23. Dr. Aaditya SULFONYLUREAS BIGUANIDES HYPOGLYCEMIC ANTIHYPERGLYCEMIC Weight gain Anorexia and Weight loss Requires atleast 30% functioning pancreas Requires presence of insulin for its action Hypoglycemia; Skin rash; Antabuse reaction & cholestatic jaundice [Chlorpropamide] Lactic acidosis GI upset B 12 and folate defeciency