication etc. Male gender Smokers Diabetics ( small vessel insufficiency) Hypothyroids
Compressive garments: Decreases bleeding Decreases swelling Decreases third spacing of fluid
Tranexamic Acid : An anti fibrinolytic agent that competitively inhibits  activation of plasminogen to plasmin which is responsible for degradation of fibrin, which causes hemorrhage A preoperative dose of 10 mg/kg of tranexamic acid in a infusion over 15-20  minutes ! Trials are awaited to prove the benefit in large volume liposuction
Post operative care: TPR, BP, Pain monitoring, input/ uotput charting IV fluids Analgesia: short acting opioids ( Fentanyl infusion), Tramadol, PCM       Avoid NSAIDs on the day of surgery        Epidural ( If tummy tuck/ abdominoplasty is done)       TAP block VIT C, Multivitamin preparations
Sequential compression device/ Low molecular weight heparin/ mobilisation/ Antiemetics Blood transfusion +/- Serratiopeptidase/ Trypsin : Chymotrypsin preparation
Delayed anemia after mega LPS: Post operative inflammatory response leading to blunting of erythropoeitic response Diminished availability of Iron Panniculitis in liposuction  systemic inflammatory response Hemodilution due to fluids
Management: Blood transfusion IV Fe Erythropoeitin Further investigation
Age: 55yrs;  BMI: 38; 14.5 liters removedReduced 12 kgDelayed healing - 4weeks Post-op Pre-op 3 months
Post op bleeding & hypothyroidism: Decrease in plasma factor VII concentration  Increased aPTT  Acquired von Willebrand  disease ( due to decreased        factor VII coagulant  activity , decreased vWF       activity)  Decreased platelet adhesiveness, due to acquired    vWF disease  Prolonged t1/2 of factor II, VII, X
Hypothyroid patients posted for surgery manifest Euthyroid Sick Syndrome due to stress The total T3 decreases 30 minutes after induction, it remains low for 24  hours They also have decreased FT3 & FT4 levels perioperatively
THANK    YOU

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Anesthesia management for Mega liposuction.

  • 1. Anesthesia management for Mega liposuction Dr AbhijitNair Dr K Sriprakash Consultant Anesthesiologist, Axon Anesthesia Associates, Care Hospital, Hyderabad.
  • 2. Definition: A cosmetic surgery done to remove fat from deposits under the skin using a cannula with a powerful suction It is also called as lipoplasty or fat moulding
  • 3. Goals of liposuction To remove target fat thereby leaving desired body contour between suctional and non suctional areas Achieved by selecting the patients carefully and using proper method to avoid contour irregularity To monitor the patient in a monitored area by trained personnel to avoid post operative complications
  • 4. Patient’s perspective: Sense of confidence Marital reasons ( pre, post ) Reduction in requirement of anti hypertensives Reduction in doses of OHAs/ Insulin But ends up spending on garments !
  • 5. History of liposuction: First suction liposuction done by French Surgeon Charles Dujarier in 1920 Patient was a famous model from Paris Died due to gangrene Liposuction went into oblivion for several decades thereafter
  • 6.
  • 7. Techniques of liposuction: Dry technique, ( EBL : 20-45% of aspirated volume ) Wet technique, ( EBL : 4-30% of aspirated volume ) Super wet technique, ( EBL : 1% of aspirated volume ) Tumescent technique, ( EBL : 1% of aspirated volume)
  • 8. Varieties: Ultrasound assisted Power assisted Laser assisted Laser lipolysis
  • 9. VASER VASER liposuction ( Vibration amplification of sound energy at resonance )
  • 10. The procedure: Not a benign procedure In 2000, a census survey of 1200 members of ASAPS ( American Society of Aesthetic Plastic Surgeons ) revealed an overall mortality rate of 19.1/100,000 liposuction Pulmonary embolism in 23.1% cases of deaths Clinical Anesthesia. Barash, 6th Edition. Page 854.
  • 11. Mega liposuction / Large volume liposuction Variable definition When more than 5 liters of total volume is removed from the patient Most of the complications associated with mega liposuction are related to fluid shifts and fluid balance, hence the procedure is described as total volume removed from the patient, including fat, wetting solution, and blood
  • 12. There is no distinct boundary line that defines the limits of safe surgery When liposuction crosses into the domain of excessive surgical trauma, it changes from a benign cosmetic procedure into a potentially lethal process There is no antidote for a toxic dose of surgical trauma
  • 13. Safe approach: Prevention of excessive trauma, Use common sense, Respect the patient’s co morbidities
  • 14. 5 pillars of safety: 1)To have a trained Surgeon, 2)To have a trained Anesthesiologist, 3)To have a decent set up, 4)Trained ICU/ operation room staff, 5)To select the patient properly.
  • 15. Patient selection: Patient’s characteristics: Unrealistic expectations Co morbidities Pharmacotherapy Previous failures
  • 16. Skin contour irregularities, asymmetries, skin laxities, redundancies to be noted/ drawn Priming in advance for secondary/ touch up procedures
  • 17. Cost of procedure: Indeed costly Quality of liposuction more important than cost Discount advertisements – misguides the patient Patient should enquire about the expertise/ experience of surgeon, place of surgery, set up etc Choosing liposuction based on price may turn out to be expensive if surgery is not up to the mark
  • 18. Undesirable outcomes: 1)Incomplete liposuction, 2)Excessive liposuction- disfigurement, 3)Irregular/ uneven depression, 4)Bad scars
  • 19. In the US, more than 341,000 liposuction procedures were performed in 2008 Indian data ? But very popular Still, information in textbooks ?!
  • 20.
  • 21. PAC: Detailed history Highlight co morbidities, OSA, PAH Note ongoing medications ( NSAIDs,steroids,garlic,anti platelets to be stopped ) Vitals, Airway, BMI Relevant investigations 2D ECHO
  • 22. Pre operative instructions ( Fasting, medications to be stopped/ to be taken ) Outline the procedure To inform in advance discomfort due to garments, ooze etc DVT prophylaxis?
  • 23. Anesthesia management GA with CV Vs Regional GA preferred over Regional for Mega liposuction Review the patient Balanced Anesthesia Use short acting agents Benzodiazepines, Opioids, NDMR, Inhalational VIMA Vs TIVA
  • 24. Premedication: Anti emetics, PPI/ H2 blockers Antibiotic Tranexamic acid / Ethamsylate / Haemocoagulase Use warm fluids Warming blankets Sequential compression device
  • 26.
  • 27. Intra operative monitoring: Heart rate, Electrocardiogram ( lead II, V5) Blood pressure ( Non invasive/ arterial if adequate sized cuff is not available) Spo2 End tidal CO2 Temperature ( nasopharyngeal/ axillary/ oral, OT) Input/ output Charting every 5 minutes
  • 28. Hemodynamic changes: Increase in: Cardiac index Heart rate Mean PAP Stroke volume index RVSWI Decrease in: MAP SVRI
  • 29. During surgery , constant communication between the Surgeon & the Anesthesiologist very important • Input , output , quality of aspirate etc to be discussed • NIBP during vigorous suctioning !? • NTG, Labetalol, Metoprolol, Narcotics , Inhalational boluses during new area suctioning
  • 30. Charting: Quantity of wetting solution used, Amount of lignocaine used ( should not exceed >35-55 mg/kg) The epinephrine in the solution :( 50 ug/kg ) decreases systemic absorption of large amount of subcutaneous injection, Oliguria, Tachycardia Fat & saline aspirate, Blood loss, Urine output
  • 31. Fluid management: Controversial practice Consider mega liposuction as burns ? PARKLAND’S formula Insensible losses can’t be predicted 3rd spacing? Colloids Vs Crystalloids! Formulas? Blood loss? Post op hemodilution!
  • 32. Goals of IVF: To replace pre operative deficit To provide maintenance fluid To avoid pre renal AKI To correct insensible losses Blood transfusion if justified
  • 33. The formulas: 0.25 ml of IVF for 1 ml aspirated over 4L i.e. 25% of lipo aspirate + maintenance [ SAFETY CONSIDERATIONS & FLUID RESUSCITAION IN LIPOSUCTION: AN ANALYSIS OF 53 PATIENTS.  Trott, Suzanne A.; Beran, Samuel J.; Rohrich, Rod J.; Kenkel, Jeffrey M.; Adams, William P. Jr.; Klein, Kevin W. Plastic & Reconstructive Surgery. 102(6):2220-2229, November 1998. ] 0.25 ml of IVF for each ml over 5L i.e. 25% of lipo aspirate ( no maintenance ) [ Fluid resuscitation in liposuction: A retrospective review of 89 consecutive patients. Rohrich, Rod J.; Leedy, Jason E.; Swamy, Ravi; Brown, Spencer A.; Coleman, Jayne. Plastic & Reconstructive Surgery. 117(2):431-435, February 2006.}
  • 34. RESIDUAL VOLUME THEORY: RESIDUAL VOLUME= TOTAL FLUID( Intravenous fluids + wetting solution + local anesthetic) – ( TOTAL SALINE IN ASPIRATE, not blood + URINE) Residual volume/ Patient’s pre op weight = 90- 120 ml/ kg If < 90 ml/kg, volume resuscitation warranted Sommer B. Advantages and disadvantages of TLA. In: Hanke CW, Sommer B, Sattler G, editors. Tumescent local anaesthesia. New York: Springer; 2001. p. 47-51. Pitman GH, Aker JS, Tripp ZD. Tumescent liposuction. A surgeon’s perspective. ClinPlastSurg 1996;23:633-4. Liposuction: Anaesthesia challenges. JayshreeSood et all. IJA 2011;55:220-7.
  • 35. Example: Total fluid = 4L IVF + 4L wetting solution + 50 ml lignocaine = 8050 ml Total output = 1200 ml saline + 800 ml urine = 2000 ml Residual volume = 8050 – 2000 = 6050 ml Pre op Weight of patient = 100 kg 6050/100 = 60.5 ml/kg Hypovolaemia, needs IVF
  • 36. Intra operative fluid volume ratio: [Volume of IVF + volume of infiltration] ÷ Aspirate volume If ratio is more, patient is overhydrated Ratio is used to compare different types of fluid resuscitation strategies
  • 37.
  • 38. Important Anesthesia considerations: Padding of pressure points, in prone ( axilla, wrist, elbow, eyes, genitals, brachial plexus, occiput) Avoid unnecessary traction Lubricate eyes Prophylaxis for deep vein thrombosis Use of epinephrine: intra operative oliguria?
  • 39. Thermoregulation: Cold wetting solutions, IVF Prolonged duration GA OT Complications: Coagulopathy Oliguria Arrythmias Electrolyte imbalance
  • 40. Complications: Rare Frustrating for Surgeon, Patient, attenders Minor complications: unpredictable Major: Avoidable ( REMEMBER 5 PILLARS )
  • 41. Minor complications: Prolonged swelling, contour related complications, Scarring, delayed healing, blistering, seromas, hyperchromia
  • 42. Major complications: PTE, Deep vein thrombosis, pulmonary edema due to fluid overload, penetrating injuries, skin/ soft tissue necrosis, shock, fat embolism, local anesthesia systemic toxicity ( LAST ) excessive bleeding leading to blood transfusion
  • 43. Bloody lipo aspirate? Terminate the surgery Reevaluate the technique, enquire about constituents of infiltration Use more wetting solution with epinephrine for haemostatic effect
  • 44. Causes of excessive intra operative bleed: Use of anti platelets Use of NSAIDs, steroids On garlic, garlic pearls, herbal medication etc. Male gender Smokers Diabetics ( small vessel insufficiency) Hypothyroids
  • 45. Compressive garments: Decreases bleeding Decreases swelling Decreases third spacing of fluid
  • 46. Tranexamic Acid : An anti fibrinolytic agent that competitively inhibits activation of plasminogen to plasmin which is responsible for degradation of fibrin, which causes hemorrhage A preoperative dose of 10 mg/kg of tranexamic acid in a infusion over 15-20 minutes ! Trials are awaited to prove the benefit in large volume liposuction
  • 47. Post operative care: TPR, BP, Pain monitoring, input/ uotput charting IV fluids Analgesia: short acting opioids ( Fentanyl infusion), Tramadol, PCM Avoid NSAIDs on the day of surgery Epidural ( If tummy tuck/ abdominoplasty is done) TAP block VIT C, Multivitamin preparations
  • 48. Sequential compression device/ Low molecular weight heparin/ mobilisation/ Antiemetics Blood transfusion +/- Serratiopeptidase/ Trypsin : Chymotrypsin preparation
  • 49. Delayed anemia after mega LPS: Post operative inflammatory response leading to blunting of erythropoeitic response Diminished availability of Iron Panniculitis in liposuction  systemic inflammatory response Hemodilution due to fluids
  • 50. Management: Blood transfusion IV Fe Erythropoeitin Further investigation
  • 51. Age: 55yrs; BMI: 38; 14.5 liters removedReduced 12 kgDelayed healing - 4weeks Post-op Pre-op 3 months
  • 52. Post op bleeding & hypothyroidism: Decrease in plasma factor VII concentration Increased aPTT Acquired von Willebrand disease ( due to decreased factor VII coagulant activity , decreased vWF activity) Decreased platelet adhesiveness, due to acquired vWF disease Prolonged t1/2 of factor II, VII, X
  • 53. Hypothyroid patients posted for surgery manifest Euthyroid Sick Syndrome due to stress The total T3 decreases 30 minutes after induction, it remains low for 24 hours They also have decreased FT3 & FT4 levels perioperatively
  • 54.
  • 55. THANK YOU