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The Application of Non-Combinatorial Chemistry to Lead Discovery

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Graham Smith
Graham Smith

The Application of Non-Combinatorial Chemistry to Lead Discovery. The evolution of purified non-combinatorial libraries as the way forward in parallel synthesis. Given at Lab automation 2002 Palm Springs

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The Application of Non-Combinatorial Chemistry to Lead Discovery Dr Graham F. Smith Library Design and Production Group Pfizer Global R & D Sandwich, UK See Drug Discovery Today, 2001, volume 6, No. 15, p779-785
Parallel synthesis is a powerful technique The application of automation, parallelisation and miniaturization of Organic Chemistry has radically changed Chemistry Departments in Pharmaceutical companies. Combinatorial Chemistry is only one possible use of parallel synthesis
Our Groups Initial Goals ,[object Object],[object Object],[object Object],[object Object],[object Object]
Non Combinatorial Chemistry ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diversity ,[object Object],[object Object],[object Object],[object Object],[object Object]
Large clusters high similarity Cluster algorithm from Mike Miller - PGRD Groton USA Small clusters low similarity Spotfire Shenghua Shi
IT for Non Combinatorial Chemistry - LiCRA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LDP - Technology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
Technology in use (2) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Unforeseen advantages of Non Combinatorial Chemistry and HPLC library purification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acknowledgements ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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The Application of Non-Combinatorial Chemistry to Lead Discovery

  • 1. The Application of Non-Combinatorial Chemistry to Lead Discovery Dr Graham F. Smith Library Design and Production Group Pfizer Global R & D Sandwich, UK See Drug Discovery Today, 2001, volume 6, No. 15, p779-785
  • 2. Parallel synthesis is a powerful technique The application of automation, parallelisation and miniaturization of Organic Chemistry has radically changed Chemistry Departments in Pharmaceutical companies. Combinatorial Chemistry is only one possible use of parallel synthesis
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  • 6. Large clusters high similarity Cluster algorithm from Mike Miller - PGRD Groton USA Small clusters low similarity Spotfire Shenghua Shi
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