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Our ressources

     StratAdviser strategic consultants are:
      – Economists, Scientists and Lawyers
             • with MSc/MD/PhD in Finance, Strategy, Business, Marketing,
               Information and communication technologies (ICT), Neuro-Sciences, and
               Medicine
      – Multinational individuals
             • who live and work in an international environment
             • have a specific knowledge focused on trans-national and trans-cultural
               issues
             • as well as they can work in a mono-national context
      – Proficient in foreign languages such as English, French, Spanish and
        German
     StratAdviser key players have:
      – 10 years or more of experience working in their respective fields
             • teach management, crisis management, strategy, marketing,
               communication and medicine
             • at Business Schools, Engineering Schools and Universities.

10/05/2010 confidential                                                                 2
Our Fields of Expertise
Our International Reach



    Beata                                 Angel
LEWANDOWSKA                           GONZALEZ




                                                Erwan
Sébastien                                       YANN
MODICOM



       Søren                            Brian
       MUUS                 Jeffrey   FLECK
                            Taylor
Our Expert Resources



          Dr Jan-Cédric
            HANSEN
Medico-Marketing European Strategist




 10/05/2010 confidential                          5
StratAdviser in short

     StratAdviser impact on Consulting
      – StratAdviser strategic package
             • Strategic Diagnosis, Strategic Recommendation and
               Strategic Follow-up
      – based on medical processes delivers
             • valuable strategic advice easy to access and implement
             • as well as adequate cost control thanks to its simple
               costing policy
     StratAdviser and You
      – Any time your company and/or you face an issue
             • just contact StratAdviser knowing that
                    – the proper strategic recommendation will be delivered and
                      followed through
                    – adapted to the availability of your financial and human resources

10/05/2010 confidential                                                                   6
Additional features

                                 Registered as a lobbyist
                                 with the European
                                 Commission
                                  – Allows us to deliver specific
                                    solutions regarding regulatory
                                    issues and the like…


                                 All of our recommendations
                                 are assessed for legal risk
                                  – by a Franco-British
                                    Independent lawyer firm
10/05/2010 confidential                                              7
Our specific
approach to
  strategy
Medical methodology inspires us

     In medicine, diagnosis is:
      – the process of identifying a medical condition or disease
        by its signs, symptoms, and from the results of various
        diagnostic procedures
     Doctors are trained to:
      – take decisions in acute and uncertain situations
      – constantly challenge and reassess their decisions
      – think strategically before taking actions
     StratAdviser considers that such a methodology
     applies nicely to its client’s needs because
     diagnosis is a fluid process
10/05/2010 confidential                                             9
High added value oriented

      In order to deliver high added value advice and
      ensure its optimal ROI we follow three steps
      1. Strategic Diagnosis - allows deeper exploration to
         re-establish and reformulate the need
      2. Strategic Recommendation - develop what to do and
         how in order to best respond to the need
      3. Strategic Follow-up - monitoring the application of
         recommendations and their positive impact




10/05/2010 confidential                                        10
–



    Proprietary
    Methodology
     in Practice
Our Strategic « 3 Step » Process
      Expression of a                  Strategic Diagnostic         Strategic Recommendation
       potential need
(prospecting or spontaneous)            Brainstorm Workshop            Brainstorm Workshop
                                    restitution and reformulation          for fine tuning
   meeting with client for                   of SD content                  of SR content
 clarification of advice level
                                     Submission of draft               Submission of draft
                                   Anamnesis, Investigations           Advice prescription,
     Brainstorm Workshop
                                        & Prognosis                      Integration plan
   for reformulation of need
   & selection of appropriate                                        & Appropriation process
         team/resources
                                       no        Your      yes
                                              Validation
   Submission of draft                                                 no       Your
                                                                                          yes
 methodology, timeline and                                                   Validation
      global estimate
                                      Strategic Follow-up


     no                  yes           Brainstorm Workshop
               Your
            Validation
                                    for Tactical Implementation


                                 Submission of strategic advice
                                         +/- plan of action
                                      +/- appropriation plan
                                   +/- related additional costs
                                                                             Delivery

                                        no                 yes
                                                 Your
 10/05/2010 confidential                      Validation                                        12
Our Stategic Diagnostic Step

                                   Brand
                                  Essence
                               Communication
                                 Positioning
                                  Statement
                                Personality &
                                 Core values
                               Brand Promise &
                              Reasons to Believe
                                Target insight
                                  Attributes
                             Features and benefits
                                    SWOT
                                 Unmet needs
                          Target Audience Descriptors
                                 Brand vision


10/05/2010 confidential                                 13
Our Strategic Recommendation Step
                                                                            Optimise pricing           Broaden                Development and
                   Rapid adoption amongst primary target                                                clinical             execution of global
    Key                                                                       and secure
                           of Sarcoma Specialists                                                     experience
                                                                            reimbursement                                      Life Cycle Plan
 Strategies
                         • Communication and PR plan to increase              • Development            • Transition of       • Develop and optimize
                    awareness of PharmaMar as an innovative oncology                of pan-            compassionate               formulations
                           company and raise awareness of disease                  European          use to commercial
                    • Working with Cooperative Groups (BC, NSCLC)                 Pricing and                 drug           • Ensure progression of
                           and Patient Groups (Potentiate formation)           reimbursement             • Phase IV              manufacturing to
                      • Corporate sponsorship of major meetings and                 strategy              programme               semi-synthetic
                          bodies PharmaMar stand-alone event ( MoA)            • HE plan and        • Life cycle plan in
                       • Promotional activities: Global branding and               economic                                   • Develop regulatory
                                                                                                       conjunction with
                                            campaign                                 model                 J&J – new            strategies for ex-US
                                                                                • Sequential                                          territories
Action Plans                       • Promotional materials                                           indications (1st line
                  • Congress activities, PharmaMar stand-alone event,             launches to             STS, breast
                                                                                                      cancer, NSCLC,           • Optimize market
                                           Publications                         optimise price
                                                                                                       ovarian cancer),        exclusivity and patent
                      • PharmaMar internet site and Yondelis website                                                                   estate
                                                                                                      more convenient
                                     • KOL development                                                   regimens (3h
                  • Vehicle (e.g. Ad Board) to review and revise clinical                            schedule, weekly),        • Develop targeted
                                     endpoints in sarcoma                                               combinations/                labeling
                                (RR does not correlate with OS)                                      sequential therapy
                        • EORTC collaboration to develop standard                                      with other major
                                  classification tools for STS                                             cytotoxics


                             • Increase awareness and usage                    • Pricing strategy    • ATU cohort after        • Target profiles for
                     • Complete territory mapping and identification of          complete by end        CPMP opinion             new indications by
                      key stakeholders, prescribers and patient pool by                2002         • Phase IV strategy                 YE
Key Expected                               2003 YE                           • Implementation by         by Q1 2003            • GLCP by YE and
  Results                         • 2003 Ex factory sales                           end 2003                                     presented to Joint
                   • SoV increases 20%p.a., versus Novartis (Glivec),           • Launch first in                               Steering Committee
                         Baxter (ifosf), S-P (Caelyx), Astra-Zeneca             Germany, UK and
                                           (Irtessa).                                Sweden
     10/05/2010 confidential                                                                                                                14
    Example of Yondelis contribution
Potential Strategic Synergies



    Strategic Diagnostic


                                                          Your communication Agency
Brand Pyramid
                                                                   Briefing
                                                            Communication Platform
                                                               Visual identity
                                                                Graphic Chart
                               Strategic Recommendation

                                                              Strategic Follow-up
                                                              (Tactical Implementation)
                             Matrix



   10/05/2010 confidential                                                                15
Continuous Dynamic Interaction
        Structure
     and/or Profit                                                Required again
and/or Resilience
 and/or Personal
     development
                                                                                   ?
                                                      Follow-up




                                          Diagnosis &
                                        Recommendation


                                                                                       StratAdviser
                         Potential                                                     achievement
                      Early diagnosis
                                                  Uncertain
                                                 environment


                                                                                             Potential
                                                                                             reaction


                                               Natural
                                               evolution

                                                                                                         time
    10/05/2010 confidential                                                                                 16
Our Strategic Advice
    in Practice
We build your strategy together

One methodology
– StratAdviser proprietary methodology
Two different kinds of deliverables
– Recommendation alone
– Recommendation and related deliverables
Three ways to collaborate
– Long term programs
– Annual supports
– 1-3 day seminars
Our Long Term Programs

Corporate/Portfolio Strategic coherence along
market evolution
Corporate/Portfolio European Strategic Lobbying
High Profile Managers Key Decisions process
assistance
International Marketing Task Force management
European Expert Group & Related Publication
Plan
Prelaunch & Launch Strategic Matrix
implementation
Our Annual Supports

Corporate/Portfolio Strategy Fine Tuning
Corporate/Portfolio Strategy Stakeholders
Appropriation
Corporate/Portfolio Strategy Tactical
Field/Market Adaptation
Prescribers Scrutiny through Sales’ Forces
Optimizing Sales’ Forces impact factor
Sales Oriented Medical Education
Contextual Incentive
Our 1-3 day seminars

Market Study Audit
New Competitive Edges
Competitors’ Strategy Simulation
Enhance Brand’s Resilience
Joint Strategic Workshops
Brand Audit
Brand Rejuvenation
Portfolio Audit
European Creative Seminar
Tender Notice Audit
Lecture & Workshops
Let Our “ Lectures & Workshops ” be
        your “ Lectures & Workshops ”
     Available conferences 2009-2010
      – “Crisis communication, legal issues & economic impact of the pandemic threat”
      – “Expanding your European position despite inhomogeneous maturation of portfolio
        among target countries”
      – “Understanding benefits of brand vs product communication strategy”
      – “Strategic healthcare communication during crisis management”
      – “Turning affiliates “specificity” into powerful European strategy”
      – “Strengthening European cooperation between pharmaceutical Industry and Private
        Hospitals: a promising competitive edge”
     Coming conferences 2011-2012
      –   “Post crisis management, frequent mistakes and consequences”
      –   “Efficient Orphan drugs marketing approach: musts and options”
      –   “Key topics to understand the Japanese market entry limitations”
      –   “Rising competition among generics: time for redesigning the brand concept?”
      –   “Terms and Conditions of Sales as a competitive edge”
      –   “Identification of new communication themes for MEDED programs”




10/05/2010 confidential                                                                  22
Samples of Strategic
Advices and Related
    Deliverables
Provide High Value European Insights

                    Situational analysis
                     – Need for global expertise regarding the
                       European Market and specificity of
                       European healthcare systems
                    Strategic Diagnostic
                     – Content analysis of available publication
                       on the disease
                     – Reassessment of available Market
                       Studies
                     – Identification and Interviews of KOL
                     – Cross matching of findings with
                       StratAdviser expertise
                    Strategic Recommendation
                     – Drafting of preliminary report to fuel the
                       strategic thinking including promising
                       positioning & potential communication
                       plan
                    Strategic follow-up
                    (Tactical Implementation)
                     – Left to our client
Deliver High Standard Expertise

                              Situational analysis
                               – A spring water trade organisation is
                                 sued by a mineral water trade company
                                 for improper health claim
                              Strategic Diagnostic
                               – The trial is backed up by a report from
                                 the French Academy of Medicine
                               – Risk is that the trial outcome will
                                 ultimately apply to all spring water
                                 manufacturers
                              Strategic Recommendation
                               – Strike back should be managed by the
                                 spring water trade union
                               – Need for a contradictory report with
                                 higher quality standards to neutralize
                                 the French Academy of Medicine
                              Strategic follow-up
                              (Tactical Implementation)
                               – Deep analysis of the French Academy
                                 of Medicine report and writing of the
                                 contradictory report
                               – Work in tandem with the trade Union
                                 Lawyer Firm
                               – Help the client in implementing its
                                 lobbying actions

10/05/2010 confidential                                             25
Elaborate Strategic Positioning

                  Situational analysis
                   –   A thermal Bath faces constant regression of
                       turnover
                  Strategic Diagnostic
                   –   Thermal Bath location and accommodations
                       inadequate to drain clients by themselves
                   –   Thermal medicine no longer considered as a
                       reference for chronic conditions by GPs
                   –   100% of French centres for burned patients
                       refer cases to the Thermal bath
                  Strategic Recommendation
                   –   Reinvest the neglected local medical
                       expertise
                   –   Position the Thermal Bath as “First
                       European Dermatology Spa”
                   –   Take into account the public (patient /
                       companion) specificity
                  Strategic follow-up
                  (Tactical Implementation)
                   –   Redesigning existing communication tools
                       and creation of new ones (detail aid, ...)
                   –   Creation and training of a sales’ force
                       dedicated to GPs
Design International Expert Group

                           Situational analysis
                            – Prescribers tend to restrict more and
                              more the use of Fluoroquinolones among
                              Companion Animals
                           Strategic Diagnostic
                            – Prescribers tend to apply Large Animals
                              prescription rules for lack of
                              spokespersons highlighting Companion
                              Animal specificity
                           Strategic Recommendation
                            – Design an European Expert Board eliciting
                              recognized European Guidelines
                           Strategic follow-up
                           (Tactical Implementation)
                            –   Recruit & support members
                            –   Suggest themes and developments
                            –   Supervise premise organisation & logistic
                            –   Develop communication tools
                            –   Work out publication plan and awareness
                                campaign

10/05/2010 confidential                                            27
Enhance Disease Awareness

              Situational analysis
               – Dravet’s syndrome is under
                 diagnosed due to insufficient
                 awareness
              Strategic Diagnostic
               – Orphan Drug status doesn’t allow
                 classic communication
              Strategic Recommendation
               – Medical Education and Unbranded
                 communication are appropriate to
                 elicit significant market penetration
              Strategic follow-up
               (Tactical Implementation)
               –   Design of support
               –   Perform interviews
               –   Editing of interviews and animations
               –   Checking of scientific and medical
                   relevance
Rejuvenate a European Brand

                              Situational analysis
                               –   Major Brand, once innovative, is loosing
                                   market shares at unexpected rate
                              Strategic Diagnostic
                               –   Recent external growth and introduction to
                                   stock exchange of company impact on
                                   stakeholders neglected
                              Strategic Recommendation
                               –   Creation of an International Brand Task Force
                                   composed of the International Marketing
                                   Team and affiliates leaders
                              Strategic follow-up
                               (Tactical Implementation)
                                – Creation of the International Marketing Team
                                    leadership
                                – Animation of task force meeting
                                – Brand rejuvenation along with task force
                                    participants
                                – Press Ad execution supervision and detail
                                    aids content


10/05/2010 confidential
                                                                          29
Re-Launch an International Brand

                  Situational analysis
                   – The launch of the Biomedic portfolio
                      didn’t match expectations
                  Strategic Diagnostic
                   – The initial pure cosmetic positioning
                      was inadequate regarding
                      Dermatologists considering the peeling
                      has a strong effect requiring medical
                      supervision
                   – Side effects elicit a negative image
                      among customers
                  Strategic Recommendation
                   – Reposition portfolio as a “Medical”
                      Must
                   – Create a European expert group to
                      endorse the new positioning
                  Strategic follow-up
                  (Tactical Implementation)
                   – Expert group design and management
                   – Drafting of guidelines for good practice
                     for the use of peeling
                   – Elaboration of CME training modules
                   – Recruit & support speakers
                   – Develop communication tools
                   – Dissemination of the group concept to
                     each target region (Asia, North
                     America, South America)
Shift Paradigms


                                    Situational analysis
                                     –   The French Defence Medical Service has to
                                         switch from an endowment driven to a client
                                         driven activity
                                    Strategic Diagnostic
                                     –   There is a need for a deep and homogeneous
                                         change in management paradigms as well as
                                         clear understanding of the new strategy
                                    Strategic Recommendation
                                     –   Develop a specific appropriation and
                                         implementation methodology
                                    Strategic follow-up
                                    (Tactical Implementation)
                                     –   Contribution to the fine tuning of the strategy
                                     –   Creation of appropriation methodology
                                     –   Develop communication & appropriation
                                         tools
                                     –   Recruit, train & support speakers/high
                                         profile managers


10/05/2010 confidential                                                          31
Manage High Risk Communication

                          Situational analysis
                           – French President elicited the creation
                             of the “multilateral cooperation for
                             defense and security in the Western
                             Mediterranean forum”
                          Strategic Diagnostic
                           –    Territorial conflicts and cultural
                               discrepancies among participants may
                               rise resistance in a highly sensitive
                               context
                          Strategic Recommendation
                           – Encourage experience, knowledge and
                             previous cooperation sharing
                           – Build an event momentum driving
                             participant to sign up a committing
                             multilateral partnership agenda
                          Strategic follow-up
                          (Tactical Implementation)
                           – Co-management of the event
                           – On site elaboration of the draft
                             Covenant
                           – One to one meetings with participant to
                             validate final draft and to encourage
                             covenant signature

10/05/2010 confidential                                        32
Provide High Standards Conferences

     Lectures & Workshops
     Institut of Directors
     Journal of Communication in Healthcare
     Henry Stewart Publishing
     ESReDA (Alstom seminar)
     Eurosatory 2010
     European Defence and Security Meetings
     Paroles d’experts HCFDC
     Ecole de Guerre Economique




10/05/2010 confidential                       33
Pharma Firms which benefited from our
       team members advices
 Abbott             Jancen-Cilag
 Alcon              La Roche Posay
 Allergan           Lilly
 AltanaPharma       Merck
 Astra Zeneca       Nestlé Infant Nutrition
 Biocodex           Novartis Santé Familial
 BMS                Novartis Animal Health
 COOPER             Pfizer
 Eisai              Pharmamar
 Ferring            Sanofi-Aventis
 Fournier           Sanofi-Pasteur
 Fresnius-Kabi      Shering-Plough
 Galderma           Stallergenes
 GSK                Vétoquinol
 Hutchinson         Wyeth
–




    Our costing
    procedure
Our Costing Grid

     StratAdviser approach consist of
      – Setting the level of strategic advice required
      – Determining the required time and team to follow our
        proprietary methodology
      – Applying our costing chart

                                    Functions       Daily rates
                          Director of Strategies             £2,317.00

                          Client Service Director           £1,472.00

                          Director of Operations            £1 227.00
                          Scientific Director               £1 227.00
                          Consultant/
                                                            £1 704.00
                          Expert
                          Account Executive                   £320.00

10/05/2010 confidential                                                  36
Five levels of advice

     Instant advice
      –   The client is confident with his own analysis of the issue he is facing. He doesn't want
          StratAdviser to challenge his analysis and his formulation of the need
      –   The client wants a solution ready to use with short notice
      –   The client doesn't need StratAdviser to integrate the advice or to provide any follow-up regarding
          tactical recommendation linked to the strategic advice that has been provided
     Classic advice
      –   The client is confident with his own analysis of the issue he is facing. He doesn't want
          StratAdviser to challenge his analysis and his formulation of the need
      –   The client wants StratAdviser to deliver a ready to use strategic Prescription as well as the proper
          systematic related Integration Plan and Appropriation Process to solve his issues
      –   The client doesn't need StratAdviser to provide any follow-up regarding tactical recommendation
          linked to the strategic advice that has been provided
     Advanced I & II advice
      –   The client expects StratAdviser to help him to analyse the issue he is facing
      –   The client wants to develop a clear understanding of the situation along with StratAdviser, then to
          build the appropriate strategic response with StratAdviser methodology, then elaborate the proper
          systematic related Integration Plan and Appropriation Process to solve his issues
      –   Eventually, the client needs StratAdviser to provide a follow-up while integrating the advice among
          his usual staff
     Custom
      –   The client expects StratAdviser to challenge his analysis and his formulation of the question
          (other selections are possible)

10/05/2010 confidential                                                                                     37
Average time spent for each levels




       AE: Account Executive ● SD: Scientific Director ● DO: Director of Operations ● CSD: Client Service Director ● DS: Director
       of Strategies ● C/E: Consultant/Expert ● TC: Technical Costs ● OOPs: Out Of Purchase

10/05/2010 confidential                                                                                                             38
Our Commercial policy

     Our estimates reflect a deep analysis of our client’s need with a constant
     concern to find the best compromise between their expectations, their real
     needs and their financial constraints
      – StratAdviser commercial team will invest appropriate time and effort during the
        negotiation phase to come up with the best case scenario estimate
      – In some rare situations, this may imply difficult choices for both parties to be made
     Therefore after the validation of the estimate no adjustment is allowed
     except for the following rules:
      – Account Executives have a goodwill up to 5% rebate
      – Client Service Director have the ability to negotiate another additional 5% rebate if
        the situation justifies it
      – In some exceptional situations, the General Manager might allow to negotiate an
        additional 5% rebate
     In any other case the estimate is voided and a new round is initiated
      – Any validated estimate voided due to client’s direct or indirect decision implies the
        payment of 10% of the estimate in addition of any ready intermediate achievements
        which would be charged “prorata temporis”.
10/05/2010 confidential                                                                         39
More precisely, what are the issues you
 are currently facing?

  Which one should benefit from our
   Strategic Diagnostic,
    Strategic Recommendation &
     Strategic Follow-up?
● Structure development ● Profit development ● Resilience development ● Personal development




   StratAdviser Ltd                                                  StratAdviser France
   Berkeley Square House                                                8 rue Saint Marc
   London W1J 6BD UK                                                 75002 Paris France
                              www.stratadviser.com
   Beata LEWANDOWSKA                                                 Sébastien MODICOM
   Tel: +44 (0) 207 8874510                                   Tel : +33 (0)9 64 25 23 92
   Fax: +44 (0) 796 4330504                                   Fax : +33 (0)1 42 33 44 76
   b.lewandowka@stratadviser.co.uk                          s.modicom@stratadviser.com


                                                                                               41

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Strat Adviser Uk Generic Presentation

  • 1.
  • 2. Our ressources StratAdviser strategic consultants are: – Economists, Scientists and Lawyers • with MSc/MD/PhD in Finance, Strategy, Business, Marketing, Information and communication technologies (ICT), Neuro-Sciences, and Medicine – Multinational individuals • who live and work in an international environment • have a specific knowledge focused on trans-national and trans-cultural issues • as well as they can work in a mono-national context – Proficient in foreign languages such as English, French, Spanish and German StratAdviser key players have: – 10 years or more of experience working in their respective fields • teach management, crisis management, strategy, marketing, communication and medicine • at Business Schools, Engineering Schools and Universities. 10/05/2010 confidential 2
  • 3. Our Fields of Expertise
  • 4. Our International Reach Beata Angel LEWANDOWSKA GONZALEZ Erwan Sébastien YANN MODICOM Søren Brian MUUS Jeffrey FLECK Taylor
  • 5. Our Expert Resources Dr Jan-Cédric HANSEN Medico-Marketing European Strategist 10/05/2010 confidential 5
  • 6. StratAdviser in short StratAdviser impact on Consulting – StratAdviser strategic package • Strategic Diagnosis, Strategic Recommendation and Strategic Follow-up – based on medical processes delivers • valuable strategic advice easy to access and implement • as well as adequate cost control thanks to its simple costing policy StratAdviser and You – Any time your company and/or you face an issue • just contact StratAdviser knowing that – the proper strategic recommendation will be delivered and followed through – adapted to the availability of your financial and human resources 10/05/2010 confidential 6
  • 7. Additional features Registered as a lobbyist with the European Commission – Allows us to deliver specific solutions regarding regulatory issues and the like… All of our recommendations are assessed for legal risk – by a Franco-British Independent lawyer firm 10/05/2010 confidential 7
  • 9. Medical methodology inspires us In medicine, diagnosis is: – the process of identifying a medical condition or disease by its signs, symptoms, and from the results of various diagnostic procedures Doctors are trained to: – take decisions in acute and uncertain situations – constantly challenge and reassess their decisions – think strategically before taking actions StratAdviser considers that such a methodology applies nicely to its client’s needs because diagnosis is a fluid process 10/05/2010 confidential 9
  • 10. High added value oriented In order to deliver high added value advice and ensure its optimal ROI we follow three steps 1. Strategic Diagnosis - allows deeper exploration to re-establish and reformulate the need 2. Strategic Recommendation - develop what to do and how in order to best respond to the need 3. Strategic Follow-up - monitoring the application of recommendations and their positive impact 10/05/2010 confidential 10
  • 11. Proprietary Methodology in Practice
  • 12. Our Strategic « 3 Step » Process Expression of a Strategic Diagnostic Strategic Recommendation potential need (prospecting or spontaneous) Brainstorm Workshop Brainstorm Workshop restitution and reformulation for fine tuning meeting with client for of SD content of SR content clarification of advice level Submission of draft Submission of draft Anamnesis, Investigations Advice prescription, Brainstorm Workshop & Prognosis Integration plan for reformulation of need & selection of appropriate & Appropriation process team/resources no Your yes Validation Submission of draft no Your yes methodology, timeline and Validation global estimate Strategic Follow-up no yes Brainstorm Workshop Your Validation for Tactical Implementation Submission of strategic advice +/- plan of action +/- appropriation plan +/- related additional costs Delivery no yes Your 10/05/2010 confidential Validation 12
  • 13. Our Stategic Diagnostic Step Brand Essence Communication Positioning Statement Personality & Core values Brand Promise & Reasons to Believe Target insight Attributes Features and benefits SWOT Unmet needs Target Audience Descriptors Brand vision 10/05/2010 confidential 13
  • 14. Our Strategic Recommendation Step Optimise pricing Broaden Development and Rapid adoption amongst primary target clinical execution of global Key and secure of Sarcoma Specialists experience reimbursement Life Cycle Plan Strategies • Communication and PR plan to increase • Development • Transition of • Develop and optimize awareness of PharmaMar as an innovative oncology of pan- compassionate formulations company and raise awareness of disease European use to commercial • Working with Cooperative Groups (BC, NSCLC) Pricing and drug • Ensure progression of and Patient Groups (Potentiate formation) reimbursement • Phase IV manufacturing to • Corporate sponsorship of major meetings and strategy programme semi-synthetic bodies PharmaMar stand-alone event ( MoA) • HE plan and • Life cycle plan in • Promotional activities: Global branding and economic • Develop regulatory conjunction with campaign model J&J – new strategies for ex-US • Sequential territories Action Plans • Promotional materials indications (1st line • Congress activities, PharmaMar stand-alone event, launches to STS, breast cancer, NSCLC, • Optimize market Publications optimise price ovarian cancer), exclusivity and patent • PharmaMar internet site and Yondelis website estate more convenient • KOL development regimens (3h • Vehicle (e.g. Ad Board) to review and revise clinical schedule, weekly), • Develop targeted endpoints in sarcoma combinations/ labeling (RR does not correlate with OS) sequential therapy • EORTC collaboration to develop standard with other major classification tools for STS cytotoxics • Increase awareness and usage • Pricing strategy • ATU cohort after • Target profiles for • Complete territory mapping and identification of complete by end CPMP opinion new indications by key stakeholders, prescribers and patient pool by 2002 • Phase IV strategy YE Key Expected 2003 YE • Implementation by by Q1 2003 • GLCP by YE and Results • 2003 Ex factory sales end 2003 presented to Joint • SoV increases 20%p.a., versus Novartis (Glivec), • Launch first in Steering Committee Baxter (ifosf), S-P (Caelyx), Astra-Zeneca Germany, UK and (Irtessa). Sweden 10/05/2010 confidential 14 Example of Yondelis contribution
  • 15. Potential Strategic Synergies Strategic Diagnostic Your communication Agency Brand Pyramid Briefing Communication Platform Visual identity Graphic Chart Strategic Recommendation Strategic Follow-up (Tactical Implementation) Matrix 10/05/2010 confidential 15
  • 16. Continuous Dynamic Interaction Structure and/or Profit Required again and/or Resilience and/or Personal development ? Follow-up Diagnosis & Recommendation StratAdviser Potential achievement Early diagnosis Uncertain environment Potential reaction Natural evolution time 10/05/2010 confidential 16
  • 17. Our Strategic Advice in Practice
  • 18. We build your strategy together One methodology – StratAdviser proprietary methodology Two different kinds of deliverables – Recommendation alone – Recommendation and related deliverables Three ways to collaborate – Long term programs – Annual supports – 1-3 day seminars
  • 19. Our Long Term Programs Corporate/Portfolio Strategic coherence along market evolution Corporate/Portfolio European Strategic Lobbying High Profile Managers Key Decisions process assistance International Marketing Task Force management European Expert Group & Related Publication Plan Prelaunch & Launch Strategic Matrix implementation
  • 20. Our Annual Supports Corporate/Portfolio Strategy Fine Tuning Corporate/Portfolio Strategy Stakeholders Appropriation Corporate/Portfolio Strategy Tactical Field/Market Adaptation Prescribers Scrutiny through Sales’ Forces Optimizing Sales’ Forces impact factor Sales Oriented Medical Education Contextual Incentive
  • 21. Our 1-3 day seminars Market Study Audit New Competitive Edges Competitors’ Strategy Simulation Enhance Brand’s Resilience Joint Strategic Workshops Brand Audit Brand Rejuvenation Portfolio Audit European Creative Seminar Tender Notice Audit Lecture & Workshops
  • 22. Let Our “ Lectures & Workshops ” be your “ Lectures & Workshops ” Available conferences 2009-2010 – “Crisis communication, legal issues & economic impact of the pandemic threat” – “Expanding your European position despite inhomogeneous maturation of portfolio among target countries” – “Understanding benefits of brand vs product communication strategy” – “Strategic healthcare communication during crisis management” – “Turning affiliates “specificity” into powerful European strategy” – “Strengthening European cooperation between pharmaceutical Industry and Private Hospitals: a promising competitive edge” Coming conferences 2011-2012 – “Post crisis management, frequent mistakes and consequences” – “Efficient Orphan drugs marketing approach: musts and options” – “Key topics to understand the Japanese market entry limitations” – “Rising competition among generics: time for redesigning the brand concept?” – “Terms and Conditions of Sales as a competitive edge” – “Identification of new communication themes for MEDED programs” 10/05/2010 confidential 22
  • 23. Samples of Strategic Advices and Related Deliverables
  • 24. Provide High Value European Insights Situational analysis – Need for global expertise regarding the European Market and specificity of European healthcare systems Strategic Diagnostic – Content analysis of available publication on the disease – Reassessment of available Market Studies – Identification and Interviews of KOL – Cross matching of findings with StratAdviser expertise Strategic Recommendation – Drafting of preliminary report to fuel the strategic thinking including promising positioning & potential communication plan Strategic follow-up (Tactical Implementation) – Left to our client
  • 25. Deliver High Standard Expertise Situational analysis – A spring water trade organisation is sued by a mineral water trade company for improper health claim Strategic Diagnostic – The trial is backed up by a report from the French Academy of Medicine – Risk is that the trial outcome will ultimately apply to all spring water manufacturers Strategic Recommendation – Strike back should be managed by the spring water trade union – Need for a contradictory report with higher quality standards to neutralize the French Academy of Medicine Strategic follow-up (Tactical Implementation) – Deep analysis of the French Academy of Medicine report and writing of the contradictory report – Work in tandem with the trade Union Lawyer Firm – Help the client in implementing its lobbying actions 10/05/2010 confidential 25
  • 26. Elaborate Strategic Positioning Situational analysis – A thermal Bath faces constant regression of turnover Strategic Diagnostic – Thermal Bath location and accommodations inadequate to drain clients by themselves – Thermal medicine no longer considered as a reference for chronic conditions by GPs – 100% of French centres for burned patients refer cases to the Thermal bath Strategic Recommendation – Reinvest the neglected local medical expertise – Position the Thermal Bath as “First European Dermatology Spa” – Take into account the public (patient / companion) specificity Strategic follow-up (Tactical Implementation) – Redesigning existing communication tools and creation of new ones (detail aid, ...) – Creation and training of a sales’ force dedicated to GPs
  • 27. Design International Expert Group Situational analysis – Prescribers tend to restrict more and more the use of Fluoroquinolones among Companion Animals Strategic Diagnostic – Prescribers tend to apply Large Animals prescription rules for lack of spokespersons highlighting Companion Animal specificity Strategic Recommendation – Design an European Expert Board eliciting recognized European Guidelines Strategic follow-up (Tactical Implementation) – Recruit & support members – Suggest themes and developments – Supervise premise organisation & logistic – Develop communication tools – Work out publication plan and awareness campaign 10/05/2010 confidential 27
  • 28. Enhance Disease Awareness Situational analysis – Dravet’s syndrome is under diagnosed due to insufficient awareness Strategic Diagnostic – Orphan Drug status doesn’t allow classic communication Strategic Recommendation – Medical Education and Unbranded communication are appropriate to elicit significant market penetration Strategic follow-up (Tactical Implementation) – Design of support – Perform interviews – Editing of interviews and animations – Checking of scientific and medical relevance
  • 29. Rejuvenate a European Brand Situational analysis – Major Brand, once innovative, is loosing market shares at unexpected rate Strategic Diagnostic – Recent external growth and introduction to stock exchange of company impact on stakeholders neglected Strategic Recommendation – Creation of an International Brand Task Force composed of the International Marketing Team and affiliates leaders Strategic follow-up (Tactical Implementation) – Creation of the International Marketing Team leadership – Animation of task force meeting – Brand rejuvenation along with task force participants – Press Ad execution supervision and detail aids content 10/05/2010 confidential 29
  • 30. Re-Launch an International Brand Situational analysis – The launch of the Biomedic portfolio didn’t match expectations Strategic Diagnostic – The initial pure cosmetic positioning was inadequate regarding Dermatologists considering the peeling has a strong effect requiring medical supervision – Side effects elicit a negative image among customers Strategic Recommendation – Reposition portfolio as a “Medical” Must – Create a European expert group to endorse the new positioning Strategic follow-up (Tactical Implementation) – Expert group design and management – Drafting of guidelines for good practice for the use of peeling – Elaboration of CME training modules – Recruit & support speakers – Develop communication tools – Dissemination of the group concept to each target region (Asia, North America, South America)
  • 31. Shift Paradigms Situational analysis – The French Defence Medical Service has to switch from an endowment driven to a client driven activity Strategic Diagnostic – There is a need for a deep and homogeneous change in management paradigms as well as clear understanding of the new strategy Strategic Recommendation – Develop a specific appropriation and implementation methodology Strategic follow-up (Tactical Implementation) – Contribution to the fine tuning of the strategy – Creation of appropriation methodology – Develop communication & appropriation tools – Recruit, train & support speakers/high profile managers 10/05/2010 confidential 31
  • 32. Manage High Risk Communication Situational analysis – French President elicited the creation of the “multilateral cooperation for defense and security in the Western Mediterranean forum” Strategic Diagnostic – Territorial conflicts and cultural discrepancies among participants may rise resistance in a highly sensitive context Strategic Recommendation – Encourage experience, knowledge and previous cooperation sharing – Build an event momentum driving participant to sign up a committing multilateral partnership agenda Strategic follow-up (Tactical Implementation) – Co-management of the event – On site elaboration of the draft Covenant – One to one meetings with participant to validate final draft and to encourage covenant signature 10/05/2010 confidential 32
  • 33. Provide High Standards Conferences Lectures & Workshops Institut of Directors Journal of Communication in Healthcare Henry Stewart Publishing ESReDA (Alstom seminar) Eurosatory 2010 European Defence and Security Meetings Paroles d’experts HCFDC Ecole de Guerre Economique 10/05/2010 confidential 33
  • 34. Pharma Firms which benefited from our team members advices Abbott Jancen-Cilag Alcon La Roche Posay Allergan Lilly AltanaPharma Merck Astra Zeneca Nestlé Infant Nutrition Biocodex Novartis Santé Familial BMS Novartis Animal Health COOPER Pfizer Eisai Pharmamar Ferring Sanofi-Aventis Fournier Sanofi-Pasteur Fresnius-Kabi Shering-Plough Galderma Stallergenes GSK Vétoquinol Hutchinson Wyeth
  • 35. Our costing procedure
  • 36. Our Costing Grid StratAdviser approach consist of – Setting the level of strategic advice required – Determining the required time and team to follow our proprietary methodology – Applying our costing chart Functions Daily rates Director of Strategies £2,317.00 Client Service Director £1,472.00 Director of Operations £1 227.00 Scientific Director £1 227.00 Consultant/ £1 704.00 Expert Account Executive £320.00 10/05/2010 confidential 36
  • 37. Five levels of advice Instant advice – The client is confident with his own analysis of the issue he is facing. He doesn't want StratAdviser to challenge his analysis and his formulation of the need – The client wants a solution ready to use with short notice – The client doesn't need StratAdviser to integrate the advice or to provide any follow-up regarding tactical recommendation linked to the strategic advice that has been provided Classic advice – The client is confident with his own analysis of the issue he is facing. He doesn't want StratAdviser to challenge his analysis and his formulation of the need – The client wants StratAdviser to deliver a ready to use strategic Prescription as well as the proper systematic related Integration Plan and Appropriation Process to solve his issues – The client doesn't need StratAdviser to provide any follow-up regarding tactical recommendation linked to the strategic advice that has been provided Advanced I & II advice – The client expects StratAdviser to help him to analyse the issue he is facing – The client wants to develop a clear understanding of the situation along with StratAdviser, then to build the appropriate strategic response with StratAdviser methodology, then elaborate the proper systematic related Integration Plan and Appropriation Process to solve his issues – Eventually, the client needs StratAdviser to provide a follow-up while integrating the advice among his usual staff Custom – The client expects StratAdviser to challenge his analysis and his formulation of the question (other selections are possible) 10/05/2010 confidential 37
  • 38. Average time spent for each levels AE: Account Executive ● SD: Scientific Director ● DO: Director of Operations ● CSD: Client Service Director ● DS: Director of Strategies ● C/E: Consultant/Expert ● TC: Technical Costs ● OOPs: Out Of Purchase 10/05/2010 confidential 38
  • 39. Our Commercial policy Our estimates reflect a deep analysis of our client’s need with a constant concern to find the best compromise between their expectations, their real needs and their financial constraints – StratAdviser commercial team will invest appropriate time and effort during the negotiation phase to come up with the best case scenario estimate – In some rare situations, this may imply difficult choices for both parties to be made Therefore after the validation of the estimate no adjustment is allowed except for the following rules: – Account Executives have a goodwill up to 5% rebate – Client Service Director have the ability to negotiate another additional 5% rebate if the situation justifies it – In some exceptional situations, the General Manager might allow to negotiate an additional 5% rebate In any other case the estimate is voided and a new round is initiated – Any validated estimate voided due to client’s direct or indirect decision implies the payment of 10% of the estimate in addition of any ready intermediate achievements which would be charged “prorata temporis”. 10/05/2010 confidential 39
  • 40. More precisely, what are the issues you are currently facing? Which one should benefit from our Strategic Diagnostic, Strategic Recommendation & Strategic Follow-up?
  • 41. ● Structure development ● Profit development ● Resilience development ● Personal development StratAdviser Ltd StratAdviser France Berkeley Square House 8 rue Saint Marc London W1J 6BD UK 75002 Paris France www.stratadviser.com Beata LEWANDOWSKA Sébastien MODICOM Tel: +44 (0) 207 8874510 Tel : +33 (0)9 64 25 23 92 Fax: +44 (0) 796 4330504 Fax : +33 (0)1 42 33 44 76 b.lewandowka@stratadviser.co.uk s.modicom@stratadviser.com 41