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The Toronto Region is world-renowned for its leading
                                                                                                    research in stem cells. In the early 1960s, Dr. James
                                                                                                    Till and Dr. Ernest McCulloch first showed the
                                                                                                    existence of stem cells. Current researchers
                                                                                                    like Dr. Gordon Keller at the McEwen Centre for
                                                                                                    Regenerative Medicine, Dr. Janet Rossant at The
                                                                                                    Hospital for Sick Children, Dr. John Dick at the
                                                                                                    University Health Network, and Dr. Mick Bhatia
                                                                                                    at McMaster University in Hamilton continue the
                                                                                                    tradition of cutting-edge research in the Toronto
                                                                                                    Region, building upon the solid foundation established
                                                                                                    by Till and McCulloch four decades ago.
                            TORONTO REGION: A GLOBAL LEADER IN




                                                                                                    This extensive level of activity has led to a series
                                                                                                    of strategic initiatives to concentrate the different
                            STEM CELLS AND REGENERATIVE MEDICINE




                            - Dr. Peter Zandstra, Canada Research Chair in Stem Cell




                                                                                                    biomedical expertise. These initiatives are meant
                              Bioengineering and Professor of Tissue Engineering at




                                                                                                    to address the most daunting challenges in stem
                              University of Toronto’s Institute of Biomaterials and




                                                                                                    cell biology research as discoveries move from the
                              Biomedical Engineering, and Department of Chemical
                              Engineering and Applied Chemistry




                                                                                                    laboratories to the clinic. One of these initiatives is
                            TORONTO REGION STEM CELL                                                the Toronto Stem Cell Initiative (TSCI), an inclusive
                            RESEARCHERS HAVE GLOBAL IMPACT                                          collection of stem cell research laboratories at the
                                                                                                    STRATEGIC INVESTMENT




                                                                                                    University of Toronto and at hospital research
                                                                                                    institutes. The goal of this initiative is to conduct
                                                                                                    IN STEM CELL RESEARCH IN




                                                                                                    stem cell research at all stages and to represent the
                            “Toronto has the critical mass and                                      THE TORONTO REGION




                                                                                                    ‘national and international face’ of stem cell research
                                                                                                    for the entire University of Toronto community.
                             collaborative environment. All the different




                                                                                                    The Cancer Stem Cell Consortium (CSCC),
                             pieces needed to solve the stem cell puzzle




                            Average Citations/Publication, 1998-2008




                                                                                                    established in 2007, will allow the biomedical
                             are in place. We provide the bioengineering




                                                                                                    community to move quickly and effectively from
                                  40
                             translation part, while others provide




                                        35.5




                                                                                                    discoveries to application in the clinic and to launch
                                  35




                                                                                                    partnerships among organizations within Canada.
                             a development or genetic engineering




                                               30.2 30.1 29.4 29.2 29.1 9.1




                                                                                                    In 2008, the CSCC announced its first international
                                                                        2
                                                                                 27.5
                             perspective. You can go right from




                                  30
                                                                                        25.7 25.2




                                                                                                    partnership with the California Institute for
                             discovery to therapy all in the same place.”




                                  25




                                                                                                    Regenerative Medicine (CIRM). One of the first
                                                                                                    initiatives will be the Disease Team Research Awards.
                                  20




                                                                                                    Proposals will be evaluated by an international team
                                  15




                                                                                                    of experts who will focus on applications that have a
                                                                                                    chance of clinical impact within five years. The CSCC
                                  10




                                                                                                    has committed up to $40 million to support the
                                   5




                                                                                                    Canadian component of this research.
                                   0



                                                            Region
                                          d     k    s        l  n     ia    d     n     ia    s
                                     tlan    Yor sett Israe Regio iforn rylan consi ylvan Texa
                                  Sco New sachu             to  Cal    Ma Wis enns
                                           Mas       To ron                    P
Average Citations/Publication
ONTARIO INSTITUTE FOR CANCER
                                                                                                                                     RESEARCH (TORONTO)
                                                                                                                                     The Ontario Institute for Cancer Research (OICR) is
                                                                     The Toronto Region has a large concentration of research        a not-for-profit corporation funded by the Province of
                                                                     centres conducting high-impact, high-value research. Stem       Ontario. This institute is dedicated to the prevention, early
                                                                     cell research activity in the region ranges from deriving new   detection, diagnosis and the treatment of cancer. As part
                                                                     stem cell lines to translational research, and rivals the       of this endeavor, a division for cancer stem cell research
                                                                     other North American stem cell centres such as Boston           was established.
                                                                     and California. More than 70 scientists and principal




                                                                     MCEWEN CENTRE FOR REGENERATIVE
                                                                     investigators focus on five broad areas: cancer stem cells,     Dr. John Dick, a Senior Scientist at the Ontario Cancer




                                                                     MEDICINE (TORONTO)
                                                                     adult stem cells, embryonic stem cells, regenerative            Institute, the research arm of the University Health
                                                                     medicine, and bioengineering/tissue engineering.                Network’s Princess Margaret Hospital, heads the OICR
                                                                                                                                     Cancer Stem Cell program. The program coordinates the
                                                                                                                                     work of 30 scientists at three sites across Ontario to identify
                                                                                                                                     ways to selectively target cancer stem cells to eradicate the
                                                                                                                                     disease, and to prevent metastases and recurrence. The
                                                                                                                                     Cancer Stem Cell group uses a variety of tools for stem cell
                                                                     The McEwen Centre for Regenerative Medicine is a                identification, including: bio-repositories and pathology,
                                                                     collaborative entity, which brings together 15 clinicians       genomics and high-throughput screening and mouse models.
                                                                     and scientists across University of Toronto-affiliated
                                                                     hospitals that focus on regenerative medicine and               OICR is one of the founding partners of the Cancer Stem
                                                                     biomedical research. The Centre focuses on three                Cell Consortium, along with Genome Canada, the
                                                                                                                                     Canadian Institutes of Health Research, the Canada




                                                                                                                                     MCMASTER STEM CELL AND CANCER
                                                                     themes: repair and regeneration, origin and modeling
                                                                     diseases, and new tool discoveries. It has brought              Foundation for Innovation and the Stem Cell Network.




                                                                                                                                     RESEARCH INSTITUTE (HAMILTON)
                                                                     together the best stem cell biology scientists in the           The CSCC is backed by an initial $100 million funding
                                                                     Toronto area and their disease-specific expertise.              commitment from its Canadian partners.
                                                                     HIGH-IMPACT, HIGH-VALUE STEM




                                                                     The Centre focuses on the following disease research
                                                                     CELL RESEARCH




                                                                     areas: heart disease, diabetes, spinal cord injury and
                                                                     neurodegenerative diseases, blood cell disorders, lung
                                                                     disease and musculoskeletal diseases. Cutting-edge stem
                                                                     cell technologies such as enhancing the regenerative            Founded in 2006, the McMaster Stem Cell and Cancer
                                                                     capacity of the heart, cellular therapy and tissue              Research Institute receives funds from the OICR. Inaugural
                                                                     engineering are used to investigate these diseases. For         Scientific Director Mick Bhatia, leads a group of eager
                                                                     example, world-renowned scientist Dr. Gordon Keller has         scientists who investigate the biology of human cancer
                                                                     optimized differentiation of human embryonic stem (ES)          stem cells, embryonic stem cells and adult stem cells.
                                                                     cells into a homogenous layer of cardiomyocytes free            The team of scientists is on the cutting-edge of human
                                                                     from animal contaminants. By understanding the                  stem cell research and has already established
                                                                     molecular requirements for heart precursors in the              themselves as experts in the field. They have integrated
                                                                     embryo, his laboratory is now able to use these cues to         expertise in epigenetics, signaling pathways, neural
                                                                     systematically differentiate uncommitted ES cells to fully      cancer stem cells, human leukemia and pluripotent stem
                                                                     differentiated cardiomyocytes fated for the different           cells. This team of investigators for the first time – have
                                                                     chambers of the heart.                                          demonstrated the difference between normal stem cells
                                                                                                                                     and cancer stem cells in humans.




                                                                                                                                     - Dr. Janet Rossant, Chief of Research at Toronto’s Hospital for
                                                                                                                                       Sick Children and Senior Scientist in the Developmental and
                                                                                                                                       Stem Cell Biology program.
           A Global Leader in Stem Cells and Regenerative Medicine




                                                                                                                                     “The culture of collaboration and cooperation
                                                                                                                                      is really quite special here. We can compete
                                                                                                                                      with the rest of the world but we try not to
                                                                                                                                      compete with each other. It makes us
                                                                                                                                      stronger but it also makes us attractive
                                                                                                                                      to other partners too.”
Toronto Region:




                         2
UNIVERSITY OF TORONTO – INSTITUTE OF
BIOMATERIAL AND BIOMEDICAL
ENGINEERING (TORONTO)
                                                                                                 discoveries. Through the Developmental & Stem Cell
                                                                                                 Biology program, the Institute has an extensive stem
                                                                                                 cell research agenda and is supported by imaging (MiCe),
                                                                                                 genome centre (The Center for Applied Genomics –
As part of the University of Toronto, the Institute of                                           sequenced chromosome 7), and the Ontario Induced
Biomaterial and Biomedical Engineering (IBBE) pursues                                            Pluripotent Cell Facility (iPS).
research in four areas: neural, sensory systems and
                                                                                                 The Institute incorporates basic stem cell research with
rehabilitation engineering; biomaterials, tissue engineering
                                                                                                 translational research and focuses on children’s health
and regenerative medicine; molecular imaging and
                                                                                                 issues. Current research activities include studying the
biomedical nanotechnology; medical devices and clinical
                                                                                                 mechanisms that determine the developmental potential
technologies. The tissue engineering and regenerative
                                                                                                 of endogenous embryonic and adult stem cells as well
medicine group study: orthopaedic, dental, cardiovascular
                                                                                                 as induced pluripotent stem cells, and how cells are
and soft tissue biomaterials; stem cell bioengineering and
                                                                                                 transformed into cancer initiating cells. As well,
functional genomics; cellular engineering; and
                                                                                                 teams are investigating how stem cells can be used
hemodynamics, cellular and tissue biomechanics.
                                                                                                 in regenerative medicine and tissue engineering,
The IBBE houses the Centre for Modeling Human                                                    e.g. spinal cord injury and bladder regeneration.
Disease (CMHD) gene trap resource headed by
                                                                                                 Scientists at SickKids have contributed greatly to the stem
Dr. William Stanford as part of the International Gene




THE HOSPITAL FOR SICK CHILDREN
                                                                                                 cell knowledge base and have collaborated in numerous
Trap Consortium. This venture has developed a library                                            important discoveries such as: producing early endoderm




(TORONTO)
of mutagenized mouse embryonic stem cells freely                                                 cells from human embryonic stem cells; the discovery of
available to the scientific community.                                                           the SIRPalpha gene which has properties that allow for
                                                                                                 the successful engraftment of stem cells from human
                                                                                                 bone marrow into mice; advances in repairing spinal cord
                                                                                                 injuries through the use of skin-derived stem cells; and
                                                                                                 the isolation and characterization of a cancer stem cell
The Research Institute at The Hospital for Sick Children                                         from human brain tumours of different phenotypes that
(SickKids) has a strong history in stem cell research with                                       express neural stem cell markers and have stem cell-like
countless collaborations and key breakthrough                                                    behaviour in vitro and in vivo.



GLOBAL STEM CELL RESEARCH ACTIVITY: CANADA RANKS AMONG TOP 5 IN NUMBERS
OF SCIENTISTS AND IN SCIENTIFIC IMPACT
Circle area: Number of Principal Investigators
Bar graph: Scientific Impact (1990-2008)




                   Average Citation/Publication,
                   1990-2008
                                                                                                                   Sweden




                   Global Average
                                                                                                        Netherlands
                                                                                                                                  Germany
                                                                                                      Scotland
                                                                                                         England                                                 South Korea
                                                                            Canada




40
                                                                                                        Switzerland

                                                                            USA                                                                                 China                      Japan




30
                                                                                                                              Israel
                                                                   Mexico




20

10
                                                                                                                                                     Singapore




 0
                                                                                        Brazil




                            a              l                        lia          ds                      ny                                      il        ea
              nd        d       US
                                  A      ae            nd                               lan
                                                                                           d     en                     pa
                                                                                                                          n
                                                                                                                                   po
                                                                                                                                     re       az         or          xic
                                                                                                                                                                        o              ina
          tla        na               Isr           rla         tra           lan     ng       ed      ma             Ja         ga         Br                     Me                Ch
       co          Ca                          itz
                                                   e          us           er       E        Sw      er                                               hK
     S
                                          Sw
                                                            A           th                          G                         Sin                   ut
                                                                     Ne                                                                        So
                                                                                                                                                                               Australia
                                                                                                                                                                                                              A Global Leader in Stem Cells and Regenerative Medicine
                                                                                                                                                                                                   Toronto Region:




                                                                                                                                                                                                          3
MOUNT SINAI HOSPITAL –
                                                                     THE SAMUEL LUNENFELD
                                                                     RESEARCH INSTITUTE (TORONTO)
                                                                                                                                • One of North America’s largest health sciences
                                                                     Established in 1985, the Samuel Lunenfeld
                                                                                                                                  complex:
                                                                     Research Institute of Mount Sinai Hospital
                                                                     is a leader in stem cell research internationally,            • 60 hospitals including 12 research hospitals
                                                                     and is one of the founding centres to have                      affiliated with medical schools at the University
                                                                     revolutionized the field of genome manipulation                 of Toronto and McMaster University (Hamilton)
                                                                     in mammalian embryonic stem cell research.                    • 37 medical institutions
                                                                     Former Lunenfeld researcher Dr. Alexandra                     • 8,200 physicians; and 54,000 health professionals
                                                                     Joyner developed technologies to ‘trap’ genes
                                                                     to follow gene expression and eliminate                    • The location of one of North America’s largest
                                                                     function at once which is now the basis of                   biomedical sectors:
                                                                     Knockout Mouse Project (KOMP). Subsequently,                  • More than 1,200 life sciences firms
                                                                     Lunenfeld Senior Investigator Dr. Andras Nagy                 • 140,000 employees
                                                                     generated mutant mice directly from the dish,
                                                                     and has since improved the process.                           • $8 billion in pharma revenues in Ontario (ethical,
                                                                                                                                     generic and OTC)
                                                                     In 2005, Dr. Nagy established the first Canadian
                                                                     human embryonic stem cell lines. He and his                • A global research centre with sophisticated resources
                                                                     colleagues across Canada have since used                     such as:
                                                                     these lines to study their regenerative                       • Structural Genomics Consortium, a $30 million
                                                                     properties. More recently, a project                            partnership between the University of Toronto,
                                                                     spearheaded by Dr. Knut Woltjen, a                              Oxford University, Karolinska Institute, Merck,
                                                                     postdoctoral fellow in the Nagy laboratory,                     Novartis and GlaxoSmithKline
                                                                                                                                QUICK FACTS ABOUT TORONTO




                                                                     achieved the derivation of stem cells from
                                                                                                                                   • Toronto Centre for Phenogenomics: a $69 million
                                                                                                                                REGION BIO LIFE SCIENCES




                                                                     fibroblasts without the use of viruses, making
                                                                                                                                     state-of-the-art research facility studying mouse
                                                                     regenerative medicine even more tangible for
                                                                                                                                     models of human disease, is the most advanced of
                                                                     translation into the clinic.
                                                                                                                                     its kind in the world
                                                                     Collaborations with the Toronto Centre for                    • Terrence Donnelly Centre for Cellular &
                                                                     Phenogenomics (TCP) and access to leading-                      Biomolecular Research at the University of
                                                                     edge robotics facilities allow the Lunenfeld                    Toronto: centre for integrative biology, disease
                                                                     to continue to build on leading research                        modeling, and functional imaging
                                                                     breakthroughs.
                                                                                                                                • Home to MaRS Innovation, a partnership of 14
                                                                                                                                  Toronto-based academic research institutions to
                                                                                                                                  accelerate the commercialization of promising
                                                                                                                                  research from its members




                                                                                                                                   For more information, please contact:
                                                                                                                                   Sam Lee, PhD
                                                                                                                                   Director, Bio Life Sciences
                                                                                                                                   slee@trra.ca www.trra.ca
                                                                                                                                   Toronto Region Research Alliance
                                                                                                                                   101 College Street, Suite HL30
                                                                          - Dr John Dick, Senior Scientist at the Toronto          Toronto, Ontario Canada M5G 1L7
                                                                            General Research Institute of the University
                                                                            Health Network (UHN) and Professor of Molecular
                                                                            and Medical Genetics at the University of Toronto
           A Global Leader in Stem Cells and Regenerative Medicine




                                                                          “The human capital in the Toronto
                                                                           Region creates a huge dynamic
                                                                           that is hard to replicate anywhere.”
Toronto Region:




                         4

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Toronto Region Stem Cell Fact Sheet Mar 09

  • 1. The Toronto Region is world-renowned for its leading research in stem cells. In the early 1960s, Dr. James Till and Dr. Ernest McCulloch first showed the existence of stem cells. Current researchers like Dr. Gordon Keller at the McEwen Centre for Regenerative Medicine, Dr. Janet Rossant at The Hospital for Sick Children, Dr. John Dick at the University Health Network, and Dr. Mick Bhatia at McMaster University in Hamilton continue the tradition of cutting-edge research in the Toronto Region, building upon the solid foundation established by Till and McCulloch four decades ago. TORONTO REGION: A GLOBAL LEADER IN This extensive level of activity has led to a series of strategic initiatives to concentrate the different STEM CELLS AND REGENERATIVE MEDICINE - Dr. Peter Zandstra, Canada Research Chair in Stem Cell biomedical expertise. These initiatives are meant Bioengineering and Professor of Tissue Engineering at to address the most daunting challenges in stem University of Toronto’s Institute of Biomaterials and cell biology research as discoveries move from the Biomedical Engineering, and Department of Chemical Engineering and Applied Chemistry laboratories to the clinic. One of these initiatives is TORONTO REGION STEM CELL the Toronto Stem Cell Initiative (TSCI), an inclusive RESEARCHERS HAVE GLOBAL IMPACT collection of stem cell research laboratories at the STRATEGIC INVESTMENT University of Toronto and at hospital research institutes. The goal of this initiative is to conduct IN STEM CELL RESEARCH IN stem cell research at all stages and to represent the “Toronto has the critical mass and THE TORONTO REGION ‘national and international face’ of stem cell research for the entire University of Toronto community. collaborative environment. All the different The Cancer Stem Cell Consortium (CSCC), pieces needed to solve the stem cell puzzle Average Citations/Publication, 1998-2008 established in 2007, will allow the biomedical are in place. We provide the bioengineering community to move quickly and effectively from 40 translation part, while others provide 35.5 discoveries to application in the clinic and to launch 35 partnerships among organizations within Canada. a development or genetic engineering 30.2 30.1 29.4 29.2 29.1 9.1 In 2008, the CSCC announced its first international 2 27.5 perspective. You can go right from 30 25.7 25.2 partnership with the California Institute for discovery to therapy all in the same place.” 25 Regenerative Medicine (CIRM). One of the first initiatives will be the Disease Team Research Awards. 20 Proposals will be evaluated by an international team 15 of experts who will focus on applications that have a chance of clinical impact within five years. The CSCC 10 has committed up to $40 million to support the 5 Canadian component of this research. 0 Region d k s l n ia d n ia s tlan Yor sett Israe Regio iforn rylan consi ylvan Texa Sco New sachu to Cal Ma Wis enns Mas To ron P Average Citations/Publication
  • 2. ONTARIO INSTITUTE FOR CANCER RESEARCH (TORONTO) The Ontario Institute for Cancer Research (OICR) is The Toronto Region has a large concentration of research a not-for-profit corporation funded by the Province of centres conducting high-impact, high-value research. Stem Ontario. This institute is dedicated to the prevention, early cell research activity in the region ranges from deriving new detection, diagnosis and the treatment of cancer. As part stem cell lines to translational research, and rivals the of this endeavor, a division for cancer stem cell research other North American stem cell centres such as Boston was established. and California. More than 70 scientists and principal MCEWEN CENTRE FOR REGENERATIVE investigators focus on five broad areas: cancer stem cells, Dr. John Dick, a Senior Scientist at the Ontario Cancer MEDICINE (TORONTO) adult stem cells, embryonic stem cells, regenerative Institute, the research arm of the University Health medicine, and bioengineering/tissue engineering. Network’s Princess Margaret Hospital, heads the OICR Cancer Stem Cell program. The program coordinates the work of 30 scientists at three sites across Ontario to identify ways to selectively target cancer stem cells to eradicate the disease, and to prevent metastases and recurrence. The Cancer Stem Cell group uses a variety of tools for stem cell The McEwen Centre for Regenerative Medicine is a identification, including: bio-repositories and pathology, collaborative entity, which brings together 15 clinicians genomics and high-throughput screening and mouse models. and scientists across University of Toronto-affiliated hospitals that focus on regenerative medicine and OICR is one of the founding partners of the Cancer Stem biomedical research. The Centre focuses on three Cell Consortium, along with Genome Canada, the Canadian Institutes of Health Research, the Canada MCMASTER STEM CELL AND CANCER themes: repair and regeneration, origin and modeling diseases, and new tool discoveries. It has brought Foundation for Innovation and the Stem Cell Network. RESEARCH INSTITUTE (HAMILTON) together the best stem cell biology scientists in the The CSCC is backed by an initial $100 million funding Toronto area and their disease-specific expertise. commitment from its Canadian partners. HIGH-IMPACT, HIGH-VALUE STEM The Centre focuses on the following disease research CELL RESEARCH areas: heart disease, diabetes, spinal cord injury and neurodegenerative diseases, blood cell disorders, lung disease and musculoskeletal diseases. Cutting-edge stem cell technologies such as enhancing the regenerative Founded in 2006, the McMaster Stem Cell and Cancer capacity of the heart, cellular therapy and tissue Research Institute receives funds from the OICR. Inaugural engineering are used to investigate these diseases. For Scientific Director Mick Bhatia, leads a group of eager example, world-renowned scientist Dr. Gordon Keller has scientists who investigate the biology of human cancer optimized differentiation of human embryonic stem (ES) stem cells, embryonic stem cells and adult stem cells. cells into a homogenous layer of cardiomyocytes free The team of scientists is on the cutting-edge of human from animal contaminants. By understanding the stem cell research and has already established molecular requirements for heart precursors in the themselves as experts in the field. They have integrated embryo, his laboratory is now able to use these cues to expertise in epigenetics, signaling pathways, neural systematically differentiate uncommitted ES cells to fully cancer stem cells, human leukemia and pluripotent stem differentiated cardiomyocytes fated for the different cells. This team of investigators for the first time – have chambers of the heart. demonstrated the difference between normal stem cells and cancer stem cells in humans. - Dr. Janet Rossant, Chief of Research at Toronto’s Hospital for Sick Children and Senior Scientist in the Developmental and Stem Cell Biology program. A Global Leader in Stem Cells and Regenerative Medicine “The culture of collaboration and cooperation is really quite special here. We can compete with the rest of the world but we try not to compete with each other. It makes us stronger but it also makes us attractive to other partners too.” Toronto Region: 2
  • 3. UNIVERSITY OF TORONTO – INSTITUTE OF BIOMATERIAL AND BIOMEDICAL ENGINEERING (TORONTO) discoveries. Through the Developmental & Stem Cell Biology program, the Institute has an extensive stem cell research agenda and is supported by imaging (MiCe), genome centre (The Center for Applied Genomics – As part of the University of Toronto, the Institute of sequenced chromosome 7), and the Ontario Induced Biomaterial and Biomedical Engineering (IBBE) pursues Pluripotent Cell Facility (iPS). research in four areas: neural, sensory systems and The Institute incorporates basic stem cell research with rehabilitation engineering; biomaterials, tissue engineering translational research and focuses on children’s health and regenerative medicine; molecular imaging and issues. Current research activities include studying the biomedical nanotechnology; medical devices and clinical mechanisms that determine the developmental potential technologies. The tissue engineering and regenerative of endogenous embryonic and adult stem cells as well medicine group study: orthopaedic, dental, cardiovascular as induced pluripotent stem cells, and how cells are and soft tissue biomaterials; stem cell bioengineering and transformed into cancer initiating cells. As well, functional genomics; cellular engineering; and teams are investigating how stem cells can be used hemodynamics, cellular and tissue biomechanics. in regenerative medicine and tissue engineering, The IBBE houses the Centre for Modeling Human e.g. spinal cord injury and bladder regeneration. Disease (CMHD) gene trap resource headed by Scientists at SickKids have contributed greatly to the stem Dr. William Stanford as part of the International Gene THE HOSPITAL FOR SICK CHILDREN cell knowledge base and have collaborated in numerous Trap Consortium. This venture has developed a library important discoveries such as: producing early endoderm (TORONTO) of mutagenized mouse embryonic stem cells freely cells from human embryonic stem cells; the discovery of available to the scientific community. the SIRPalpha gene which has properties that allow for the successful engraftment of stem cells from human bone marrow into mice; advances in repairing spinal cord injuries through the use of skin-derived stem cells; and the isolation and characterization of a cancer stem cell The Research Institute at The Hospital for Sick Children from human brain tumours of different phenotypes that (SickKids) has a strong history in stem cell research with express neural stem cell markers and have stem cell-like countless collaborations and key breakthrough behaviour in vitro and in vivo. GLOBAL STEM CELL RESEARCH ACTIVITY: CANADA RANKS AMONG TOP 5 IN NUMBERS OF SCIENTISTS AND IN SCIENTIFIC IMPACT Circle area: Number of Principal Investigators Bar graph: Scientific Impact (1990-2008) Average Citation/Publication, 1990-2008 Sweden Global Average Netherlands Germany Scotland England South Korea Canada 40 Switzerland USA China Japan 30 Israel Mexico 20 10 Singapore 0 Brazil a l lia ds ny il ea nd d US A ae nd lan d en pa n po re az or xic o ina tla na Isr rla tra lan ng ed ma Ja ga Br Me Ch co Ca itz e us er E Sw er hK S Sw A th G Sin ut Ne So Australia A Global Leader in Stem Cells and Regenerative Medicine Toronto Region: 3
  • 4. MOUNT SINAI HOSPITAL – THE SAMUEL LUNENFELD RESEARCH INSTITUTE (TORONTO) • One of North America’s largest health sciences Established in 1985, the Samuel Lunenfeld complex: Research Institute of Mount Sinai Hospital is a leader in stem cell research internationally, • 60 hospitals including 12 research hospitals and is one of the founding centres to have affiliated with medical schools at the University revolutionized the field of genome manipulation of Toronto and McMaster University (Hamilton) in mammalian embryonic stem cell research. • 37 medical institutions Former Lunenfeld researcher Dr. Alexandra • 8,200 physicians; and 54,000 health professionals Joyner developed technologies to ‘trap’ genes to follow gene expression and eliminate • The location of one of North America’s largest function at once which is now the basis of biomedical sectors: Knockout Mouse Project (KOMP). Subsequently, • More than 1,200 life sciences firms Lunenfeld Senior Investigator Dr. Andras Nagy • 140,000 employees generated mutant mice directly from the dish, and has since improved the process. • $8 billion in pharma revenues in Ontario (ethical, generic and OTC) In 2005, Dr. Nagy established the first Canadian human embryonic stem cell lines. He and his • A global research centre with sophisticated resources colleagues across Canada have since used such as: these lines to study their regenerative • Structural Genomics Consortium, a $30 million properties. More recently, a project partnership between the University of Toronto, spearheaded by Dr. Knut Woltjen, a Oxford University, Karolinska Institute, Merck, postdoctoral fellow in the Nagy laboratory, Novartis and GlaxoSmithKline QUICK FACTS ABOUT TORONTO achieved the derivation of stem cells from • Toronto Centre for Phenogenomics: a $69 million REGION BIO LIFE SCIENCES fibroblasts without the use of viruses, making state-of-the-art research facility studying mouse regenerative medicine even more tangible for models of human disease, is the most advanced of translation into the clinic. its kind in the world Collaborations with the Toronto Centre for • Terrence Donnelly Centre for Cellular & Phenogenomics (TCP) and access to leading- Biomolecular Research at the University of edge robotics facilities allow the Lunenfeld Toronto: centre for integrative biology, disease to continue to build on leading research modeling, and functional imaging breakthroughs. • Home to MaRS Innovation, a partnership of 14 Toronto-based academic research institutions to accelerate the commercialization of promising research from its members For more information, please contact: Sam Lee, PhD Director, Bio Life Sciences slee@trra.ca www.trra.ca Toronto Region Research Alliance 101 College Street, Suite HL30 - Dr John Dick, Senior Scientist at the Toronto Toronto, Ontario Canada M5G 1L7 General Research Institute of the University Health Network (UHN) and Professor of Molecular and Medical Genetics at the University of Toronto A Global Leader in Stem Cells and Regenerative Medicine “The human capital in the Toronto Region creates a huge dynamic that is hard to replicate anywhere.” Toronto Region: 4