3. MALE REPRODUCTIVE SYSTEM
TESTIS
Type of structure – parenchymal lobulated
Stroma – Connective tissue + smooth myocytes + elastic fibres
- Capsule - tunica albuginea (DCT + serosa)
- Mediastinum (DCT)
- Interlobular septae (DCT)
- Intralobular LCT with calillaries and intersticial (endocrine) cells
Parenchyma – seminiferous tubules
6 5 1
1
7 2
2
4
3
8
4. MALE REPRODUCTIVE SYSTEM
Peculiarities of stroma in testis
- T.albuginea is covered by serosa
- includes SM and EF
- in lobules fenestrated capillaries are located
- Intersticial cell – endocrine – produce TESTOSTERON
- endocrine function is under the hypothalamo-pituatary system control (LH)
- interstitial (Leidig) cells form groups near capllaries, have round N and
oxyphilic cytoplasm
- EM: smooth ER, mitochondriae with tubulo-vesicular crysts, lipid droplets,
crystalloid.
5. MALE REPRODUCTIVE SYSTEM
SEMINIFEROUS TULULES
1. Convoluted
2. 1-4 tubules in one lobule
3. Wall is lined by epitheliospermatogenic layer (ESL)
4. ESL includes supporting (Sertolli) cells +
spermatogenic cells
5. Surrounded by myoid cells.
6. MALE REPRODUCTIVE SYSTEM
Sertolly`s cells
- Pyramidal shape
- Processes are joined by tight junctions and
subdivide ESL into 2 poles
- Poles: basal and adluminal
- make microenvironment for prermatogenic cells
- Participate in formation of blood-testis barrier
1
2
3
4
5
7. MALE REPRODUCTIVE SYSTEM
SPERMATOGENIC cells
- Spermatogonia
- Primary spermatocytes
- Secondary spermatocytes
- Spermatides
- Spermatozoa
3
3
1
1
3
3
2 1
2 1
А Б
А Б
8. MALE REPRODUCTIVE SYSTEM
SPERMATOGENESIS includes:
1. Proliferation (mitosis)
2. Growth (prophase of 1st meiotic division)
3. Maturation (1st and 2nd meiotic division)
4. Formation (differentiation – spermiogenesis)
1
2
3
4
5
6
9. MALE REPRODUCTIVE SYSTEM
Spermiogenesis includes changes of:
1. Shape
2. Size of Nucleus
3. Number of mitochondriae
4. Location of Golgi apparatus
3. Acrosome formation
4. Microtubules arrangement with tail formation
3
2
3
2
3 4
7 5
6
5
5
4
А Б
1
8
