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DOUBLE BLIND CONTROLLED CLINICALDOUBLE BLIND CONTROLLED CLINICAL
STUDIES OF A UNANI HERBO-MINERALSTUDIES OF A UNANI HERBO-MINERAL
CREAM IN PATIENTS OF PSORIASISCREAM IN PATIENTS OF PSORIASIS
Latif A. , Saleem A., Rahman S. Z. , & Tahseen M. *Latif A. , Saleem A., Rahman S. Z. , & Tahseen M. *
Department of Ilmul Advia, A. K. Tibbiya CollegeDepartment of Ilmul Advia, A. K. Tibbiya College
Aligarh Muslim University Aligarh. * Department ofAligarh Muslim University Aligarh. * Department of
Dermatology, J. N. Medical College, A. M. U. Aligarh.Dermatology, J. N. Medical College, A. M. U. Aligarh.
2
INTRODUCTIONINTRODUCTION
Psoriasis is a chronic remitting and relapsing scaly, inflammatoryPsoriasis is a chronic remitting and relapsing scaly, inflammatory
and common skin disorder which is being treated by Unaniand common skin disorder which is being treated by Unani
System of Medicine ( a recognised traditional system by WHO )System of Medicine ( a recognised traditional system by WHO )
from a very long time*. Sources of Unani drugs for Psoriasis arefrom a very long time*. Sources of Unani drugs for Psoriasis are
herbs, animals & minerals.herbs, animals & minerals.
The present study, double - blind placebo controlled, is done byThe present study, double - blind placebo controlled, is done by
using herbo-mineral preparation as topical application in cases ofusing herbo-mineral preparation as topical application in cases of
Psoriasis.Psoriasis.
________________________________________________________________________________________________________________________
* Kitabul- Hashaish of Dioscarides ( 70th B. C.)* Kitabul- Hashaish of Dioscarides ( 70th B. C.)
* Jameal- Mufradat-al-advia wa alaghzia of Ibn Baitar. (1248 A. D. )* Jameal- Mufradat-al-advia wa alaghzia of Ibn Baitar. (1248 A. D. )
* Al-Qanoon-fial-tibb (Cannon of Medicine) of Avicenna (980 - 1037 A. D.)* Al-Qanoon-fial-tibb (Cannon of Medicine) of Avicenna (980 - 1037 A. D.)
* Al- Hawi of Mohammad b. Zakaria al-Razi (866- 925 A. D.)* Al- Hawi of Mohammad b. Zakaria al-Razi (866- 925 A. D.)
3
Material & MethodsMaterial & Methods
Drugs:Drugs:
The formulation of Cream consists of the followingThe formulation of Cream consists of the following
ingredients:-ingredients:-
1- Calomel (Hgcl- RasKapoor)1- Calomel (Hgcl- RasKapoor) 5% w/w5% w/w
2- Camphor (2- Camphor (Cinnamomum camphoraCinnamomum camphora LinnLinn.. )) 5% w/w5% w/w
3- Litharge (Pbo- Murdarsang)3- Litharge (Pbo- Murdarsang) 12% w/w12% w/w
4-4- Psoralea corylifoliaPsoralea corylifolia Linn. oilLinn. oil 10% w/w10% w/w
5- Cream base5- Cream base SQSQ
4
Material and Method (Contd.)Material and Method (Contd.)
STUDY PROTOCOLSTUDY PROTOCOL
((A) - Phsico-chemical studies: - Solubility, Smooth flow Test, pH, M. p., Absorption of Cream by filter paperA) - Phsico-chemical studies: - Solubility, Smooth flow Test, pH, M. p., Absorption of Cream by filter paper
method & Tared Blade method:method & Tared Blade method:
(B) PATCH TEST(B) PATCH TEST
(C) - Clinical Studies: - three groups of 25 patients of Psoriasis (Total numbers of Patients 75) of either sex and(C) - Clinical Studies: - three groups of 25 patients of Psoriasis (Total numbers of Patients 75) of either sex and
different age groups were made as follows:different age groups were made as follows:
(I) Test Drugs(I) Test Drugs
(Herbo-mineral cream)(Herbo-mineral cream)
(II) Standard Drug(II) Standard Drug
(Dithranol ointment)(Dithranol ointment)
(III) Placebo-(III) Placebo-
(Pet Jelly)(Pet Jelly)
(D) Mode of Administration of Cream: Topical Application of Cream followed by exposure to sunlight for 5(D) Mode of Administration of Cream: Topical Application of Cream followed by exposure to sunlight for 5
minutes in morning & eveningminutes in morning & evening
(E) Routine investigation and "Candle Grease" examination is made by scrapping of affected part of the skin.(E) Routine investigation and "Candle Grease" examination is made by scrapping of affected part of the skin.
(F) Evaluation of Cases after every 15 days up to 90 Days & Post treatment Followup is also done.(F) Evaluation of Cases after every 15 days up to 90 Days & Post treatment Followup is also done.
5
Physico- Chemical Studies:Physico- Chemical Studies:
General CharacteristicsGeneral Characteristics
SolubilitySolubility pHpH M. P.M. P. Smooth FlowSmooth Flow
TestTest
ColourColour
(a) Soluble in(a) Soluble in
chloroformchloroform
& CCl4& CCl4
b) Partiallyb) Partially
Soluble inSoluble in
Hot WaterHot Water
c)InSolublec)InSoluble
in Alcohol,in Alcohol,
Water (Cold),Water (Cold),
Pet-ether &Pet-ether &
etherether
Range-Range-
6. 6- 6. 86. 6- 6. 8
(By Elico(By Elico
pH Meter)pH Meter)
IndicatedIndicated
slightlyslightly
acidicacidic
Range fromRange from
8383 00
C- 86C- 86 00
CC
By ReichertBy Reichert
ThermovarThermovar
InstrumentInstrument
Uniform &Uniform &
SmoothSmooth
DistributionDistribution
BlackishBlackish
BrownBrown
6
Drug absorption
0
25
50
75
100
125
150
175
0 5 10 15 20 25 30 35 40
Time (Minute)
Time Absorption Curve
(By Filter Paper Method)
DrugAbsorption
Drug absorption
7
Time Absorption Curve (By Tared Razor Blade)
8
PATCH TEST OF HM-CREAM ON NORMAL HUMANPATCH TEST OF HM-CREAM ON NORMAL HUMAN
SKIN OF FOREARMSKIN OF FOREARM
S.No.S.No. SexSex
M FM F
IrritationIrritation RednessRedness
(Rashes)(Rashes)
HyperpigmentationHyperpigmentation BlisterBlister
11
22
33
44
55
66
77
88
99
1010
MM
MM
MM
MM
MM
FF
FF
FF
FF
FF
--
--
--
--
--
--
--
--
--
--
--
--
--
--
--
MildMild
--
--
--
--
--
Light BlackishLight Blackish
--
Light BlackishLight Blackish
Light BlackishLight Blackish
Light BlackishLight Blackish
Light BlackishLight Blackish
Light BlackishLight Blackish
Light BlackishLight Blackish
Light BlackishLight Blackish
--
--
--
--
--
--
--
--
--
--
10%10% 80%80%
9
PATCH TEST OF DITHRANOL ON NORMAL HUMAN SKIN OFPATCH TEST OF DITHRANOL ON NORMAL HUMAN SKIN OF
FOREARMFOREARM
S.No.S.No. AgeAge
YearsYears
SexSex IrritationIrritation RashesRashes HyperpigmentationHyperpigmentation BlistersBlisters
11
22
33
44
55
66
77
88
99
1010
2828
2525
1515
0606
1010
2828
2020
2424
1717
2121
M FM F
MM
FF
MM
MM
FF
FF
MM
MM
FF
FF
++
--
++
--
++
++
--
--
++
--
MildMild
--
--
MildMild
--
--
MildMild
MildMild
MildMild
MildMild
BlackishBlackish
BlackishBlackish
Dark BlackishDark Blackish
Dark BlackishDark Blackish
Light BlackishLight Blackish
Dark BlackishDark Blackish
BlackishBlackish
BlackishBlackish
Light BlackishLight Blackish
Light BlackishLight Blackish
--
--
++
++
--
++
--
--
++
++
50 %50 % 60%60% 80%80% 70 %70 %
10
CLINICAL STUDIESCLINICAL STUDIES
11
Before Treatment Cured (30 Days)
Cured (90 Days)Before Treatment
1
2
12
3
4
Before Treatment Cured (45 Days)
Cured (65 Days)Before Treatment
13
Before Treatment Cured (40 Days)
14
A COMPARATIVE STATEMENT SHOWING TOTAL RESPONSE OFA COMPARATIVE STATEMENT SHOWING TOTAL RESPONSE OF
THREE GROUPSTHREE GROUPS
GroupsGroups CompoundCompound
NameName
TotalTotal
TherapeuticTherapeutic
ResponseResponse
(a+b+c)(a+b+c)
CuredCured
aa
RelivedRelived
bb
Partially RelivedPartially Relived
cc
NoNo
ResponseResponse
11
22
33
HM CreamHM Cream
(Test)(Test)
DithranolDithranol
(Standard)(Standard)
PlaceboPlacebo
(Pet- Jelly)(Pet- Jelly)
92 %92 %
88 %88 %
32 %32 %
68 %68 %
60 %60 %
NilNil
12 %12 %
16 %16 %
NilNil
12 %12 %
12 %12 %
32 %32 %
8 %8 %
12 %12 %
68 %68 %
15
TOTAL RESPONSE OF HM CREAM, DIATHRANOL & PET JELLYTOTAL RESPONSE OF HM CREAM, DIATHRANOL & PET JELLY
0
10
20
30
40
50
60
70
80
90
100
HM
CREAM
DITH.
OINT.
PET
JELLY
TOTAL RESPONSE
CURED
RELEIVED
PARTIALLY
RELIVED
NO RESPONSE
16
A COMPARATIVE STATEMENT SHOWING SIDEA COMPARATIVE STATEMENT SHOWING SIDE
EFFECTS IN TEST & STANDARD GROUPSEFFECTS IN TEST & STANDARD GROUPS
GroupsGroups Irritation (%)Irritation (%) Redness (%)Redness (%) Hyperpigmentation (%)Hyperpigmentation (%) Blister (%)Blister (%)
TestTest MildMild ModerateModerate SevereSevere MildMild ModerateModerate SevereSevere Light BlackishLight Blackish Dark BlackishDark Blackish
66
(24.6 )(24.6 )
NilNil NilNil 22
(8)(8)
NilNil NilNil 1717
(68 )(68 )
NilNil NilNil
StandardStandard
NilNil 55
(20)(20)
NilNil NilNil NilNil 77
(28)(28)
NilNil 1010
(40)(40)
33
(12)(12)
17
S.S.
NoNo
Period ofPeriod of
RelapseRelapse
afterafter
CuredCured
ChronicityChronicity AgeAge sexsex Site of RecurrenceSite of Recurrence No. of RelapseNo. of Relapse
11
22
33
44
55
66
77
3 Months3 Months
5 Months5 Months
3 Months3 Months
2 Months2 Months
4 Months4 Months
7 Months7 Months
9 Months9 Months
1-2 Yrs1-2 Yrs
2-5 Yrs2-5 Yrs
5-12 Yrs.5-12 Yrs.
12-24 Yrs.12-24 Yrs.
2-5 Yrs.2-5 Yrs.
5-12 Yrs.5-12 Yrs.
10-12 Yrs10-12 Yrs..
12 Yrs.12 Yrs.
31 Yrs.31 Yrs.
45 Yrs.45 Yrs.
47 Yrs.47 Yrs.
28 Yrs.28 Yrs.
35 Yrs.35 Yrs.
45 Yrs.45 Yrs.
MaleMale
MaleMale
FemaleFemale
FemaleFemale
MaleMale
FemaleFemale
MaleMale
Abd, legAbd, leg
Neck, ScalpNeck, Scalp
Neck, ScalpNeck, Scalp
BacksideBackside
ChestChest
Forearm & LegForearm & Leg
Scalp, Leg & ArmScalp, Leg & Arm
WholeWhole
Scalp OneScalp One
WholeWhole
WholeWhole
WholeWhole
WholeWhole
WholeWhole
RECURRANCE STATUS OF STANDARD GROUP (Dithranol Ointment)RECURRANCE STATUS OF STANDARD GROUP (Dithranol Ointment)
18
RECURRANCE STATUS OF TEST GROUPRECURRANCE STATUS OF TEST GROUP
(Herbo-mineral Cream)(Herbo-mineral Cream)
S. NoS. No Period ofPeriod of
RelapseRelapse
after Curedafter Cured
ChronicityChronicity AgeAge sexsex Site of RecurrenceSite of Recurrence No. of RelapseNo. of Relapse
11
22
33
44
55
6 Months6 Months
8 Months8 Months
8 Months8 Months
11 Months11 Months
12 Months12 Months
1-2 Yrs1-2 Yrs
2-5 Yrs2-5 Yrs
5-12 Yrs.5-12 Yrs.
12-24 Yrs.12-24 Yrs.
10-12 Yrs.10-12 Yrs.
8 Yrs.8 Yrs.
35 Yrs.35 Yrs.
38 Yrs.38 Yrs.
45 Yrs.45 Yrs.
50 Yrs.50 Yrs.
FemaleFemale
MaleMale
MaleMale
FemaleFemale
MaleMale
ScalpScalp
LegLeg
ForearmForearm
LegLeg
LegLeg
WholeWhole
Scalp OneScalp One
WholeWhole
WholeWhole
WholeWhole
No. Cases 5 (20 %)No. Cases 5 (20 %)
19
The test drug (containing Litharge) is described as anti-inflammatory andThe test drug (containing Litharge) is described as anti-inflammatory and
has a quality of potentiating drug when applied topically (Ghani, 1921).has a quality of potentiating drug when applied topically (Ghani, 1921).
During our study we also found that the test drug is beneficial in psoriasisDuring our study we also found that the test drug is beneficial in psoriasis
total therapeutic response- 92% and has more absorption capacity intotal therapeutic response- 92% and has more absorption capacity in
comparison to normal skin .As mentioned in classical literature that thecomparison to normal skin .As mentioned in classical literature that the
drug is safe, we could also found less adverse effects with test drug indrug is safe, we could also found less adverse effects with test drug in
comparison to dithranol. The recurrence rate of psoriasis with dithranol iscomparison to dithranol. The recurrence rate of psoriasis with dithranol is
28% while observed less number side effects with test drug (i. e., 20%)28% while observed less number side effects with test drug (i. e., 20%)
also shows the better option of drug therapy with test drug.also shows the better option of drug therapy with test drug.
The above favouring remarks clearly shows that the drug is effective whenThe above favouring remarks clearly shows that the drug is effective when
applied topically. The drug seems to decrease proliferation ofapplied topically. The drug seems to decrease proliferation of
keratinocytes. The mechanism by which the test drug causes inhibitorykeratinocytes. The mechanism by which the test drug causes inhibitory
effects on Keratinocyts proliferation are not understood, and needs furthereffects on Keratinocyts proliferation are not understood, and needs further
clarification.clarification.
DISCUSSIONDISCUSSION
20
CONCLUSIONCONCLUSION
It is concluded that topical application of thisIt is concluded that topical application of this
Herbo- mineral cream with phototherapy isHerbo- mineral cream with phototherapy is
having clinical significance in the treatment ofhaving clinical significance in the treatment of
Psoriasis with less side effects.Psoriasis with less side effects.
21
Drug absorption
0
25
50
75
100
125
150
175
0 5 10 15 20 25 30 35 40
Time (Minute)
Time Absorption Curve
(By Filter Paper Method)
DrugAbsorption
Drug absorption
22
Time Absorption Curve (By Tared Razor Blade)

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DOUBLE BLIND CONTROLLED CLINICAL STUDIES OF A UNANI HERBO-MINERAL CREAM IN PATIENTS OF PSORIASIS

  • 1. 1 DOUBLE BLIND CONTROLLED CLINICALDOUBLE BLIND CONTROLLED CLINICAL STUDIES OF A UNANI HERBO-MINERALSTUDIES OF A UNANI HERBO-MINERAL CREAM IN PATIENTS OF PSORIASISCREAM IN PATIENTS OF PSORIASIS Latif A. , Saleem A., Rahman S. Z. , & Tahseen M. *Latif A. , Saleem A., Rahman S. Z. , & Tahseen M. * Department of Ilmul Advia, A. K. Tibbiya CollegeDepartment of Ilmul Advia, A. K. Tibbiya College Aligarh Muslim University Aligarh. * Department ofAligarh Muslim University Aligarh. * Department of Dermatology, J. N. Medical College, A. M. U. Aligarh.Dermatology, J. N. Medical College, A. M. U. Aligarh.
  • 2. 2 INTRODUCTIONINTRODUCTION Psoriasis is a chronic remitting and relapsing scaly, inflammatoryPsoriasis is a chronic remitting and relapsing scaly, inflammatory and common skin disorder which is being treated by Unaniand common skin disorder which is being treated by Unani System of Medicine ( a recognised traditional system by WHO )System of Medicine ( a recognised traditional system by WHO ) from a very long time*. Sources of Unani drugs for Psoriasis arefrom a very long time*. Sources of Unani drugs for Psoriasis are herbs, animals & minerals.herbs, animals & minerals. The present study, double - blind placebo controlled, is done byThe present study, double - blind placebo controlled, is done by using herbo-mineral preparation as topical application in cases ofusing herbo-mineral preparation as topical application in cases of Psoriasis.Psoriasis. ________________________________________________________________________________________________________________________ * Kitabul- Hashaish of Dioscarides ( 70th B. C.)* Kitabul- Hashaish of Dioscarides ( 70th B. C.) * Jameal- Mufradat-al-advia wa alaghzia of Ibn Baitar. (1248 A. D. )* Jameal- Mufradat-al-advia wa alaghzia of Ibn Baitar. (1248 A. D. ) * Al-Qanoon-fial-tibb (Cannon of Medicine) of Avicenna (980 - 1037 A. D.)* Al-Qanoon-fial-tibb (Cannon of Medicine) of Avicenna (980 - 1037 A. D.) * Al- Hawi of Mohammad b. Zakaria al-Razi (866- 925 A. D.)* Al- Hawi of Mohammad b. Zakaria al-Razi (866- 925 A. D.)
  • 3. 3 Material & MethodsMaterial & Methods Drugs:Drugs: The formulation of Cream consists of the followingThe formulation of Cream consists of the following ingredients:-ingredients:- 1- Calomel (Hgcl- RasKapoor)1- Calomel (Hgcl- RasKapoor) 5% w/w5% w/w 2- Camphor (2- Camphor (Cinnamomum camphoraCinnamomum camphora LinnLinn.. )) 5% w/w5% w/w 3- Litharge (Pbo- Murdarsang)3- Litharge (Pbo- Murdarsang) 12% w/w12% w/w 4-4- Psoralea corylifoliaPsoralea corylifolia Linn. oilLinn. oil 10% w/w10% w/w 5- Cream base5- Cream base SQSQ
  • 4. 4 Material and Method (Contd.)Material and Method (Contd.) STUDY PROTOCOLSTUDY PROTOCOL ((A) - Phsico-chemical studies: - Solubility, Smooth flow Test, pH, M. p., Absorption of Cream by filter paperA) - Phsico-chemical studies: - Solubility, Smooth flow Test, pH, M. p., Absorption of Cream by filter paper method & Tared Blade method:method & Tared Blade method: (B) PATCH TEST(B) PATCH TEST (C) - Clinical Studies: - three groups of 25 patients of Psoriasis (Total numbers of Patients 75) of either sex and(C) - Clinical Studies: - three groups of 25 patients of Psoriasis (Total numbers of Patients 75) of either sex and different age groups were made as follows:different age groups were made as follows: (I) Test Drugs(I) Test Drugs (Herbo-mineral cream)(Herbo-mineral cream) (II) Standard Drug(II) Standard Drug (Dithranol ointment)(Dithranol ointment) (III) Placebo-(III) Placebo- (Pet Jelly)(Pet Jelly) (D) Mode of Administration of Cream: Topical Application of Cream followed by exposure to sunlight for 5(D) Mode of Administration of Cream: Topical Application of Cream followed by exposure to sunlight for 5 minutes in morning & eveningminutes in morning & evening (E) Routine investigation and "Candle Grease" examination is made by scrapping of affected part of the skin.(E) Routine investigation and "Candle Grease" examination is made by scrapping of affected part of the skin. (F) Evaluation of Cases after every 15 days up to 90 Days & Post treatment Followup is also done.(F) Evaluation of Cases after every 15 days up to 90 Days & Post treatment Followup is also done.
  • 5. 5 Physico- Chemical Studies:Physico- Chemical Studies: General CharacteristicsGeneral Characteristics SolubilitySolubility pHpH M. P.M. P. Smooth FlowSmooth Flow TestTest ColourColour (a) Soluble in(a) Soluble in chloroformchloroform & CCl4& CCl4 b) Partiallyb) Partially Soluble inSoluble in Hot WaterHot Water c)InSolublec)InSoluble in Alcohol,in Alcohol, Water (Cold),Water (Cold), Pet-ether &Pet-ether & etherether Range-Range- 6. 6- 6. 86. 6- 6. 8 (By Elico(By Elico pH Meter)pH Meter) IndicatedIndicated slightlyslightly acidicacidic Range fromRange from 8383 00 C- 86C- 86 00 CC By ReichertBy Reichert ThermovarThermovar InstrumentInstrument Uniform &Uniform & SmoothSmooth DistributionDistribution BlackishBlackish BrownBrown
  • 6. 6 Drug absorption 0 25 50 75 100 125 150 175 0 5 10 15 20 25 30 35 40 Time (Minute) Time Absorption Curve (By Filter Paper Method) DrugAbsorption Drug absorption
  • 7. 7 Time Absorption Curve (By Tared Razor Blade)
  • 8. 8 PATCH TEST OF HM-CREAM ON NORMAL HUMANPATCH TEST OF HM-CREAM ON NORMAL HUMAN SKIN OF FOREARMSKIN OF FOREARM S.No.S.No. SexSex M FM F IrritationIrritation RednessRedness (Rashes)(Rashes) HyperpigmentationHyperpigmentation BlisterBlister 11 22 33 44 55 66 77 88 99 1010 MM MM MM MM MM FF FF FF FF FF -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- MildMild -- -- -- -- -- Light BlackishLight Blackish -- Light BlackishLight Blackish Light BlackishLight Blackish Light BlackishLight Blackish Light BlackishLight Blackish Light BlackishLight Blackish Light BlackishLight Blackish Light BlackishLight Blackish -- -- -- -- -- -- -- -- -- -- 10%10% 80%80%
  • 9. 9 PATCH TEST OF DITHRANOL ON NORMAL HUMAN SKIN OFPATCH TEST OF DITHRANOL ON NORMAL HUMAN SKIN OF FOREARMFOREARM S.No.S.No. AgeAge YearsYears SexSex IrritationIrritation RashesRashes HyperpigmentationHyperpigmentation BlistersBlisters 11 22 33 44 55 66 77 88 99 1010 2828 2525 1515 0606 1010 2828 2020 2424 1717 2121 M FM F MM FF MM MM FF FF MM MM FF FF ++ -- ++ -- ++ ++ -- -- ++ -- MildMild -- -- MildMild -- -- MildMild MildMild MildMild MildMild BlackishBlackish BlackishBlackish Dark BlackishDark Blackish Dark BlackishDark Blackish Light BlackishLight Blackish Dark BlackishDark Blackish BlackishBlackish BlackishBlackish Light BlackishLight Blackish Light BlackishLight Blackish -- -- ++ ++ -- ++ -- -- ++ ++ 50 %50 % 60%60% 80%80% 70 %70 %
  • 11. 11 Before Treatment Cured (30 Days) Cured (90 Days)Before Treatment 1 2
  • 12. 12 3 4 Before Treatment Cured (45 Days) Cured (65 Days)Before Treatment
  • 14. 14 A COMPARATIVE STATEMENT SHOWING TOTAL RESPONSE OFA COMPARATIVE STATEMENT SHOWING TOTAL RESPONSE OF THREE GROUPSTHREE GROUPS GroupsGroups CompoundCompound NameName TotalTotal TherapeuticTherapeutic ResponseResponse (a+b+c)(a+b+c) CuredCured aa RelivedRelived bb Partially RelivedPartially Relived cc NoNo ResponseResponse 11 22 33 HM CreamHM Cream (Test)(Test) DithranolDithranol (Standard)(Standard) PlaceboPlacebo (Pet- Jelly)(Pet- Jelly) 92 %92 % 88 %88 % 32 %32 % 68 %68 % 60 %60 % NilNil 12 %12 % 16 %16 % NilNil 12 %12 % 12 %12 % 32 %32 % 8 %8 % 12 %12 % 68 %68 %
  • 15. 15 TOTAL RESPONSE OF HM CREAM, DIATHRANOL & PET JELLYTOTAL RESPONSE OF HM CREAM, DIATHRANOL & PET JELLY 0 10 20 30 40 50 60 70 80 90 100 HM CREAM DITH. OINT. PET JELLY TOTAL RESPONSE CURED RELEIVED PARTIALLY RELIVED NO RESPONSE
  • 16. 16 A COMPARATIVE STATEMENT SHOWING SIDEA COMPARATIVE STATEMENT SHOWING SIDE EFFECTS IN TEST & STANDARD GROUPSEFFECTS IN TEST & STANDARD GROUPS GroupsGroups Irritation (%)Irritation (%) Redness (%)Redness (%) Hyperpigmentation (%)Hyperpigmentation (%) Blister (%)Blister (%) TestTest MildMild ModerateModerate SevereSevere MildMild ModerateModerate SevereSevere Light BlackishLight Blackish Dark BlackishDark Blackish 66 (24.6 )(24.6 ) NilNil NilNil 22 (8)(8) NilNil NilNil 1717 (68 )(68 ) NilNil NilNil StandardStandard NilNil 55 (20)(20) NilNil NilNil NilNil 77 (28)(28) NilNil 1010 (40)(40) 33 (12)(12)
  • 17. 17 S.S. NoNo Period ofPeriod of RelapseRelapse afterafter CuredCured ChronicityChronicity AgeAge sexsex Site of RecurrenceSite of Recurrence No. of RelapseNo. of Relapse 11 22 33 44 55 66 77 3 Months3 Months 5 Months5 Months 3 Months3 Months 2 Months2 Months 4 Months4 Months 7 Months7 Months 9 Months9 Months 1-2 Yrs1-2 Yrs 2-5 Yrs2-5 Yrs 5-12 Yrs.5-12 Yrs. 12-24 Yrs.12-24 Yrs. 2-5 Yrs.2-5 Yrs. 5-12 Yrs.5-12 Yrs. 10-12 Yrs10-12 Yrs.. 12 Yrs.12 Yrs. 31 Yrs.31 Yrs. 45 Yrs.45 Yrs. 47 Yrs.47 Yrs. 28 Yrs.28 Yrs. 35 Yrs.35 Yrs. 45 Yrs.45 Yrs. MaleMale MaleMale FemaleFemale FemaleFemale MaleMale FemaleFemale MaleMale Abd, legAbd, leg Neck, ScalpNeck, Scalp Neck, ScalpNeck, Scalp BacksideBackside ChestChest Forearm & LegForearm & Leg Scalp, Leg & ArmScalp, Leg & Arm WholeWhole Scalp OneScalp One WholeWhole WholeWhole WholeWhole WholeWhole WholeWhole RECURRANCE STATUS OF STANDARD GROUP (Dithranol Ointment)RECURRANCE STATUS OF STANDARD GROUP (Dithranol Ointment)
  • 18. 18 RECURRANCE STATUS OF TEST GROUPRECURRANCE STATUS OF TEST GROUP (Herbo-mineral Cream)(Herbo-mineral Cream) S. NoS. No Period ofPeriod of RelapseRelapse after Curedafter Cured ChronicityChronicity AgeAge sexsex Site of RecurrenceSite of Recurrence No. of RelapseNo. of Relapse 11 22 33 44 55 6 Months6 Months 8 Months8 Months 8 Months8 Months 11 Months11 Months 12 Months12 Months 1-2 Yrs1-2 Yrs 2-5 Yrs2-5 Yrs 5-12 Yrs.5-12 Yrs. 12-24 Yrs.12-24 Yrs. 10-12 Yrs.10-12 Yrs. 8 Yrs.8 Yrs. 35 Yrs.35 Yrs. 38 Yrs.38 Yrs. 45 Yrs.45 Yrs. 50 Yrs.50 Yrs. FemaleFemale MaleMale MaleMale FemaleFemale MaleMale ScalpScalp LegLeg ForearmForearm LegLeg LegLeg WholeWhole Scalp OneScalp One WholeWhole WholeWhole WholeWhole No. Cases 5 (20 %)No. Cases 5 (20 %)
  • 19. 19 The test drug (containing Litharge) is described as anti-inflammatory andThe test drug (containing Litharge) is described as anti-inflammatory and has a quality of potentiating drug when applied topically (Ghani, 1921).has a quality of potentiating drug when applied topically (Ghani, 1921). During our study we also found that the test drug is beneficial in psoriasisDuring our study we also found that the test drug is beneficial in psoriasis total therapeutic response- 92% and has more absorption capacity intotal therapeutic response- 92% and has more absorption capacity in comparison to normal skin .As mentioned in classical literature that thecomparison to normal skin .As mentioned in classical literature that the drug is safe, we could also found less adverse effects with test drug indrug is safe, we could also found less adverse effects with test drug in comparison to dithranol. The recurrence rate of psoriasis with dithranol iscomparison to dithranol. The recurrence rate of psoriasis with dithranol is 28% while observed less number side effects with test drug (i. e., 20%)28% while observed less number side effects with test drug (i. e., 20%) also shows the better option of drug therapy with test drug.also shows the better option of drug therapy with test drug. The above favouring remarks clearly shows that the drug is effective whenThe above favouring remarks clearly shows that the drug is effective when applied topically. The drug seems to decrease proliferation ofapplied topically. The drug seems to decrease proliferation of keratinocytes. The mechanism by which the test drug causes inhibitorykeratinocytes. The mechanism by which the test drug causes inhibitory effects on Keratinocyts proliferation are not understood, and needs furthereffects on Keratinocyts proliferation are not understood, and needs further clarification.clarification. DISCUSSIONDISCUSSION
  • 20. 20 CONCLUSIONCONCLUSION It is concluded that topical application of thisIt is concluded that topical application of this Herbo- mineral cream with phototherapy isHerbo- mineral cream with phototherapy is having clinical significance in the treatment ofhaving clinical significance in the treatment of Psoriasis with less side effects.Psoriasis with less side effects.
  • 21. 21 Drug absorption 0 25 50 75 100 125 150 175 0 5 10 15 20 25 30 35 40 Time (Minute) Time Absorption Curve (By Filter Paper Method) DrugAbsorption Drug absorption
  • 22. 22 Time Absorption Curve (By Tared Razor Blade)

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