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Kolesterol
- 1. Dewi Wulan Sari Ifat Uzlifat Ivon Novinda Sri Rahayu
- 3. 1.BAHAN PEMBENTUK HORMON STEROID SPT ESTROGEN, PROGESTERON, TESTOSTERON 2.MEMBANTU MEMBENTUK PRO VIT D 3.MEMBENTUK MEMBRAN SEL
- 4. Fungsi Lemak • Sumber energi terbesar • Pelindung organ penting, spt organ perut, pantat • Pengangkut vitamin: A, D, E dan K • Nutrisi esensial: As linoleat dan linolenat • Jenis yg ditimbun di bawah kulit:Trigliserid • Waktu muda langsing, sekarang langsung • Dulu bau parfum, sekarang bau ….
- 5. Jenis Lemak • Fatty acids – Saturated – Unsaturated – Triglycerides • Sterols – Cholesterol – Testosterone – Estradiol • Phospholipids – Lecithin • Sphingolipids – Cerebrosides
- 6. BAHAYA KOLESTEROL • ATHEROSKLEROSIS • TROMBUS • PENYEMPITAN PEMBULUH DARAH: – STROKE (3S) – PENYAKIT JANTUNG KORONER – GANGREN KAKI
- 10. Atherothrombotic : Spectrum of Disease Cerebro Vascular Diseases Cardio Vascular Diseases Peripheral Vascular Diseases Impotensi-baru takut?
- 13. Balon
- 14. Kolesterol exogen dan endogen, kurus kol tinggi —rugi doubel porsi Pabrik pembuat kolesterol, tempat menyimpan 4. Menyimpan:Feritin, glikogen, vit ADEK, bahkan
- 15. Obat-obatan : Antibiotik, Analgesik- antipiretik, OAT Penggunaan Narkoba dan Alkohol yang berlebihan Infeksi mikroorganisme patologis : Virus Hepatitis, Aflatoxin dll.
- 16. Profil Lemak yang penting • LDL (bad) cholesterol • Total Cholesterol • HDL (good) cholesterol • Triglycerides
- 18. Buah dan Sayuran
- 19. Kasus Kolesterol • Banyak makan lemak, kolesterol tinggi- wajar. • Sudah kurus, tidak banyak makan yg enak berlemak, tetapi kolesterol tinggi, rugi double porsi ini terjadi karena sumber kolesterol tidak hanya exogen tetapi juga endogen di hati.
- 22. Lipoprotein Subclasses 5 10 20 40 60 80 1000 Diameter (nm) 1.20 1.10 1.06 1.02 1.006 0.95 Density(g/ml) HDL2 HDL3 Chylomicron Remnants VLDL IDL Chylo- microns Lp(a) LDL
- 23. Lipoprotein class Density (g/mL) Diameter (nm) Protein % of dry wt Phosphol ipid % Triacylglycerol % of dry wt HDL 1.063-1.21 5 – 15 33 29 8 LDL 1.019 – 1.063 18 – 28 25 21 4 IDL 1.006-1.019 25 - 50 18 22 31 VLDL 0.95 – 1.006 30 - 80 10 18 50 chylomicrons < 0.95 100 - 500 1 - 2 7 84 Composition and properties of human lipoproteins most proteins have densities of about 1.3 – 1.4 g/mL and lipid aggregates usually have densities of about 0.8 g/mL
- 24. KOMPOSISI PROTEIN dan LEMAK pada HDL dan LDL • HDL: Lebih banyak Protein • LDL: Lebih banyak Lemak
- 25. HDL dan LDL • HDL: Lemak yang baik hati (Friendly lipid) • LDL: Lemak yang jahat
- 26. HDL
- 27. LDL molecule
- 28. Fungsi HDL vs LDL
- 29. Intestine Excretion Dietary intake Liver Biliary Excretion Exogenous pathway Endogenous pathway Reverse Cholesterol Transport Extra-hepatic tissues Rifai, Handbook of Lipoprotein Testing, An Overview of Cholesterol Metabolism Large Intestine Small Intestine LDL-C HDL-C Extra-hepatic tissues Extra-hepatic tissues
- 31. Fungsi HDL vs LDL Ilustrasi • HDL: -Mengangkut butir lemak dari arteri perifer spt arteri koroner dan arteri di otak ke tempat penyimpanannya di hepar -Ibarat pasukan pembersih sampah • LDL: -Mengangkut butir lemak dari hepar ke arteri perifer spt arteri koroner dan arteri di otak -Ibarat pasukan provokator
- 32. Diharapkan: HDL tinggi, LDL rendah
- 33. Blood Lipids (Fats) Normal Artery Source: Pfizer, Inc.
- 34. Blood Lipids (Fats) Occluded (clogged) Artery Source: Pfizer, Inc.
- 36. Profil Lipid yang diharapkan • HDL tinggi • LDL rendah • Trigliserida normal atau rendah • Kolesterol total rendah atau normal saja
- 37. TERIMA KASIH
- 38. TERIMA KASIH
- 39. TERIMA KASIH
- 40. TERIMA KASIH
- 41. TERIMA KASIH
Notas do Editor
- Seperti yang Prof/dokter ketahui, fungsi Hati/hepar sangatlah penting diantaranya untuk : metabolisme lemak, karbohidrat & protein, metabolisme obat-obatan, serta detoksifikasi racun & toksin
- Tetapi berbagai faktor perusak hepar dapat mengurangi fungsi hati. Faktor-faktor perusak hepar itu diantaranya : Pemakaian obat-obat yang hepatotoksik seperti Antibiotika, analgesik antipiretik, dan obat Anti Tuberkulosis Penggunaan Nerkoba dan Alkohol yang berlebihan Infeksi mikroorganisme patologis seperti virus hepatitis, aflatoksin
- Blood fats, or lipids, include several types of cholesterol and triglycerides. Cholesterol is a fat-like substance which is transported around the body in a protein package, the main ones being LDL and HDL Triglycerides are basically fats in the blood. High blood fats or lipids are caused by a combination of genetics and lifestyle factors. LDL cholesterol and total cholesterol are most directly related to heart disease risk. Blood lipids should be checked at least every 5 years after the age of 20. If heart disease is present, they should be tested more often.
- Lipoprotein particles have historically been segregated into groups based on common physical size, density, core cholesterol and triglyceride content, and what surface lipoproteins are attached. The most common class groupings appear above. Each lipoprotein class is composed of a continuum of individual lipoprotein particles which span a defined range of size or density. Traditional lipid panels determine the amount of cholesterol or triglyceride carried by all particles within a lipoprotein class. While this approach allows for generalizations about the lipoproteins involved in lipid transport, it does not allow for quantification of the number or size of individual lipoprotein particles present.
- This slide shows a normal artery without any restriction of blood flow. The white dot indicates cholesterol.
- Deposits of fatty substances and cholesterol build up in the inner lining of an artery. This build-up, called plaque, can partially block the blood flow through an artery. If the artery becomes totally blocked, it can cause a stroke or heart attack. Hardening of the arteries occurs normally as we get older, but occurs at an earlier age and to a greater degree with high blood fat levels, smoking, high blood pressure, and certain diseases like diabetes.