Melanocytes are not completely absent in the depigmented epidermis
Comment:
A subpopulation of “resistant” epidermal melanocytes can persist independent of disease duration
Repigmentation can always occur independent of disease duration and with non-perifollicular pattern
20. Results of a study on 734 patients after 2 years of BIOSKIN ® treatment
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23. CONCLUSION? VITILIGO Both Narrow Band UVB Excimer Laser and Narrow Band UVB Light show similar results in similar time of treatment even if they can be used only in limited skin surfaces.
28. Group 1 BIOSKIN ® alone Group 2 0.1%Tacrolimus+ BIOSKIN ® Group 3 1% Pimecrolimus+BIOSKIN ® Group 4 Betamethasone dipropionate 0.05%+BIOSKIN ® Group 5 Calcipotriol ointment 50mcg/g+BIOSKIN ® Group 6 10% L-phenylalanine+BIOSKIN ® Group 7 0.1% Tacrolimus alone Group 8 Group 1 Group 9 Betamethasone dipropionate 0.05% Group 10 Calcipotriol ointment 50mcg/g alone Group 11 10% L-Phenylalanine alone
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30. Percentage of repigmentation in patients treated with BIOSKIN ® alone or in combination, or with active topicals alone. Treatment (n° of patients) Excellent (>75%) Marked (50-75%) Moderate (25-50%) Minimal (<25%) Group 1: BIOSKIN ® alone (100) 72% 19.8% 4.6% 3.6% Group 2: 0.1% Tacrolimus + BIOSKIN ® (59) 76.5% 18.2% 3.3% 2% Group 3: 1% Pimecrolimus + BIOSKIN ® (63) 76.1% 20.1% 2.7% 1.1% Group 4: Betamethasone dipropionate 0.05% + BIOSKIN ® (28) 90.2% 6.7% 2.2% 0.9% Group 5: Calcipotriol ointment 50 mcg/g + BIOSKIN ® (60) 75.6% 14.1% 7.4% 2.9% Group 6: 10% L-Phenylalanine + BIOSKIN ® (60) 74.8% 11.3% 10.1% 3.8% Group 7: 0.1% Tacrolimus alone (22) 61% 16.1% 18.4% 4.5% Group 8: 1% Pimecrolimus alone (19) 54.6% 18.4% 21.7% 5.3% Group 9: Betamethasone dipropionate 0.05% alone (23) 71.2% 25% 2.1% 1.7% Group 10: Calcipotriol ointment 50 mcg/g (18) 59.1% 10.6% 27.1% 3.2% Group 11: 10% L-Phenylalanine alone (18) 29.3% 8.1% 55% 7.6%