Recomendados
Recomendados
Mais conteúdo relacionado
Destaque
Destaque (20)
Semelhante a Examples From Medical Device Clinical Trials To Illustrate Advantages Of The Bayesian Approach
Semelhante a Examples From Medical Device Clinical Trials To Illustrate Advantages Of The Bayesian Approach (20)
Examples From Medical Device Clinical Trials To Illustrate Advantages Of The Bayesian Approach
- 1. Economic and Statistical Analysis of Healthcare Technology Teresa Nelson, MS Principal Statistician ©Technomics Research 2009
- 3. Outline
- 4. Bayesian Jokes Stat #2 shoots left Stat #1 shoots right
- 5. FDA Requirements for Bayesian Designs
- 6. Example #1 - Utilization of Prior Data to Reduce Overall Sample Size by Two Methods
- 7. Example #1 - Utilization of Prior Data to Reduce Overall Sample Size
- 8. Example #1 - Utilization of Pilot Data via the Prior Data to Reduce Overall Sample Size Prior Distributions N=75, p=65%, # success=49 N=19, p=63%, # success=12 N=6, p=66%, # success = 4 Non-informative, N=2, p=50%, # success=1
- 9. Example #1 - Utilization of Pilot Data via the Prior to Reduce Overall Sample Size – Operating Characteristics
- 10. Example #1 - Utilization of Pilot Data via a Hierarchical Model Pools Pilot and Pivotal Study Results for Treatment Pcontrol - Ptreatment Patient Success due to Control Patient Success due to Treatment Uses Only Pivotal Study Control Group Results Pilot Study Patient Success Pivotal Study Patient Success
- 11. Example #1 - Utilization of Pilot Data via Hierarchical Model – Operating Characteristics
- 12. Example #1 – Regulatory Update
- 13. Example #1 – Summary and Advantages
- 14. Example #2 - Incorporation of Multiple Looks Via A Bayesian Design Allows Earlier Trial Stopping
- 15. Example #2 - Incorporation of Multiple Looks Via A Bayesian Design Allows Earlier Trial Stopping – Frequentist and Bayesian Designs
- 16. Ex. #2 -Incorporation of Multiple Looks Via A Bayesian Design Allows Earlier Trial Stopping – Operating Characteristics
- 17. Ex. #2: Incorporation of Multiple Looks Via A Bayesian Design Allows Earlier Trial Stopping – Compare Bayesian and Frequentist Design
- 18. Ex. #2: Incorporation of Multiple Looks Via A Bayesian Design Allows Earlier Trial Stopping – Compare Bayesian and Frequentist Design
- 19. Regulatory Update – Example #2
- 20. Example #2 – Summary and Advantages
- 21. Example # 3 - Utilization of predictive distribution to calculate probability of a successful trial result
- 22. Example #3 – Predictive Distribution
- 23. Example #3 – Results reviewed by DSMB
- 24. Example #3 – Predictive Distribution Results
- 25. Example #3 - Another Possible Scenario
- 26. Example #3 – Is it Futile to Continue?
- 27. Example #3 – Regulatory Update and Summary and Advantages
- 28. Example # 4 - Interesting Application for Bayesian Meta-Analysis
- 29. Example #4 - Bayesian Solution
- 30. Example #4: Bayesian Meta-Analysis
- 31. Example #4: Bayesian Meta-Analysis
- 32. Example #4: Bayesian Meta-Analysis
- 33. Example #4 – Bayesian Hierarchical Model for Meta-Analysis for Device Experience
- 34. Example #4 - Bayesian Random Effects Model for Meta-Analysis of Device Experience
- 35. Example #4 - Bayesian Random Effects Model for Meta-Analysis of Control Experience
- 36. Example #4 – Bayesian Meta-Analysis
- 37. Example #4 – Bayesian Meta-Analysis Results cont’d.
- 38. Additional Features to Bayesian Designs Results cont’d.
- 39. Priors for Sensitivity Analysis *Assumes a 3% mortality rate
- 40. Results of Sensitivity Analysis on Hierarchical Model
- 41. Results of Sensitivity Analysis on Random Effects Models
- 42. An Example where Bayesian Hierarchical Modeling was Used to Garner FDA Approval
- 43. Summary - Advantages to Bayesian Trial Design
- 44. Thank you! Teresa Nelson, MS Ph: 218 463 5627 tnelson@technomicsresearch.com www.technomicsresearch.com
- 45. If interested in contracting our services please contact: Kim Martinson Vice President-Business Development Email: Kmartinson@TechnomicsResearch.com Ph: 218-331-2272 www.technomicsresearch.com