Caco-2 cell permeability assay for drug absorption
Heart
1.
2. Our pump — the heart
The heart is a muscular organ as big as our
fist.
The heart has different chambers to transport
oxygenated and de-oxygenated blood and to
prevent them from mixing.
The conversion takes place in the lungs
3.
4. WORKING OF A HEART
• Oxygen-rich blood from the lungs comes to
the thin-walled upper chamber of the heart
on the left, the left atrium.
• The left atrium relaxes when it is collecting
this blood. It then contracts, while the next
chamber, the left ventricle, expands, so that
the blood is transferred to it.
• When the muscular left ventricle contracts in
its turn, the blood is pumped out to the body.
5. Working Cont……..
• De-oxygenated blood comes from the body to
the upper chamber on the right, the right
atrium, as it expands.
• As the right atrium contracts, the
corresponding lower chamber, the right
ventricle, dilates.
• This transfers blood to the right ventricle,
which in turn pumps it to the lungs for
oxygenation.
7. Heart Diseases
• Coronary Artery Disease – Problem with blood
vessels.
• Congestive Heart Failure- Pumping not at normal
levels.
• Bad Heart Rhythms – related to electrical activity.
8.
9. Symptoms of Heart Disease
• Pain in the chest--the heart muscle is not getting
enough flow to keep it going.
• Trouble breathing--blood may back up into the lungs.
• Palpitations (a feeling that the heart is beating too fast,
too hard, or not regular).
• Swelling of feet or legs--blood is backing up from in the
lower body.
• Feeling weak because the body and brain are not
getting enough blood to supply them with oxygen.
• Cyanosis (skin turning a blue colour) means that too
little oxygen is in the bloodstream to supply the cells in
the body.
10.
11. Causes
• High blood pressure
• High Blood cholesterol
• Diabetes
• Obesity
• Smoking
• Heredity
• Stress