The document discusses various applications of biomaterials and biomedical devices. It covers implants for organs like eyes, ears, brain, heart, liver and kidneys. It also discusses dental and orthopedic implants, including various biomaterials used for hard and soft tissues. The document also mentions recent advancements in biomaterials, such as biodegradable materials, tissue engineering and stem cell research. Current priority research areas discussed include regenerative medicine, nano-technology and developing more biocompatible bionic devices.

1. Application
 Adverse effects.
 Recent Advancement
Current Priority
Research
 Conclusion.

2. Application Of Bio-materials/ medical devices.
 Adverse effects of Biomaterials/Bio-devices.
 Recent Advancement of Bio-materials/ Bio-
medical Science.
 Current Priority Research on Biomaterial/
bio-medical science.

3. Prepared By-
Dr. Md Nazrul Islam.
MBBS, M.sc.(BME).
Supervised By-
Associate Prof. ZiaulHaq -
MBBS, MS (Orthopedic).
2

4. Application Of
Bio-implant & Biomedical
Devices-
Biodegradable cranial implant
made
of PLA-β-TCP produced using
SLM.
1. Implants for Eye, ENT, Brain
2. Implants for Heart, Liver and Kidney.
3. Implants for Orthopedic and Dental.

5. Application Of
Bio-implant & Biomedical Devices-
Implants for
Eye, ENT, Brain-
Lens(ocular) Prosthesis Retinal Prosthesis
The Bio-eye (HA) ARTIFICIAL-CORNEA
Hydroxyapatite Ocular implant

6. Application Of
Bio-implant & Biomedical
Implants
Devices- for
Eye, ENT, Bra
in-
implanted device Cochlear Implant:
to treat balance disorder Most Commonly Used Ear Implant.

7. Application Of
Bio-implant & Biomedical
Implants
Devices- for
Heart, Liver
and Kidney.
Implant
for Heart:.
Stent for Heart:.
Implant
for Kidney:
First Implantable
artificial kidney / Technology .
Metallic Heart
Valve:.
Collagen Heart
Valve:.

8. Application Of
Bio-implant & Biomedical
Implants
Devices- for
Dental and
Orthopedic-
Biomaterial
For Hard Tissue-
β-tricalcium synthetic
•Bone Repair Osteoset—calcium bone product.
sulfate pellets.
• Joint Implants
• Joint Replacements
Resorbable Tricalcium
Phosphate (β-TCP)
Implants for bone void
Collagen Bone Graft

9. Application Of
Bio-implant & Biomedical
Devices-
Dental
Biomedical Implants:
Metallic Glass- Glass Orthopedic Bone
New Bioabsorbable Graft
Option for Bone Implants
Material For New Bone
Growth,
Timeline of the recent
past, near future, and
far future for the use of
synthetic dental
biomaterials versus
truly biological
materials
An artificial
dental crown

10. Application Of
Bio-implant & Biomedical
Devices-
Orthopedic
Biomedical Implants:
Biomaterial
For Hard Tissue- Limbs
• Bone Repair
• Joint Implants
• Joint Replacements
Orthopedic Implant Finger Plate

11. Application Of
Bio-implant & Biomedical
Devices-
Orthopedic
Biomedical Implants:
Biomaterial
For Hard Tissue- Lower Limbs
KNEE- prosthesis.
HIP- prosthesis.
ANKLE- prosthesis.

12. Application Of
Bio-implant & Biomedical
Devices-
Orthopedic
Biomedical Implants:
Biomaterial-
For Hard Tissue- Lower Limbs: Application
5
Composite–(Metal ,Polymer
And Ceramic) Hip prostheses. Composite–(Metal ,Polymer
And Ceramic) Knee prostheses.

13. Application Of
Bio-implant & Biomedical
Devices-
Orthopedic
Biomedical Implants:
Biomaterial-
For Hard Tissue- Limbs
Patellar
Augmentation implant.
Ankle- Synthetic Biomaterial
Replacement-Prosthesis for Tendon Replacement

14. Application Of
Bio-implant & Biomedical
Devices-
Orthopedic
Biomedical Implants:
Biomaterial
For Hard Tissue- Limbs: Application

15. Application Of
Bio-implant & Biomedical
Devices-
Orthopedic
Biomedical Implants: Biomaterial:
For Hard Tissue- Spine

16. Application Of
Bio-implant & Biomedical
Devices-
Orthopedic
Biomedical Implants:
Biomaterial-
For Hard Tissue- Spine: Application
Baguera L - Lumbar Disc
Prosthesis. MRI compatible

17. Application Of
Bio-implant & Biomedical
Devices-
Orthopedic
Biomedical Implants:
Biomaterial- Biodegradable:
For Hard Tissue- Limbs & Spine
5

18. Application Of
Bio-implant & Biomedical
Devices-
Biomaterial-
For Soft Tissue-
Tissue Engineering
Of Skin - Withy Polymer Scaffold
Polyform® Synthetic Mesh Bio-Engineering
Hydro-gel for Tissue Repair

19. Application Of
Bio-implant & Biomedical
Devices-
Biomaterial-
For Soft Tissue-
Tissue Engineering
Of Skin – for Burn Patients

20. Application Of
Bio-implant & Biomedical
Devices-
Cancer detection
from an implantable device,
Insulin Pumps - Diabetes
1. Artificial Device / Organs for Eye, ENT, Brain
2. Artificial Device / Organs for Heart, Lungs, Liver and Kidney.
3. Artificial Device/Organs for Dental, Maxillofacial and
Orthopedic.

21. Classification:
 Class I: General controls.
 Class II: General controls with special
controls
(infusion pumps, and surgical drapes…).
 Class III: General controls and premarket
approval (implantable pacemaker, pulse
generators, automated external
defibrillators).

22. Application Of
Bio-implant & Biomedical
Artificial
Devices-
Device/ Organsfor
Eye, ENT, Brain
Scientists Set
Sights on an
Implantable
Prosthetic for
the Blind .
Implantable Miniature
Telescope for Macular
Degeneration
Implantable Smart Chip implantable-
device- seizure
Fights Chronic Pain -

23. Application Of
Artificial Device/
Bio-implant & Biomedical
Organs
Devices-
For
Heart,Lungs,Liver,Kid
ney and Stomach.
Artificial Lung
Without Need for Extra Oxygen
Artificial Heart
iv
ad Device blocking stomach n
signals shows promise in o

24. Application Of
Bio-implant & Biomedical
Devices-
Application:
Pace-maker in-situ.
First_pacemaker_
Siemens-Elema_19581
Blood-power-hydroelectric-turbine... devices that use
Small turbines designed to fit inside a human artery.

25. Application Of
Bio-implant & Biomedical
Artificial
Devices- Device/
Organs
For Heart, Lungs, Liver
and Kidney.
Liver device helps
man
survive until
transplant – FGate
6

26. Application Of
Bio-implant & Biomedical
Artificial
Devices- Device/
Organs
For Heart, Lungs, Liver
and Kidney.
5
Artificial mechanical kidney

27. Application Of
Artificial
Bio-implant & Biomedical Device/
Devices-
Organs
for Dental and
Orthopedic
Implantation.
Surgically implanted titanium
And stainless steel plates
Flexible (nylon)
dental prostheses.
Composite– (Metal and Orthopedic /Dental
Ceramic) dental prostheses. Implants Pulse Generators (CRM

28. Application Of
Artificial
Bio-implant & Biomedical Device/
Devices-
Organs
for Dental and
Orthopedic
Implantation.
Wireless Implantable Chip
Delivers Osteoporosis Drug-
When It Is Needed.
Remote
Control-
Microchips
... 9

29. Adverse
Effects Of Biomaterial/Bio-
device:
Hemolysis,Thrombosis &
Coagulation.
(Exaggerated)
 Inflammation
Acute Inflammation
(Exaggerated)
Chronic Inflammation
(Specific for foreign body)
 Immunogenicity and toxicity
 Infection
 Corrosion/ Wear/ Tear
 Loosening
 Fracture of implant and bone
 Rejection of Implant
 Tumorogenesis
/Carcinogenesis.

30. Recent Advancement
Of Biomaterial/Biomedical
Science.
Mesh_Titanium_
orthopedic implant.

31. Recent Advancement
Of Biomaterial
Science.
Biodegradable Biomaterial.

32. Recent Advancement
Of Biomaterial
Science.
Biomaterials that form bonds with the
living
tissues and perform specific biological
response at the interface -
• Capable of direct chemical bonding
with
the host tissue.
• Stimulatory effects on bone-building
cells.
IdealBioglass SiO2, cement filler and
o as bone
coating due Na2its biological activity–
oCaO and to O,
Cannot Calcium Phosphate.
o
be used for load bearing
Bone ingrowth around applications-
synthetic hydroxyapatite

33. Recent Advancement
Of Biomaterial
Biologic
Science.
Biomateri
als. Are Biological components- either from-
Natural (Plant), or xeno, allo or auto biological
components-
Whole /part of Cell- adult /stem, Cell-secreted
extracellular matrix or fluid,
Living Tissue Components (e.g. Collagen, liver
or pancreatic tissue) or
Lab grown biological cell, fluid/ tissue or organ
to augment, regenerate, replace or implantation
in the living biological system.
Implantation of cell / tissue / fluid for regeneration.
Research of interest  Restorable Collagen- Based Medical Implant/ tissue.
-
 Tissue Engineering for Tissue and Organ Regeneration.

34. Recent Advancement
Of Biomaterial
Science.
Tissue Engineering
For Tissue and Organ
Regeneration.
Stem Cell
Researchers – An artificial human trachea implanted in
A Step Closer to Sweden: A cancer patient has received
the first synthetic windpipe transplant.
Growing New
Organs-
5
The synthetic scaffold of an ear sits bathed in cartilage-
producing cells, part of an effort to grow new ears for
wounded soldiers.

35. Recent Advancement
Of Biomaterial
Science.
Restorable
Collagen-
Based
Medical
Implant.
Collagen is an
important ECM
molecule and is the
major structural
component in the
body. 5
It is biocompatible
and degrades into
harmless products
that are metabolized
or excreted. a very
Pulpal
poor antigen , non-
toxic. Regeneration -

36. Antibiotic-
coated
Recent Advancement
Bio-
Of Biomaterial
Science.
implants/de
vice -
 New multifunctional
ciprofloxacin-releasing
SR-PLGA 80/20 screws
(A).
 Screws that do not
contain ciprofloxacin
(B).

37. Recent Advancement
Of Biomaterial
Aesthetic/
Science.
Cosmetic
Biomaterial.
Nose
implants
Popular- cosmetic-dental-
treatments-
Porous-polyethylene-implant-Reconstruction of
the total external ear has two major approaches-
alloplastic prosthesis implantation.
Cosmetic-dentistry-

38. Recent Advancement
Of Biomaterial
Science.
Aesthetic
Biomaterial.
Popular- Aesthetic
Replacement of
Testis-
5

39. Recent Advancement
Of Biomaterial
Science.
Cosmetic
Biomaterial.
Biomaterials
in plastic -
surgery-
Saline-breast implant
5
Autogenous-cartilage-graft
Silicone-breast implant in-situ

40. Recent
Advancement
Micro-chip
Of Biomaterial
Science.
Controlled
Bionic Devices.
Bionic bodies have been depicted in
science fiction for decades.
Now, researchers are making bionics
the new frontier of medical science, by
creating hi-tech devices to help people
walk, see and hear again.
8

41. Recent
Advancement • Positron emission tomography (PET)
Of Biomaterial • Single photon emission computed
Innovation-
Science. tomography (SPECT)
• Magnetic resonance imaging (MRI)
MolecularImaging Technique› • Computed tomography (CT)
• Optical bioluminescence imaging
• Optical fluorescence imaging
• Ultrasound.
Molecular imaging is a new biomedical research
discipline enabling the visualization,
characterization, and quantification of biologic
processes taking place at the cellular and sub-
cellular levels.
Human Bone Osteosarcoma
Cells (Fluorescent Digital
Image technology)
It provides a number of unique advantages
over more traditional tools such as histology:
Non-Invasive
 Real-Time
 Physiological Conditions
 Intact Tissue
 Living Subject
 Longitudinal and Quantitative
 Assessments Complementary to Histology.
Bimolecular Image of Chest-

42. Current Priority Research
On Biomedical/ Biomaterial
Science. Application:
 Genomic and personalized medicine.
Nano -technology oriented Medical
science and Regenerative Medicine.
 3rd And 4th Generation Biomaterial –
• Tissue Engineered- Cell and Gene
activating Biomaterials.
• Adult/Stem Cell derived
Advance
d cell, tissue/Organ and Medication.
Biomate
rial-  Innovation:
Regener
ative  Biodegradable and Bioactive-
medicin
e, able
biomaterial8 /drug delivery system.
to  Biocompatible and comfortable bionic
interac
t with
living
limbs/ Organs.
cells,  Newer technology for
and to
promote Aesthetic,Cosmetic,Dental,Orthopedic &
tissue
repair. Maxillofacial Surgery.
 Bio-fuel/auto-fueled/ Self controlled
Biomedical devices.

43. Current Priority Research
On Biomedical/ Biomaterial Science-
Stem Cell
Research:
Live human lungs grown in lab using stem
cells in potential transplant breakthrough -
8

44. Current Priority Research
On Biomedical/ Biomaterial Science-
Stem Cell
Research:
Live human heart grown in lab using stem
cells in potential transplant breakthrough-
6

45. Current Priority Research
On Biomedical/ Biomaterial Science-
Stem Cell
Research:
Dr. Anthony Ata-la and his team has grown
bladders and blood vessels using Stem Cell.
Tissue Engineered Bladder

46. Current Priority Research
On Biomedical/ Biomaterial Science-
Stem Cell
Research:
Spray On Stem Cells for Treating
Burns and Open Wounds–Regenerative

47.  Most current applications of
biomaterials /biomedical device involve
structural functions, or very simple
chemical or electrical functions.
Complex chemical functions
(e.g., those of liver), and
Complex electrical or
electrochemical functions (e.g.,
those of brain and sense organs)
– cannot be carried out by
biomaterials.
Regenerative Medicine  Transplantation of organs and tissues
In 2012- Assessing Predictions
is inevitable when biomaterials are not

48. Tissue engineering will change the face
of biomaterials.
 Regenerative medicine will reduce the
need for synthetic materials in the body.
 In the near-future, biomaterials will be
incorporated with biological factors
(such as bone growth) directly into an
implant’s surface to improve
biocompatibility and bioactivity.
 Bionic device- Now researchers are
making bionics, the new frontier of
medical science, by creating hi-tech
devices to help people walk, see and
hear again.

49. &

50. 6