Almost all pharmacies sell sildenafil either as generic or with a business name like Viagra, Kamagra, etc so it is important for a medical personnel to know this drug thoroughly

1. EMMANUEL
EMMANUEL MICHAEL

2. 1.INTRODUCTION
Sildenafil citrate sold as Viagra,Revatio and
under various other trade name
Is a drug used to treat erectile dysfuction
and pulmonary arterial hypertension.

3. STRUCTURE

4. Mechanism of Action
It acts by inhibiting Cgmp
specific phosphodiasterase
type 5 PDE5 an enzyme that
promotes degradation of c
GMP which regulate blood
in the penis.

6. OTHER DRUGS WITH SIMILAR
MECHANISM OF ACTION
•Tadalafil-Cialis
•Vardenafil-Levitra

7. INDICATION
•The primary indication of
sildenafil is treatment of erectile
dysfuction(inability to sustain
satisfactory erection to complete
intercourse)
•Its use is now standard
treatment for erectile dysfuction
in all setting

8. Indication continued……………………
•As well as erectile dysfuction sildenafil
citrate is also effective in Pulmonary
Arterial Hypertension(PAH)
•It relaxes the arterial wall,leading to
decreased pulmonary arterial resistance
and pressure.

9. DOSAGE
Viagra pills are available in 25mg,50mg
and 100mg from

10. ADVERSE EFFECTS
•Dyspepsia
•Nausea
•Headache
•Visual disturbance
•Back pain
•Dizziness
•Less common are
tinnitus,dry
mouth,drowsiness,vertigo
and fatigue

11. INTERACTION

12. • Protease inhibitors for treatment of HIV
• Its recommended that patients using
protease inhibitor limit their use of
sildenafil to more than one 25mg every 48
hours
• Alpha blockers-concomitant use lead to low
blood pressure.

13. CONTRAINDICATION
•When taking nitric oxide donors,organic
nitrites,and nitrates such as
nitroglycerin,sodium nitroprusside and
amy nitrite
•Severe hepatic impairment
•Severe impairment in renal function
•Cardiovascular problem
•Recent stroke or heart attack