The document discusses the challenges of translating biomedical research into meaningful health improvements, especially for resource-poor countries disproportionately affected by infection-associated cancers. It provides examples from Uganda, which has one of the highest cancer rates in the world but very limited resources and capacity for cancer treatment. Effective translation requires identifying high-burden diseases, conducting etiology research, determining feasibility of implementation, and assessing impact on population health.

1. Clinical Research in Global Health: Lost in Translation? Corey Casper, MD MPH Vaccine and Infectious Disease Institute, Clinical Research and Public Health Sciences Divisions Fred Hutchinson Cancer Research Center Division of Infectious Disease, Department of Medicine University of Washington

3. Blueprint for Translational Research Identify Diseases Causing Significant Morbidity / Mortality to a Population (Epidemiology) Conduct Basic or Translational Research to Identify Etiology, Pathogenesis, Biomarkers, and Treatments Conduct Operational Research to Determine Feasibility of Implementing Research Findings Assess Impact of Translational Research on the Health of a Population

5. 23% of Cancers Worldwide are Due to Chronic Infections

7. From Infection to Cancer Primary Infection Chronic Infection Replication Progression to Cancer Vaccine eliciting neutralizing antibodies Genetic and Environmental Factors Antimicrobial Agents Chemotherapy

8. So where in the world…