10. COMPARATIVE PATHOLOGIC FEATURES OF COMPLETE AND PARTIAL HYDATIDIFORM MOLE Feature Complete Mole Partial Mole Karyotype Usually diploid 46XX Usually triploidy 69XXX most common. Villi All villi hydropin; no normal adjacent villi Normal adjacent villi may be present vessels present they contain no fetal blood cells blood cells Fetal tissue None present Usually present Trophoblast Hyperplasia usually present to variable degrees Hyperplasia mild and focal Uterine size More than date Less than date Theca Lutein cyst 30-60% common Uncommon b HCG High more than 50 thousand Less than 50 thousand Risk of persistent GTN 20% <5% Classical clinical symptoms Common Uncommon
14. Here is a partial mole in a case of triploidy. Note the scattered grape-like masses with intervening normal-appearing placental tissue.
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16. CLINICAL RISK FACTORS FOR MOLAR PREGNANCY Age (extremes of reproductive years) <15 >40 Reproductive history prior hydatidiform mole prior spontaneous abortion Diet Vitamin A deficiency Birthplace Outside North America( occasionally has this disease)
21. Color Dopplor facilitates visualization of the enlarged spiral arteriesclose proximity to the “ snow storm ” appearance
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23. Large bilateral theca lutein cysts resembling ovarian germ cell tumors. With resolution of the human chorionic gonadotropin(HCG) stimulation, they return to normal-appearing ovaries.
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26. A sonographic findings of a molar pregnancy. The characteristic “ snowstorm ” pattern is evident.
34. Invasive mole: the tissue invades into the myometrial layer. No obvious borderline, with obvious bleeding.
35. A case of invasive mole: inside the uterine cavity the typical “ snow storm ” appearance can be detected, The location of blood flow suggest an invasive mole.