7. ۳۹۹ ﺍﻭﺳﺘﺌﻮﭘﺮﻭﺯ ﺩﺭ ﻣﺮﺩﺍﻥ ﺭﻭﺳﺘﺎﻫﺎﻱ ﻓﺎﺭﺱ ﺩﻛﺘﺮ ﺍﻣﻴﺮ ﺁﺩﻳﻨﻪﭘﻮﺭ ﻭ ﻫﻤﻜﺎﺭﺍﻥ
ﺭﺍ ﺩﺭ ﻣﺮﺩﺍﻥT-score ﻭBMD ﺟﻤﻊﺑﻨﺪﻱ ﺍﻃﻼﻋﺎﺕ، ﻣﻨﺒﻊ ﺑﺮﺧﻮﺭﺩ ﻣﻨﺎﺳﺐ ﺑﺎ ﭘﻮﮐﻲ ﺍﺳﺘﺨﻮﺍﻥ ﺑﺎﻳﺪ ﺍﺯ ﺗﻤﺎﻡ ﻋﻠﺖﻫﺎ ﻭ
ﺭﻭﺳﺘﺎﻳﻲ ﺍﻳﺮﺍﻧﻲ ﻣﻲﺗﻮﺍﻥ ﺗﻌﻴﻴﻦ ﻛﺮﺩ ﻭ ﺍﺯ ﺧﻄﺮﻫﺎﻱ ﻧﺎﺷﻲ ﺍﺯ ، ﺍﺳﺘﻔﺎﺩﻩT-Score ﻋﻮﺍﻣﻞ ﻣﺆﺛﺮ ﺩﺭ ﻭﻗﻮﻉ ﺷﮑﺴﺘﮕﻲ، ﻧﻪ ﻓﻘﻂ
.ﺍﻳﻦ ﺑﻴﻤﺎﺭﻱ ﺟﻠﻮﮔﻴﺮﻱ ﻧﻤﻮﺩ ﮐﺮﺩ. ﻫﻢﭼﻨﻴﻦ، ﺑﻪ ﻋﻠﺖ ﺍﻳﻦ ﮐﻪ ﺑﺎ ﺍﺳﺘﻔﺎﺩﻩ ﺍﺯ ﻣﻌﻴﺎﺭ ﻣﺤﻠﻲ ﻳﺎ
ﺩﺭ ﻣﺠﻤﻮﻉ ﺑﺮ ﺍﺳﺎﺱ ﻳﺎﻓﺘﻪﻫﺎﻱ ﺍﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺍﺳﺘﻔﺎﺩﻩ ﺍﺯ ، ﻣﻤﻜﻦ ﺍﺳﺖ ﺗﺸﺨﻴﺺ، ﺑﻴﺸﺘﺮ ﻳﺎ ﮐﻤﺘﺮ ﺍﺯ ﺣﺪ ﻭﺍﻗﻌﻲWHO
ﺑﺮﺍﻱ ﺑﺮﺭﺳﻲ ﭘﻮﮐﻲWHO ﻣﻌﻴﺎﺭﻫﺎﻱ ﻣﺤﻠﻲ ﻳﺎ ﻣﻌﻴﺎﺭﻫﺎﻱ ،ﮔﺰﺍﺭﺵ ﺷﻮﺩ، ﻭ ﻫﺰﻳﻨﻪﻫﺎﻱ ﺑﺨﺶ ﺩﺭﻣﺎﻥ ﺳﻨﮕﻴﻦﺗﺮ ﮔﺮﺩﺩ
ﺍﺳﺘﺨﻮﺍﻥ، ﻣﻤﻜﻦ ﺍﺳﺖ ﻧﺘﺎﻳﺞ ﻣﺘﻔﺎﻭﺗﻲ ﺩﺭ ﺷﻴﻮﻉ ﺍﻳﻦ ﺑﻴﻤﺎﺭﻱ ﺑﻨﺎﺑﺮﺍﻳﻦ ﻫﻴﭻ ﻣﺪﺭﮎ ﻗﺎﻧﻊﮐﻨﻨﺪﻩﺍﻱ ﻭﺟﻮﺩ ﻧﺪﺍﺭﺩ ﮐﻪ ﺗﻌﻴﻴﻦ ﻛﻨﺪ
ﺩﺍﺷﺘﻪ ﺑﺎﺷﺪ. ﺑﻨﺎﺑﺮﺍﻳﻦ، ﺑﺮﺭﺳﻲﻫﺎﻱ ﺁﻳﻨﺪﻩﻧﮕﺮ ﺩﺭﺑﺎﺭﻩﻱ ﺍﺣﺘﻤﺎﻝ T-Score ﺧﻄﺮ ﺷﮑﺴﺘﮕﻲ ﺩﺭ ﺟﻮﺍﻣﻊ ﺭﻭﺳﺘﺎﻳﻲ ﺑﺎ ﮐﺪﺍﻡ
.ﺷﮑﺴﺘﮕﻲ ﺍﺳﺘﺨﻮﺍﻥ ﺑﺎ ﺩﻭ ﻣﻌﻴﺎﺭ ﻧﺎﻣﺒﺮﺩﻩ ﺗﻮﺻﻴﻪ ﻣﻲﺷﻮﺩ ﻫﻢﺧﻮﺍﻧﻲ ﺩﺍﺭﺩ ﻭ ﺗﻨﻬﺎ ﺑﺎ ﻣﻄﺎﻟﻌﻪﻫﺎﻱ ﺁﻳﻨﺪﻩﻧﮕﺮ ﺩﺭ ﻣﻮﺭﺩ ﻭﻗﻮﻉ
۲۴،۲۵
ﺳﭙﺎﺳﮕﺰﺍﺭﻱ: ﺍﺯ ﻫﻤﻪﻱ ﺍﻓﺮﺍﺩﻱ ﻛﻪ ﺩﺭ ﺍﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺷﺮﻛﺖ ﻛﺮﺩﻧﺪ ﻭ ﻻﺯﻡ ﺑﻪ .ﺷﮑﺴﺘﮕﻲﻫﺎ ﻣﻲﺗﻮﺍﻥ ﺑﻪ ﻧﺘﻴﺠﻪﻱ ﺩﻟﺨﻮﺍﻩ ﺭﺳﻴﺪ
ﻫﻢﭼﻨﻴﻦ ﺍﺯ ﻛﺎﺭﻛﻨﺎﻥ ﻣﺮﻛﺰ ﺗﺤﻘﻴﻘﺎﺕ ﻏﺪﺩ ﺩﺭﻭﻥﺭﻳﺰ ﻭ ﻣﺘﺎﺑﻮﻟﻴﺴﻢ ﺫﮐﺮ ﺍﺳﺖ ﺩﺭ ﺍﻳﻦ ﭘﮋﻭﻫﺶ ﻓﻘﻂ ﺟﻤﻌﻴﺖ ﻣﺤﺪﻭﺩﻱ ﺍﺯ ﻳﻚ
ﺩﺍﻧﺸﮕﺎﻩ ﻋﻠﻮﻡ ﭘﺰﺷﻜﻲ ﺷﻴﺮﺍﺯ ﻭ ﺍﺯ ﺧﺎﻧﻢ ﺩﻛﺘﺮ ﻣﺮﺿﻴﻪ ﺑﺨﺸﺎﻳﺶ ﻣﻨﻄﻘﻪﻱ ﺭﻭﺳﺘﺎﻳﻲ ﻣﻮﺭﺩ ﺑﺮﺭﺳﻲ ﻗﺮﺍﺭ ﮔﺮﻓﺖ ﻭ ﺑﺮﺍﻱ
ﻛﺮﻡ، ﺧﺎﻧﻢ ﺩﻛﺘﺮ ﻫﻠﻦ ﻃﺎﻫﺮﻱ ﻭ ﺧﺎﻧﻢ ﺯﻫﺮﺍ ﮊﻭﻟﻴﺪﻩﭘﻮﺭ ﺗﺸﻜﺮ ﻭ ﺑﻬﺮﻩﺑﺮﺩﺍﺭﻱ ﺳﻮﺩﻣﻨﺪ ﺍﺯ ﺍﻳﻦ ﻣﻌﻴﺎﺭﻫﺎ ﻻﺯﻡ ﺍﺳﺖ ﻣﻄﺎﻟﻌﻪﻫﺎﻱ
.ﻗﺪﺭﺩﺍﻧﻲ ﻣﻲﻧﻤﺎﻳﻴﻢ
ﺑﻴﺸﺘﺮﻱ ﺩﺭ ﺳﺎﻳﺮ ﻣﻨﻄﻘﻪﻫﺎﻱ ﺭﻭﺳﺘﺎﻳﻲ ﺍﻳﺮﺍﻥ ﺍﻧﺠﺎﻡ ﺷﻮﺩ ﺑﺎ
11. Wang Y, Tao Y, Hyman ME, Li J, Chen Y.
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9. 453/Iranian Journal of Endocrinology and Metabolism Vol 12 No.4 November 2010
Original Article
Prevalence of Osteoporosis in Rural Men of Fars Based on
Both Local and WHO Reference Data
Adine pour A1, Tohidi M1, Dabbaghmanesh M1, Jafari P2, Fattahi M3, Ranjbar Omrani Gh1
1Endocrine and Metabolism Research Center, 2Department of Biostatistic, 3Gastroenterology and Hepatology
Research Center Shiraz University of Medical Sciences, Shiraz, I.R. Iran
e-mail:hormone@ sums .ac.ir
Received: 12/03/2010 Accepted: 04/08/2010
Abstract
Introduction: Recently osteoporosis (OP) has emerged as a basic public health problem. It is
characterized by low bone mass with micro architectural destruction of bone, resulting in
increased bone fractures, morbidity and mortality. Materials and Methods: To evaluate the
prevalence of OP using the local reference data of rural males of Fars and to compare it with WHO
criteria, a total of 263 male adults, aged between 20-94 yrs, participated in this cross-sectional
study. Bone Mineral Density (BMD) was measured by DXA. We utilized a fit curve method to
determine the best age range over which to calculate Peak Bone Mass (PBM) and we used
regression analysis for association of OP with age and Body mass index (BMI). Results: PBM was
observed at the age range of 20-24 years, at the various sites. The prevalence of OP increased with
age. It was negatively correlated with BMI and varied dramatically based on local versus WHO
criteria. Based on local criteria, prevalence of OP in the lumbar spine, femoral neck and total femur
were 3.8%, 24.8% and 14.8%, respectively, and, based on WHO criteria, they were 10%, 6.1% and
24%, respectively. Conclusion: Using local or WHO reference values for evaluation of OP may yield
different prevalences. Therefore prospective fracture studies in correlation with the two above
reference values are recommended.
Keywords: Osteoporosis, Peak Bone Mass, Reference data, WHO