Oral presentation by Lars Ramström at the Annual 8th Conference of ISPTID, Boston, USA, 29 Septemner to 1 October 2010

1. Characteristics of new tobacco products emerging on the tobacco market: implications for tobacco control policies Lars M. Ramström Institute for Tobacco Studies Stockholm, Sweden Annual 8th Conference of ISPTID, Boston, USA, 29 Septemner to 1 October 2010

3. Electronic cigarettes

4. Nicotine concentrations and craving relief by E-Cigarettes Eissenberg et al 2010

6. Waterpipe (Hookah, Hubble-Bubble)

7. (Am J Prev Med 2009;37(6):518–523) Eissenberg T, Shihadeh A

8. Khabour et al. Assessment of Genotoxicity of Waterpipe and Cigarette Smoking in Lymphocytes Using the Sister-Chromatid Exchange Assay: A Comparative Study . Environmental and molecular mutagenesis 2010 The results show that waterpipe smoking and cigarette smoking significantly increase the frequencies of SCEs (P < 0.01) compared with those of nonsmokers, indicating the genotoxic effect of tobacco smoking. In addition, frequencies of SCEs were significantly higher among waterpipe smokers compared with CS (P < 0.01), indicating that waterpipe smoking is more genotoxic than cigarette smoking . Moreover, the frequency of SCEs increased with the extent of waterpipe use.

9. Swedish snus Fine ground tobacco leaves predominantly from air-cured dark tobacco Manufactured by a pasteurizing-like heating process (without fermentation as in manufacturing of American snuff), which results in v ery low levels of tobacco-specific nitrosamines and benzo(a)pyrene

10. Mean nitrosamine content of moist snuff products from various sources based on dry weight

13. Gartner et al. Lancet 2007

14. “ Our argument is that nicotine products should all be regulated rationally in relation to each other, in proportion to their level of hazard , in a system designed to reduce the overall harm caused by nicotine dependence and use.” John Britton, Richard Edwards. Tobacco smoking, harm reduction, and nicotine product Regulation. Lancet 2008; 371: 441–45.

15. HARM 100% 10 0% Nicotine replacement products Snus Traditional cigarettes, Waterpipes Modified cigarettes E-cig ? THE CONTINUUM OF HARM FROM NICOTINE-DELIVERING PRODUCTS Snokless tobacco, e.g. India No tobacco use

17. Recommendations for regulation of smokeless tobacco ● The combined concentration of NNN plus NNK in smokeless tobacco should be limited to 2 μ g/g dry weight of tobacco. ● The concentration of benzo[a]pyrene in smokeless tobacco should be limited to 5 ng/g dry weight of tobacco.

20. ” Although nearly half of the smokers surveyed were willing to purchase an LNSLT product, most were interested in using these products for cessation rather than as a long-term substitute or for dual use with cigarettes.”