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Gut Flora & Probiotic 11
    Saira Salmon   DipNN, MFNTP
Your gut….
• Is teeming with microbes – up to 70% of the
  body’s total number
• It is an extremely complex ecosystem
  harbouring more than 100
  trillion micro-organisms
• There are thought to be
  around 30 – 40 different
  species of bacteria.
Many of these have a symbiotic relationship with us –
    and help to keep less beneficial strains at bay.
A healthy gut in an adult human has somewhere in the
      region of 2 kg of these bacteria in the gut.
They play a vital role in the body – without them
              we would not survive.
 Sterilise your gut and you die, have good levels
       of probiotic bacteria and you thrive!
Hippocrates
 The Father of Modern Medicine

“All disease begins in the gut”
What Role Do They Play?
 Beneficial bacteria take part in our digestion and
                absorption of food

They produce a number of enzymes to break down
      proteins, carbohydrates, fibre and fats

   They produce various substances to transport
vitamins, minerals and other nutrients through the
                     gut wall
What Role Do They Play?
They can actively synthesize nutrients such as
 K2, many of the B vitamins and some amino
                    acids
  They help chelate heavy metals from our
                   system.
           Help control parasites
What Role Do They Play
They play a crucial role in our immune system,
    keeping the body’s immunity active.
Around 83% of our immunity is located in the
                    gut wall.
   Beneficial flora imbalance will have an
   immediate impact on immune system.
How it Starts
 We inherit our gut flora from our mother at birth.
     As the baby comes through the birth canal it
swallows its first mouthfuls of bacteria, which begin
             to inhabit baby’s sterile gut.
         Breast feeding continues the process.
 It takes about 2 years for a baby’s immune system
                    to fully develop
Dysbiosis
When gut flora is damaged or in imbalance it is
called dysbiosis.

Opportunistic gut microbes including yeast, harmful
bacteria, viruses and parasites
start to take hold.

They can be very difficult to
eradicate once they have moved
in.
When Good Guts Turn Bad…….
What Can Damage Gut Flora
Antibiotics      Steroids, The Pill
Other drugs      Stress
Poor diet        Infections
Bottle feeding   Old Age
Pollution        Radiation
Alcohol          Toxic chemicals
Dental work
When gut flora is damaged…
• Microbes ie. ‘bad’ bacteria, multiply.
• They can perforate and damage the thin layer
  of epithelial cells lining the gut, which then
  allows unwanted microbes and toxins to inter
  into our bloodstream.
• This is termed ‘leaky gut’ syndrome.
Leaky gut
• Causes include:
   – poorly digested foods      alcohol
   – antibiotics or infection   painkillers
   – heavy metal toxicity       smoking
   – birth control pills        antacids
   – chlorinated water          food additives
   – high homocysteine levels   parasites, yeasts food
     allergies

• Underactive & constipated bowel will also cause
  problems
Leaky gut
Consequences
  Body has to use whatever routes it can to eliminate toxins.
  They initially get taken to liver.
  The increased flow leads to blocked detox pathways
  All liver functions suffer
  Toxins bypass the filtering and go into blood stream.
  Get taken:
  To lungs -asthma, and other chronic lung conditions
  To skin – eczema, rashes and other skin problems
  Urine – cystitis, thrush, bedwetting
  Through mucous membranes – sinusitis, post nasal drip, rhinitis,
  gingivitis, vaginitis, diarrhea/constipation
all this – and more – from damaged gut flora

          These guys are important!
Bowel Bacteria & Health
                    IBS
A variety of studies have found evidence
 of the benefit of using probiotics in the
management of irritable bowel syndrome.
Bowel Bacteria & Health

                   Cholesterol
       Some strains of bowel bacteria, including
L. Acidophilus and Bifidobacteria seem to have a
   direct action on lowering cholesterol levels.
Bowel Bacteria & Health
                  Colon Cancer
        Bowel bacteria have also been linked to
                  colon cancer.
      Many enzyme pathways are influenced eg.
Bifido longum inhibits B-glucuronidase, elevated
  levels of which are associated with increased
                   colon cancer
Bowel Bacteria & Health
Autism
     People with autistic spectrum disorders
have been shown to have imbalances in gut
bacteria. Research in this field suggests
improving bowel flora levels is an important part
of managing this disorder.
Bowel Bacteria & Health
Autism
     People with autistic spectrum disorders
have been shown to have imbalances in gut
bacteria. Research in this field suggests
improving bowel flora levels is an important part
of managing this disorder.
Bowel Bacteria & Health
Therapeutically
     A probiotic is used within a wide range of
     therapeutic regimes by practitioners
How to Maintain Probiotic Health
Avoid things which damage gut flora

Eat prebiotic foods
       Raw chicory root, Jerusalem artichoke, garlic and leek,
asparagus, banana, raw and cooked onion.
How to Maintain Probiotic Health
Eat probiotic (fermented) foods
     Live yoghurt, Miso, tempeh, sauerkraut, natto




Supplement with a good probiotic
Introducing Probiotic 11!
 A high potency, broad spectrum probiotic.

 11 different strains of friendly bacteria.

 Contains almost 12 billion bacteria per serving.

 Enteric coated to disperse in the intestines.

 In a prebiotic blend to spread and nourish.
The Bacteria in Probiotic 11
7 strains of Lactobacillus:
• Lactobacillus acidophilus (acid loving milk
  bacteria).
      Grown on milk but doesn’t contain it, and helps
      break down lactose.
      Supports immune system by stimulating production
      of regulation T cells
      Inhibits patogenic growth in urinary tract
      infections by adhering to uro-epithelial cells
The Bacteria in Probiotic 11
• L rhamnosus
      - may help reduce the incidence of developing
      childhood allergies and tooth decay in children
      - Increases cell mediated immunity in Chron’s
      disease
• L brevis
• L bulgaricus
• L plantarum
• L casei
• L salvarius
The Bacteria in Probiotic 11
3 strains of Bifidobacterium:
• Bifidobacterium longum
   – creates B vitamins.
• B.bifidum
   – significantly improves pain and bowel habits in irritable bowel
     syndrome
   – Prevents diarrhea that occurs with post-antibiotic overgrowths of C
     difficile and Candida albicans
• B.infantis
   – Helped improve abdominal pain and discomfort in IBS

– see table on Wikipedia for more information.
The Bacteria in Probiotic 11
          Streptococcus thermophilus
         Used to start fermentation process of
                   making yoghurt.




Also some interesting research conducted on this – see
               Wikipedia for more info.
The Bacteria in Probiotic 11
  FOS (Fructo Oligo Saccharides )
Prebiotic - food for healthy bacteria
 Help to nourish and spread the bacteria
        throughout the gut.
When to Use Probiotic 11
•   Following a course of antibiotics, or a cleanse.
•   Before and after hospital treatment
•   During preconception & pregnancy
•   With confirmed dairy intolerance
•   During treatment for candidiasis
When to Use Probiotic 11
• During and after a stomach upset
• With those prone to low mood / behavioural
  disturbance
• With someone who has regular
  colonic irrigation
• Combined with Caprylic Acid for a
  week before going on holiday, until
  returning home.
How to Use Probiotic 11

Take 1-2 capsules daily
     with a meal

Each pot last 6 weeks
     - 2 months.
What Makes Probiotic 11 Special?
 One of the most potent probiotics available on
  the market

 Also unusual to get so many strains in
  one supplement – would appeal to
  many clinical therapists.

 Built in prebiotic

 Enteric coated
The End

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Gut flora & probiotic 11

  • 1.
  • 2. Gut Flora & Probiotic 11 Saira Salmon DipNN, MFNTP
  • 3. Your gut…. • Is teeming with microbes – up to 70% of the body’s total number • It is an extremely complex ecosystem harbouring more than 100 trillion micro-organisms • There are thought to be around 30 – 40 different species of bacteria.
  • 4. Many of these have a symbiotic relationship with us – and help to keep less beneficial strains at bay. A healthy gut in an adult human has somewhere in the region of 2 kg of these bacteria in the gut.
  • 5. They play a vital role in the body – without them we would not survive. Sterilise your gut and you die, have good levels of probiotic bacteria and you thrive!
  • 6. Hippocrates The Father of Modern Medicine “All disease begins in the gut”
  • 7. What Role Do They Play? Beneficial bacteria take part in our digestion and absorption of food They produce a number of enzymes to break down proteins, carbohydrates, fibre and fats They produce various substances to transport vitamins, minerals and other nutrients through the gut wall
  • 8. What Role Do They Play? They can actively synthesize nutrients such as K2, many of the B vitamins and some amino acids They help chelate heavy metals from our system. Help control parasites
  • 9. What Role Do They Play They play a crucial role in our immune system, keeping the body’s immunity active. Around 83% of our immunity is located in the gut wall. Beneficial flora imbalance will have an immediate impact on immune system.
  • 10. How it Starts We inherit our gut flora from our mother at birth. As the baby comes through the birth canal it swallows its first mouthfuls of bacteria, which begin to inhabit baby’s sterile gut. Breast feeding continues the process. It takes about 2 years for a baby’s immune system to fully develop
  • 11. Dysbiosis When gut flora is damaged or in imbalance it is called dysbiosis. Opportunistic gut microbes including yeast, harmful bacteria, viruses and parasites start to take hold. They can be very difficult to eradicate once they have moved in.
  • 12. When Good Guts Turn Bad…….
  • 13. What Can Damage Gut Flora Antibiotics Steroids, The Pill Other drugs Stress Poor diet Infections Bottle feeding Old Age Pollution Radiation Alcohol Toxic chemicals Dental work
  • 14. When gut flora is damaged… • Microbes ie. ‘bad’ bacteria, multiply. • They can perforate and damage the thin layer of epithelial cells lining the gut, which then allows unwanted microbes and toxins to inter into our bloodstream. • This is termed ‘leaky gut’ syndrome.
  • 15. Leaky gut • Causes include: – poorly digested foods alcohol – antibiotics or infection painkillers – heavy metal toxicity smoking – birth control pills antacids – chlorinated water food additives – high homocysteine levels parasites, yeasts food allergies • Underactive & constipated bowel will also cause problems
  • 16. Leaky gut Consequences Body has to use whatever routes it can to eliminate toxins. They initially get taken to liver. The increased flow leads to blocked detox pathways All liver functions suffer Toxins bypass the filtering and go into blood stream. Get taken: To lungs -asthma, and other chronic lung conditions To skin – eczema, rashes and other skin problems Urine – cystitis, thrush, bedwetting Through mucous membranes – sinusitis, post nasal drip, rhinitis, gingivitis, vaginitis, diarrhea/constipation
  • 17. all this – and more – from damaged gut flora These guys are important!
  • 18. Bowel Bacteria & Health IBS A variety of studies have found evidence of the benefit of using probiotics in the management of irritable bowel syndrome.
  • 19. Bowel Bacteria & Health Cholesterol Some strains of bowel bacteria, including L. Acidophilus and Bifidobacteria seem to have a direct action on lowering cholesterol levels.
  • 20. Bowel Bacteria & Health Colon Cancer Bowel bacteria have also been linked to colon cancer. Many enzyme pathways are influenced eg. Bifido longum inhibits B-glucuronidase, elevated levels of which are associated with increased colon cancer
  • 21. Bowel Bacteria & Health Autism People with autistic spectrum disorders have been shown to have imbalances in gut bacteria. Research in this field suggests improving bowel flora levels is an important part of managing this disorder.
  • 22. Bowel Bacteria & Health Autism People with autistic spectrum disorders have been shown to have imbalances in gut bacteria. Research in this field suggests improving bowel flora levels is an important part of managing this disorder.
  • 23. Bowel Bacteria & Health Therapeutically A probiotic is used within a wide range of therapeutic regimes by practitioners
  • 24. How to Maintain Probiotic Health Avoid things which damage gut flora Eat prebiotic foods Raw chicory root, Jerusalem artichoke, garlic and leek, asparagus, banana, raw and cooked onion.
  • 25. How to Maintain Probiotic Health Eat probiotic (fermented) foods Live yoghurt, Miso, tempeh, sauerkraut, natto Supplement with a good probiotic
  • 26. Introducing Probiotic 11!  A high potency, broad spectrum probiotic.  11 different strains of friendly bacteria.  Contains almost 12 billion bacteria per serving.  Enteric coated to disperse in the intestines.  In a prebiotic blend to spread and nourish.
  • 27. The Bacteria in Probiotic 11 7 strains of Lactobacillus: • Lactobacillus acidophilus (acid loving milk bacteria). Grown on milk but doesn’t contain it, and helps break down lactose. Supports immune system by stimulating production of regulation T cells Inhibits patogenic growth in urinary tract infections by adhering to uro-epithelial cells
  • 28. The Bacteria in Probiotic 11 • L rhamnosus - may help reduce the incidence of developing childhood allergies and tooth decay in children - Increases cell mediated immunity in Chron’s disease • L brevis • L bulgaricus • L plantarum • L casei • L salvarius
  • 29. The Bacteria in Probiotic 11 3 strains of Bifidobacterium: • Bifidobacterium longum – creates B vitamins. • B.bifidum – significantly improves pain and bowel habits in irritable bowel syndrome – Prevents diarrhea that occurs with post-antibiotic overgrowths of C difficile and Candida albicans • B.infantis – Helped improve abdominal pain and discomfort in IBS – see table on Wikipedia for more information.
  • 30. The Bacteria in Probiotic 11 Streptococcus thermophilus Used to start fermentation process of making yoghurt. Also some interesting research conducted on this – see Wikipedia for more info.
  • 31. The Bacteria in Probiotic 11 FOS (Fructo Oligo Saccharides ) Prebiotic - food for healthy bacteria Help to nourish and spread the bacteria throughout the gut.
  • 32. When to Use Probiotic 11 • Following a course of antibiotics, or a cleanse. • Before and after hospital treatment • During preconception & pregnancy • With confirmed dairy intolerance • During treatment for candidiasis
  • 33. When to Use Probiotic 11 • During and after a stomach upset • With those prone to low mood / behavioural disturbance • With someone who has regular colonic irrigation • Combined with Caprylic Acid for a week before going on holiday, until returning home.
  • 34. How to Use Probiotic 11 Take 1-2 capsules daily with a meal Each pot last 6 weeks - 2 months.
  • 35. What Makes Probiotic 11 Special?  One of the most potent probiotics available on the market  Also unusual to get so many strains in one supplement – would appeal to many clinical therapists.  Built in prebiotic  Enteric coated

Notas do Editor

  1. Main source of K2 and many B vitamins. Why? These are water soluble and will not stay in body long so will be periods in day when we are deficient. Gut flora provides our own factory of these to release these into our bloodstream all the time.
  2. Naturopaths believe that nearly all disease can be traced back to damaged or abnormal gut flora.
  3. Caesarean births, lack of breast feeding etc all impact on gut flora and immune system. Bottle fed babies acquire a completely different balance of gut flora to those breast fed. Medication, antibiotics etc all affect this as well.
  4. V vulnerable to antibiotics – die first and take weeks to recover giving time for less vulnerable microbes like candida and clostridia to take over.Other drugs – all prescription medications taken on a repeat basis will change the makeup of the gut floraBottle feeding – much higher chance of allergies, eczema, asthma, glue ear etcDental work – most of what he puts into your mouth is toxic to gut flora and will be for weeks afterwards
  5. Behavioural changes in children, failure to thrive
  6. Botschinsky B et al (2011) A review of the evidence available for the use and effectiveness of probiotic drinks and supplements for the treatment of IBS> Int J ProbitoicsPrebitoics 6:21-33, 2011Moayyedi P et al (2008) The efficacy of probitoics in the therapy of irritable bowel syndrome: a systematic review. E Gut 17Wu (2010) Complementary and Alternataive Medicine Modalities for the Treatment of IBS: Fact or Myths? Gastr Hep 6: 705-711
  7. Grill, J.P. et al (1995) Purification and characterisation of conjugated bile salt hydrolase from Bifidobacteriumlongum BB536. Appl Environ Microbiol 61:2577–2582Lye, H. et al (2009) The improvement of hypertension by probiotics: Effects on cholesterol, diabetes, rennin and phytoestrogens. Int J MolSci 10:3755-3775Oh, C.Y., Lee, W.K. (2000) Cholesterol lowering effect of lactic acid bacteria isolated from the human intestine. Korean J Vet Public Health 24:181-188Ooi, L-G., Liong, M-T. (2010) Cholesterol lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings. Int J MolSci 11:2499-2522
  8. Iannitti, T., Palmeieri, B., (2010) Therapeutical use of probiotic formulations in clinical practice. ClinNutr 1-25Kulkarni, N., Reddy, B.S. (1994) Inhibitory effect of Bifidobacteriumlongum cultures on the azoxymethane induced aberrant crypt foci formation and faecal bacterial ß-glucuronidase. ProcSocExptBiol Med 207: 278-283Rowland, I. (2008) Probiotics and cancer – from in vitro to human studies. Int J Probiotics Prebiotics 3:165-168Tang, Y. et al (2011) The role of short-chain fatty acids in orchestrating two types of programmed cell death in colon cancer. Autophagy 7:235-7
  9. Adams, J. et al (2011) Gastrointestinal flora and gastrointestinal status in children with autism–comparisons to typical children and correlation with autism severity Gastroenterology 11:22Finegold, et al (2010) Pyrosequencing study of fecalmicroflora of autistic and control children. Anaerobe 16:444-53Garvey, J. (2002) Diet in autism and associated disorders. J Fam Health Care 12:34-38Melmed, R. et al (2000) Metabolic markers and GI symptoms in children with autism and related disorders. J PediatrGasteroenterolNutr 31:31-32
  10. Adams, J. et al (2011) Gastrointestinal flora and gastrointestinal status in children with autism–comparisons to typical children and correlation with autism severity Gastroenterology 11:22Finegold, et al (2010) Pyrosequencing study of fecalmicroflora of autistic and control children. Anaerobe 16:444-53Garvey, J. (2002) Diet in autism and associated disorders. J Fam Health Care 12:34-38Melmed, R. et al (2000) Metabolic markers and GI symptoms in children with autism and related disorders. J PediatrGasteroenterolNutr 31:31-32
  11. Adams, J. et al (2011) Gastrointestinal flora and gastrointestinal status in children with autism–comparisons to typical children and correlation with autism severity Gastroenterology 11:22Finegold, et al (2010) Pyrosequencing study of fecalmicroflora of autistic and control children. Anaerobe 16:444-53Garvey, J. (2002) Diet in autism and associated disorders. J Fam Health Care 12:34-38Melmed, R. et al (2000) Metabolic markers and GI symptoms in children with autism and related disorders. J PediatrGasteroenterolNutr 31:31-32
  12. T cells – Boirivant 2007UTI – Zuccotti 2008
  13. Allergies tooth decay – Nase 2001, Wickens 2008Chrons – Hessle 1999
  14. IBS – William 2008Diarrhea – Plummer 2004Whorwell PJ, Altringer L, Morel J et al (July 2006). "Efficacy of an encapsulated probiotic Bifidobacteriuminfantis 35624 in women with irritable bowel syndrome". Am. J. Gastroenterol.101 (7): 1581–90. doi:10.1111/j.1572-0241.2006.00734.x. PMID 16863564.
  15. IBS – William 2008Diarrhea – Plummer 2004Whorwell PJ, Altringer L, Morel J et al (July 2006). "Efficacy of an encapsulated probiotic Bifidobacteriuminfantis 35624 in women with irritable bowel syndrome". Am. J. Gastroenterol.101 (7): 1581–90. doi:10.1111/j.1572-0241.2006.00734.x. PMID 16863564.