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Emkay Research

         Generic Pharma Sector
                                             BAL
DifferentiatingG L lO c a l from the rest
                the obest

               Geographically                      Dominance in a niche
          well diversified business                     segment




                                       Global
                                      Generics
                                      US$135bn




           Healthy Para IV pipeline                Lean cost structure




  n     Generic markets to become a US$135bn market by 2013

  n     Varied growth triggers for different geographies

  n     Our generic scorecard ranks companies on their ability to become
        global generic players
  n     Lupin, DRL and Cadila are our top picks


  Reco              Company                         CMP (Rs)             TP (Rs)
  BUY               Cadila Healthcare Ltd.                787                962
  ACCUMULATE        Cipla Ltd.                            314                366
  BUY               Dr Reddy's Laboratories Ltd.         1168               1478
  BUY               Lupin Ltd.                           1585               2111
  SELL              Ranbaxy Laboratories Ltd.             453                329
  HOLD              Sun Pharma Industries Ltd.           1655               1644




                                                                                          March 2010

                                                                                             Manoj Garg
                                                                               Research Analyst-Pharma
                                                                             manoj.garg@emkayglobal.com
                                                                                        +91 22 6612 1257

                                                                                           Akshat Vyas
                                                                                      Research Associate
                                                                            akshat.vyas@emkayglobal.com
                                                                                        +91 22 6612 1491
Generic Pharma Sector




                                                    Content
Synopsis                                                                                             3

Valuation Matrix                                                                                     6

Investment Argument                                                                                  8
     Generic industry: greener pastures                                                              8

     US$135bn opportunity awaits generic drugs by 2013                                               8

     Key growth drivers for generics                                                                 9
     Key geographies: macro environment and growth drivers                                          11

     Global Generics - Overview                                                                     13

     Indian generics: Well placed to capture the growing generic opportunities                      15

     Scorecard of Indian pharma companies                                                           17

     Expect earning CAGR of 28% over FY09-12E                                                       17

Valuations                                                                                          18

     Premium valuations to sustain                                                                  18

     Top picks                                                                                      18

Sector Risks                                                                                        21



                                                    Companies
Cadila Healthcare Ltd.                                                                              23

Cipla Ltd.                                                                                          27

Dr Reddy's Laboratories Ltd.                                                                        37

Lupin Ltd.                                                                                          41
Ranbaxy Laboratories Ltd.                                                                           45

Sun Pharma Industries Ltd.                                                                          57




Emkay Research                         10 March, 2010                                                2
Generic Pharma Sector
      Synopsis
                 Synopsis

                 The generic pharma industry has evolved and grown over the years to become a
                 US$87bn market, with the potential of touching US$135bn by 2013. However, with
                 time, the growth opportunities have shifted from being solely US centric to a global one
                 as economies around the globe are increasingly favoring generics. Too much of focus
                 and dependence on any single market is turning out to be a risky proposition. We
                 believe that generic players have to be dynamic in their approach if they want to fully
                 capitalize on the growth opportunities that the sector offers. We have identified four
                 parameters, which will enable them to tackle the diverse issues across geographies
                 and emerge as strong players in the generic space. They are - a) Geographically well
                 diversified business, b) Dominance in a niche segment, c) Healthy Para IV pipeline and
                 d) Lean cost structure. We believe that these parameters will ensure that a generic
                 player is able to capitalize on the opportunities available across regions and also grow
                 profitably in the highly competitive generic space.


                 We have assessed the companies in our universe on each of these parameters and
                 assigned scores accordingly. Sun Pharma and DRL emerge as the highest generic
                 scorers with a score of 17 each, while Cadila and Cipla rank lowest with a generic
                 score of 12 each. We have rated the companies on the basis of their generic score,
                 earnings growth and valuations. As a result, we have rated Sun Pharma and Ranbaxy
                 as a Hold and Sell respectively, despite them scoring high on our generic scorecard
                 owing to expensive valuations. Similarly, Lupin and Cadila are our top picks despite
                 lower generic scores on account of the immense upside potential (34% and 22%) that
                 they offer from current levels. Lupin, DRL and Cadila are our top picks. We initiate
                 coverage on Cipla with an Accumulate rating, Sun Pharma with a Hold rating and
                 Ranbaxy with a Sell rating. We have a positive bias on all these stocks and will upgrade
                 our ratings on Cipla, Sun Pharma and Ranbaxy, subject to materialization of the positive
                 triggers that we have anticipated for each of them.

                 Generic markets to become a US$135bn market by 2013
                 We believe the growth drivers for generics are clear and sustainable. We expect the
                 generic industry to grow at a faster pace (9% CAGR over CY08-13E) compared to the
                 overall pharmaceutical market (2-3% CAGR over CY08-13E). The global generic market,
                 which stands at US$87bn, is likely to grow at 9% CAGR over CY08-13E to US$135bn on
                 the back of a) drugs worth US$235bn going off patent over FY10-15E, b) tripling of elderly
                 population (60+ population-700mn in 2005 to 1900mn by 2050), c) spiraling healthcare
                 expenses across the globe and d) favorable government policies.

                 Varied growth triggers for different geographies
                 We are of the view that while we expect generics to grow across geographies, the factors
                 driving growth for generics are varied. To elaborate further - In the US - the largest generic
                 market - generic usage is being driven by a) pro-generic environment, b) huge patent
                 expiry, c) rising healthcare cost. In the EU territory, we are of the view that the generic
                 industry has yet to reach its full potential. Pro generic policies will drive growth in the more
                 developed Western EU markets while Central and East European (CEE) markets offer
                 higher growth prospects because of low generic penetration and lower per capita spending
                 on drugs. Similarly, Japan is going to be the most exciting market for generic companies
                 on account of a) It being the second largest pharmaceutical market in the world, b) low
                 generic penetration and c) government initiative to promote generic usage. Though
                 developed markets continue to remain critical markets because of their sheer size,
                 developing markets are emerging as a compelling opportunity because of higher growth
                 prospects. We expect the generic opportunity outside the US, western EU and Japan to



Emkay Research   10 March, 2010                                                                                3
Generic Pharma Sector


                                           reach US$92bn by 2013 (CAGR of 11.5% over CY08-13E). Emerging geographies offer
                                           higher growth potential on the back of a) rising prevalence of life-style related diseases,
                                           b) aging population, c) increasing per capita spend, d) lower penetration of modern
                                           medicine and e) increasing insurance penetration.

                                           We have identified four parameters essential for becoming generic majors
                                           While there exists huge opportunity in the generic space, we believe that to become a
                                           major generic player calls for certain requirements. We have identified four parameters,
                                           which will enable companies to become strong contenders for generic opportunities.

                                           Geographically well diversified business - Too much of focus and dependence on any
                                           single market is turning out to be a risky proposition. In order to capitalize on the growth
                                           opportunities that different regions offer, a well diversified geographical presence is a
                                           must.

                                           Dominance in a niche segment - In order to remain profitable in the highly price sensitive
                                           generic market, it is advantageous to have dominance in a niche segment, which will
                                           provide the much required hedge against price erosion in the competitive generic
                                           segments.

                                           Healthy Para IV pipeline - will boost profitability and also ensure a competitive edge post
                                           the exclusivity period

                                           Lean cost structure - to ensure profitable growth

                                           We believe that companies that can differentiate from competition by building niche product
                                           portfolios, novel drug delivery systems, chart a geographically diversified presence and
                                           sustain and nurture vertically integrated operations will benefit the most. We believe that
                                           companies, which fare well on these parameters, are well placed to cash in on generic
                                           opportunities.

                                           Our generic scorecard ranks companies on their ability to become global
                                           generic players
                                           We believe that companies which fare well on the above mentioned parameters, are well
                                           placed to cash in on generic opportunities. We have rated and assigned scores to the
                                           companies in our universe on each of these parameters and have arrived at an overall
                                           generic scorecard. As per our scorecard, Sun Pharma and DRL emerge as most preferred
                                           companies with the highest score of 17 each. Cipla and Cadila feature last with a score
                                           of 12 each. Cipla scores low because of absence of Para IV pipeline as it has adopted
                                           partnership model.

                                           We have valued companies in our universe using valuation tools that best capture their
                                           value. Based on their generic score, we have valued them at premium, par or discount.

Generic score card
 Company                               Parameters                           Total Score    Valuation Criteria
                  Geographical    Dominance in      Para IV       Cost
                   presence      niche segment      pipeline    structure
Sun Pharma               3             5                4           5            17        10% premium to sector multiple
Dr Reddy                 4             5                5           3            17        15% premium to its 5 year mean multiple
Ranbaxy                  5             5                5           1            16        5% premium to sector multiple
Lupin                    4             5                3           3            15        In-line with the sector multiple
Cipla                    4             5                0           3            12        In-line with sector multiple because of low
                                                                                           risk business model
Cadila                   4             5                0           3            12        10% discount to sector multiple

Source: Emkay Research


Emkay Research                             10 March, 2010                                                                                4
Generic Pharma Sector


                 Initiate coverage on Sun Pharma with Hold rating, Ranbaxy with Sell
                 rating and Cipla with Accumulate rating
                 We initiate coverage on Sun Pharma with a Hold rating and Ranbaxy with a Sell rating.
                 Given their high generic scores, we have ascribed 10% and 5% premium to Sun Pharma
                 and Ranbaxy, arriving at a price targets of Rs1644 and Rs329 respectively. Despite this
                 premium, we believe that current valuations are expensive. We believe that the growth
                 prospects for Sun Pharma and Ranbaxy in the generic space are extremely promising.
                 They are however, marred by US FDA ban on certain facilities (Caraco for Sun and Paonta
                 Sahib and Dewas for Ranbaxy). While we are confident that the worst is behind and that
                 these issues will be resolved in the near future, we have not factored the potential upsides
                 from a positive outcome on these issues. We shall be keenly watching the developments
                 and will revise our rating on the stocks when clarity emerges. We initiate coverage on
                 Cipla with an Accumulate rating as our current estimates have not factored in the upsides
                 from launch of combination inhalers in EU. Despite a low generic score (12) due to the
                 absence of Para IV filing, we value Cipla in line with the sector average because we
                 believe that its dominance in the lucrative inhaler space and established business model
                 makes it a low risk bet on the generic opportunity.

                 Lupin, DRL and Cadila are our top picks
                 We re-iterate our Buy rating on Lupin, DRL and Cadila with price targets of Rs2111,
                 Rs1478 and Rs962 respectively. Lupin, third in our generic scorecard (score of 15), with
                 its well diversified geographical reach, foray into high growth oral contraceptive segment
                 along with attractive Para IV pipeline is an attractive investment proposition because of
                 valuations discount to its large cap peers (20%). Lupin provides the highest upside (34%)
                 in our universe with a price target of Rs2111 (20xSep'11 EPS; NPV of Rs22/share for Para
                 IV pipeline).


                 DRL, with the highest score of 17 on our generic scorecard, is among the best bets to buy
                 into the generic growth story. We have ascribed a 15% premium to its 5 year average
                 multiple and valued the company in line with the sector multiple of 20x Sep'11 EPS and
                 arrived at a target price of Rs1478 (20xSep'11 EPS; NPV of Rs77/share for Para IV pipeline),
                 an upside potential of 26%.


                 Cadila, despite featuring last in our generic scorecard, is one of our top picks. Even after
                 ascribing a 10% discount to sector multiple, our fair value of Rs962 (18xSep'11E) provides
                 an upside potential of 22%. We believe that strong earnings growth and visibility in Cadila
                 and Lupin compensate for its lower generic scores and provide huge upsides from the
                 current levels.


                 We have valued the companies on the average of FY11E and FY12E earnings reflected
                 as on September’11 EPS.




Emkay Research   10 March, 2010                                                                            5
Valuation Matrix
                                                                    CADILA                                  CIPLA                            DR REDDY
                                                         2009   2010         2011    2012   2009     2010      2011      2012     2009    2010     2011        2012
                       Financials (Rs mn)
                       Sales                            29275   37734    45673      54626   52343   58299     65990      75313   68830   72727    86682       100626




Emkay Research
                       Sales (base)                                                                                              63566   70338    79985        90141
                       EBIDTA                            6058   8164         9797   11706   12218   15135     17312      19854   14749   15594    21170        26205
                       EBIDTA (base)                                                                                              9718   11910    14565        16916
                       PAT                               3272   5077         6391    8182   9719    11305     13610      15745    7571    9481    13680        18066
                       PAT (base)                                                                                                 4301    8087    10458        13134
                       Growth (%)
                       Sales                              26      29          21      20      24       11           13     14      38       6           19       16
                       Sales (base)                                                                                                30      11           14       13
                       EBIDTA                             32      35          20      19      47      24            14     15      93       6           36       24
                       EBIDTA (base)                                                                                               31      23           22       16
                       PAT                                24      55          26      28      51      16            20     16     127      25           44       32
                       PAT (base)                                                                                                 124      88           29       26
                       Profitability (%)




     10 March, 2010
                       EBIDTAM                            21      22          22      22      23      26            26     26      22      22           25       27
                       EBIDTAM base                                                                                                16      17           19       19
                       PATM                                11     14          14      15      19      19            21     21      11      13           16       18
                       PATM base                                                                                                    7      12           13       15
                       RoE                                29      35          33      31      19      22            22     22      19      24           28       28
                       RoCE                               22      26          29      32      20      21            22     22      16      20           28       31
                       Per Share Data (Rs)
                       EPS                               24.0    37.2        46.9     60     12.1    14.1      17.0        20      45      56        81         107
                       EPS Base                                                                                                    26      48        62          78
                       CEPS                              32.2    46.4        56.9     71     11.5    16.0      19.7        23      75      81       108         137
                       BVPS                                89     123        165     218     55.9    72.2      84.2        98     209     257       329         425
                       DVPS                               4.5     5.0         5.0      7      2.0     3.4       4.2         5       6       7         8          10
                       Valuation (x)
                       P/E                               29.1    18.8        14.9    11.6    26.1    22.4      18.6       16.1     26       21          14        11
                       CPER                              21.7    15.0        12.3     9.9    27.5    19.8      16.1       14.0     16       14           11        9
                       P/BV                               7.8     5.7         4.2     3.2     5.6     4.4       3.8        3.2     5.6     4.5          3.5      2.7
                       EV/Sales                           3.7     3.1         2.5     2.0     5.1     4.6       4.0        3.4     3.1     2.9          2.3      1.9
                       EV/EBIDTA                         17.4    12.7        10.4     8.3    26.8    20.7      17.7       15.1    14.3    13.1          9.3      7.0
                       Dividend Yield (%)                 0.6     0.7         0.7     0.9       1       1         1          2     0.5     0.6          0.7      0.9
                       Turnover (Days)
                       Debtors Turnover                   61      56          55      55    134.5   133.2     133.2      133.2     77      72           70       70
                       Inventory Turnover                 76      75          75      75    101.5   100.8     100.4      100.4     71      72           71       70
                       Gearing Ratio (x)
                       Net Debt/Equity                   0.84    0.51        0.28     0.1     0.2   -0.01      -0.04      -0.1     0.4     0.2          0.0     -0.2
                                                                                                                                                                       Generic Pharma Sector




                      Source: Emkay Research, Company




     6
Valuation Matrix
                                                                        LUPIN                                  RANBAXY                      SUN PHARMA
                                                         2009   2010            2011    2012   2008     2009       2010    2011    2009    2010    2011     2012
                       Financials (Rs mn)
                       Sales                            38523   47346       56526      64749   74214   75970      84753   91777   41870   40515   45218    49765




Emkay Research
                       Sales (base)                                                            71854   70157      71780   78453   34448   33861   41389    50269
                       EBIDTA                            7284   9565        12241      14163    5732    7124      13052   15014   18676   13465   16116    16978
                       EBIDTA (base)                                                            5242    3055       4666    8630   11702    8973   12830    16589
                       PAT                               5058   6559            8438   10109    2597    4338       8212    8910   18178   13622   15297    16596
                       PAT (base)                                                               2254    1693       2549    4639   12947   10288   12818    16315
                       Growth (%)
                       Sales                              41      23             19      15        9      2          12     8.3    27.1    -3.2     11.6    10.1
                       Sales (base)                                                                8     -2           2       9    28.8    -1.7     22.2    21.5
                       EBIDTA                             61      31             28      16      -37     24          83     15     20.2   -27.9     19.7     5.4
                       EBIDTA (base)                                                                                               25.2   -23.3     43.0    29.3
                       PAT                                51      30             29      20      -53      67         89      9     22.3   -25.1     12.3     8.5
                       PAT (base)                                                                -57     -25         51     82     26.5   -20.5     24.6    27.3
                       Profitability (%)




     10 March, 2010
                       EBIDTAM                            19      20             22      22      7.7     9.4       15.4    16.4    44.6    33.2     35.6    34.1
                       EBIDTAM base                                                              7.3     4.4        6.5    11.0    34.0    26.5     31.0    33.0
                       PATM                               13      14             15      16        3       6         10     10     43.4    33.6     33.8    33.3
                       PATM base                                                                   3       2          4       6    37.6    30.4     31.0    32.5
                       RoE                                37      36             33      32      7.3     9.9       17.4    17.2    31.2    18.5     17.9    17.0
                       RoCE                               25      28             30      32     -0.6     7.5       12.3    15.5    27.4    14.9     15.8    14.5
                       Per Share Data (Rs)
                       EPS                                57      74             95      114     0.0     0.0        0.1     0.1    87.8    61.3     73.9    80.1
                       EPS Base                                                                  0.0     0.0        0.0     0.0    62.5    49.7     61.9    78.8
                       CEPS                               67      88            115     135      6.2    10.3       19.5    21.2    68.5    57.2     70.0    87.5
                       BVPS                              172     251            318     399      5.4     4.0        6.1    11.0   340.1   394.0    454.5   520.1
                       DVPS                               13      18             24      28     88.4    22.7       15.6    13.6    27.5    20.3     22.8    24.8
                       Valuation (x)
                       P/E                                28      21             17      14     73.3    43.9       23.2    21.4    18.9    27.0     22.4    20.7
                       CPER                               23      18             14      12     35.1    27.1       17.2    16.0    24.2    28.9     23.6    18.9
                       P/BV                                9       6              5       4      4.4     4.3        3.8     3.6     4.9     4.2      3.6     3.2
                       EV/Sales                            4       3              3       2      2.9     2.8        2.5     2.3     7.8     7.9      6.9     6.0
                       EV/EBIDTA                          19      16             14      11     88.4    22.7       15.6    13.6    17.6    23.7     19.2    17.6
                       Dividend Yield (%)                  1       1              2       2      0.0     0.7        1.1     1.2     1.7     1.2      1.4     1.5
                       Turnover (Days)
                       Debtors Turnover                   99      98             98      98     66.2    65.8       62.3    62.3    75.8   108.0    108.0   108.0
                       Inventory Turnover                 91      91             91      91     97.7    96.5       91.8    88.2    84.0    86.4     86.4    86.4
                       Gearing Ratio (x)
                       Net Debt/Equity                    0.8     0.3            0.1     0.0     0.4     0.3        0.3     0.3    -0.2    -0.3     -0.4    -0.4
                                                                                                                                                                   Generic Pharma Sector




                      Source: Emkay Research, Company




     7
Generic Pharma Sector
Investment Argument
                                        Investment Argument

                                        Generic industry: greener pastures
By 2050, world population of the 60+    The growth outlook for generics remains robust. An aging population, rising healthcare
age group is expected to jump 2.7x to   spending and increasing acceptance, coupled with favorable government policies are
1.9bn.                                  key growth drivers for generics. By 2050, the world population of the 60+ age group is
                                        expected to jump 2.7x to 1.9bn. As elderly people consume 66% more medicine than the
                                        younger group, this jump is likely to further pressurize healthcare costs of developed
                                        countries. The healthcare costs of developed countries have already been growing faster
                                        than their GDP. As more brand-name drugs come off patent and payers push for cost cuts
                                        in health care, the demand for generics are likely to scale new highs.


Global generic market to grow at a      Overall, we expect the global generic market to grow at a CAGR of 9% to US$135bn by
CAGR of 9% to US$135bn by 2013          2013, which will be higher than the growth of the branded pharmaceutical market. We are
                                        of the view that non-US markets will be the key growth drivers and will grow faster than the
                                        developed markets. The share of the US generic market is likely to come down from 20%
                                        to 16% by 2013.

                                        US$135bn opportunity awaits generic drugs by 2013
Generic opportunity outside the US,     The global generic market, which stands at US$87bn as on CY2008 (IMS Health) is likely
Western EU and Japan to reach US$       to grow to US$135bn by 2013 (CAGR of 9%). Though US would continue to remain the
92 bn by 2013                           largest generic market (currently 20% of total generic market), emerging markets are
                                        likely to grow at a faster pace and narrow the gap going further. We expect the generic
                                        opportunity outside the US, Western EU and Japan to reach US$92 bn by 2013 from the
                                        current level of US$53bn (CAGR of 11.5% over CY08-13E).


                                        Generic industry growth estimates

                                                   160
                                                   140                                                                         $135b
                                                   120
                                                   100                 $87b                                                                    $50b
                                          US$ bn




                                                   80
                                                   60
                                                   40
                                                   20
                                                    0
                                                                        2008                                                 2013
                                                                          North America               Europe       International

                                        Source: Emkay Research, Teva


                                        Generic penetration in key markets

                                         70%             64%   65%
                                         60%                                  54%
                                                                                        50%
                                         50%
                                         40%
                                         30%
                                                                                                         17%                                   17%
                                         20%                                                                          12%
                                                                                                                                       7%
                                         10%
                                          0%
                                                                                                          France
                                                         US



                                                                UK



                                                                              Germany




                                                                                                                                               Japan
                                                                                        Netherlands




                                                                                                                       Spain



                                                                                                                                       Italy




                                        Source: Emkay Research, Stada



Emkay Research                          10 March, 2010                                                                                                 8
Generic Pharma Sector


                                          Key growth drivers for generics
                                          Patent expiries, rising healthcare costs coupled with aging population and favorable
                                          government policies are the key drivers of increased generic penetration the world over.


                                          Drugs worth US$235bn are likely to go off-patent over 2010-2015
Patent expiry likely to open a plethora   Drugs worth US$235bn are likely to go off-patent over 2010-2015. With high profile drugs
of opportunities for generics             like Lipitor (US$13.5bn) and Plavix (US$8.7bn) going off-patent in 2011, the global pharma
                                          market is likely to see a further slowdown in sales. Other key products going off-patent in
                                          the next five years are Takepron (Lansoprazole; US$4.2bn revenue; 2009), Seretide
                                          (Salmetrol + Fluticasone; US$7.7bn; 2010), Effexor (Venlafexine, US$4bn, 2010), Seroquel
                                          (Quitapine, US$5.4bn, 2012) and Nexium (Esomeprazole, US$7.9bn, 2014), etc. These
                                          patent expirations are likely to open a plethora of opportunities for generics and ensure
                                          that their growth momentum is maintained.

                                          Generic growth driven by patent expiries ($bn)


                                                                                      121



                                                                                                                          235
                                                    114




                                                 2010 - 2012                      2013 - 2015                            Total
                                          Source: Emkay Research, Teva

                                          2010-2014 - Key patent expiries
                                          2010                    2011            2012              2013              2014
                                          Arimidex                US Plavix       Symbicort         Oxycontin         Nexium
                                          Cozaar/ Hyzaar          Advair          Seroquel          Cymbalta          Copaxone
                                          Aricept                 Zyprexa         Avapro            Zometa            Actonel
                                          Taxotere                Femara          Avandia           Yasmin            Micardis
                                                                  Lipitor         Singulair
                                                                  Xalatan         Diovan
                                                                                  Viagra
                                                                                  Detrol
                                                                                  Geodon
                                                                                  Lovenox
                                                                                  Avapro

                                          Source: Emkay Research, Industry


                                          Spiraling healthcare expenses indicate greater acceptance of generics
Healthcare expenditures of OECD           With spiraling healthcare expenses across the globe, the acceptance of generics is
countries (ex-US) are likely to rise to   steadily increasing. In a bid to cut healthcare costs, countries hitherto using only branded
16% of their GDP by 2020                  drugs are gradually resorting to use of generics. As a result, branded markets like Germany
                                          are resorting to use of generic drugs. Similarly, we have also seen a steady increase in
                                          the generic penetration of developed markets like US, UK. The healthcare expenditures of
                                          OECD countries (ex-US) are likely to rise to 16% of their GDP by 2020 (currently, it is 10%
                                          of GDP). By 2020, the US is likely to spend around 21% of GDP on healthcare from the
                                          current level of 16%. In all, the US will spend approximately US$10tn by 2020. Curtailment
                                          of this uptrend is a very significant factor driving generic growth.



Emkay Research                            10 March, 2010                                                                            9
Generic Pharma Sector


                                      Healthcare spending as % of GDP in the US




                                                                                                                        17%
                                                                                                     15%
                                                                                   12%
                                                                     9%
                                               7%


                                              1970                   1980          1990              2003               2008

                                      Source: Emkay Research, Teva


                                      Graying planet
Elderly people consume 66% more       Growing proportion of elderly population is expected to add to the already burgeoning
medicine than the younger group       healthcare costs in both developed as well as developing countries. As per WHO estimates,
                                      global elderly population (65+) is expected to almost double from 480mn in 2000 to
                                      800mn by 2025. As per industry estimates, there are currently 30 pension eligible elders
                                      in the developed world for every 100 working age adults. By the year 2040, there will be 70
                                      elders for every 100 working adults. Elderly people consume 66% more medicine than
                                      the younger group, further adding to healthcare costs.


                                      World population by age (in bn)

                                                                                                            9.1
                                                                                                            1.9
                                                              6.5
                                          60 above            0.7                                           2.3
                                          40 to 59            1.4

                                                               2                                            2.5
                                          20 to 39

                                                              2.4                                           2.4
                                          0 to 19

                                                             2005                                          2050

                                      Source: Emkay Research, Teva


                                      Biosimilars: the future
Between 2010 and 2015, biotec drugs   Generic biologics or Biosimilars have the potential to be the next growth driver for the
worth US$101bn are set to loose       generic industry. Biosimilars promise remarkable cost-savings for spiraling healthcare
patent protection                     budgets. Yet, the full potential can only be harvested when a number of significant markets,
                                      regulatory and clinical hurdles have been overcome globally. There is still lack of clarity for
                                      product launches in the US market. However, Europe has already begun to approve
                                      generic biologics and till date has approved 13 biosimilars for launch. Biosimilar legislation
                                      is evolving rapidly in other countries as well. Other national authorities have already
                                      successfully addressed the biosimilar regulatory and legal framework, prominent among
                                      them being Australia, Canada, Malaysia and Japan. On October 5, 2009, the Japanese
                                      government has approved the first biosimilar. However, progress in the US, the most
                                      lucrative biopharmaceuticals market with two thirds of global biological sales, is still
                                      painfully slow. Legislation has been introduced in Congress to provide a similar pathway
                                      for approval and regulation of generic biologics in the US. Now that this legislation has the
                                      backing of the Obama administration, we expect the first biosimilar approval in 2011.
                                      Between 2010 and 2015, biotec drugs worth US$101bn are set to loose patent protection.


Emkay Research                        10 March, 2010                                                                              10
Generic Pharma Sector


                                        Biologics patent expiry ($ bn)


                                                                                                                        20


                                                                                                               9
                                                                                                                                 59



                                                                                            8
                                                                           2       1
                                                        1         1

                                        Number of
                                                        1         3        4       2        3         9        7        16       45
                                        molecules
                                        Source: Emkay Research, Industry



                                        The impending expiry of several patented blockbuster biopharmaceuticals and the
                                        increasing demand from patients, insurers, and government agencies to reduce drug
                                        costs have created numerous opportunities in the global biosimilar markets. This is new
                                        territory for most generic players with the commercial rewards of their foray paying off in
                                        the long run.

                                        Key geographies: macro environment and growth drivers
US generic market to grow at a CAGR     Our analysis of macro and micro environments of key geographies clearly reveals that
of 5% to US$22 bn over 2008-13          each of the markets present ample opportunities and challenges in terms of generic
                                        usage. To put things in perspective, despite multiple challenges, US continues to remain
                                        the largest and most exciting market in the generic space. The generic penetration in the
                                        US is as high as 65%. The new healthcare bill under discussion, proposes to discount
                                        prices of certain drugs by 50% from their current levels and provide coverage for people
                                        currently not eligible for coverage (15% of US population). Though the new bill is expected
                                        to act as a disincentive to research and innovation, it is expected to provide a big impetus
                                        to generic drug manufacturers globally. Pro-generic environment, huge patent expiry (drugs
                                        worth US$94 bn are likely to go off-patent in next 5 years) and rising health care costs are
                                        some of the key growth drivers for increased generic usage, going forward. We expect this
                                        market to grow at a CAGR of 5% to US$22 bn over 2008-13.

CEE generic markets offer significant   Similarly, we are of the view that the EU generic industry has yet to reach its full potential.
growth opportunity (12-13%)             The EU generic industry is highly fragmented and on the basis of usage, can be classified
                                        as mature generic markets (generic penetration of more than 40%) and developing generic
                                        markets. Countries having pro-generic policies such as Germany (generic penetration
                                        59%), UK, Denmark, Netherland and Poland are the mature generic markets, while
                                        countries like France, Italy and Spain, where the current generic penetration is very low are
                                        developing generic markets. These developing generic markets offer significant growth
                                        opportunity (12-13%), going forward.


Japan is aiming to raise its generic    Similarly, Central and East European (CEE) markets offer higher growth prospects because
exposure to 30% of volume by 2012       of low generic penetration and lower per capita spending on drugs (10-30% of Western
                                        Europe). On the other hand, Japan, the world's second largest pharmaceutical market, is
                                        expected to be the most exciting market for generic companies, going forward. While the
                                        Japanese pharma market constituted 9.9% of global sales in 2008, it had one of the
                                        world's lowest consumption rates for generic drugs. Japan, which currently has 19%
                                        generic penetration in volume and 4% in value (US$2.7bn), is aiming to raise its generic
                                        exposure to 30% of volume by 2012.




Emkay Research                          10 March, 2010                                                                                11
Generic Pharma Sector


Emerging geographies offer higher   Though developed markets continue to remain critical markets because of their sheer
growth potential                    size, developing markets are emerging as a compelling opportunity because of higher
                                    growth prospects. Although, the generic market value of these countries are not as
                                    impressive as mature markets, most are experiencing tremendous growth rates compared
                                    to the modest 2-5% growth seen in the US and Europe. We are of the view that emerging
                                    geographies like India, Brazil, China, Russia, Mexico, Turkey and South Africa offer higher
                                    growth potential on the back of a) rising prevalence of life-style related diseases, b) aging
                                    population, c) increasing per capita spend, d) lower penetration of modern medicine and
                                    e) increasing insurance penetration. Being branded generic in nature, these markets not
                                    only offer higher margins but also have strong entry barriers because of doctor relationship
                                    and brand equity.


                                    We expect these pharemerging markets to grow at a sustainable rate of 12-13% over the
                                    next decade to become a US$400bn market by 2020. Ongoing economic growth in these
                                    countries will not only improve socio-economic profile and healthcare infrastructure but
                                    also result in increased spending on chronic diseases.


                                    The table overleaf is a snapshot of various regions in terms of size, growth potential,
                                    regulatory environment, key growth drivers and challenges for each of the key geographies.



                                    Genericisation of the global pharma market:
                                    n    Governments across the globe, and particularly those in major pharma markets
                                         such as UK, US, Germany and Japan, have come under increasing cost contain-
                                         ment pressure, leading to creation of regulations that encourage the use of lower
                                         priced generics.

                                    n    The era of 'blockbusters' has passed. As recently as 2006, there were nearly 90
                                         drugs that had achieved the blockbuster status, generating 30% of total global
                                         pharma sales at US$200bn. By 2009, eight of these block buster drug ($18 bn)
                                         were facing patent expiry.

                                    n    Failure of newly launched drugs due to safety concerns and dwindling pipeline of
                                         small molecule drugs

                                    n    Increasing acceptance of generic drugs in large, highly regulated pharma markets.

                                    n    Emergence of biotechnology as an alternative to traditional small molecule phar-
                                         maceutical

                                    n    A spate of M&As, driven primarily by pharma majors like Pfizer, Merck and Roche to
                                         gain wider R&D pipeline

                                    n    Pharma majors are increasingly turning towards emerging markets as these mar-
                                         kets offer higher growth potential

                                    n    Pharma majors are eying the generics and biosimilars markets as an alternate
                                         revenue source.




Emkay Research                      10 March, 2010                                                                            12
Global Generics - Overview

                                                                                                                                                              Europe
                                                             US                                                       Germany          UK             France          CEE             Spain           Italy
                      Nature of market                       Mature                                                   Mature           Mature         Developing    Developing        Developing      Developing
                      Generic penetration                    64%                                                      54%              65%            17%           20-25%            12%             7%




Emkay Research
                      Market size as of 2007 (US$ bn)        17                                                       6.7              4.5            5.4           14                2.7             3
                      Expected market size by 2013 (US$bn)   22                                                       7.8              4.8            7.3           26                3.4             3.5
                      CAGR                                   5%                                                       3%               1.3%           6%            13%               4.7%            3.1%
                      Drugs going off patent (US$bn)         94                                                                                                 50
                      Regulatory Environment                 Pro generic                                              Pro generic      Pro generic    Encouraging generic usage
                      Key growth drivers                     • Largest generic market                                 • Various healthcare reforms introduced by the German government have resulted in
                                                             • Drugs worth $94bn are going off patent                   progeneric structural and regulatory changes
                                                             • Regulatory & political environment is pro-generic      • Government in other European markets such as France, Hungary, Spain and Italy have also
                                                                                                                        initiated various reforms to combat the healthcare cost
                                                                                                                      • Rising healthcare cost is leading to legislative changes that are likely to see an increasing
                                                                                                                        penetration of generics in Europe
                                                                                                                      • 0.5bn people- aging population
                                                                                                                      • Low generic penetration




     10 March, 2010
                      Key challenges                         • Price Erosion                                          •   No long term generic medicine policies
                                                             • Competition                                            •   Limited transparency on prices and availability
                                                             • Stringent FDA regualtions                              •   Continued price linkage to originator products
                                                                                                                      •   Market entry delays due to post-market authorization procedures for establishing pricing
                                                                                                                          and re-imbursement status
                                                                                                                      •   Economic disincentives for pharmacists to dispense generic medicines
                                                                                                                      •   Lack of economic incentives for physicians to prescribe the generic medicines
                                                                                                                      •   Limited incentives for patients to request generic medicines
                                                                                                                      •   Evergreening of medicines

                      Indian company's presence              • US has always remained an important destination        • Indian companies have expanded their presence in the EU market through M&A
                                                               for Indian generic companies                           • Increased penetration of generic drugs in EU countries is long term positive for Indian
                                                             • Indian companies have scaled up their presence in        companies
                                                               the US market                                          • DRL was the second highest contract winner of AOK tender.
                                                             • Indian companies are ranked one among the top 5
                                                               companies in terms of ANDA and FTF filings
                                                             • Built up strong Para IV pipeline
                                                             • Companies like DRL and Lupin stand one among
                                                               the top 10 generic companies in the US
                                                             • Despite 90-95% price erosion, realizations are still
                                                               higher in the US

                      Key opportunities                      •   Large market share                                   •   Generics have yet to reach its full potential
                                                             •   Para IV monetization                                 •   Increased pace of generic penetration
                                                             •   Focus in the niche segment                           •   Some of the Western European markets still have low level of penetration
                                                             •   Biosimilars can be a key opportunity                 •   Central and Eastern European markets offer higher growth prospects
                                                                                                                      •   Bio-similars can be a key opportunity
                      Source: Emkay Research
                                                                                                                                                                                                                        Generic Pharma Sector




     13
Global Generics - Overview

                                                                                                                                                      Emerging markets
                                                             Japan                                                   Brazil                  Russia                 India                  South Africa
                      Nature of market                       Developing                                              Branded Generic         Branded Generic        Branded Generic        Branded Generic
                      Generic penetration                    17%                                                     20%                     30%                    70%                    40%




Emkay Research
                      Market size as of 2007 (US$ bn)        2.7                                                     1.5                     2.5                    6.6                    1
                      Expected market size by 2013 (US$bn)   4.9                                                     4.6                     5.2                    9.3                    1.5
                      CAGR                                   15%                                                     25%                     16%                    14-15%                 15%
                      Drugs going off patent (US$bn)
                      Regulatory Environment                 Encouraging generic usage                               Pro-generic             Pro-generic            Pro-generic            Pro-generic

                      Key growth drivers                     • Large number of patent expiries                       •   Improving economic condition
                                                             • Largely under penetrated nature of market             •   Aging population
                                                             • Government's initiative to encourage generic usage    •   Low per capita drug consumption
                                                                                                                     •   Higher purchasing power
                                                                                                                     •   Rapid growth in insurance sector
                                                                                                                     •   Increased prevalance of chronic diseases
                                                                                                                     •   Low penetration of modern medicine




     10 March, 2010
                      Key challenges                         • People’s perception and cultural difference towards   •   Upfront investment to establish front end marketing and distribution network
                                                               generic                                               •   Opportunities spread over 100 markets
                                                             • Prescribers' attitudes                                •   Government and regulatory interference
                                                             • Japanese patients perceive generics as inferior to    •   Acceptance of patent regime
                                                               branded products                                      •   Currency fluctuations
                                                                                                                     •   Competition


                      Indian company's presence              • The Indian pharma industry is diversifying its        • Indian companies have fairly large presence in some of the key emerging markets
                                                               geographical presence to reduce dependency on         • Indian pharma companies have higher familiarity with emerging market dynamics
                                                               US                                                    • Most of the Indian companies have built-up front end marketing and distribution network in
                                                             • Japanese generic market offers huge opportunity         these countries except Cipla, who mainly rely on partnership model
                                                             • Ranbaxy plans to capitalize Daiichi’s presence in     • With large product baskets, regulatory expertise, low costs and successful experience in
                                                               Japanese market                                         operating profitably in semi-regulated branded generic markets, India pharmas are targeting
                                                             • Lupin and Cadila have built presence the market         large opportunities in emerging markets


                      Key opportunities                      • Government provides traction for higher generic       • Emerging markets are likely to grow 5-6x faster than developed markets (expect this
                                                               utilization                                             market to be US$400bn by 2020)
                                                             • Under patented market                                 • Offers higher margins because of branded generics
                                                                                                                     • High entry barriers because of doctor relationship and brand equity
                                                                                                                     • Renewed interest of MNCs towards emerging markets




                      Source: Emkay Research
                                                                                                                                                                                                                     Generic Pharma Sector




     14
Generic Pharma Sector


                                         Indian generics: Well placed to capture the growing generic
                                         opportunities
Geographical         diversification,    Indian pharma companies, by virtue of their strong presence in the domestic pharma
dominance in a niche segment, Para       market, highest number of US FDA approved plants outside the US and considerable
IV pipeline and cost structure are the   exposure to developed generic markets are in the forefront for capitalizing opportunities in
qualifying parameters for a formidable   the generic space. Global presence, a wide and diversified product pipeline spread
generic player                           across multiple segments, presence in niche segments, strong FTF pipeline and
                                         integration across the product value chain coupled with lean cost structure are the key
                                         fundamental drivers for Indian generic companies. We have identified four parameters for
                                         a company to qualify as a formidable generic player. They are geographical well diversified
                                         business, dominance in a niche segment, Healthy Para IV pipeline and Lean cost structure.
                                         We believe that companies, which fare well on these parameters are well placed to cash
                                         in on generic opportunities. We have explained each of these parameters in detail below
                                         and have also rated the companies in our universe on each of these parameters.


                                         Geographically well diversified business
Widespread geographic footprint          Indian pharma companies operate in multiple geographies with a majority of their revenues
reduces earnings volatility and          coming from the sale of branded formulations in India and other semi-regulated markets.
enables them to capture oppurtunities    A widespread geographic footprint reduces earnings volatility, especially as traditionally
                                         lucrative markets such as US, Germany and UK have turned extremely competitive.
                                         Moreover, a well diversified geographical mix will enable them to cash in on the growth
                                         opportunities that different markets provide. Most Indian pharma companies are well
                                         diversified geographically, but Ranbaxy clearly has the widest global footprint, with products
                                         available in 125 countries, operations in 49 countries and manufacturing base in 8 of
                                         them. Cipla would be the second with exports to 175 countries mainly through a partnership
                                         model. DRL has built a significant presence in CIS/Russia as well as in Germany and US
                                         and the partnership with GSK will further strengthen its presence in the emerging markets.
                                         Sun Pharma has a strong presence in the US and exports formulations to 26 countries-
                                         mainly in the emerging markets. It is now diversifying into European territories. After
                                         building strong franchises in US, Japan, India and 22 countries in AAMLA region, Lupin is
                                         gearing to enhance its presence in other key markets such as EU territories and Latin
                                         American countries.


                                         Geographical presence

                                                        120%
                                                        100%
                                          (Revenue %)




                                                        80%
                                                        60%
                                                        40%
                                                        20%
                                                         0%
                                                               Ranbaxy     Cipla    Sun pharma   Dr Reddy       Cadila      Lupin
                                                                         US        EU    Emerging market      Japan

                                         Source: Emkay Research, Company



                                         Dominance in a niche segment
Dominance in a niche segment             Apart from having presence across various product categories, we believe that dominance
enables them to have pricing power       in a niche segment is a pre-requisite for becoming a major generic player. Dominance in
and better margins                       a niche segment enables them to have pricing power and better margins, which will
                                         largely insulate them from the tough competition in the generic space. A more specialized


Emkay Research                           10 March, 2010                                                                             15
Generic Pharma Sector


                                          focus on products that are difficult to manufacture or have limited generic competition,
                                          even though the target market may be small, differentiate them from 'me too' generic
                                          companies and reduce the sensitivity of earnings to price erosion. Most Indian generic
                                          players have already identified and are establishing themselves in a particular niche
                                          segment, which will afford them insulation against the vagaries of the highly competitive
                                          generics market. Cipla, with its dominance in inhalers, DRL in bio-similars, Sun Pharma
                                          in controlled substances and Lupin in oral contraceptives are working towards these
                                          directions.

                                          Building a niche in complex generics
                                                     Ranbaxy       Cipla       Sun pharma    Dr Reddy           Cadila        Lupin
                                          ANDAs      241                       107           159                92            90
                                          DMFs       271                       133           148                76            85
                                          Complex    Penem's       Inhalers    Controlled    Biosimilars        Transdermal   Oral
                                          generics                             Substances                       patches;      Contraceptives
                                                                                                                vaccines
                                          Source: Emkay Research


                                          Healthy Para IV pipeline
                                          The 180-day period of exclusivity for the first generic company is a very strong incentive for
                                          generic companies to stay ahead of the competition. Strong Para IV pipeline with potential
                                          FTFs not only provide 6-months exclusivity (one time profit) but also help to maintain
                                          leadership position in that molecule. Indian pharma majors are likely to derive significant
                                          benefit from some non-recurring Para IV earnings and their first mover advantage will
                                          also help them retain market share, even post exclusivity. Among Indian companies, we
                                          believe that DRL with 38 potential FTFs, Ranbaxy with 26 potential FTFs, Sun Pharma with
                                          24 potential FTFs and Lupin with 15 potential FTFs will benefit the most from this
                                          development. Cipla, on account of adopting the partnership model, has no Para IV pipeline.



                                          Para IV - product differentiation

                                           Dr Reddys                                                                                  38


                                             Ranbaxy                                                            26


                                                  Sun                                                      24


                                                Lupin                                 15


                                                        0          5          10     15      20            25        30        35       40
                                          Source: Emkay Research

                                          Lean cost structure
Companies with lean cost structure        Being cost competitive is one of the key ingredients of a successful global generic company.
and front end presence across region      While integration across the value chain from intermediate to formulation yields cost
will be better positioned to capitalize   advantages, forward integration by way of having front end distribution network lowers the
on generic opportunities                  risk of increasing competition and allows a company to capture large share of profit from
                                          a product. As it is difficult to predict the future revenue, the only thing which a company can
                                          do is to control cost. Our view is that companies with lean cost structure and front end
                                          presence in key geographies will be better positioned to capitalize on generic opportunities.
                                          Sun Pharma has the leanest cost structure with low fixed costs, while Ranbaxy and DRL
                                          (high manpower cost and other expenditures) are aggressively cutting cost by closing
                                          down their non-profitable operations.


Emkay Research                            10 March, 2010                                                                                   16
Generic Pharma Sector


                                   Cost structure of Indian companies
                                                            Ranbaxy    Cipla    Sun pharma      Dr Reddy     Cadila     Lupin
                                   Raw material cost            42%     47%               20%        34%          33%    42%
                                   GPM                          46%     53%               80%        66%          67%    58%
                                   Employee cost                13%      5%                8%        15%          11%    13%
                                   R&D cost                      6%      5%                7%         6%           5%     6%
                                   Other exp                    33%     23%               19%        25%          31%    21%
                                   OPM                           7%     19%               45%        20%          21%    19%
                                   Source: Emkay Research


                                   Scorecard of Indian pharma companies
                                   We believe that companies that can differentiate from competition by building niche product
                                   portfolios, novel drug delivery systems, chart a geographical diversified presence and
                                   sustain and nurture vertically integrated operations will benefit the most. We have ranked
                                   the companies on the basis of above parameters. As per our scorecard, Sun Pharma and
                                   DRL emerge as most preferred companies with the highest score of 17 each. Cipla and
                                   Cadila feature last with a score of 12 each.

Generic score card
Company                                        Parameters                                               Total Score
                   Geographical    Dominance in             Para IV                 Cost
                    presence      niche segment             pipeline              structure
Sun Pharma               3              5                      4                      5                      17
Dr Reddy                 4              5                      5                      3                      17
Ranbaxy                  5              5                      5                      1                      16
Lupin                    4              5                      3                      3                      15
Cipla                    4              5                      0                      3                      12
Cadila                   4              5                      0                      3                      12

Source: Emkay Research



                                   Expect earning CAGR of 28% over FY09-12E
                                   We expect our generic universe' revenues to grow at a CAGR of 15% over FY09-12E,
                                   driven by 23% and 19% growth in Cadila Healthcare and Lupin pharma respectively.
                                   $235bn patent expiry, double digit growth in the emerging markets and sustainable
                                   momentum in the domestic markets would be the key growth drivers going forward. We
                                   expect operating margins to expand by 215 bps to 21.7% over FY09-12E. We expect
                                   Ranbaxy’s margin to expand by 660bps and Cipla’s margin to expand by 310bps during
                                   the same period. We expect 15% revenue CAGR and strong operating performance to
                                   drive a 28% earning CAGR over FY09-12E.




Emkay Research                      10 March, 2010                                                                         17
Generic Pharma Sector
        Valuations
                                     Valuations

                                     Premium valuations to sustain
Premium valuations to sustain        Our universe currently trades at 20x (ex-Ranbaxy) FY11E EPS and 16x (ex-Ranbaxy) FY12E
because of 28% earning CAGR,         EPS. Current sector valuations are at a 20% premium to its 5 year average historical PE.
strong return ratios, low leverage   Historically, generics have traded at a 10-15% premium to the broader markets on account
(0.2x) and free cash flow            of consistent earnings growth, healthy balance sheet and non-cyclical nature. Going
                                     forward, we expect premium valuations to sustain because of 28% earning CAGR, strong
                                     return ratios, low leverage (0.2x ) and free cash flow. Moreover, we are of the view that
                                     because of emergence of innovator-generic partnership model, premium valuations for
                                     Indian pharma are likely to sustain.


                                     We expect our large cap universe to continue to trade at 20x one year forward PE (in-line
                                     with its 5 year mean multiple; 20% premium to sensex). However, in case of companies
                                     like Lupin and Cadila, who have historically traded at 5 year mean multiples of 13-14x
                                     (mid cap valuations), the gap to large cap multiple is narrowing down as these companies
                                     have gradually moved into the league of big pharma companies and we expect this gap
                                     (trading at 20% discount to comparable peers) to further narrow down. We initiate coverage
                                     on Cipla, Sun Pharma and Ranbaxy with an Accumulate, Hold & Sell rating respectively.
                                     Lupin, DRL and Cadila are our top picks in the sector.


                                     Historically, the pharma sector has outperformed in times of uncertainty as well as downturn
                                     and has underperformed when the market is bullish. As the broader market is likely to
                                     remain zigzag, we are of the view that investors will continue to hold pharma stocks to
                                     balance their high beta exposure. Apart from appreciating currency coupled with company
                                     specific issues, the sector is largely insulated from the concerns that prevail in a slowdown.

                                     Lupin, DRL and Cadila are our top picks
                                     Cadila Healthcare
                                     Cadila Healthcare emerges as our top pick given its strong growth prospects, wide
                                     geographical reach, foray into difficult to manufacture generics and attractive valuations.
                                     We expect Cadila's earnings to grow at 27% CAGR over FY10-12E on the back of strong
                                     growth in its international business, steady growth from domestic operations & meaningful
                                     contribution from Hospira JV. We believe that over time, Cadila's Hospira JV will not only
                                     make up for losses on its Nycomed JV but also add to Cadila's overall profitability. Despite
                                     ascribing 10% discount to sector multiple because of low generic score (12, last in the
                                     universe), its discounted valuations are sufficient to provide huge upsides. Our fair value
                                     for Cadila is Rs962 (18xSep'11E), an upside potential of 22%. The fact that Cadila has
                                     surpassed all our estimates since we initiated coverage on the stock, increases our
                                     confidence in its ability to meet our future estimates. We re-iterate our Buy rating on the
                                     stock with a target price of Rs962.


                                     Cipla Ltd
                                     We initiate coverage on Cipla with an Accumulate rating and a price target of Rs366. Apart
                                     from being the largest Indian pharma company by market size, it is one of the most
                                     diversified companies with presence in more than 175 countries. Its strategy for export is
                                     built around supply chain model and tie-ups with global players, without investing in
                                     building up front-end presence. We are of the view that huge capacity expansion made
                                     over last four years will start delivering now, improving its RoCE, going forward. Moreover,
                                     despite significant capex, Cipla's balance sheet continues to remain healthy with a D/E of
                                     0.2x and expect company to generate net free cash flow from FY11E onwards. We expect
                                     earnings CAGR of 18% over FY10-12E driven by a) 11.8% CAGR in domestic market,



Emkay Research                       10 March, 2010                                                                             18
Generic Pharma Sector


                 b) 12.6% CAGR in export formulation. Since Cipla has adopted the tie-up route in the
                 generic space, it has no Para IV pipeline, resulting in it being one of the lowest scorers
                 (generic score of 12). However, its dominance in the lucrative inhaler space and established
                 business model makes it a low risk bet on the generic opportunity. As a result, we have
                 valued Cipla in line with the sector average (20x Sep'11 EPS of Rs18.3) and arrived at a
                 target price of Rs366 (upside of 16%). Signing of MNC contracts and launch of inhalers in
                 EU could be potential upside triggers.


                 Dr Reddy’s Laboratories (DRL)
                 DRL, with the highest score of 17 on our generic scorecard, is among the best bets to buy
                 into the generic growth story. Its well diversified geographic reach, strong presence in the
                 high growth potential biosimilars space, healthy Para IV pipeline and strong earnings
                 growth are likely to ensure upside potential from the current level. Strong growth in base
                 business (barring Betapharm), revenue upsides from its Omeprazole OTC launch and its
                 GSK alliance are likely to result in a 38% earnings CAGR over FY10-12E. Despite 38%
                 out-performance to broader market over the last six months, we continue to remain positive
                 on the stock and reiterate our buy rating with a target price of Rs1478, an upside potential
                 of 26%.


                 Lupin Laboratories
                 Lupin's outperformance across segments along with its well charted growth strategy
                 makes it our best bet in the Indian generic pharma space. We expect Lupin's earnings to
                 grow at 24% CAGR over FY10-12E driven by a) strong growth across the key geographies,
                 b) launch of oral contraceptives in the US market, c) increasing generic penetration in the
                 Japanese market and d) 200 bps operating margin expansion in next 3 years. Lupin, third
                 in our generic scorecard (score of 15), with its well diversified geographical reach, foray
                 into high growth oral contraceptive segment along with attractive Para IV pipeline is an
                 attractive investment proposition because of its valuation discount to large cap peers
                 (20%). Despite 57% absolute return and 47% outperformance to broader market over the
                 last six months, strong execution across the markets and increasing visibility in revenue
                 and earnings (17% and 24% CAGR over FY10-12E), makes Lupin our preferred pick in
                 the large cap pharma space. With the Mandideep issue getting resolved in favor of Lupin,
                 we are of the view that Lupin should now trade in-line with its large cap peers. We re-
                 iterate our Buy rating on the stock with a target price of Rs2111 (20x Sep'11 EPS of
                 Rs104.5; NPV of Rs22/share for Para IV).


                 Ranbaxy Labs
                 We initiate coverage on Ranbaxy with a Sell rating and a price target of Rs329. With
                 dominance in niche segments such as penems, strong para IV pipeline coupled with
                 well diversified geographical reach, Ranbaxy features second in our generic scorecard
                 (score of 16). Our base business earnings of Rs6 and Rs11 for CY10E and CY11E factors
                 a gradual improvement in the base business as we believe that most of the initiatives will
                 start contributing from CY11E onwards. We have valued its FTF pipeline on NPV basis
                 unlike the practise of treating FTF as recurring earnings.This itself has brought a valuation
                 difference of Rs95 per share. We have arrived at a price target of Rs 329, assigning
                 Rs220 for its base business (20xCY11E) and Rs 109per share as NPV of FTF pipeline.
                 Though we are positive on the long term prospects of the company, we believe that current
                 valuations are way ahead of actual improvement in the business and hence, recommend
                 a sell on the stock. Earlier than expected resolution of FDA issue at Dewas or strong
                 earning visibility from CY11E onwards are positive catalysts to the stock price.




Emkay Research   10 March, 2010                                                                            19
Generic Pharma Sector


                 Sun Pharma
                 We initiate coverage on Sun Pharma with a Hold rating and a price target of Rs1644. Sun
                 Pharma's strong foothold in the domestic formulation business, robust pipeline for
                 regulated markets and healthy balance sheet are the positives, which will enable it to
                 maintain its leadership position.


                 While Sun Pharma ranks high on parameters like dominance in niche segments such as
                 controlled substances and attractive para IV pipeline, it is its lean cost structure that gives
                 it a distinct advantage over its peers. We have ascribed 10% premium to sector multiple
                 because of its high generic score (17). Our fair value for Sun Pharma works out to Rs1644
                 (22x Sep'11E base business EPS; NPV of Rs66/share for Para IV pipeline; Taro Investment-
                 Rs30/share). Despite ascribing 10% premium because of high generic score, our target
                 price of Rs1644 does not offer much upside from the current levels. Earlier than expected
                 clearance of Caraco, visibility of high end product launches or successful acquisition of
                 Taro are potential positive catalysts to the stock price. Delay in clearance of Caraco could
                 impact our numbers adversely.




Emkay Research   10 March, 2010                                                                              20
Generic Pharma Sector
      Sector Risks
                     Sector Risks

                     Increasing scrutiny by the US FDA
                     The US FDA has become increasingly stringent about Good Manufacturing Practices
                     (GMPs) in order to maintain the quality of drugs to be supplied in the US. This has resulted
                     in a sharp rise in Form 483 and warning letters, even at minor deviations. Till date, FDA
                     has issued 5 warning letters compared to 12 and 16 in 2009 and 2008 respectively.
                     Indian companies like Ranbaxy, Caraco (US subsidiary of Sun Pharma), Lupin and Cipla
                     (already cleared) are under the FDA scanner. We are of the view that managing regulatory
                     issues have become a big challenge for Indian generic companies.

                     Currency movements
                     68% of our universe revenues come from exports and most of it is dollar denominated.
                     Movement in currency adversely impacts the profitability of the companies. Our universe
                     is exposed to various cross currencies and therefore, the impact of currency movement
                     on their profitability is difficult to estimate.

                     Pricing pressure in the US
                     Higher than expected pricing pressure for the US generic business can further erode the
                     profitability of the companies. We have currently built in 10% price erosion in the base
                     business.

                     Healthcare reforms in EU territories can lead to tender systems
                     Spiraling healthcare costs in developed countries have resulted in introduction of various
                     bills to encourage generic penetration in the EU territories. In order to further restrict their
                     healthcare spending, Germany, last year adopted the tender model moving away from the
                     branded generic market. This has hurt the profitability of the companies. If this model
                     becomes successful, then many countries may be encouraged to adopt it, which can
                     further put pressure on companies in our universe.

                     Increasing competitive landscape for emerging markets
                     With global pharma companies targeting the emerging markets for growth, there is a fair
                     possibility of price wars in these geographies. We believe this can impact the profitability
                     of Indian companies and therefore, the valuations also.

                     Domestic drug policy
                     Indian government's proposal to expand the scope of price controls from existing 74
                     drugs to 354 drugs might impact domestic formulation business of Indian pharma
                     companies. Generally, domestic business contributes 20-50% of overall revenue and 30-
                     60% of recurring EBIDTA.




Emkay Research       10 March, 2010                                                                               21
Generic Pharma Sector




                 Companies
                 Cadila Healthcare Ltd.
                 Cipla Ltd.
                 Dr Reddy's Laboratories Ltd.
                 Lupin Ltd.
                 Ranbaxy Laboratories Ltd.
                 Sun Pharma Industries Ltd.




Emkay Research   10 March, 2010                                    22
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest
Generic pharma sector; differentiating the best from the rest

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Generic pharma sector; differentiating the best from the rest

  • 1. Emkay Research Generic Pharma Sector BAL DifferentiatingG L lO c a l from the rest the obest Geographically Dominance in a niche well diversified business segment Global Generics US$135bn Healthy Para IV pipeline Lean cost structure n Generic markets to become a US$135bn market by 2013 n Varied growth triggers for different geographies n Our generic scorecard ranks companies on their ability to become global generic players n Lupin, DRL and Cadila are our top picks Reco Company CMP (Rs) TP (Rs) BUY Cadila Healthcare Ltd. 787 962 ACCUMULATE Cipla Ltd. 314 366 BUY Dr Reddy's Laboratories Ltd. 1168 1478 BUY Lupin Ltd. 1585 2111 SELL Ranbaxy Laboratories Ltd. 453 329 HOLD Sun Pharma Industries Ltd. 1655 1644 March 2010 Manoj Garg Research Analyst-Pharma manoj.garg@emkayglobal.com +91 22 6612 1257 Akshat Vyas Research Associate akshat.vyas@emkayglobal.com +91 22 6612 1491
  • 2. Generic Pharma Sector Content Synopsis 3 Valuation Matrix 6 Investment Argument 8 Generic industry: greener pastures 8 US$135bn opportunity awaits generic drugs by 2013 8 Key growth drivers for generics 9 Key geographies: macro environment and growth drivers 11 Global Generics - Overview 13 Indian generics: Well placed to capture the growing generic opportunities 15 Scorecard of Indian pharma companies 17 Expect earning CAGR of 28% over FY09-12E 17 Valuations 18 Premium valuations to sustain 18 Top picks 18 Sector Risks 21 Companies Cadila Healthcare Ltd. 23 Cipla Ltd. 27 Dr Reddy's Laboratories Ltd. 37 Lupin Ltd. 41 Ranbaxy Laboratories Ltd. 45 Sun Pharma Industries Ltd. 57 Emkay Research 10 March, 2010 2
  • 3. Generic Pharma Sector Synopsis Synopsis The generic pharma industry has evolved and grown over the years to become a US$87bn market, with the potential of touching US$135bn by 2013. However, with time, the growth opportunities have shifted from being solely US centric to a global one as economies around the globe are increasingly favoring generics. Too much of focus and dependence on any single market is turning out to be a risky proposition. We believe that generic players have to be dynamic in their approach if they want to fully capitalize on the growth opportunities that the sector offers. We have identified four parameters, which will enable them to tackle the diverse issues across geographies and emerge as strong players in the generic space. They are - a) Geographically well diversified business, b) Dominance in a niche segment, c) Healthy Para IV pipeline and d) Lean cost structure. We believe that these parameters will ensure that a generic player is able to capitalize on the opportunities available across regions and also grow profitably in the highly competitive generic space. We have assessed the companies in our universe on each of these parameters and assigned scores accordingly. Sun Pharma and DRL emerge as the highest generic scorers with a score of 17 each, while Cadila and Cipla rank lowest with a generic score of 12 each. We have rated the companies on the basis of their generic score, earnings growth and valuations. As a result, we have rated Sun Pharma and Ranbaxy as a Hold and Sell respectively, despite them scoring high on our generic scorecard owing to expensive valuations. Similarly, Lupin and Cadila are our top picks despite lower generic scores on account of the immense upside potential (34% and 22%) that they offer from current levels. Lupin, DRL and Cadila are our top picks. We initiate coverage on Cipla with an Accumulate rating, Sun Pharma with a Hold rating and Ranbaxy with a Sell rating. We have a positive bias on all these stocks and will upgrade our ratings on Cipla, Sun Pharma and Ranbaxy, subject to materialization of the positive triggers that we have anticipated for each of them. Generic markets to become a US$135bn market by 2013 We believe the growth drivers for generics are clear and sustainable. We expect the generic industry to grow at a faster pace (9% CAGR over CY08-13E) compared to the overall pharmaceutical market (2-3% CAGR over CY08-13E). The global generic market, which stands at US$87bn, is likely to grow at 9% CAGR over CY08-13E to US$135bn on the back of a) drugs worth US$235bn going off patent over FY10-15E, b) tripling of elderly population (60+ population-700mn in 2005 to 1900mn by 2050), c) spiraling healthcare expenses across the globe and d) favorable government policies. Varied growth triggers for different geographies We are of the view that while we expect generics to grow across geographies, the factors driving growth for generics are varied. To elaborate further - In the US - the largest generic market - generic usage is being driven by a) pro-generic environment, b) huge patent expiry, c) rising healthcare cost. In the EU territory, we are of the view that the generic industry has yet to reach its full potential. Pro generic policies will drive growth in the more developed Western EU markets while Central and East European (CEE) markets offer higher growth prospects because of low generic penetration and lower per capita spending on drugs. Similarly, Japan is going to be the most exciting market for generic companies on account of a) It being the second largest pharmaceutical market in the world, b) low generic penetration and c) government initiative to promote generic usage. Though developed markets continue to remain critical markets because of their sheer size, developing markets are emerging as a compelling opportunity because of higher growth prospects. We expect the generic opportunity outside the US, western EU and Japan to Emkay Research 10 March, 2010 3
  • 4. Generic Pharma Sector reach US$92bn by 2013 (CAGR of 11.5% over CY08-13E). Emerging geographies offer higher growth potential on the back of a) rising prevalence of life-style related diseases, b) aging population, c) increasing per capita spend, d) lower penetration of modern medicine and e) increasing insurance penetration. We have identified four parameters essential for becoming generic majors While there exists huge opportunity in the generic space, we believe that to become a major generic player calls for certain requirements. We have identified four parameters, which will enable companies to become strong contenders for generic opportunities. Geographically well diversified business - Too much of focus and dependence on any single market is turning out to be a risky proposition. In order to capitalize on the growth opportunities that different regions offer, a well diversified geographical presence is a must. Dominance in a niche segment - In order to remain profitable in the highly price sensitive generic market, it is advantageous to have dominance in a niche segment, which will provide the much required hedge against price erosion in the competitive generic segments. Healthy Para IV pipeline - will boost profitability and also ensure a competitive edge post the exclusivity period Lean cost structure - to ensure profitable growth We believe that companies that can differentiate from competition by building niche product portfolios, novel drug delivery systems, chart a geographically diversified presence and sustain and nurture vertically integrated operations will benefit the most. We believe that companies, which fare well on these parameters, are well placed to cash in on generic opportunities. Our generic scorecard ranks companies on their ability to become global generic players We believe that companies which fare well on the above mentioned parameters, are well placed to cash in on generic opportunities. We have rated and assigned scores to the companies in our universe on each of these parameters and have arrived at an overall generic scorecard. As per our scorecard, Sun Pharma and DRL emerge as most preferred companies with the highest score of 17 each. Cipla and Cadila feature last with a score of 12 each. Cipla scores low because of absence of Para IV pipeline as it has adopted partnership model. We have valued companies in our universe using valuation tools that best capture their value. Based on their generic score, we have valued them at premium, par or discount. Generic score card Company Parameters Total Score Valuation Criteria Geographical Dominance in Para IV Cost presence niche segment pipeline structure Sun Pharma 3 5 4 5 17 10% premium to sector multiple Dr Reddy 4 5 5 3 17 15% premium to its 5 year mean multiple Ranbaxy 5 5 5 1 16 5% premium to sector multiple Lupin 4 5 3 3 15 In-line with the sector multiple Cipla 4 5 0 3 12 In-line with sector multiple because of low risk business model Cadila 4 5 0 3 12 10% discount to sector multiple Source: Emkay Research Emkay Research 10 March, 2010 4
  • 5. Generic Pharma Sector Initiate coverage on Sun Pharma with Hold rating, Ranbaxy with Sell rating and Cipla with Accumulate rating We initiate coverage on Sun Pharma with a Hold rating and Ranbaxy with a Sell rating. Given their high generic scores, we have ascribed 10% and 5% premium to Sun Pharma and Ranbaxy, arriving at a price targets of Rs1644 and Rs329 respectively. Despite this premium, we believe that current valuations are expensive. We believe that the growth prospects for Sun Pharma and Ranbaxy in the generic space are extremely promising. They are however, marred by US FDA ban on certain facilities (Caraco for Sun and Paonta Sahib and Dewas for Ranbaxy). While we are confident that the worst is behind and that these issues will be resolved in the near future, we have not factored the potential upsides from a positive outcome on these issues. We shall be keenly watching the developments and will revise our rating on the stocks when clarity emerges. We initiate coverage on Cipla with an Accumulate rating as our current estimates have not factored in the upsides from launch of combination inhalers in EU. Despite a low generic score (12) due to the absence of Para IV filing, we value Cipla in line with the sector average because we believe that its dominance in the lucrative inhaler space and established business model makes it a low risk bet on the generic opportunity. Lupin, DRL and Cadila are our top picks We re-iterate our Buy rating on Lupin, DRL and Cadila with price targets of Rs2111, Rs1478 and Rs962 respectively. Lupin, third in our generic scorecard (score of 15), with its well diversified geographical reach, foray into high growth oral contraceptive segment along with attractive Para IV pipeline is an attractive investment proposition because of valuations discount to its large cap peers (20%). Lupin provides the highest upside (34%) in our universe with a price target of Rs2111 (20xSep'11 EPS; NPV of Rs22/share for Para IV pipeline). DRL, with the highest score of 17 on our generic scorecard, is among the best bets to buy into the generic growth story. We have ascribed a 15% premium to its 5 year average multiple and valued the company in line with the sector multiple of 20x Sep'11 EPS and arrived at a target price of Rs1478 (20xSep'11 EPS; NPV of Rs77/share for Para IV pipeline), an upside potential of 26%. Cadila, despite featuring last in our generic scorecard, is one of our top picks. Even after ascribing a 10% discount to sector multiple, our fair value of Rs962 (18xSep'11E) provides an upside potential of 22%. We believe that strong earnings growth and visibility in Cadila and Lupin compensate for its lower generic scores and provide huge upsides from the current levels. We have valued the companies on the average of FY11E and FY12E earnings reflected as on September’11 EPS. Emkay Research 10 March, 2010 5
  • 6. Valuation Matrix CADILA CIPLA DR REDDY 2009 2010 2011 2012 2009 2010 2011 2012 2009 2010 2011 2012 Financials (Rs mn) Sales 29275 37734 45673 54626 52343 58299 65990 75313 68830 72727 86682 100626 Emkay Research Sales (base) 63566 70338 79985 90141 EBIDTA 6058 8164 9797 11706 12218 15135 17312 19854 14749 15594 21170 26205 EBIDTA (base) 9718 11910 14565 16916 PAT 3272 5077 6391 8182 9719 11305 13610 15745 7571 9481 13680 18066 PAT (base) 4301 8087 10458 13134 Growth (%) Sales 26 29 21 20 24 11 13 14 38 6 19 16 Sales (base) 30 11 14 13 EBIDTA 32 35 20 19 47 24 14 15 93 6 36 24 EBIDTA (base) 31 23 22 16 PAT 24 55 26 28 51 16 20 16 127 25 44 32 PAT (base) 124 88 29 26 Profitability (%) 10 March, 2010 EBIDTAM 21 22 22 22 23 26 26 26 22 22 25 27 EBIDTAM base 16 17 19 19 PATM 11 14 14 15 19 19 21 21 11 13 16 18 PATM base 7 12 13 15 RoE 29 35 33 31 19 22 22 22 19 24 28 28 RoCE 22 26 29 32 20 21 22 22 16 20 28 31 Per Share Data (Rs) EPS 24.0 37.2 46.9 60 12.1 14.1 17.0 20 45 56 81 107 EPS Base 26 48 62 78 CEPS 32.2 46.4 56.9 71 11.5 16.0 19.7 23 75 81 108 137 BVPS 89 123 165 218 55.9 72.2 84.2 98 209 257 329 425 DVPS 4.5 5.0 5.0 7 2.0 3.4 4.2 5 6 7 8 10 Valuation (x) P/E 29.1 18.8 14.9 11.6 26.1 22.4 18.6 16.1 26 21 14 11 CPER 21.7 15.0 12.3 9.9 27.5 19.8 16.1 14.0 16 14 11 9 P/BV 7.8 5.7 4.2 3.2 5.6 4.4 3.8 3.2 5.6 4.5 3.5 2.7 EV/Sales 3.7 3.1 2.5 2.0 5.1 4.6 4.0 3.4 3.1 2.9 2.3 1.9 EV/EBIDTA 17.4 12.7 10.4 8.3 26.8 20.7 17.7 15.1 14.3 13.1 9.3 7.0 Dividend Yield (%) 0.6 0.7 0.7 0.9 1 1 1 2 0.5 0.6 0.7 0.9 Turnover (Days) Debtors Turnover 61 56 55 55 134.5 133.2 133.2 133.2 77 72 70 70 Inventory Turnover 76 75 75 75 101.5 100.8 100.4 100.4 71 72 71 70 Gearing Ratio (x) Net Debt/Equity 0.84 0.51 0.28 0.1 0.2 -0.01 -0.04 -0.1 0.4 0.2 0.0 -0.2 Generic Pharma Sector Source: Emkay Research, Company 6
  • 7. Valuation Matrix LUPIN RANBAXY SUN PHARMA 2009 2010 2011 2012 2008 2009 2010 2011 2009 2010 2011 2012 Financials (Rs mn) Sales 38523 47346 56526 64749 74214 75970 84753 91777 41870 40515 45218 49765 Emkay Research Sales (base) 71854 70157 71780 78453 34448 33861 41389 50269 EBIDTA 7284 9565 12241 14163 5732 7124 13052 15014 18676 13465 16116 16978 EBIDTA (base) 5242 3055 4666 8630 11702 8973 12830 16589 PAT 5058 6559 8438 10109 2597 4338 8212 8910 18178 13622 15297 16596 PAT (base) 2254 1693 2549 4639 12947 10288 12818 16315 Growth (%) Sales 41 23 19 15 9 2 12 8.3 27.1 -3.2 11.6 10.1 Sales (base) 8 -2 2 9 28.8 -1.7 22.2 21.5 EBIDTA 61 31 28 16 -37 24 83 15 20.2 -27.9 19.7 5.4 EBIDTA (base) 25.2 -23.3 43.0 29.3 PAT 51 30 29 20 -53 67 89 9 22.3 -25.1 12.3 8.5 PAT (base) -57 -25 51 82 26.5 -20.5 24.6 27.3 Profitability (%) 10 March, 2010 EBIDTAM 19 20 22 22 7.7 9.4 15.4 16.4 44.6 33.2 35.6 34.1 EBIDTAM base 7.3 4.4 6.5 11.0 34.0 26.5 31.0 33.0 PATM 13 14 15 16 3 6 10 10 43.4 33.6 33.8 33.3 PATM base 3 2 4 6 37.6 30.4 31.0 32.5 RoE 37 36 33 32 7.3 9.9 17.4 17.2 31.2 18.5 17.9 17.0 RoCE 25 28 30 32 -0.6 7.5 12.3 15.5 27.4 14.9 15.8 14.5 Per Share Data (Rs) EPS 57 74 95 114 0.0 0.0 0.1 0.1 87.8 61.3 73.9 80.1 EPS Base 0.0 0.0 0.0 0.0 62.5 49.7 61.9 78.8 CEPS 67 88 115 135 6.2 10.3 19.5 21.2 68.5 57.2 70.0 87.5 BVPS 172 251 318 399 5.4 4.0 6.1 11.0 340.1 394.0 454.5 520.1 DVPS 13 18 24 28 88.4 22.7 15.6 13.6 27.5 20.3 22.8 24.8 Valuation (x) P/E 28 21 17 14 73.3 43.9 23.2 21.4 18.9 27.0 22.4 20.7 CPER 23 18 14 12 35.1 27.1 17.2 16.0 24.2 28.9 23.6 18.9 P/BV 9 6 5 4 4.4 4.3 3.8 3.6 4.9 4.2 3.6 3.2 EV/Sales 4 3 3 2 2.9 2.8 2.5 2.3 7.8 7.9 6.9 6.0 EV/EBIDTA 19 16 14 11 88.4 22.7 15.6 13.6 17.6 23.7 19.2 17.6 Dividend Yield (%) 1 1 2 2 0.0 0.7 1.1 1.2 1.7 1.2 1.4 1.5 Turnover (Days) Debtors Turnover 99 98 98 98 66.2 65.8 62.3 62.3 75.8 108.0 108.0 108.0 Inventory Turnover 91 91 91 91 97.7 96.5 91.8 88.2 84.0 86.4 86.4 86.4 Gearing Ratio (x) Net Debt/Equity 0.8 0.3 0.1 0.0 0.4 0.3 0.3 0.3 -0.2 -0.3 -0.4 -0.4 Generic Pharma Sector Source: Emkay Research, Company 7
  • 8. Generic Pharma Sector Investment Argument Investment Argument Generic industry: greener pastures By 2050, world population of the 60+ The growth outlook for generics remains robust. An aging population, rising healthcare age group is expected to jump 2.7x to spending and increasing acceptance, coupled with favorable government policies are 1.9bn. key growth drivers for generics. By 2050, the world population of the 60+ age group is expected to jump 2.7x to 1.9bn. As elderly people consume 66% more medicine than the younger group, this jump is likely to further pressurize healthcare costs of developed countries. The healthcare costs of developed countries have already been growing faster than their GDP. As more brand-name drugs come off patent and payers push for cost cuts in health care, the demand for generics are likely to scale new highs. Global generic market to grow at a Overall, we expect the global generic market to grow at a CAGR of 9% to US$135bn by CAGR of 9% to US$135bn by 2013 2013, which will be higher than the growth of the branded pharmaceutical market. We are of the view that non-US markets will be the key growth drivers and will grow faster than the developed markets. The share of the US generic market is likely to come down from 20% to 16% by 2013. US$135bn opportunity awaits generic drugs by 2013 Generic opportunity outside the US, The global generic market, which stands at US$87bn as on CY2008 (IMS Health) is likely Western EU and Japan to reach US$ to grow to US$135bn by 2013 (CAGR of 9%). Though US would continue to remain the 92 bn by 2013 largest generic market (currently 20% of total generic market), emerging markets are likely to grow at a faster pace and narrow the gap going further. We expect the generic opportunity outside the US, Western EU and Japan to reach US$92 bn by 2013 from the current level of US$53bn (CAGR of 11.5% over CY08-13E). Generic industry growth estimates 160 140 $135b 120 100 $87b $50b US$ bn 80 60 40 20 0 2008 2013 North America Europe International Source: Emkay Research, Teva Generic penetration in key markets 70% 64% 65% 60% 54% 50% 50% 40% 30% 17% 17% 20% 12% 7% 10% 0% France US UK Germany Japan Netherlands Spain Italy Source: Emkay Research, Stada Emkay Research 10 March, 2010 8
  • 9. Generic Pharma Sector Key growth drivers for generics Patent expiries, rising healthcare costs coupled with aging population and favorable government policies are the key drivers of increased generic penetration the world over. Drugs worth US$235bn are likely to go off-patent over 2010-2015 Patent expiry likely to open a plethora Drugs worth US$235bn are likely to go off-patent over 2010-2015. With high profile drugs of opportunities for generics like Lipitor (US$13.5bn) and Plavix (US$8.7bn) going off-patent in 2011, the global pharma market is likely to see a further slowdown in sales. Other key products going off-patent in the next five years are Takepron (Lansoprazole; US$4.2bn revenue; 2009), Seretide (Salmetrol + Fluticasone; US$7.7bn; 2010), Effexor (Venlafexine, US$4bn, 2010), Seroquel (Quitapine, US$5.4bn, 2012) and Nexium (Esomeprazole, US$7.9bn, 2014), etc. These patent expirations are likely to open a plethora of opportunities for generics and ensure that their growth momentum is maintained. Generic growth driven by patent expiries ($bn) 121 235 114 2010 - 2012 2013 - 2015 Total Source: Emkay Research, Teva 2010-2014 - Key patent expiries 2010 2011 2012 2013 2014 Arimidex US Plavix Symbicort Oxycontin Nexium Cozaar/ Hyzaar Advair Seroquel Cymbalta Copaxone Aricept Zyprexa Avapro Zometa Actonel Taxotere Femara Avandia Yasmin Micardis Lipitor Singulair Xalatan Diovan Viagra Detrol Geodon Lovenox Avapro Source: Emkay Research, Industry Spiraling healthcare expenses indicate greater acceptance of generics Healthcare expenditures of OECD With spiraling healthcare expenses across the globe, the acceptance of generics is countries (ex-US) are likely to rise to steadily increasing. In a bid to cut healthcare costs, countries hitherto using only branded 16% of their GDP by 2020 drugs are gradually resorting to use of generics. As a result, branded markets like Germany are resorting to use of generic drugs. Similarly, we have also seen a steady increase in the generic penetration of developed markets like US, UK. The healthcare expenditures of OECD countries (ex-US) are likely to rise to 16% of their GDP by 2020 (currently, it is 10% of GDP). By 2020, the US is likely to spend around 21% of GDP on healthcare from the current level of 16%. In all, the US will spend approximately US$10tn by 2020. Curtailment of this uptrend is a very significant factor driving generic growth. Emkay Research 10 March, 2010 9
  • 10. Generic Pharma Sector Healthcare spending as % of GDP in the US 17% 15% 12% 9% 7% 1970 1980 1990 2003 2008 Source: Emkay Research, Teva Graying planet Elderly people consume 66% more Growing proportion of elderly population is expected to add to the already burgeoning medicine than the younger group healthcare costs in both developed as well as developing countries. As per WHO estimates, global elderly population (65+) is expected to almost double from 480mn in 2000 to 800mn by 2025. As per industry estimates, there are currently 30 pension eligible elders in the developed world for every 100 working age adults. By the year 2040, there will be 70 elders for every 100 working adults. Elderly people consume 66% more medicine than the younger group, further adding to healthcare costs. World population by age (in bn) 9.1 1.9 6.5 60 above 0.7 2.3 40 to 59 1.4 2 2.5 20 to 39 2.4 2.4 0 to 19 2005 2050 Source: Emkay Research, Teva Biosimilars: the future Between 2010 and 2015, biotec drugs Generic biologics or Biosimilars have the potential to be the next growth driver for the worth US$101bn are set to loose generic industry. Biosimilars promise remarkable cost-savings for spiraling healthcare patent protection budgets. Yet, the full potential can only be harvested when a number of significant markets, regulatory and clinical hurdles have been overcome globally. There is still lack of clarity for product launches in the US market. However, Europe has already begun to approve generic biologics and till date has approved 13 biosimilars for launch. Biosimilar legislation is evolving rapidly in other countries as well. Other national authorities have already successfully addressed the biosimilar regulatory and legal framework, prominent among them being Australia, Canada, Malaysia and Japan. On October 5, 2009, the Japanese government has approved the first biosimilar. However, progress in the US, the most lucrative biopharmaceuticals market with two thirds of global biological sales, is still painfully slow. Legislation has been introduced in Congress to provide a similar pathway for approval and regulation of generic biologics in the US. Now that this legislation has the backing of the Obama administration, we expect the first biosimilar approval in 2011. Between 2010 and 2015, biotec drugs worth US$101bn are set to loose patent protection. Emkay Research 10 March, 2010 10
  • 11. Generic Pharma Sector Biologics patent expiry ($ bn) 20 9 59 8 2 1 1 1 Number of 1 3 4 2 3 9 7 16 45 molecules Source: Emkay Research, Industry The impending expiry of several patented blockbuster biopharmaceuticals and the increasing demand from patients, insurers, and government agencies to reduce drug costs have created numerous opportunities in the global biosimilar markets. This is new territory for most generic players with the commercial rewards of their foray paying off in the long run. Key geographies: macro environment and growth drivers US generic market to grow at a CAGR Our analysis of macro and micro environments of key geographies clearly reveals that of 5% to US$22 bn over 2008-13 each of the markets present ample opportunities and challenges in terms of generic usage. To put things in perspective, despite multiple challenges, US continues to remain the largest and most exciting market in the generic space. The generic penetration in the US is as high as 65%. The new healthcare bill under discussion, proposes to discount prices of certain drugs by 50% from their current levels and provide coverage for people currently not eligible for coverage (15% of US population). Though the new bill is expected to act as a disincentive to research and innovation, it is expected to provide a big impetus to generic drug manufacturers globally. Pro-generic environment, huge patent expiry (drugs worth US$94 bn are likely to go off-patent in next 5 years) and rising health care costs are some of the key growth drivers for increased generic usage, going forward. We expect this market to grow at a CAGR of 5% to US$22 bn over 2008-13. CEE generic markets offer significant Similarly, we are of the view that the EU generic industry has yet to reach its full potential. growth opportunity (12-13%) The EU generic industry is highly fragmented and on the basis of usage, can be classified as mature generic markets (generic penetration of more than 40%) and developing generic markets. Countries having pro-generic policies such as Germany (generic penetration 59%), UK, Denmark, Netherland and Poland are the mature generic markets, while countries like France, Italy and Spain, where the current generic penetration is very low are developing generic markets. These developing generic markets offer significant growth opportunity (12-13%), going forward. Japan is aiming to raise its generic Similarly, Central and East European (CEE) markets offer higher growth prospects because exposure to 30% of volume by 2012 of low generic penetration and lower per capita spending on drugs (10-30% of Western Europe). On the other hand, Japan, the world's second largest pharmaceutical market, is expected to be the most exciting market for generic companies, going forward. While the Japanese pharma market constituted 9.9% of global sales in 2008, it had one of the world's lowest consumption rates for generic drugs. Japan, which currently has 19% generic penetration in volume and 4% in value (US$2.7bn), is aiming to raise its generic exposure to 30% of volume by 2012. Emkay Research 10 March, 2010 11
  • 12. Generic Pharma Sector Emerging geographies offer higher Though developed markets continue to remain critical markets because of their sheer growth potential size, developing markets are emerging as a compelling opportunity because of higher growth prospects. Although, the generic market value of these countries are not as impressive as mature markets, most are experiencing tremendous growth rates compared to the modest 2-5% growth seen in the US and Europe. We are of the view that emerging geographies like India, Brazil, China, Russia, Mexico, Turkey and South Africa offer higher growth potential on the back of a) rising prevalence of life-style related diseases, b) aging population, c) increasing per capita spend, d) lower penetration of modern medicine and e) increasing insurance penetration. Being branded generic in nature, these markets not only offer higher margins but also have strong entry barriers because of doctor relationship and brand equity. We expect these pharemerging markets to grow at a sustainable rate of 12-13% over the next decade to become a US$400bn market by 2020. Ongoing economic growth in these countries will not only improve socio-economic profile and healthcare infrastructure but also result in increased spending on chronic diseases. The table overleaf is a snapshot of various regions in terms of size, growth potential, regulatory environment, key growth drivers and challenges for each of the key geographies. Genericisation of the global pharma market: n Governments across the globe, and particularly those in major pharma markets such as UK, US, Germany and Japan, have come under increasing cost contain- ment pressure, leading to creation of regulations that encourage the use of lower priced generics. n The era of 'blockbusters' has passed. As recently as 2006, there were nearly 90 drugs that had achieved the blockbuster status, generating 30% of total global pharma sales at US$200bn. By 2009, eight of these block buster drug ($18 bn) were facing patent expiry. n Failure of newly launched drugs due to safety concerns and dwindling pipeline of small molecule drugs n Increasing acceptance of generic drugs in large, highly regulated pharma markets. n Emergence of biotechnology as an alternative to traditional small molecule phar- maceutical n A spate of M&As, driven primarily by pharma majors like Pfizer, Merck and Roche to gain wider R&D pipeline n Pharma majors are increasingly turning towards emerging markets as these mar- kets offer higher growth potential n Pharma majors are eying the generics and biosimilars markets as an alternate revenue source. Emkay Research 10 March, 2010 12
  • 13. Global Generics - Overview Europe US Germany UK France CEE Spain Italy Nature of market Mature Mature Mature Developing Developing Developing Developing Generic penetration 64% 54% 65% 17% 20-25% 12% 7% Emkay Research Market size as of 2007 (US$ bn) 17 6.7 4.5 5.4 14 2.7 3 Expected market size by 2013 (US$bn) 22 7.8 4.8 7.3 26 3.4 3.5 CAGR 5% 3% 1.3% 6% 13% 4.7% 3.1% Drugs going off patent (US$bn) 94 50 Regulatory Environment Pro generic Pro generic Pro generic Encouraging generic usage Key growth drivers • Largest generic market • Various healthcare reforms introduced by the German government have resulted in • Drugs worth $94bn are going off patent progeneric structural and regulatory changes • Regulatory & political environment is pro-generic • Government in other European markets such as France, Hungary, Spain and Italy have also initiated various reforms to combat the healthcare cost • Rising healthcare cost is leading to legislative changes that are likely to see an increasing penetration of generics in Europe • 0.5bn people- aging population • Low generic penetration 10 March, 2010 Key challenges • Price Erosion • No long term generic medicine policies • Competition • Limited transparency on prices and availability • Stringent FDA regualtions • Continued price linkage to originator products • Market entry delays due to post-market authorization procedures for establishing pricing and re-imbursement status • Economic disincentives for pharmacists to dispense generic medicines • Lack of economic incentives for physicians to prescribe the generic medicines • Limited incentives for patients to request generic medicines • Evergreening of medicines Indian company's presence • US has always remained an important destination • Indian companies have expanded their presence in the EU market through M&A for Indian generic companies • Increased penetration of generic drugs in EU countries is long term positive for Indian • Indian companies have scaled up their presence in companies the US market • DRL was the second highest contract winner of AOK tender. • Indian companies are ranked one among the top 5 companies in terms of ANDA and FTF filings • Built up strong Para IV pipeline • Companies like DRL and Lupin stand one among the top 10 generic companies in the US • Despite 90-95% price erosion, realizations are still higher in the US Key opportunities • Large market share • Generics have yet to reach its full potential • Para IV monetization • Increased pace of generic penetration • Focus in the niche segment • Some of the Western European markets still have low level of penetration • Biosimilars can be a key opportunity • Central and Eastern European markets offer higher growth prospects • Bio-similars can be a key opportunity Source: Emkay Research Generic Pharma Sector 13
  • 14. Global Generics - Overview Emerging markets Japan Brazil Russia India South Africa Nature of market Developing Branded Generic Branded Generic Branded Generic Branded Generic Generic penetration 17% 20% 30% 70% 40% Emkay Research Market size as of 2007 (US$ bn) 2.7 1.5 2.5 6.6 1 Expected market size by 2013 (US$bn) 4.9 4.6 5.2 9.3 1.5 CAGR 15% 25% 16% 14-15% 15% Drugs going off patent (US$bn) Regulatory Environment Encouraging generic usage Pro-generic Pro-generic Pro-generic Pro-generic Key growth drivers • Large number of patent expiries • Improving economic condition • Largely under penetrated nature of market • Aging population • Government's initiative to encourage generic usage • Low per capita drug consumption • Higher purchasing power • Rapid growth in insurance sector • Increased prevalance of chronic diseases • Low penetration of modern medicine 10 March, 2010 Key challenges • People’s perception and cultural difference towards • Upfront investment to establish front end marketing and distribution network generic • Opportunities spread over 100 markets • Prescribers' attitudes • Government and regulatory interference • Japanese patients perceive generics as inferior to • Acceptance of patent regime branded products • Currency fluctuations • Competition Indian company's presence • The Indian pharma industry is diversifying its • Indian companies have fairly large presence in some of the key emerging markets geographical presence to reduce dependency on • Indian pharma companies have higher familiarity with emerging market dynamics US • Most of the Indian companies have built-up front end marketing and distribution network in • Japanese generic market offers huge opportunity these countries except Cipla, who mainly rely on partnership model • Ranbaxy plans to capitalize Daiichi’s presence in • With large product baskets, regulatory expertise, low costs and successful experience in Japanese market operating profitably in semi-regulated branded generic markets, India pharmas are targeting • Lupin and Cadila have built presence the market large opportunities in emerging markets Key opportunities • Government provides traction for higher generic • Emerging markets are likely to grow 5-6x faster than developed markets (expect this utilization market to be US$400bn by 2020) • Under patented market • Offers higher margins because of branded generics • High entry barriers because of doctor relationship and brand equity • Renewed interest of MNCs towards emerging markets Source: Emkay Research Generic Pharma Sector 14
  • 15. Generic Pharma Sector Indian generics: Well placed to capture the growing generic opportunities Geographical diversification, Indian pharma companies, by virtue of their strong presence in the domestic pharma dominance in a niche segment, Para market, highest number of US FDA approved plants outside the US and considerable IV pipeline and cost structure are the exposure to developed generic markets are in the forefront for capitalizing opportunities in qualifying parameters for a formidable the generic space. Global presence, a wide and diversified product pipeline spread generic player across multiple segments, presence in niche segments, strong FTF pipeline and integration across the product value chain coupled with lean cost structure are the key fundamental drivers for Indian generic companies. We have identified four parameters for a company to qualify as a formidable generic player. They are geographical well diversified business, dominance in a niche segment, Healthy Para IV pipeline and Lean cost structure. We believe that companies, which fare well on these parameters are well placed to cash in on generic opportunities. We have explained each of these parameters in detail below and have also rated the companies in our universe on each of these parameters. Geographically well diversified business Widespread geographic footprint Indian pharma companies operate in multiple geographies with a majority of their revenues reduces earnings volatility and coming from the sale of branded formulations in India and other semi-regulated markets. enables them to capture oppurtunities A widespread geographic footprint reduces earnings volatility, especially as traditionally lucrative markets such as US, Germany and UK have turned extremely competitive. Moreover, a well diversified geographical mix will enable them to cash in on the growth opportunities that different markets provide. Most Indian pharma companies are well diversified geographically, but Ranbaxy clearly has the widest global footprint, with products available in 125 countries, operations in 49 countries and manufacturing base in 8 of them. Cipla would be the second with exports to 175 countries mainly through a partnership model. DRL has built a significant presence in CIS/Russia as well as in Germany and US and the partnership with GSK will further strengthen its presence in the emerging markets. Sun Pharma has a strong presence in the US and exports formulations to 26 countries- mainly in the emerging markets. It is now diversifying into European territories. After building strong franchises in US, Japan, India and 22 countries in AAMLA region, Lupin is gearing to enhance its presence in other key markets such as EU territories and Latin American countries. Geographical presence 120% 100% (Revenue %) 80% 60% 40% 20% 0% Ranbaxy Cipla Sun pharma Dr Reddy Cadila Lupin US EU Emerging market Japan Source: Emkay Research, Company Dominance in a niche segment Dominance in a niche segment Apart from having presence across various product categories, we believe that dominance enables them to have pricing power in a niche segment is a pre-requisite for becoming a major generic player. Dominance in and better margins a niche segment enables them to have pricing power and better margins, which will largely insulate them from the tough competition in the generic space. A more specialized Emkay Research 10 March, 2010 15
  • 16. Generic Pharma Sector focus on products that are difficult to manufacture or have limited generic competition, even though the target market may be small, differentiate them from 'me too' generic companies and reduce the sensitivity of earnings to price erosion. Most Indian generic players have already identified and are establishing themselves in a particular niche segment, which will afford them insulation against the vagaries of the highly competitive generics market. Cipla, with its dominance in inhalers, DRL in bio-similars, Sun Pharma in controlled substances and Lupin in oral contraceptives are working towards these directions. Building a niche in complex generics Ranbaxy Cipla Sun pharma Dr Reddy Cadila Lupin ANDAs 241 107 159 92 90 DMFs 271 133 148 76 85 Complex Penem's Inhalers Controlled Biosimilars Transdermal Oral generics Substances patches; Contraceptives vaccines Source: Emkay Research Healthy Para IV pipeline The 180-day period of exclusivity for the first generic company is a very strong incentive for generic companies to stay ahead of the competition. Strong Para IV pipeline with potential FTFs not only provide 6-months exclusivity (one time profit) but also help to maintain leadership position in that molecule. Indian pharma majors are likely to derive significant benefit from some non-recurring Para IV earnings and their first mover advantage will also help them retain market share, even post exclusivity. Among Indian companies, we believe that DRL with 38 potential FTFs, Ranbaxy with 26 potential FTFs, Sun Pharma with 24 potential FTFs and Lupin with 15 potential FTFs will benefit the most from this development. Cipla, on account of adopting the partnership model, has no Para IV pipeline. Para IV - product differentiation Dr Reddys 38 Ranbaxy 26 Sun 24 Lupin 15 0 5 10 15 20 25 30 35 40 Source: Emkay Research Lean cost structure Companies with lean cost structure Being cost competitive is one of the key ingredients of a successful global generic company. and front end presence across region While integration across the value chain from intermediate to formulation yields cost will be better positioned to capitalize advantages, forward integration by way of having front end distribution network lowers the on generic opportunities risk of increasing competition and allows a company to capture large share of profit from a product. As it is difficult to predict the future revenue, the only thing which a company can do is to control cost. Our view is that companies with lean cost structure and front end presence in key geographies will be better positioned to capitalize on generic opportunities. Sun Pharma has the leanest cost structure with low fixed costs, while Ranbaxy and DRL (high manpower cost and other expenditures) are aggressively cutting cost by closing down their non-profitable operations. Emkay Research 10 March, 2010 16
  • 17. Generic Pharma Sector Cost structure of Indian companies Ranbaxy Cipla Sun pharma Dr Reddy Cadila Lupin Raw material cost 42% 47% 20% 34% 33% 42% GPM 46% 53% 80% 66% 67% 58% Employee cost 13% 5% 8% 15% 11% 13% R&D cost 6% 5% 7% 6% 5% 6% Other exp 33% 23% 19% 25% 31% 21% OPM 7% 19% 45% 20% 21% 19% Source: Emkay Research Scorecard of Indian pharma companies We believe that companies that can differentiate from competition by building niche product portfolios, novel drug delivery systems, chart a geographical diversified presence and sustain and nurture vertically integrated operations will benefit the most. We have ranked the companies on the basis of above parameters. As per our scorecard, Sun Pharma and DRL emerge as most preferred companies with the highest score of 17 each. Cipla and Cadila feature last with a score of 12 each. Generic score card Company Parameters Total Score Geographical Dominance in Para IV Cost presence niche segment pipeline structure Sun Pharma 3 5 4 5 17 Dr Reddy 4 5 5 3 17 Ranbaxy 5 5 5 1 16 Lupin 4 5 3 3 15 Cipla 4 5 0 3 12 Cadila 4 5 0 3 12 Source: Emkay Research Expect earning CAGR of 28% over FY09-12E We expect our generic universe' revenues to grow at a CAGR of 15% over FY09-12E, driven by 23% and 19% growth in Cadila Healthcare and Lupin pharma respectively. $235bn patent expiry, double digit growth in the emerging markets and sustainable momentum in the domestic markets would be the key growth drivers going forward. We expect operating margins to expand by 215 bps to 21.7% over FY09-12E. We expect Ranbaxy’s margin to expand by 660bps and Cipla’s margin to expand by 310bps during the same period. We expect 15% revenue CAGR and strong operating performance to drive a 28% earning CAGR over FY09-12E. Emkay Research 10 March, 2010 17
  • 18. Generic Pharma Sector Valuations Valuations Premium valuations to sustain Premium valuations to sustain Our universe currently trades at 20x (ex-Ranbaxy) FY11E EPS and 16x (ex-Ranbaxy) FY12E because of 28% earning CAGR, EPS. Current sector valuations are at a 20% premium to its 5 year average historical PE. strong return ratios, low leverage Historically, generics have traded at a 10-15% premium to the broader markets on account (0.2x) and free cash flow of consistent earnings growth, healthy balance sheet and non-cyclical nature. Going forward, we expect premium valuations to sustain because of 28% earning CAGR, strong return ratios, low leverage (0.2x ) and free cash flow. Moreover, we are of the view that because of emergence of innovator-generic partnership model, premium valuations for Indian pharma are likely to sustain. We expect our large cap universe to continue to trade at 20x one year forward PE (in-line with its 5 year mean multiple; 20% premium to sensex). However, in case of companies like Lupin and Cadila, who have historically traded at 5 year mean multiples of 13-14x (mid cap valuations), the gap to large cap multiple is narrowing down as these companies have gradually moved into the league of big pharma companies and we expect this gap (trading at 20% discount to comparable peers) to further narrow down. We initiate coverage on Cipla, Sun Pharma and Ranbaxy with an Accumulate, Hold & Sell rating respectively. Lupin, DRL and Cadila are our top picks in the sector. Historically, the pharma sector has outperformed in times of uncertainty as well as downturn and has underperformed when the market is bullish. As the broader market is likely to remain zigzag, we are of the view that investors will continue to hold pharma stocks to balance their high beta exposure. Apart from appreciating currency coupled with company specific issues, the sector is largely insulated from the concerns that prevail in a slowdown. Lupin, DRL and Cadila are our top picks Cadila Healthcare Cadila Healthcare emerges as our top pick given its strong growth prospects, wide geographical reach, foray into difficult to manufacture generics and attractive valuations. We expect Cadila's earnings to grow at 27% CAGR over FY10-12E on the back of strong growth in its international business, steady growth from domestic operations & meaningful contribution from Hospira JV. We believe that over time, Cadila's Hospira JV will not only make up for losses on its Nycomed JV but also add to Cadila's overall profitability. Despite ascribing 10% discount to sector multiple because of low generic score (12, last in the universe), its discounted valuations are sufficient to provide huge upsides. Our fair value for Cadila is Rs962 (18xSep'11E), an upside potential of 22%. The fact that Cadila has surpassed all our estimates since we initiated coverage on the stock, increases our confidence in its ability to meet our future estimates. We re-iterate our Buy rating on the stock with a target price of Rs962. Cipla Ltd We initiate coverage on Cipla with an Accumulate rating and a price target of Rs366. Apart from being the largest Indian pharma company by market size, it is one of the most diversified companies with presence in more than 175 countries. Its strategy for export is built around supply chain model and tie-ups with global players, without investing in building up front-end presence. We are of the view that huge capacity expansion made over last four years will start delivering now, improving its RoCE, going forward. Moreover, despite significant capex, Cipla's balance sheet continues to remain healthy with a D/E of 0.2x and expect company to generate net free cash flow from FY11E onwards. We expect earnings CAGR of 18% over FY10-12E driven by a) 11.8% CAGR in domestic market, Emkay Research 10 March, 2010 18
  • 19. Generic Pharma Sector b) 12.6% CAGR in export formulation. Since Cipla has adopted the tie-up route in the generic space, it has no Para IV pipeline, resulting in it being one of the lowest scorers (generic score of 12). However, its dominance in the lucrative inhaler space and established business model makes it a low risk bet on the generic opportunity. As a result, we have valued Cipla in line with the sector average (20x Sep'11 EPS of Rs18.3) and arrived at a target price of Rs366 (upside of 16%). Signing of MNC contracts and launch of inhalers in EU could be potential upside triggers. Dr Reddy’s Laboratories (DRL) DRL, with the highest score of 17 on our generic scorecard, is among the best bets to buy into the generic growth story. Its well diversified geographic reach, strong presence in the high growth potential biosimilars space, healthy Para IV pipeline and strong earnings growth are likely to ensure upside potential from the current level. Strong growth in base business (barring Betapharm), revenue upsides from its Omeprazole OTC launch and its GSK alliance are likely to result in a 38% earnings CAGR over FY10-12E. Despite 38% out-performance to broader market over the last six months, we continue to remain positive on the stock and reiterate our buy rating with a target price of Rs1478, an upside potential of 26%. Lupin Laboratories Lupin's outperformance across segments along with its well charted growth strategy makes it our best bet in the Indian generic pharma space. We expect Lupin's earnings to grow at 24% CAGR over FY10-12E driven by a) strong growth across the key geographies, b) launch of oral contraceptives in the US market, c) increasing generic penetration in the Japanese market and d) 200 bps operating margin expansion in next 3 years. Lupin, third in our generic scorecard (score of 15), with its well diversified geographical reach, foray into high growth oral contraceptive segment along with attractive Para IV pipeline is an attractive investment proposition because of its valuation discount to large cap peers (20%). Despite 57% absolute return and 47% outperformance to broader market over the last six months, strong execution across the markets and increasing visibility in revenue and earnings (17% and 24% CAGR over FY10-12E), makes Lupin our preferred pick in the large cap pharma space. With the Mandideep issue getting resolved in favor of Lupin, we are of the view that Lupin should now trade in-line with its large cap peers. We re- iterate our Buy rating on the stock with a target price of Rs2111 (20x Sep'11 EPS of Rs104.5; NPV of Rs22/share for Para IV). Ranbaxy Labs We initiate coverage on Ranbaxy with a Sell rating and a price target of Rs329. With dominance in niche segments such as penems, strong para IV pipeline coupled with well diversified geographical reach, Ranbaxy features second in our generic scorecard (score of 16). Our base business earnings of Rs6 and Rs11 for CY10E and CY11E factors a gradual improvement in the base business as we believe that most of the initiatives will start contributing from CY11E onwards. We have valued its FTF pipeline on NPV basis unlike the practise of treating FTF as recurring earnings.This itself has brought a valuation difference of Rs95 per share. We have arrived at a price target of Rs 329, assigning Rs220 for its base business (20xCY11E) and Rs 109per share as NPV of FTF pipeline. Though we are positive on the long term prospects of the company, we believe that current valuations are way ahead of actual improvement in the business and hence, recommend a sell on the stock. Earlier than expected resolution of FDA issue at Dewas or strong earning visibility from CY11E onwards are positive catalysts to the stock price. Emkay Research 10 March, 2010 19
  • 20. Generic Pharma Sector Sun Pharma We initiate coverage on Sun Pharma with a Hold rating and a price target of Rs1644. Sun Pharma's strong foothold in the domestic formulation business, robust pipeline for regulated markets and healthy balance sheet are the positives, which will enable it to maintain its leadership position. While Sun Pharma ranks high on parameters like dominance in niche segments such as controlled substances and attractive para IV pipeline, it is its lean cost structure that gives it a distinct advantage over its peers. We have ascribed 10% premium to sector multiple because of its high generic score (17). Our fair value for Sun Pharma works out to Rs1644 (22x Sep'11E base business EPS; NPV of Rs66/share for Para IV pipeline; Taro Investment- Rs30/share). Despite ascribing 10% premium because of high generic score, our target price of Rs1644 does not offer much upside from the current levels. Earlier than expected clearance of Caraco, visibility of high end product launches or successful acquisition of Taro are potential positive catalysts to the stock price. Delay in clearance of Caraco could impact our numbers adversely. Emkay Research 10 March, 2010 20
  • 21. Generic Pharma Sector Sector Risks Sector Risks Increasing scrutiny by the US FDA The US FDA has become increasingly stringent about Good Manufacturing Practices (GMPs) in order to maintain the quality of drugs to be supplied in the US. This has resulted in a sharp rise in Form 483 and warning letters, even at minor deviations. Till date, FDA has issued 5 warning letters compared to 12 and 16 in 2009 and 2008 respectively. Indian companies like Ranbaxy, Caraco (US subsidiary of Sun Pharma), Lupin and Cipla (already cleared) are under the FDA scanner. We are of the view that managing regulatory issues have become a big challenge for Indian generic companies. Currency movements 68% of our universe revenues come from exports and most of it is dollar denominated. Movement in currency adversely impacts the profitability of the companies. Our universe is exposed to various cross currencies and therefore, the impact of currency movement on their profitability is difficult to estimate. Pricing pressure in the US Higher than expected pricing pressure for the US generic business can further erode the profitability of the companies. We have currently built in 10% price erosion in the base business. Healthcare reforms in EU territories can lead to tender systems Spiraling healthcare costs in developed countries have resulted in introduction of various bills to encourage generic penetration in the EU territories. In order to further restrict their healthcare spending, Germany, last year adopted the tender model moving away from the branded generic market. This has hurt the profitability of the companies. If this model becomes successful, then many countries may be encouraged to adopt it, which can further put pressure on companies in our universe. Increasing competitive landscape for emerging markets With global pharma companies targeting the emerging markets for growth, there is a fair possibility of price wars in these geographies. We believe this can impact the profitability of Indian companies and therefore, the valuations also. Domestic drug policy Indian government's proposal to expand the scope of price controls from existing 74 drugs to 354 drugs might impact domestic formulation business of Indian pharma companies. Generally, domestic business contributes 20-50% of overall revenue and 30- 60% of recurring EBIDTA. Emkay Research 10 March, 2010 21
  • 22. Generic Pharma Sector Companies Cadila Healthcare Ltd. Cipla Ltd. Dr Reddy's Laboratories Ltd. Lupin Ltd. Ranbaxy Laboratories Ltd. Sun Pharma Industries Ltd. Emkay Research 10 March, 2010 22