Outbreak of High Patogen Avian Influenza H5N8 in Germany
Science café zeist, maart 2011.ppt ingepakt
1. Infectieziekten, Risico of Fictie? Science café Zeist, 10 maart 2011 Roel A. Coutinho 5 maart 2011 Center for Infectious Disease Control National Institute for Public Health and the Environment Bilthoven Academic Medical Center University of Amsterdam
17. 5 maart 2011 PB2 PB1 PA HA NP NA MA NS A/California/4/2009 Vermoedelijke samenstelling van het H1N1 Mexicaanse griep virus Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team*, New England Journal of Medicine, 2009 Nieuwe griep virus is ontstaan door mengen van genen PB2,PA: PB1: ~ 1998 ~ 1968 ~ 1998 HA, NP, NS: ~ 1918 NA, MA: ~ 1979 Classical swine Eurasian swine Triple reassortant
18. Leeftijdsverdeling van patiënten met ziekenhuisopname wegens laboratorium bevestigde of waarschijnlijke Nieuwe Influenza A (H1N1) t/m 10 maart 2010 ( n=2201*) 5 maart 2011 Bron: Osiris / Pandora / CIb * Er ontbreken 46 ziekenhuisopnames in de grafiek door onvolledige informatie.
19. Aantal sterfgevallen met laboratorium bevestigde Nieuwe Influenza A (H1N1) per week t/m 10 maart 2010 ( n=56*) 5 maart 2011 Bron: Osiris / Pandora / CIb * Van 2 sterfgevallen zijn nog niet alle gegevens bekend waardoor deze niet in de grafiek worden getoond.
26. Risk of new vectors 5 maart 2011 Aedes albopictus (vector for flaviviruses, SE-Asia) Since nineties in Southern Europe 2005 imports through “lucky-bamboo” in Holland Can it survive, settle in Holland?
27. 5 maart 2011 Map 2 – Areas for possible establishment of Aedes albopictus in Europe based on 5 climate scenarios.
28. 5 maart 2011 Day 7 : : KAD informs surrounding area (mostly companies) and starts with removal potential breeding sites. One albopictus female is found close to company site (in BG sentinel trap) and one Ae. aegypti female (on human), also close to the company. Two French experts arrive, treatment starts late evening at company site in Heijningen with adulticiding (aqua-K-othrine). VROM inspection is present.
29. 5 maart 2011 Methicillin-resistant Staphylococcus aureus in Pig Farming Andreas Voss,*† Frans Loeffen,* Judith Bakker,* Corne Klaassen,† and Mireille Wulf* *Radboud University Medical Centre, Nijmegen, the Netherlands; and †Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands We conducted a study among a group of 26 regional pig farmers to determine the methicillin-resistant Staphylococcus aureus prevalence rate and found it was >760 times greater than the rate of patients admitted to Dutch hospitals. While spa -type t108 is apparently a more widespread clone among pig farmers and their environment, we did find other spa -types. Emerg Infect Dis. 2005 Dec;11(12):1965-6
31. The proportion of ESBL positive BLOOD isolates per year 3.9% 5.7% 4.6% 6.3% 5.7% 9.1% = E. coli = K. pneumoniae 2008 2009 2010 Increase : E. coli 46% K. pneumoniae 60%
42. 5 maart 2011 Summary of evidence for an environmental route of resistance development A single dominant resistance mechanism: TR/L98H A TR is a common resistance mechanism in plant pathogenic molds TR/L98H A. fumigatus in azole-naïve patients TR/L98H A. fumigatus was found in cultivated soil
43. 5 maart 2011 VWS / ZonMw Universiteit ziekenhuis WIP SWAB GGD Nederland BZK / LNV beroepsvereniging onderzoek preventie bestrijding Beleid VGZ Centrum GGD MML huisarts specialist KNCV-TB WHO SOA AIDS VWA ECDC