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Data Management in Research:
      Your data is an asset



Philips Research
e-Science Support group
September, 2012
Your data is an asset
       Observations
•   Science is getting data-centric/intensive
•   Many Research projects are data-intensive
•   Upcoming business models are data-intensive
•   Data are expensive assets: re-use of data is needed
•   Data analytics combines information from very heterogeneous data sets


       Examples of Data
• Data from clinical trials, captured by instruments, generated by
  simulations and generated by sensor networks.
• Data are medical images, patient records, physiological data, laboratory
  data, genetic data, logging data, surveys, etc.

                                                                             2
Example: Clinical Decision Support
             (data generation)                    (knowledge
                                                    creation)
    Imaging physics                   Clinical science
    • CT and PET                       • clinical trials
      scanners                         • medical literature
    • MRI magnet design                • evidence-based
      and pulse sequences                medicine
    • high resolution /
      contrast

   (data augmentation/ improvement)                   (evidence
                                                     integration)
    Image processing                      Imaging informatics
                                          •   computer-aided detection
    •   segmentation
                                          •   computer-aided quantification
    •   registration
                                          •   computer-aided diagnosis
    •   modeling
                                          •   intelligent image retrieval
    •   visualization
                                          •   therapy planning



                                                                              3
Example: Home Health Care




                  +



                            4
Example: Embedded Neonatal Monitoring
Develop and validate embedded neonatal monitoring targeted at the NICU
workstation that will improve the workflow and increase patient comfort.



                                                                     Contactless
                                                                     Core and Peripheral
                                                                     Temperature




                           Mechanical                                                                       Capacitive ECG
                           sensors for Heart                                                                sensing
                           Rate and
                           Breathing Rate




                                                                     Reflective SpO2




                                                                                                                             5
                                               Courtesy: Martijn Schellekens, Patient Care Solutions, Philips Research
Your data is an asset


                Challenges
 • Legal requirements like protecting sensitive data (privacy)
 • End-to-end solutions: from data acquisition to analytics
 • The very large heteroginity of data
 • Need to re-use of data sets which requires to largely improve the data
   management maturity level
 • Preservation: archiving for long term use and retrieval




                                                                            6
Data Management Maturity Level
             Level 4:
             - Integration of workflows and data management
             - Frameworks that handle data, workflows and applications

             Level 3:
             - Data standards in place, (e.g. from naming conventions to interfaces)
             - High level data interfaces
   Improve




             - Data can be used across projects

             Level 2:
             - Handling Data privacy is in place
             - Data about the data is available (metadata)

             Level 1:
             - Disaster recovery (backup, archive).
             - Access control: Authentication and authorization

                                                                                       7
Example: Data Acquisition and Analysis Workflow
Reusable implementation for time series
                                                    Central catalogue
                                                      of data sets


                                   Viewer
      Data
    Acquisition
                                                        Data Vault                        Data
                    e.g. Labview




                                    Local




                                                                                   API
                                   Storage                                               Analysis
                                                           Standard                      (Offline)
     Analysis                      Standard                data format
     (Real-time)                                     e.g. (tdms, edf, bdf, wfdb)
                                   data format
                      (e.g. tdms, edf, bdf, wfdb)




     On-site Data Acquisition                       Off-site Storage and Data Analysis



                                                                                                     8
Example: CTMM TraIT data flows
  Hospital (IT)                      Translational Research (IT)
                      data domains
           HIS
                        clinical                       integrated                 translational
                                                          data                      research
                          Open
                          Clinica                                                  workspace
          PACS

                        imaging
                  T
           LIS    T       NBIA
                                                             e.g.
                  P   biobanking
                                                         tranSMART

  Research (IT)
                           e.g.
                                                                                             e.g. R
   LIMS                  caTissue


                      experimental
   Public Data
                          Various
                         solutions
    …


                                     Courtesy: Wim van der Linden, Henk Obbink, Philips Research and CTMM TraIT
                                                                                                              9
Your data is an asset!
            Recommendations
• Think end-to-end: from data acquisition
  to data analytics
• Enable and support re-use of data
    – Mature data management in the data lifecycle is a pre-requisite
    – Add meta data and annotations, Use ontologies
    – Manage data privacy
    – Provide catalogue of available data sets
• Introduce standard data management solutions
    – Use what is out there!
• Provide dedicated expertise and support
    – Surf eScience Center




                                                                        10
11

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Developments in datamanagement

  • 1. Data Management in Research: Your data is an asset Philips Research e-Science Support group September, 2012
  • 2. Your data is an asset Observations • Science is getting data-centric/intensive • Many Research projects are data-intensive • Upcoming business models are data-intensive • Data are expensive assets: re-use of data is needed • Data analytics combines information from very heterogeneous data sets Examples of Data • Data from clinical trials, captured by instruments, generated by simulations and generated by sensor networks. • Data are medical images, patient records, physiological data, laboratory data, genetic data, logging data, surveys, etc. 2
  • 3. Example: Clinical Decision Support (data generation) (knowledge creation) Imaging physics Clinical science • CT and PET • clinical trials scanners • medical literature • MRI magnet design • evidence-based and pulse sequences medicine • high resolution / contrast (data augmentation/ improvement) (evidence integration) Image processing Imaging informatics • computer-aided detection • segmentation • computer-aided quantification • registration • computer-aided diagnosis • modeling • intelligent image retrieval • visualization • therapy planning 3
  • 5. Example: Embedded Neonatal Monitoring Develop and validate embedded neonatal monitoring targeted at the NICU workstation that will improve the workflow and increase patient comfort. Contactless Core and Peripheral Temperature Mechanical Capacitive ECG sensors for Heart sensing Rate and Breathing Rate Reflective SpO2 5 Courtesy: Martijn Schellekens, Patient Care Solutions, Philips Research
  • 6. Your data is an asset Challenges • Legal requirements like protecting sensitive data (privacy) • End-to-end solutions: from data acquisition to analytics • The very large heteroginity of data • Need to re-use of data sets which requires to largely improve the data management maturity level • Preservation: archiving for long term use and retrieval 6
  • 7. Data Management Maturity Level Level 4: - Integration of workflows and data management - Frameworks that handle data, workflows and applications Level 3: - Data standards in place, (e.g. from naming conventions to interfaces) - High level data interfaces Improve - Data can be used across projects Level 2: - Handling Data privacy is in place - Data about the data is available (metadata) Level 1: - Disaster recovery (backup, archive). - Access control: Authentication and authorization 7
  • 8. Example: Data Acquisition and Analysis Workflow Reusable implementation for time series Central catalogue of data sets Viewer Data Acquisition Data Vault Data e.g. Labview Local API Storage Analysis Standard (Offline) Analysis Standard data format (Real-time) e.g. (tdms, edf, bdf, wfdb) data format (e.g. tdms, edf, bdf, wfdb) On-site Data Acquisition Off-site Storage and Data Analysis 8
  • 9. Example: CTMM TraIT data flows Hospital (IT) Translational Research (IT) data domains HIS clinical integrated translational data research Open Clinica workspace PACS imaging T LIS T NBIA e.g. P biobanking tranSMART Research (IT) e.g. e.g. R LIMS caTissue experimental Public Data Various solutions … Courtesy: Wim van der Linden, Henk Obbink, Philips Research and CTMM TraIT 9
  • 10. Your data is an asset! Recommendations • Think end-to-end: from data acquisition to data analytics • Enable and support re-use of data – Mature data management in the data lifecycle is a pre-requisite – Add meta data and annotations, Use ontologies – Manage data privacy – Provide catalogue of available data sets • Introduce standard data management solutions – Use what is out there! • Provide dedicated expertise and support – Surf eScience Center 10
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